Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review
Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 C...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ueno, Hideki [verfasserIn] Hase, Kazuo [verfasserIn] Hashiguchi, Yojiro [verfasserIn] Shimazaki, Hideyuki [verfasserIn] Yoshii, Shinji [verfasserIn] Kudo, Shin-ei [verfasserIn] Tanaka, Masafumi [verfasserIn] Akagi, Yoshito [verfasserIn] Suto, Takeshi [verfasserIn] Nagata, Shinji [verfasserIn] Matsuda, Keiji [verfasserIn] Komori, Koji [verfasserIn] Yoshimatsu, Kazuhiko [verfasserIn] Tomita, Yasuhiko [verfasserIn] Yokoyama, Shozo [verfasserIn] Shinto, Eiji [verfasserIn] Nakamura, Takahiro [verfasserIn] Sugihara, Kenichi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of gastroenterology - Tokyo : Springer, 1994, 49(2013), 9 vom: 25. Sept., Seite 1314-1323 |
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| Übergeordnetes Werk: |
volume:49 ; year:2013 ; number:9 ; day:25 ; month:09 ; pages:1314-1323 |
| Links: |
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| DOI / URN: |
10.1007/s00535-013-0881-3 |
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| Katalog-ID: |
SPR006770274 |
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| 100 | 1 | |a Ueno, Hideki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
| 264 | 1 | |c 2013 | |
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| 520 | |a Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. | ||
| 650 | 4 | |a T1 colorectal cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Endoscopic excision |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Poorly differentiated clusters |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tumor budding |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lymph node metastases |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hase, Kazuo |e verfasserin |4 aut | |
| 700 | 1 | |a Hashiguchi, Yojiro |e verfasserin |4 aut | |
| 700 | 1 | |a Shimazaki, Hideyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshii, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Kudo, Shin-ei |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Masafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Akagi, Yoshito |e verfasserin |4 aut | |
| 700 | 1 | |a Suto, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Nagata, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuda, Keiji |e verfasserin |4 aut | |
| 700 | 1 | |a Komori, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshimatsu, Kazuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Tomita, Yasuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Yokoyama, Shozo |e verfasserin |4 aut | |
| 700 | 1 | |a Shinto, Eiji |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Sugihara, Kenichi |e verfasserin |4 aut | |
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10.1007/s00535-013-0881-3 doi (DE-627)SPR006770274 (SPR)s00535-013-0881-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Ueno, Hideki verfasserin aut Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. T1 colorectal cancer (dpeaa)DE-He213 Endoscopic excision (dpeaa)DE-He213 Poorly differentiated clusters (dpeaa)DE-He213 Tumor budding (dpeaa)DE-He213 Lymph node metastases (dpeaa)DE-He213 Hase, Kazuo verfasserin aut Hashiguchi, Yojiro verfasserin aut Shimazaki, Hideyuki verfasserin aut Yoshii, Shinji verfasserin aut Kudo, Shin-ei verfasserin aut Tanaka, Masafumi verfasserin aut Akagi, Yoshito verfasserin aut Suto, Takeshi verfasserin aut Nagata, Shinji verfasserin aut Matsuda, Keiji verfasserin aut Komori, Koji verfasserin aut Yoshimatsu, Kazuhiko verfasserin aut Tomita, Yasuhiko verfasserin aut Yokoyama, Shozo verfasserin aut Shinto, Eiji verfasserin aut Nakamura, Takahiro verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 49(2013), 9 vom: 25. Sept., Seite 1314-1323 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:49 year:2013 number:9 day:25 month:09 pages:1314-1323 https://dx.doi.org/10.1007/s00535-013-0881-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 49 2013 9 25 09 1314-1323 |
| spelling |
10.1007/s00535-013-0881-3 doi (DE-627)SPR006770274 (SPR)s00535-013-0881-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Ueno, Hideki verfasserin aut Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. T1 colorectal cancer (dpeaa)DE-He213 Endoscopic excision (dpeaa)DE-He213 Poorly differentiated clusters (dpeaa)DE-He213 Tumor budding (dpeaa)DE-He213 Lymph node metastases (dpeaa)DE-He213 Hase, Kazuo verfasserin aut Hashiguchi, Yojiro verfasserin aut Shimazaki, Hideyuki verfasserin aut Yoshii, Shinji verfasserin aut Kudo, Shin-ei verfasserin aut Tanaka, Masafumi verfasserin aut Akagi, Yoshito verfasserin aut Suto, Takeshi verfasserin aut Nagata, Shinji verfasserin aut Matsuda, Keiji verfasserin aut Komori, Koji verfasserin aut Yoshimatsu, Kazuhiko verfasserin aut Tomita, Yasuhiko verfasserin aut Yokoyama, Shozo verfasserin aut Shinto, Eiji verfasserin aut Nakamura, Takahiro verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 49(2013), 9 vom: 25. Sept., Seite 1314-1323 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:49 year:2013 number:9 day:25 month:09 pages:1314-1323 https://dx.doi.org/10.1007/s00535-013-0881-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 49 2013 9 25 09 1314-1323 |
