Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey
Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is ne...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tokushige, Katsutoshi [verfasserIn] Hyogo, Hideyuki [verfasserIn] Nakajima, Tomoaki [verfasserIn] Ono, Masafumi [verfasserIn] Kawaguchi, Takumi [verfasserIn] Honda, Koichi [verfasserIn] Eguchi, Yuichiro [verfasserIn] Nozaki, Yuichi [verfasserIn] Kawanaka, Miwa [verfasserIn] Tanaka, Saiyu [verfasserIn] Imajo, Kento [verfasserIn] Sumida, Yoshio [verfasserIn] Kamada, Yoshihiro [verfasserIn] Fujii, Hideki [verfasserIn] Suzuki, Yasuaki [verfasserIn] Kogiso, Tomomi [verfasserIn] Karino, Yoshiyasu [verfasserIn] Munekage, Kensuke [verfasserIn] Kuromatsu, Ryoko [verfasserIn] Oeda, Satoshi [verfasserIn] Yanase, Mikio [verfasserIn] Mori, Kohjiro [verfasserIn] Ogawa, Yuji [verfasserIn] Seko, Yuya [verfasserIn] Takehara, Tetsuo [verfasserIn] Itoh, Yoshito [verfasserIn] Nakajima, Atsushi [verfasserIn] Kanemasa, Kazuyuki [verfasserIn] Nishino, Ken [verfasserIn] Masaki, Naohiko [verfasserIn] Takahashi, Hirokazu [verfasserIn] Seike, Masataka [verfasserIn] Torimura, Takuji [verfasserIn] Saibara, Toshiji [verfasserIn] Toyota, Joji [verfasserIn] Chayama, Kazuaki [verfasserIn] Hashimoto, Etsuko [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of gastroenterology - Tokyo : Springer, 1994, 51(2015), 6 vom: 11. Okt., Seite 586-596 |
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| Übergeordnetes Werk: |
volume:51 ; year:2015 ; number:6 ; day:11 ; month:10 ; pages:586-596 |
| Links: |
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| DOI / URN: |
10.1007/s00535-015-1129-1 |
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SPR006772722 |
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| 245 | 1 | 0 | |a Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
| 264 | 1 | |c 2015 | |
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| 520 | |a Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. | ||
| 650 | 4 | |a Alcoholic liver disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nonalcoholic fatty liver disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hepatocellular carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Survival |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Recurrence |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hyogo, Hideyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajima, Tomoaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Masafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaguchi, Takumi |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Eguchi, Yuichiro |e verfasserin |4 aut | |
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| 700 | 1 | |a Seko, Yuya |e verfasserin |4 aut | |
| 700 | 1 | |a Takehara, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Itoh, Yoshito |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajima, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Kanemasa, Kazuyuki |e verfasserin |4 aut | |
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| 700 | 1 | |a Hashimoto, Etsuko |e verfasserin |4 aut | |
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10.1007/s00535-015-1129-1 doi (DE-627)SPR006772722 (SPR)s00535-015-1129-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Tokushige, Katsutoshi verfasserin aut Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. Alcoholic liver disease (dpeaa)DE-He213 Nonalcoholic fatty liver disease (dpeaa)DE-He213 Hepatocellular carcinoma (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Hyogo, Hideyuki verfasserin aut Nakajima, Tomoaki verfasserin aut Ono, Masafumi verfasserin aut Kawaguchi, Takumi verfasserin aut Honda, Koichi verfasserin aut Eguchi, Yuichiro verfasserin aut Nozaki, Yuichi verfasserin aut Kawanaka, Miwa verfasserin aut Tanaka, Saiyu verfasserin aut Imajo, Kento verfasserin aut Sumida, Yoshio verfasserin aut Kamada, Yoshihiro verfasserin aut Fujii, Hideki verfasserin aut Suzuki, Yasuaki verfasserin aut Kogiso, Tomomi verfasserin aut Karino, Yoshiyasu verfasserin aut Munekage, Kensuke verfasserin aut Kuromatsu, Ryoko verfasserin aut Oeda, Satoshi verfasserin aut Yanase, Mikio verfasserin aut Mori, Kohjiro verfasserin aut Ogawa, Yuji verfasserin aut Seko, Yuya verfasserin aut Takehara, Tetsuo verfasserin aut Itoh, Yoshito verfasserin aut Nakajima, Atsushi verfasserin aut Kanemasa, Kazuyuki verfasserin aut Nishino, Ken verfasserin aut Masaki, Naohiko verfasserin aut Takahashi, Hirokazu verfasserin aut Seike, Masataka verfasserin aut Torimura, Takuji verfasserin aut Saibara, Toshiji verfasserin aut Toyota, Joji verfasserin aut Chayama, Kazuaki verfasserin aut Hashimoto, Etsuko verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 51(2015), 6 vom: 11. Okt., Seite 586-596 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:51 year:2015 number:6 day:11 month:10 pages:586-596 https://dx.doi.org/10.1007/s00535-015-1129-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 51 2015 6 11 10 586-596 |
| spelling |
