Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison
Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Phillips, Kristin M. [verfasserIn] Pinilla-Ibarz, Javier [verfasserIn] Sotomayor, Eduardo [verfasserIn] Lee, Morgan R. [verfasserIn] Jim, Heather S. L. [verfasserIn] Small, Brent J. [verfasserIn] Sokol, Lubomir [verfasserIn] Lancet, Jeffrey [verfasserIn] Tinsley, Sara [verfasserIn] Sweet, Kendra [verfasserIn] Komrokji, Rami [verfasserIn] Jacobsen, Paul B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Supportive care in cancer - Berlin : Springer, 1993, 21(2012), 4 vom: 20. Nov., Seite 1097-1103 |
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| Übergeordnetes Werk: |
volume:21 ; year:2012 ; number:4 ; day:20 ; month:11 ; pages:1097-1103 |
| Links: |
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| DOI / URN: |
10.1007/s00520-012-1630-5 |
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| Katalog-ID: |
SPR006592929 |
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| 245 | 1 | 0 | |a Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
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| 520 | |a Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. | ||
| 650 | 4 | |a Cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Quality of life |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Depression |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Fatigue |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Pinilla-Ibarz, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Sotomayor, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Morgan R. |e verfasserin |4 aut | |
| 700 | 1 | |a Jim, Heather S. L. |e verfasserin |4 aut | |
| 700 | 1 | |a Small, Brent J. |e verfasserin |4 aut | |
| 700 | 1 | |a Sokol, Lubomir |e verfasserin |4 aut | |
| 700 | 1 | |a Lancet, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Tinsley, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Sweet, Kendra |e verfasserin |4 aut | |
| 700 | 1 | |a Komrokji, Rami |e verfasserin |4 aut | |
| 700 | 1 | |a Jacobsen, Paul B. |e verfasserin |4 aut | |
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10.1007/s00520-012-1630-5 doi (DE-627)SPR006592929 (SPR)s00520-012-1630-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Phillips, Kristin M. verfasserin aut Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. Cancer (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Fatigue (dpeaa)DE-He213 Pinilla-Ibarz, Javier verfasserin aut Sotomayor, Eduardo verfasserin aut Lee, Morgan R. verfasserin aut Jim, Heather S. L. verfasserin aut Small, Brent J. verfasserin aut Sokol, Lubomir verfasserin aut Lancet, Jeffrey verfasserin aut Tinsley, Sara verfasserin aut Sweet, Kendra verfasserin aut Komrokji, Rami verfasserin aut Jacobsen, Paul B. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 21(2012), 4 vom: 20. Nov., Seite 1097-1103 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 https://dx.doi.org/10.1007/s00520-012-1630-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 21 2012 4 20 11 1097-1103 |
| spelling |
10.1007/s00520-012-1630-5 doi (DE-627)SPR006592929 (SPR)s00520-012-1630-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Phillips, Kristin M. verfasserin aut Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. Cancer (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Fatigue (dpeaa)DE-He213 Pinilla-Ibarz, Javier verfasserin aut Sotomayor, Eduardo verfasserin aut Lee, Morgan R. verfasserin aut Jim, Heather S. L. verfasserin aut Small, Brent J. verfasserin aut Sokol, Lubomir verfasserin aut Lancet, Jeffrey verfasserin aut Tinsley, Sara verfasserin aut Sweet, Kendra verfasserin aut Komrokji, Rami verfasserin aut Jacobsen, Paul B. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 21(2012), 4 vom: 20. Nov., Seite 1097-1103 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 https://dx.doi.org/10.1007/s00520-012-1630-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 21 2012 4 20 11 1097-1103 |
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10.1007/s00520-012-1630-5 doi (DE-627)SPR006592929 (SPR)s00520-012-1630-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Phillips, Kristin M. verfasserin aut Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. Cancer (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Fatigue (dpeaa)DE-He213 Pinilla-Ibarz, Javier verfasserin aut Sotomayor, Eduardo verfasserin aut Lee, Morgan R. verfasserin aut Jim, Heather S. L. verfasserin aut Small, Brent J. verfasserin aut Sokol, Lubomir verfasserin aut Lancet, Jeffrey verfasserin aut Tinsley, Sara verfasserin aut Sweet, Kendra verfasserin aut Komrokji, Rami verfasserin aut Jacobsen, Paul B. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 21(2012), 4 vom: 20. Nov., Seite 1097-1103 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 https://dx.doi.org/10.1007/s00520-012-1630-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 21 2012 4 20 11 1097-1103 |
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10.1007/s00520-012-1630-5 doi (DE-627)SPR006592929 (SPR)s00520-012-1630-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Phillips, Kristin M. verfasserin aut Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. Cancer (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Fatigue (dpeaa)DE-He213 Pinilla-Ibarz, Javier verfasserin aut Sotomayor, Eduardo verfasserin aut Lee, Morgan R. verfasserin aut Jim, Heather S. L. verfasserin aut Small, Brent J. verfasserin aut Sokol, Lubomir verfasserin aut Lancet, Jeffrey verfasserin aut Tinsley, Sara verfasserin aut Sweet, Kendra verfasserin aut Komrokji, Rami verfasserin aut Jacobsen, Paul B. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 21(2012), 4 vom: 20. Nov., Seite 1097-1103 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 https://dx.doi.org/10.1007/s00520-012-1630-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 21 2012 4 20 11 1097-1103 |
