Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors
Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Puri, Sonam [verfasserIn] Hyland, Kelly A. [verfasserIn] Weiss, Kristine Crowe [verfasserIn] Bell, Gillian C. [verfasserIn] Gray, Jhanelle E. [verfasserIn] Kim, Richard [verfasserIn] Lin, Hui-Yi [verfasserIn] Hoogland, Aasha I. [verfasserIn] Gonzalez, Brian D. [verfasserIn] Nelson, Ashley M. [verfasserIn] Kinney, Anita Y. [verfasserIn] Fischer, Stacy M. [verfasserIn] Li, Daneng [verfasserIn] Jacobsen, Paul B. [verfasserIn] McLeod, Howard L. [verfasserIn] Jim, Heather S. L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Supportive care in cancer - Berlin : Springer, 1993, 26(2018), 8 vom: 15. März, Seite 2911-2918 |
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| Übergeordnetes Werk: |
volume:26 ; year:2018 ; number:8 ; day:15 ; month:03 ; pages:2911-2918 |
| Links: |
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| DOI / URN: |
10.1007/s00520-018-4120-6 |
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| Katalog-ID: |
SPR006618928 |
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| 245 | 1 | 0 | |a Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
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| 520 | |a Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. | ||
| 650 | 4 | |a Chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neoplasms |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nausea |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Vomiting |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Risk factors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Genetic variation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hyland, Kelly A. |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Kristine Crowe |e verfasserin |4 aut | |
| 700 | 1 | |a Bell, Gillian C. |e verfasserin |4 aut | |
| 700 | 1 | |a Gray, Jhanelle E. |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Hui-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Hoogland, Aasha I. |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzalez, Brian D. |e verfasserin |4 aut | |
| 700 | 1 | |a Nelson, Ashley M. |e verfasserin |4 aut | |
| 700 | 1 | |a Kinney, Anita Y. |e verfasserin |4 aut | |
| 700 | 1 | |a Fischer, Stacy M. |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Daneng |e verfasserin |4 aut | |
| 700 | 1 | |a Jacobsen, Paul B. |e verfasserin |4 aut | |
| 700 | 1 | |a McLeod, Howard L. |e verfasserin |4 aut | |
| 700 | 1 | |a Jim, Heather S. L. |e verfasserin |4 aut | |
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10.1007/s00520-018-4120-6 doi (DE-627)SPR006618928 (SPR)s00520-018-4120-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Puri, Sonam verfasserin aut Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. Chemotherapy (dpeaa)DE-He213 Neoplasms (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Genetic variation (dpeaa)DE-He213 Hyland, Kelly A. verfasserin aut Weiss, Kristine Crowe verfasserin aut Bell, Gillian C. verfasserin aut Gray, Jhanelle E. verfasserin aut Kim, Richard verfasserin aut Lin, Hui-Yi verfasserin aut Hoogland, Aasha I. verfasserin aut Gonzalez, Brian D. verfasserin aut Nelson, Ashley M. verfasserin aut Kinney, Anita Y. verfasserin aut Fischer, Stacy M. verfasserin aut Li, Daneng verfasserin aut Jacobsen, Paul B. verfasserin aut McLeod, Howard L. verfasserin aut Jim, Heather S. L. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 26(2018), 8 vom: 15. März, Seite 2911-2918 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:26 year:2018 number:8 day:15 month:03 pages:2911-2918 https://dx.doi.org/10.1007/s00520-018-4120-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2018 8 15 03 2911-2918 |
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10.1007/s00520-018-4120-6 doi (DE-627)SPR006618928 (SPR)s00520-018-4120-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Puri, Sonam verfasserin aut Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. Chemotherapy (dpeaa)DE-He213 Neoplasms (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Genetic variation (dpeaa)DE-He213 Hyland, Kelly A. verfasserin aut Weiss, Kristine Crowe verfasserin aut Bell, Gillian C. verfasserin aut Gray, Jhanelle E. verfasserin aut Kim, Richard verfasserin aut Lin, Hui-Yi verfasserin aut Hoogland, Aasha I. verfasserin aut Gonzalez, Brian D. verfasserin aut Nelson, Ashley M. verfasserin aut Kinney, Anita Y. verfasserin aut Fischer, Stacy M. verfasserin aut Li, Daneng verfasserin aut Jacobsen, Paul B. verfasserin aut McLeod, Howard L. verfasserin aut Jim, Heather S. L. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 26(2018), 8 vom: 15. März, Seite 2911-2918 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:26 year:2018 number:8 day:15 month:03 pages:2911-2918 https://dx.doi.org/10.1007/s00520-018-4120-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2018 8 15 03 2911-2918 |
