Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy
Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with...
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| Autor*in: |
Ardissino, Gianluigi [verfasserIn] Testa, Sara [verfasserIn] Daccò, Valeria [verfasserIn] Viganò, Sara [verfasserIn] Taioli, Emanuela [verfasserIn] Claris-Appiani, Aldo [verfasserIn] Procaccio, Mirella [verfasserIn] Avolio, Luigi [verfasserIn] Ciofani, Antonio [verfasserIn] Dello Strologo, Luca [verfasserIn] Montini, Giovanni [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2003 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Pediatric nephrology - Berlin : Springer, 1987, 19(2003), 2 vom: 13. Dez., Seite 172-177 |
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| Übergeordnetes Werk: |
volume:19 ; year:2003 ; number:2 ; day:13 ; month:12 ; pages:172-177 |
| Links: |
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| DOI / URN: |
10.1007/s00467-003-1268-0 |
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| Katalog-ID: |
SPR006661718 |
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| 100 | 1 | |a Ardissino, Gianluigi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
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| 520 | |a Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. | ||
| 650 | 4 | |a Hypodysplasia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Proteinuria |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Progression |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chronic renal failure |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Testa, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Daccò, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Viganò, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Taioli, Emanuela |e verfasserin |4 aut | |
| 700 | 1 | |a Claris-Appiani, Aldo |e verfasserin |4 aut | |
| 700 | 1 | |a Procaccio, Mirella |e verfasserin |4 aut | |
| 700 | 1 | |a Avolio, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Ciofani, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Dello Strologo, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Montini, Giovanni |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology |d Berlin : Springer, 1987 |g 19(2003), 2 vom: 13. Dez., Seite 172-177 |w (DE-627)254638872 |w (DE-600)1463004-7 |x 1432-198X |7 nnns |
| 773 | 1 | 8 | |g volume:19 |g year:2003 |g number:2 |g day:13 |g month:12 |g pages:172-177 |
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10.1007/s00467-003-1268-0 doi (DE-627)SPR006661718 (SPR)s00467-003-1268-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Ardissino, Gianluigi verfasserin aut Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. Hypodysplasia (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Progression (dpeaa)DE-He213 Chronic renal failure (dpeaa)DE-He213 Testa, Sara verfasserin aut Daccò, Valeria verfasserin aut Viganò, Sara verfasserin aut Taioli, Emanuela verfasserin aut Claris-Appiani, Aldo verfasserin aut Procaccio, Mirella verfasserin aut Avolio, Luigi verfasserin aut Ciofani, Antonio verfasserin aut Dello Strologo, Luca verfasserin aut Montini, Giovanni verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2003), 2 vom: 13. Dez., Seite 172-177 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2003 number:2 day:13 month:12 pages:172-177 https://dx.doi.org/10.1007/s00467-003-1268-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2003 2 13 12 172-177 |
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10.1007/s00467-003-1268-0 doi (DE-627)SPR006661718 (SPR)s00467-003-1268-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Ardissino, Gianluigi verfasserin aut Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. Hypodysplasia (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Progression (dpeaa)DE-He213 Chronic renal failure (dpeaa)DE-He213 Testa, Sara verfasserin aut Daccò, Valeria verfasserin aut Viganò, Sara verfasserin aut Taioli, Emanuela verfasserin aut Claris-Appiani, Aldo verfasserin aut Procaccio, Mirella verfasserin aut Avolio, Luigi verfasserin aut Ciofani, Antonio verfasserin aut Dello Strologo, Luca verfasserin aut Montini, Giovanni verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2003), 2 vom: 13. Dez., Seite 172-177 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2003 number:2 day:13 month:12 pages:172-177 https://dx.doi.org/10.1007/s00467-003-1268-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2003 2 13 12 172-177 |
| allfields_unstemmed |
10.1007/s00467-003-1268-0 doi (DE-627)SPR006661718 (SPR)s00467-003-1268-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Ardissino, Gianluigi verfasserin aut Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. Hypodysplasia (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Progression (dpeaa)DE-He213 Chronic renal failure (dpeaa)DE-He213 Testa, Sara verfasserin aut Daccò, Valeria verfasserin aut Viganò, Sara verfasserin aut Taioli, Emanuela verfasserin aut Claris-Appiani, Aldo verfasserin aut Procaccio, Mirella verfasserin aut Avolio, Luigi verfasserin aut Ciofani, Antonio verfasserin aut Dello Strologo, Luca verfasserin aut Montini, Giovanni verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2003), 2 vom: 13. Dez., Seite 172-177 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2003 number:2 day:13 month:12 pages:172-177 https://dx.doi.org/10.1007/s00467-003-1268-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2003 2 13 12 172-177 |
| allfieldsGer |
10.1007/s00467-003-1268-0 doi (DE-627)SPR006661718 (SPR)s00467-003-1268-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Ardissino, Gianluigi verfasserin aut Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. Hypodysplasia (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Progression (dpeaa)DE-He213 Chronic renal failure (dpeaa)DE-He213 Testa, Sara verfasserin aut Daccò, Valeria verfasserin aut Viganò, Sara verfasserin aut Taioli, Emanuela verfasserin aut Claris-Appiani, Aldo verfasserin aut Procaccio, Mirella verfasserin aut Avolio, Luigi verfasserin aut Ciofani, Antonio verfasserin aut Dello Strologo, Luca verfasserin aut Montini, Giovanni verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2003), 2 vom: 13. Dez., Seite 172-177 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2003 number:2 day:13 month:12 pages:172-177 https://dx.doi.org/10.1007/s00467-003-1268-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2003 2 13 12 172-177 |