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10.1007/s00520-012-1630-5 doi (DE-627)SPR006592929 (SPR)s00520-012-1630-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Phillips, Kristin M. verfasserin aut Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. Cancer (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Fatigue (dpeaa)DE-He213 Pinilla-Ibarz, Javier verfasserin aut Sotomayor, Eduardo verfasserin aut Lee, Morgan R. verfasserin aut Jim, Heather S. L. verfasserin aut Small, Brent J. verfasserin aut Sokol, Lubomir verfasserin aut Lancet, Jeffrey verfasserin aut Tinsley, Sara verfasserin aut Sweet, Kendra verfasserin aut Komrokji, Rami verfasserin aut Jacobsen, Paul B. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 21(2012), 4 vom: 20. Nov., Seite 1097-1103 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 https://dx.doi.org/10.1007/s00520-012-1630-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 21 2012 4 20 11 1097-1103 |
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Enthalten in Supportive care in cancer 21(2012), 4 vom: 20. Nov., Seite 1097-1103 volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 |
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Enthalten in Supportive care in cancer 21(2012), 4 vom: 20. Nov., Seite 1097-1103 volume:21 year:2012 number:4 day:20 month:11 pages:1097-1103 |
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Phillips, Kristin M. @@aut@@ Pinilla-Ibarz, Javier @@aut@@ Sotomayor, Eduardo @@aut@@ Lee, Morgan R. @@aut@@ Jim, Heather S. L. @@aut@@ Small, Brent J. @@aut@@ Sokol, Lubomir @@aut@@ Lancet, Jeffrey @@aut@@ Tinsley, Sara @@aut@@ Sweet, Kendra @@aut@@ Komrokji, Rami @@aut@@ Jacobsen, Paul B. @@aut@@ |
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While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). 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Phillips, Kristin M. |
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Phillips, Kristin M. ddc 610 bkl 44.81 misc Cancer misc Quality of life misc Depression misc Fatigue Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
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610 ASE 44.81 bkl Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison Cancer (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Fatigue (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Cancer misc Quality of life misc Depression misc Fatigue |
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Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
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Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
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Phillips, Kristin M. |
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Phillips, Kristin M. Pinilla-Ibarz, Javier Sotomayor, Eduardo Lee, Morgan R. Jim, Heather S. L. Small, Brent J. Sokol, Lubomir Lancet, Jeffrey Tinsley, Sara Sweet, Kendra Komrokji, Rami Jacobsen, Paul B. |
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Phillips, Kristin M. |
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10.1007/s00520-012-1630-5 |
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quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
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Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
| abstract |
Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. |
| abstractGer |
Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. |
| abstract_unstemmed |
Purpose Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL). Methods This study compared CML patients taking a TKI for an average of 4.01 years (range 0.50–9.79 years) to age- and gender-matched controls with no history of cancer on measures of symptom burden, depression, fatigue, sleep, and health-related QOL. Results Compared to controls (n = 62), CML patients (n = 62) taking a TKI (imatinib 55 %, nilotinib 31 %, and dasatinib 14 %) reported significantly worse fatigue severity (p < .001), fatigue interference (p < .001), depression (p = .007), symptom burden (p < .001), and physical QOL (p < .001). TKI patients were also more likely meet established cutoffs for clinically meaningful fatigue (p values < .001) and depression (p = .004). There were no differences in mental QOL or sleep (p values > .010). Regarding specific symptoms, TKI patients were more likely to report nausea, diarrhea, itching, skin changes, swelling of arms or legs, and not looking like themselves (p values < .001). Conclusions These data suggest the need for interventions to address QOL in CML patients taking TKIs. |
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Quality of life outcomes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a controlled comparison |
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Pinilla-Ibarz, Javier Sotomayor, Eduardo Lee, Morgan R. Jim, Heather S. L. Small, Brent J. Sokol, Lubomir Lancet, Jeffrey Tinsley, Sara Sweet, Kendra Komrokji, Rami Jacobsen, Paul B. |
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Pinilla-Ibarz, Javier Sotomayor, Eduardo Lee, Morgan R. Jim, Heather S. L. Small, Brent J. Sokol, Lubomir Lancet, Jeffrey Tinsley, Sara Sweet, Kendra Komrokji, Rami Jacobsen, Paul B. |
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| score |
7.3985376 |