| allfields_unstemmed |
10.1007/s00520-018-4120-6 doi (DE-627)SPR006618928 (SPR)s00520-018-4120-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Puri, Sonam verfasserin aut Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. Chemotherapy (dpeaa)DE-He213 Neoplasms (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Genetic variation (dpeaa)DE-He213 Hyland, Kelly A. verfasserin aut Weiss, Kristine Crowe verfasserin aut Bell, Gillian C. verfasserin aut Gray, Jhanelle E. verfasserin aut Kim, Richard verfasserin aut Lin, Hui-Yi verfasserin aut Hoogland, Aasha I. verfasserin aut Gonzalez, Brian D. verfasserin aut Nelson, Ashley M. verfasserin aut Kinney, Anita Y. verfasserin aut Fischer, Stacy M. verfasserin aut Li, Daneng verfasserin aut Jacobsen, Paul B. verfasserin aut McLeod, Howard L. verfasserin aut Jim, Heather S. L. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 26(2018), 8 vom: 15. März, Seite 2911-2918 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:26 year:2018 number:8 day:15 month:03 pages:2911-2918 https://dx.doi.org/10.1007/s00520-018-4120-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2018 8 15 03 2911-2918 |
| allfieldsGer |
10.1007/s00520-018-4120-6 doi (DE-627)SPR006618928 (SPR)s00520-018-4120-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Puri, Sonam verfasserin aut Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. Chemotherapy (dpeaa)DE-He213 Neoplasms (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Genetic variation (dpeaa)DE-He213 Hyland, Kelly A. verfasserin aut Weiss, Kristine Crowe verfasserin aut Bell, Gillian C. verfasserin aut Gray, Jhanelle E. verfasserin aut Kim, Richard verfasserin aut Lin, Hui-Yi verfasserin aut Hoogland, Aasha I. verfasserin aut Gonzalez, Brian D. verfasserin aut Nelson, Ashley M. verfasserin aut Kinney, Anita Y. verfasserin aut Fischer, Stacy M. verfasserin aut Li, Daneng verfasserin aut Jacobsen, Paul B. verfasserin aut McLeod, Howard L. verfasserin aut Jim, Heather S. L. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 26(2018), 8 vom: 15. März, Seite 2911-2918 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:26 year:2018 number:8 day:15 month:03 pages:2911-2918 https://dx.doi.org/10.1007/s00520-018-4120-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2018 8 15 03 2911-2918 |
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10.1007/s00520-018-4120-6 doi (DE-627)SPR006618928 (SPR)s00520-018-4120-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Puri, Sonam verfasserin aut Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. Chemotherapy (dpeaa)DE-He213 Neoplasms (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Genetic variation (dpeaa)DE-He213 Hyland, Kelly A. verfasserin aut Weiss, Kristine Crowe verfasserin aut Bell, Gillian C. verfasserin aut Gray, Jhanelle E. verfasserin aut Kim, Richard verfasserin aut Lin, Hui-Yi verfasserin aut Hoogland, Aasha I. verfasserin aut Gonzalez, Brian D. verfasserin aut Nelson, Ashley M. verfasserin aut Kinney, Anita Y. verfasserin aut Fischer, Stacy M. verfasserin aut Li, Daneng verfasserin aut Jacobsen, Paul B. verfasserin aut McLeod, Howard L. verfasserin aut Jim, Heather S. L. verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 26(2018), 8 vom: 15. März, Seite 2911-2918 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:26 year:2018 number:8 day:15 month:03 pages:2911-2918 https://dx.doi.org/10.1007/s00520-018-4120-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2018 8 15 03 2911-2918 |
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Enthalten in Supportive care in cancer 26(2018), 8 vom: 15. März, Seite 2911-2918 volume:26 year:2018 number:8 day:15 month:03 pages:2911-2918 |
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Puri, Sonam @@aut@@ Hyland, Kelly A. @@aut@@ Weiss, Kristine Crowe @@aut@@ Bell, Gillian C. @@aut@@ Gray, Jhanelle E. @@aut@@ Kim, Richard @@aut@@ Lin, Hui-Yi @@aut@@ Hoogland, Aasha I. @@aut@@ Gonzalez, Brian D. @@aut@@ Nelson, Ashley M. @@aut@@ Kinney, Anita Y. @@aut@@ Fischer, Stacy M. @@aut@@ Li, Daneng @@aut@@ Jacobsen, Paul B. @@aut@@ McLeod, Howard L. @@aut@@ Jim, Heather S. L. @@aut@@ |
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Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. 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Puri, Sonam |
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Puri, Sonam ddc 610 bkl 44.81 misc Chemotherapy misc Neoplasms misc Nausea misc Vomiting misc Risk factors misc Genetic variation Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
