Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study
Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 el...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ogata, Yutaka [verfasserIn] Ishibashi, Nobuya [verfasserIn] Yamaguchi, Keizou [verfasserIn] Uchida, Shinji [verfasserIn] Kamei, Hideki [verfasserIn] Nakayama, Goichi [verfasserIn] Hirakawa, Hiroaki [verfasserIn] Tanigawa, Masahiko [verfasserIn] Akagi, Yoshito [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Supportive care in cancer - Berlin : Springer, 1993, 24(2015), 2 vom: 13. Aug., Seite 783-789 |
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| Übergeordnetes Werk: |
volume:24 ; year:2015 ; number:2 ; day:13 ; month:08 ; pages:783-789 |
| Links: |
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| DOI / URN: |
10.1007/s00520-015-2844-0 |
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| Katalog-ID: |
SPR006605591 |
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| 100 | 1 | |a Ogata, Yutaka |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
| 264 | 1 | |c 2015 | |
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| 520 | |a Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. | ||
| 650 | 4 | |a Chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oral mucositis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Elemental diet (ED) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nourishment academic intervention |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colorectal cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Amino acid |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ishibashi, Nobuya |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Keizou |e verfasserin |4 aut | |
| 700 | 1 | |a Uchida, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Kamei, Hideki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakayama, Goichi |e verfasserin |4 aut | |
| 700 | 1 | |a Hirakawa, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Tanigawa, Masahiko |e verfasserin |4 aut | |
| 700 | 1 | |a Akagi, Yoshito |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Supportive care in cancer |d Berlin : Springer, 1993 |g 24(2015), 2 vom: 13. Aug., Seite 783-789 |w (DE-627)254909574 |w (DE-600)1463166-0 |x 1433-7339 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2015 |g number:2 |g day:13 |g month:08 |g pages:783-789 |
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10.1007/s00520-015-2844-0 doi (DE-627)SPR006605591 (SPR)s00520-015-2844-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ogata, Yutaka verfasserin aut Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. Chemotherapy (dpeaa)DE-He213 Oral mucositis (dpeaa)DE-He213 Elemental diet (ED) (dpeaa)DE-He213 Nourishment academic intervention (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Amino acid (dpeaa)DE-He213 Ishibashi, Nobuya verfasserin aut Yamaguchi, Keizou verfasserin aut Uchida, Shinji verfasserin aut Kamei, Hideki verfasserin aut Nakayama, Goichi verfasserin aut Hirakawa, Hiroaki verfasserin aut Tanigawa, Masahiko verfasserin aut Akagi, Yoshito verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 24(2015), 2 vom: 13. Aug., Seite 783-789 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:24 year:2015 number:2 day:13 month:08 pages:783-789 https://dx.doi.org/10.1007/s00520-015-2844-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2015 2 13 08 783-789 |
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10.1007/s00520-015-2844-0 doi (DE-627)SPR006605591 (SPR)s00520-015-2844-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ogata, Yutaka verfasserin aut Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. Chemotherapy (dpeaa)DE-He213 Oral mucositis (dpeaa)DE-He213 Elemental diet (ED) (dpeaa)DE-He213 Nourishment academic intervention (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Amino acid (dpeaa)DE-He213 Ishibashi, Nobuya verfasserin aut Yamaguchi, Keizou verfasserin aut Uchida, Shinji verfasserin aut Kamei, Hideki verfasserin aut Nakayama, Goichi verfasserin aut Hirakawa, Hiroaki verfasserin aut Tanigawa, Masahiko verfasserin aut Akagi, Yoshito verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 24(2015), 2 vom: 13. Aug., Seite 783-789 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:24 year:2015 number:2 day:13 month:08 pages:783-789 https://dx.doi.org/10.1007/s00520-015-2844-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2015 2 13 08 783-789 |
| allfields_unstemmed |
10.1007/s00520-015-2844-0 doi (DE-627)SPR006605591 (SPR)s00520-015-2844-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ogata, Yutaka verfasserin aut Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. Chemotherapy (dpeaa)DE-He213 Oral mucositis (dpeaa)DE-He213 Elemental diet (ED) (dpeaa)DE-He213 Nourishment academic intervention (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Amino acid (dpeaa)DE-He213 Ishibashi, Nobuya verfasserin aut Yamaguchi, Keizou verfasserin aut Uchida, Shinji verfasserin aut Kamei, Hideki verfasserin aut Nakayama, Goichi verfasserin aut Hirakawa, Hiroaki verfasserin aut Tanigawa, Masahiko verfasserin aut Akagi, Yoshito verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 24(2015), 2 vom: 13. Aug., Seite 783-789 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:24 year:2015 number:2 day:13 month:08 pages:783-789 https://dx.doi.org/10.1007/s00520-015-2844-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2015 2 13 08 783-789 |
| allfieldsGer |
10.1007/s00520-015-2844-0 doi (DE-627)SPR006605591 (SPR)s00520-015-2844-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ogata, Yutaka verfasserin aut Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. Chemotherapy (dpeaa)DE-He213 Oral mucositis (dpeaa)DE-He213 Elemental diet (ED) (dpeaa)DE-He213 Nourishment academic intervention (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Amino acid (dpeaa)DE-He213 Ishibashi, Nobuya verfasserin aut Yamaguchi, Keizou verfasserin aut Uchida, Shinji verfasserin aut Kamei, Hideki verfasserin aut Nakayama, Goichi verfasserin aut Hirakawa, Hiroaki verfasserin aut Tanigawa, Masahiko verfasserin aut Akagi, Yoshito verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 24(2015), 2 vom: 13. Aug., Seite 783-789 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:24 year:2015 number:2 day:13 month:08 pages:783-789 https://dx.doi.org/10.1007/s00520-015-2844-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2015 2 13 08 783-789 |