| allfields_unstemmed |
10.1007/s00535-013-0881-3 doi (DE-627)SPR006770274 (SPR)s00535-013-0881-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Ueno, Hideki verfasserin aut Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. T1 colorectal cancer (dpeaa)DE-He213 Endoscopic excision (dpeaa)DE-He213 Poorly differentiated clusters (dpeaa)DE-He213 Tumor budding (dpeaa)DE-He213 Lymph node metastases (dpeaa)DE-He213 Hase, Kazuo verfasserin aut Hashiguchi, Yojiro verfasserin aut Shimazaki, Hideyuki verfasserin aut Yoshii, Shinji verfasserin aut Kudo, Shin-ei verfasserin aut Tanaka, Masafumi verfasserin aut Akagi, Yoshito verfasserin aut Suto, Takeshi verfasserin aut Nagata, Shinji verfasserin aut Matsuda, Keiji verfasserin aut Komori, Koji verfasserin aut Yoshimatsu, Kazuhiko verfasserin aut Tomita, Yasuhiko verfasserin aut Yokoyama, Shozo verfasserin aut Shinto, Eiji verfasserin aut Nakamura, Takahiro verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 49(2013), 9 vom: 25. Sept., Seite 1314-1323 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:49 year:2013 number:9 day:25 month:09 pages:1314-1323 https://dx.doi.org/10.1007/s00535-013-0881-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 49 2013 9 25 09 1314-1323 |
| allfieldsGer |
10.1007/s00535-013-0881-3 doi (DE-627)SPR006770274 (SPR)s00535-013-0881-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Ueno, Hideki verfasserin aut Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. T1 colorectal cancer (dpeaa)DE-He213 Endoscopic excision (dpeaa)DE-He213 Poorly differentiated clusters (dpeaa)DE-He213 Tumor budding (dpeaa)DE-He213 Lymph node metastases (dpeaa)DE-He213 Hase, Kazuo verfasserin aut Hashiguchi, Yojiro verfasserin aut Shimazaki, Hideyuki verfasserin aut Yoshii, Shinji verfasserin aut Kudo, Shin-ei verfasserin aut Tanaka, Masafumi verfasserin aut Akagi, Yoshito verfasserin aut Suto, Takeshi verfasserin aut Nagata, Shinji verfasserin aut Matsuda, Keiji verfasserin aut Komori, Koji verfasserin aut Yoshimatsu, Kazuhiko verfasserin aut Tomita, Yasuhiko verfasserin aut Yokoyama, Shozo verfasserin aut Shinto, Eiji verfasserin aut Nakamura, Takahiro verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 49(2013), 9 vom: 25. Sept., Seite 1314-1323 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:49 year:2013 number:9 day:25 month:09 pages:1314-1323 https://dx.doi.org/10.1007/s00535-013-0881-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 49 2013 9 25 09 1314-1323 |
| allfieldsSound |
10.1007/s00535-013-0881-3 doi (DE-627)SPR006770274 (SPR)s00535-013-0881-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Ueno, Hideki verfasserin aut Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. T1 colorectal cancer (dpeaa)DE-He213 Endoscopic excision (dpeaa)DE-He213 Poorly differentiated clusters (dpeaa)DE-He213 Tumor budding (dpeaa)DE-He213 Lymph node metastases (dpeaa)DE-He213 Hase, Kazuo verfasserin aut Hashiguchi, Yojiro verfasserin aut Shimazaki, Hideyuki verfasserin aut Yoshii, Shinji verfasserin aut Kudo, Shin-ei verfasserin aut Tanaka, Masafumi verfasserin aut Akagi, Yoshito verfasserin aut Suto, Takeshi verfasserin aut Nagata, Shinji verfasserin aut Matsuda, Keiji verfasserin aut Komori, Koji verfasserin aut Yoshimatsu, Kazuhiko verfasserin aut Tomita, Yasuhiko verfasserin aut Yokoyama, Shozo verfasserin aut Shinto, Eiji verfasserin aut Nakamura, Takahiro verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 49(2013), 9 vom: 25. Sept., Seite 1314-1323 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:49 year:2013 number:9 day:25 month:09 pages:1314-1323 https://dx.doi.org/10.1007/s00535-013-0881-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 49 2013 9 25 09 1314-1323 |
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T1 colorectal cancer Endoscopic excision Poorly differentiated clusters Tumor budding Lymph node metastases |
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Ueno, Hideki @@aut@@ Hase, Kazuo @@aut@@ Hashiguchi, Yojiro @@aut@@ Shimazaki, Hideyuki @@aut@@ Yoshii, Shinji @@aut@@ Kudo, Shin-ei @@aut@@ Tanaka, Masafumi @@aut@@ Akagi, Yoshito @@aut@@ Suto, Takeshi @@aut@@ Nagata, Shinji @@aut@@ Matsuda, Keiji @@aut@@ Komori, Koji @@aut@@ Yoshimatsu, Kazuhiko @@aut@@ Tomita, Yasuhiko @@aut@@ Yokoyama, Shozo @@aut@@ Shinto, Eiji @@aut@@ Nakamura, Takahiro @@aut@@ Sugihara, Kenichi @@aut@@ |
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Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). 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|
| author |
Ueno, Hideki |
| spellingShingle |
Ueno, Hideki ddc 610 bkl 44.87 misc T1 colorectal cancer misc Endoscopic excision misc Poorly differentiated clusters misc Tumor budding misc Lymph node metastases Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