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610 ASE 44.81 bkl Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors Chemotherapy (dpeaa)DE-He213 Neoplasms (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Genetic variation (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Chemotherapy misc Neoplasms misc Nausea misc Vomiting misc Risk factors misc Genetic variation |
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ddc 610 bkl 44.81 misc Chemotherapy misc Neoplasms misc Nausea misc Vomiting misc Risk factors misc Genetic variation |
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ddc 610 bkl 44.81 misc Chemotherapy misc Neoplasms misc Nausea misc Vomiting misc Risk factors misc Genetic variation |
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Supportive care in cancer |
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Supportive care in cancer |
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Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
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(DE-627)SPR006618928 (SPR)s00520-018-4120-6-e |
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Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
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Puri, Sonam |
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Supportive care in cancer |
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Supportive care in cancer |
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Puri, Sonam Hyland, Kelly A. Weiss, Kristine Crowe Bell, Gillian C. Gray, Jhanelle E. Kim, Richard Lin, Hui-Yi Hoogland, Aasha I. Gonzalez, Brian D. Nelson, Ashley M. Kinney, Anita Y. Fischer, Stacy M. Li, Daneng Jacobsen, Paul B. McLeod, Howard L. Jim, Heather S. L. |
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Puri, Sonam |
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10.1007/s00520-018-4120-6 |
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610 |
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verfasserin |
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prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
| title_auth |
Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
| abstract |
Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. |
| abstractGer |
Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. |
| abstract_unstemmed |
Purpose Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. Additional studies examining other genetic variants are needed, as well as the development of risk prediction models including both patient-reported and genetic risk factors. |
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Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors |
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Hyland, Kelly A. Weiss, Kristine Crowe Bell, Gillian C. Gray, Jhanelle E. Kim, Richard Lin, Hui-Yi Hoogland, Aasha I. Gonzalez, Brian D. Nelson, Ashley M. Kinney, Anita Y. Fischer, Stacy M. Li, Daneng Jacobsen, Paul B. McLeod, Howard L. Jim, Heather S. L. |
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Hyland, Kelly A. Weiss, Kristine Crowe Bell, Gillian C. Gray, Jhanelle E. Kim, Richard Lin, Hui-Yi Hoogland, Aasha I. Gonzalez, Brian D. Nelson, Ashley M. Kinney, Anita Y. Fischer, Stacy M. Li, Daneng Jacobsen, Paul B. McLeod, Howard L. Jim, Heather S. L. |
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10.1007/s00520-018-4120-6 |
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2024-07-03T23:53:43.595Z |
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Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. Methods Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score. The M.D. Anderson Symptom Inventory was completed at 24 h and 5-day post-infusion to assess the severity of acute and delayed CINV, respectively. Results Participants were 88 patients (55% female, M = 60 years). A total of 23% experienced acute nausea and 55% delayed nausea. Younger age, history of pregnancy-related nausea, fewer hours slept the night prior to infusion, and variation in ABCB1 were associated with more severe acute nausea; advanced-stage cancer and receipt of highly emetogenic chemotherapy were associated with more severe delayed nausea (p values < 0.05). In multivariable analyses, ABCB1 added an additional 5% predictive value beyond the 13% variance explained by patient-reported risk factors. Conclusions The current study identified patient-reported and genetic factors that may place patients at risk for acute nausea despite receipt of guideline-consistent anti-emetic prophylaxis. 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