| allfieldsSound |
10.1007/s00520-015-2844-0 doi (DE-627)SPR006605591 (SPR)s00520-015-2844-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ogata, Yutaka verfasserin aut Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. Chemotherapy (dpeaa)DE-He213 Oral mucositis (dpeaa)DE-He213 Elemental diet (ED) (dpeaa)DE-He213 Nourishment academic intervention (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Amino acid (dpeaa)DE-He213 Ishibashi, Nobuya verfasserin aut Yamaguchi, Keizou verfasserin aut Uchida, Shinji verfasserin aut Kamei, Hideki verfasserin aut Nakayama, Goichi verfasserin aut Hirakawa, Hiroaki verfasserin aut Tanigawa, Masahiko verfasserin aut Akagi, Yoshito verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 24(2015), 2 vom: 13. Aug., Seite 783-789 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:24 year:2015 number:2 day:13 month:08 pages:783-789 https://dx.doi.org/10.1007/s00520-015-2844-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2015 2 13 08 783-789 |
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Enthalten in Supportive care in cancer 24(2015), 2 vom: 13. Aug., Seite 783-789 volume:24 year:2015 number:2 day:13 month:08 pages:783-789 |
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Ogata, Yutaka @@aut@@ Ishibashi, Nobuya @@aut@@ Yamaguchi, Keizou @@aut@@ Uchida, Shinji @@aut@@ Kamei, Hideki @@aut@@ Nakayama, Goichi @@aut@@ Hirakawa, Hiroaki @@aut@@ Tanigawa, Masahiko @@aut@@ Akagi, Yoshito @@aut@@ |
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2015-08-13T00:00:00Z |
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The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. 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Ogata, Yutaka |
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Ogata, Yutaka ddc 610 bkl 44.81 misc Chemotherapy misc Oral mucositis misc Elemental diet (ED) misc Nourishment academic intervention misc Colorectal cancer misc Amino acid Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
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610 ASE 44.81 bkl Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study Chemotherapy (dpeaa)DE-He213 Oral mucositis (dpeaa)DE-He213 Elemental diet (ED) (dpeaa)DE-He213 Nourishment academic intervention (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Amino acid (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Chemotherapy misc Oral mucositis misc Elemental diet (ED) misc Nourishment academic intervention misc Colorectal cancer misc Amino acid |
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ddc 610 bkl 44.81 misc Chemotherapy misc Oral mucositis misc Elemental diet (ED) misc Nourishment academic intervention misc Colorectal cancer misc Amino acid |
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ddc 610 bkl 44.81 misc Chemotherapy misc Oral mucositis misc Elemental diet (ED) misc Nourishment academic intervention misc Colorectal cancer misc Amino acid |
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Supportive care in cancer |
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Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
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(DE-627)SPR006605591 (SPR)s00520-015-2844-0-e |
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Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
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Ogata, Yutaka |
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Supportive care in cancer |
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Ogata, Yutaka Ishibashi, Nobuya Yamaguchi, Keizou Uchida, Shinji Kamei, Hideki Nakayama, Goichi Hirakawa, Hiroaki Tanigawa, Masahiko Akagi, Yoshito |
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preventive effects of amino-acid-rich elemental diet $ elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
| title_auth |
Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
| abstract |
Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. |
| abstractGer |
Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. |
| abstract_unstemmed |
Purpose The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), $ Elental^{®} $, on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods A total of 22 eligible patients with colorectal cancer experiencing grade 1–3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and $ Elental^{®} $ concurrently after recovery to grade 0 or 1 oral mucositis. Results FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with $ Elental^{®} $ (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion The amino-acid-rich elemental diet $ Elental^{®} $ may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer. |
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| title_short |
Preventive effects of amino-acid-rich elemental diet $ Elental^{®} $ on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study |
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https://dx.doi.org/10.1007/s00520-015-2844-0 |
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Ishibashi, Nobuya Yamaguchi, Keizou Uchida, Shinji Kamei, Hideki Nakayama, Goichi Hirakawa, Hiroaki Tanigawa, Masahiko Akagi, Yoshito |
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Ishibashi, Nobuya Yamaguchi, Keizou Uchida, Shinji Kamei, Hideki Nakayama, Goichi Hirakawa, Hiroaki Tanigawa, Masahiko Akagi, Yoshito |
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10.1007/s00520-015-2844-0 |
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2024-07-03T23:49:06.569Z |
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| score |
7.399846 |