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10.1007/s00467-003-1268-0 doi (DE-627)SPR006661718 (SPR)s00467-003-1268-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Ardissino, Gianluigi verfasserin aut Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. Hypodysplasia (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Progression (dpeaa)DE-He213 Chronic renal failure (dpeaa)DE-He213 Testa, Sara verfasserin aut Daccò, Valeria verfasserin aut Viganò, Sara verfasserin aut Taioli, Emanuela verfasserin aut Claris-Appiani, Aldo verfasserin aut Procaccio, Mirella verfasserin aut Avolio, Luigi verfasserin aut Ciofani, Antonio verfasserin aut Dello Strologo, Luca verfasserin aut Montini, Giovanni verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2003), 2 vom: 13. Dez., Seite 172-177 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2003 number:2 day:13 month:12 pages:172-177 https://dx.doi.org/10.1007/s00467-003-1268-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2003 2 13 12 172-177 |
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Enthalten in Pediatric nephrology 19(2003), 2 vom: 13. Dez., Seite 172-177 volume:19 year:2003 number:2 day:13 month:12 pages:172-177 |
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Enthalten in Pediatric nephrology 19(2003), 2 vom: 13. Dez., Seite 172-177 volume:19 year:2003 number:2 day:13 month:12 pages:172-177 |
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Hypodysplasia Proteinuria Progression Chronic renal failure |
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Pediatric nephrology |
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Ardissino, Gianluigi @@aut@@ Testa, Sara @@aut@@ Daccò, Valeria @@aut@@ Viganò, Sara @@aut@@ Taioli, Emanuela @@aut@@ Claris-Appiani, Aldo @@aut@@ Procaccio, Mirella @@aut@@ Avolio, Luigi @@aut@@ Ciofani, Antonio @@aut@@ Dello Strologo, Luca @@aut@@ Montini, Giovanni @@aut@@ |
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2003-12-13T00:00:00Z |
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| author |
Ardissino, Gianluigi |
| spellingShingle |
Ardissino, Gianluigi ddc 610 bkl 44.88 bkl 44.67 misc Hypodysplasia misc Proteinuria misc Progression misc Chronic renal failure Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
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610 ASE 44.88 bkl 44.67 bkl Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy Hypodysplasia (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Progression (dpeaa)DE-He213 Chronic renal failure (dpeaa)DE-He213 |
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ddc 610 bkl 44.88 bkl 44.67 misc Hypodysplasia misc Proteinuria misc Progression misc Chronic renal failure |
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ddc 610 bkl 44.88 bkl 44.67 misc Hypodysplasia misc Proteinuria misc Progression misc Chronic renal failure |
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ddc 610 bkl 44.88 bkl 44.67 misc Hypodysplasia misc Proteinuria misc Progression misc Chronic renal failure |
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Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
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Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
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Ardissino, Gianluigi |
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Pediatric nephrology |
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Ardissino, Gianluigi Testa, Sara Daccò, Valeria Viganò, Sara Taioli, Emanuela Claris-Appiani, Aldo Procaccio, Mirella Avolio, Luigi Ciofani, Antonio Dello Strologo, Luca Montini, Giovanni |
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Ardissino, Gianluigi |
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10.1007/s00467-003-1268-0 |
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proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
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Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
| abstract |
Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. |
| abstractGer |
Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. |
| abstract_unstemmed |
Abstract Little is known about the role of proteinuria in the progression of childhood renal diseases. We analyzed the decline in creatinine clearance (CCr) and kidney survival in 225 children (185 males) with chronic renal failure (CRF) due to isolated hypodysplasia or hypodysplasia associated with urological abnormalities. The data were based on the information available in the Italian Pediatric Registry of CRF (ItalKid Project), which includes patients from all of Italy aged <20 years with CCr levels of <75 ml/min per 1.73 $ m^{2} $. Patients aged <2 years and those with CCr levels of <20 ml/min per 1.73 $ m^{2} $ or a follow-up of <1 year were excluded from the analysis, as were those receiving angiotensin-converting enzyme inhibitors. At baseline, the patients had a mean age of 7.8±4.2 years, a mean CCr of 50±16.3 ml/min per 1.73 $ m^{2} $, a median urinary protein/urinary creatinine (uPr/uCr) ratio of 0.38 (range 0.02–7.21), and a mean duration of follow-up of 3.5±1.1 years. The patients were divided into three groups on the basis of their baseline proteinuria levels: group A normal (uPr/uCr <0.2) n=83; group B low (uPr/uCr 0.2–0.9) n=71; and group C mild (uPr/uCr >0.9) n=71. Patients in groups A and B showed a significantly slower decline in CCr than those in group C (slope +0.16±3.64 and −0.54±3.67 vs. −3.61±5.47, P<0.0001) and a higher rate of kidney survival after 5 years (96.7% and 94.1% vs. 44.9%, P<0.01). By multivariate analysis, the baseline uPr/uCr ratio (P<0.01) and age (P<0.0001) correlated with a faster decline in CCr irrespective of baseline CCr. There was no correlation with mean arterial blood pressure. We conclude that proteinuria is an independent predictor of progression to end-stage renal failure also in children whose renal impairment is due to congenital hypodysplasia. |
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Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy |
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https://dx.doi.org/10.1007/s00467-003-1268-0 |
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Testa, Sara Daccò, Valeria Viganò, Sara Taioli, Emanuela Claris-Appiani, Aldo Procaccio, Mirella Avolio, Luigi Ciofani, Antonio Dello Strologo, Luca Montini, Giovanni |
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Testa, Sara Daccò, Valeria Viganò, Sara Taioli, Emanuela Claris-Appiani, Aldo Procaccio, Mirella Avolio, Luigi Ciofani, Antonio Dello Strologo, Luca Montini, Giovanni |
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10.1007/s00467-003-1268-0 |
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2024-07-04T00:06:02.224Z |
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| score |
7.398184 |