Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis
Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC &...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Macfarlane, Robyn J. [verfasserIn] McCully, Barbara J. [verfasserIn] Fernandez, Conrad V. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Pediatric nephrology - Berlin : Springer, 1987, 19(2004), 8 vom: 04. Juni, Seite 924-927 |
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| Übergeordnetes Werk: |
volume:19 ; year:2004 ; number:8 ; day:04 ; month:06 ; pages:924-927 |
| Links: |
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| DOI / URN: |
10.1007/s00467-004-1524-y |
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| Katalog-ID: |
SPR006676871 |
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| 100 | 1 | |a Macfarlane, Robyn J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
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| 520 | |a Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. | ||
| 650 | 4 | |a Leukemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hyperleukocytosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tumor lysis syndrome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Rasburicase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a McCully, Barbara J. |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, Conrad V. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology |d Berlin : Springer, 1987 |g 19(2004), 8 vom: 04. Juni, Seite 924-927 |w (DE-627)254638872 |w (DE-600)1463004-7 |x 1432-198X |7 nnns |
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| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
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| 912 | |a GBV_ILN_4313 | ||
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| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
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2004 |
| allfields |
10.1007/s00467-004-1524-y doi (DE-627)SPR006676871 (SPR)s00467-004-1524-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Macfarlane, Robyn J. verfasserin aut Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. Leukemia (dpeaa)DE-He213 Hyperleukocytosis (dpeaa)DE-He213 Tumor lysis syndrome (dpeaa)DE-He213 Rasburicase (dpeaa)DE-He213 McCully, Barbara J. verfasserin aut Fernandez, Conrad V. verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2004), 8 vom: 04. Juni, Seite 924-927 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2004 number:8 day:04 month:06 pages:924-927 https://dx.doi.org/10.1007/s00467-004-1524-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2004 8 04 06 924-927 |
| spelling |
10.1007/s00467-004-1524-y doi (DE-627)SPR006676871 (SPR)s00467-004-1524-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Macfarlane, Robyn J. verfasserin aut Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. Leukemia (dpeaa)DE-He213 Hyperleukocytosis (dpeaa)DE-He213 Tumor lysis syndrome (dpeaa)DE-He213 Rasburicase (dpeaa)DE-He213 McCully, Barbara J. verfasserin aut Fernandez, Conrad V. verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2004), 8 vom: 04. Juni, Seite 924-927 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2004 number:8 day:04 month:06 pages:924-927 https://dx.doi.org/10.1007/s00467-004-1524-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2004 8 04 06 924-927 |
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10.1007/s00467-004-1524-y doi (DE-627)SPR006676871 (SPR)s00467-004-1524-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Macfarlane, Robyn J. verfasserin aut Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. Leukemia (dpeaa)DE-He213 Hyperleukocytosis (dpeaa)DE-He213 Tumor lysis syndrome (dpeaa)DE-He213 Rasburicase (dpeaa)DE-He213 McCully, Barbara J. verfasserin aut Fernandez, Conrad V. verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2004), 8 vom: 04. Juni, Seite 924-927 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2004 number:8 day:04 month:06 pages:924-927 https://dx.doi.org/10.1007/s00467-004-1524-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2004 8 04 06 924-927 |
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10.1007/s00467-004-1524-y doi (DE-627)SPR006676871 (SPR)s00467-004-1524-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Macfarlane, Robyn J. verfasserin aut Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. Leukemia (dpeaa)DE-He213 Hyperleukocytosis (dpeaa)DE-He213 Tumor lysis syndrome (dpeaa)DE-He213 Rasburicase (dpeaa)DE-He213 McCully, Barbara J. verfasserin aut Fernandez, Conrad V. verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2004), 8 vom: 04. Juni, Seite 924-927 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2004 number:8 day:04 month:06 pages:924-927 https://dx.doi.org/10.1007/s00467-004-1524-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2004 8 04 06 924-927 |