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Ueno, Hideki |
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electronic Article |
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610 - Medicine & health |
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keep |
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aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
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springer |
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true |
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Not Illustrated |
| issn |
1435-5922 |
| topic_title |
610 ASE 44.87 bkl Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review T1 colorectal cancer (dpeaa)DE-He213 Endoscopic excision (dpeaa)DE-He213 Poorly differentiated clusters (dpeaa)DE-He213 Tumor budding (dpeaa)DE-He213 Lymph node metastases (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.87 misc T1 colorectal cancer misc Endoscopic excision misc Poorly differentiated clusters misc Tumor budding misc Lymph node metastases |
| topic_unstemmed |
ddc 610 bkl 44.87 misc T1 colorectal cancer misc Endoscopic excision misc Poorly differentiated clusters misc Tumor budding misc Lymph node metastases |
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ddc 610 bkl 44.87 misc T1 colorectal cancer misc Endoscopic excision misc Poorly differentiated clusters misc Tumor budding misc Lymph node metastases |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Journal of gastroenterology |
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268761671 |
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610 - Medicine & health |
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Journal of gastroenterology |
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(DE-627)268761671 (DE-600)1473159-9 |
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Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
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(DE-627)SPR006770274 (SPR)s00535-013-0881-3-e |
| title_full |
Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
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Ueno, Hideki |
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Journal of gastroenterology |
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Journal of gastroenterology |
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eng |
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600 - Technology |
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2013 |
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1314 |
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Ueno, Hideki Hase, Kazuo Hashiguchi, Yojiro Shimazaki, Hideyuki Yoshii, Shinji Kudo, Shin-ei Tanaka, Masafumi Akagi, Yoshito Suto, Takeshi Nagata, Shinji Matsuda, Keiji Komori, Koji Yoshimatsu, Kazuhiko Tomita, Yasuhiko Yokoyama, Shozo Shinto, Eiji Nakamura, Takahiro Sugihara, Kenichi |
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49 |
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610 ASE 44.87 bkl |
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Elektronische Aufsätze |
| author-letter |
Ueno, Hideki |
| doi_str_mv |
10.1007/s00535-013-0881-3 |
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610 |
| author2-role |
verfasserin |
| title_sort |
novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
| title_auth |
Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
| abstract |
Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. |
| abstractGer |
Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. |
| abstract_unstemmed |
Background Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. Methods A pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC). Results PDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48). Conclusions PDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. |
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Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review |
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https://dx.doi.org/10.1007/s00535-013-0881-3 |
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Hase, Kazuo Hashiguchi, Yojiro Shimazaki, Hideyuki Yoshii, Shinji Kudo, Shin-ei Tanaka, Masafumi Akagi, Yoshito Suto, Takeshi Nagata, Shinji Matsuda, Keiji Komori, Koji Yoshimatsu, Kazuhiko Tomita, Yasuhiko Yokoyama, Shozo Shinto, Eiji Nakamura, Takahiro Sugihara, Kenichi |
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Hase, Kazuo Hashiguchi, Yojiro Shimazaki, Hideyuki Yoshii, Shinji Kudo, Shin-ei Tanaka, Masafumi Akagi, Yoshito Suto, Takeshi Nagata, Shinji Matsuda, Keiji Komori, Koji Yoshimatsu, Kazuhiko Tomita, Yasuhiko Yokoyama, Shozo Shinto, Eiji Nakamura, Takahiro Sugihara, Kenichi |
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10.1007/s00535-013-0881-3 |
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2024-07-04T00:35:07.801Z |
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| score |
7.3994207 |