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10.1007/s00467-004-1524-y doi (DE-627)SPR006676871 (SPR)s00467-004-1524-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Macfarlane, Robyn J. verfasserin aut Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. Leukemia (dpeaa)DE-He213 Hyperleukocytosis (dpeaa)DE-He213 Tumor lysis syndrome (dpeaa)DE-He213 Rasburicase (dpeaa)DE-He213 McCully, Barbara J. verfasserin aut Fernandez, Conrad V. verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 19(2004), 8 vom: 04. Juni, Seite 924-927 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:19 year:2004 number:8 day:04 month:06 pages:924-927 https://dx.doi.org/10.1007/s00467-004-1524-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 19 2004 8 04 06 924-927 |
| language |
English |
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Enthalten in Pediatric nephrology 19(2004), 8 vom: 04. Juni, Seite 924-927 volume:19 year:2004 number:8 day:04 month:06 pages:924-927 |
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Enthalten in Pediatric nephrology 19(2004), 8 vom: 04. Juni, Seite 924-927 volume:19 year:2004 number:8 day:04 month:06 pages:924-927 |
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findex.gbv.de |
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Leukemia Hyperleukocytosis Tumor lysis syndrome Rasburicase |
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610 |
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Pediatric nephrology |
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Macfarlane, Robyn J. @@aut@@ McCully, Barbara J. @@aut@@ Fernandez, Conrad V. @@aut@@ |
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2004-06-04T00:00:00Z |
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3610 |
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Macfarlane, Robyn J. |
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Macfarlane, Robyn J. ddc 610 bkl 44.88 bkl 44.67 misc Leukemia misc Hyperleukocytosis misc Tumor lysis syndrome misc Rasburicase Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
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610 ASE 44.88 bkl 44.67 bkl Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis Leukemia (dpeaa)DE-He213 Hyperleukocytosis (dpeaa)DE-He213 Tumor lysis syndrome (dpeaa)DE-He213 Rasburicase (dpeaa)DE-He213 |
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ddc 610 bkl 44.88 bkl 44.67 misc Leukemia misc Hyperleukocytosis misc Tumor lysis syndrome misc Rasburicase |
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ddc 610 bkl 44.88 bkl 44.67 misc Leukemia misc Hyperleukocytosis misc Tumor lysis syndrome misc Rasburicase |
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ddc 610 bkl 44.88 bkl 44.67 misc Leukemia misc Hyperleukocytosis misc Tumor lysis syndrome misc Rasburicase |
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Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
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Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
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Macfarlane, Robyn J. |
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Pediatric nephrology |
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Macfarlane, Robyn J. McCully, Barbara J. Fernandez, Conrad V. |
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rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
| title_auth |
Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
| abstract |
Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. |
| abstractGer |
Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. |
| abstract_unstemmed |
Abstract Hyperleukocytosis [white blood cell count (WBC) >100×$ 10^{9} $/l] occurs in 5%–22% of pediatric patients with acute leukemia. Rasburicase (recombinant urate oxidase) is very effective for the prophylaxis and treatment of hyperuricemia, but its efficacy in marked hyperleukocytosis (WBC >200×$ 10^{9} $/l) is not well known. We describe three children with marked hyperleukocytosis (WBC of 508, 320, and 242×$ 10^{9} $/l) at initiation of induction chemotherapy. All three received rasburicase. Minimal metabolic disturbance occurred in all patients. We conclude that WBC reduction strategies may not be required solely for the risk of tumor lysis syndrome in patients with very high WBC (>200×$ 10^{9} $/l) who are treated with rasburicase. |
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8 |
| title_short |
Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis |
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https://dx.doi.org/10.1007/s00467-004-1524-y |
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McCully, Barbara J. Fernandez, Conrad V. |
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McCully, Barbara J. Fernandez, Conrad V. |
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| doi_str |
10.1007/s00467-004-1524-y |
| up_date |
2024-07-04T00:10:06.732Z |
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1803605043298959360 |
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| score |
7.4017296 |