10.1007/s00535-015-1129-1 doi (DE-627)SPR006772722 (SPR)s00535-015-1129-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Tokushige, Katsutoshi verfasserin aut Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. Alcoholic liver disease (dpeaa)DE-He213 Nonalcoholic fatty liver disease (dpeaa)DE-He213 Hepatocellular carcinoma (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Hyogo, Hideyuki verfasserin aut Nakajima, Tomoaki verfasserin aut Ono, Masafumi verfasserin aut Kawaguchi, Takumi verfasserin aut Honda, Koichi verfasserin aut Eguchi, Yuichiro verfasserin aut Nozaki, Yuichi verfasserin aut Kawanaka, Miwa verfasserin aut Tanaka, Saiyu verfasserin aut Imajo, Kento verfasserin aut Sumida, Yoshio verfasserin aut Kamada, Yoshihiro verfasserin aut Fujii, Hideki verfasserin aut Suzuki, Yasuaki verfasserin aut Kogiso, Tomomi verfasserin aut Karino, Yoshiyasu verfasserin aut Munekage, Kensuke verfasserin aut Kuromatsu, Ryoko verfasserin aut Oeda, Satoshi verfasserin aut Yanase, Mikio verfasserin aut Mori, Kohjiro verfasserin aut Ogawa, Yuji verfasserin aut Seko, Yuya verfasserin aut Takehara, Tetsuo verfasserin aut Itoh, Yoshito verfasserin aut Nakajima, Atsushi verfasserin aut Kanemasa, Kazuyuki verfasserin aut Nishino, Ken verfasserin aut Masaki, Naohiko verfasserin aut Takahashi, Hirokazu verfasserin aut Seike, Masataka verfasserin aut Torimura, Takuji verfasserin aut Saibara, Toshiji verfasserin aut Toyota, Joji verfasserin aut Chayama, Kazuaki verfasserin aut Hashimoto, Etsuko verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 51(2015), 6 vom: 11. Okt., Seite 586-596 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:51 year:2015 number:6 day:11 month:10 pages:586-596 https://dx.doi.org/10.1007/s00535-015-1129-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 51 2015 6 11 10 586-596 |
| allfields_unstemmed |
10.1007/s00535-015-1129-1 doi (DE-627)SPR006772722 (SPR)s00535-015-1129-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Tokushige, Katsutoshi verfasserin aut Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. Alcoholic liver disease (dpeaa)DE-He213 Nonalcoholic fatty liver disease (dpeaa)DE-He213 Hepatocellular carcinoma (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Hyogo, Hideyuki verfasserin aut Nakajima, Tomoaki verfasserin aut Ono, Masafumi verfasserin aut Kawaguchi, Takumi verfasserin aut Honda, Koichi verfasserin aut Eguchi, Yuichiro verfasserin aut Nozaki, Yuichi verfasserin aut Kawanaka, Miwa verfasserin aut Tanaka, Saiyu verfasserin aut Imajo, Kento verfasserin aut Sumida, Yoshio verfasserin aut Kamada, Yoshihiro verfasserin aut Fujii, Hideki verfasserin aut Suzuki, Yasuaki verfasserin aut Kogiso, Tomomi verfasserin aut Karino, Yoshiyasu verfasserin aut Munekage, Kensuke verfasserin aut Kuromatsu, Ryoko verfasserin aut Oeda, Satoshi verfasserin aut Yanase, Mikio verfasserin aut Mori, Kohjiro verfasserin aut Ogawa, Yuji verfasserin aut Seko, Yuya verfasserin aut Takehara, Tetsuo verfasserin aut Itoh, Yoshito verfasserin aut Nakajima, Atsushi verfasserin aut Kanemasa, Kazuyuki verfasserin aut Nishino, Ken verfasserin aut Masaki, Naohiko verfasserin aut Takahashi, Hirokazu verfasserin aut Seike, Masataka verfasserin aut Torimura, Takuji verfasserin aut Saibara, Toshiji verfasserin aut Toyota, Joji verfasserin aut Chayama, Kazuaki verfasserin aut Hashimoto, Etsuko verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 51(2015), 6 vom: 11. Okt., Seite 586-596 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:51 year:2015 number:6 day:11 month:10 pages:586-596 https://dx.doi.org/10.1007/s00535-015-1129-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 51 2015 6 11 10 586-596 |
| allfieldsGer |
10.1007/s00535-015-1129-1 doi (DE-627)SPR006772722 (SPR)s00535-015-1129-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Tokushige, Katsutoshi verfasserin aut Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. Alcoholic liver disease (dpeaa)DE-He213 Nonalcoholic fatty liver disease (dpeaa)DE-He213 Hepatocellular carcinoma (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Hyogo, Hideyuki verfasserin aut Nakajima, Tomoaki verfasserin aut Ono, Masafumi verfasserin aut Kawaguchi, Takumi verfasserin aut Honda, Koichi verfasserin aut Eguchi, Yuichiro verfasserin aut Nozaki, Yuichi verfasserin aut Kawanaka, Miwa verfasserin aut Tanaka, Saiyu verfasserin aut Imajo, Kento verfasserin aut Sumida, Yoshio verfasserin aut Kamada, Yoshihiro verfasserin aut Fujii, Hideki verfasserin aut Suzuki, Yasuaki verfasserin aut Kogiso, Tomomi verfasserin aut Karino, Yoshiyasu verfasserin aut Munekage, Kensuke verfasserin aut Kuromatsu, Ryoko verfasserin aut Oeda, Satoshi verfasserin aut Yanase, Mikio verfasserin aut Mori, Kohjiro verfasserin aut Ogawa, Yuji verfasserin aut Seko, Yuya verfasserin aut Takehara, Tetsuo verfasserin aut Itoh, Yoshito verfasserin aut Nakajima, Atsushi verfasserin aut Kanemasa, Kazuyuki verfasserin aut Nishino, Ken verfasserin aut Masaki, Naohiko verfasserin aut Takahashi, Hirokazu verfasserin aut Seike, Masataka verfasserin aut Torimura, Takuji verfasserin aut Saibara, Toshiji verfasserin aut Toyota, Joji verfasserin aut Chayama, Kazuaki verfasserin aut Hashimoto, Etsuko verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 51(2015), 6 vom: 11. Okt., Seite 586-596 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:51 year:2015 number:6 day:11 month:10 pages:586-596 https://dx.doi.org/10.1007/s00535-015-1129-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 51 2015 6 11 10 586-596 |
| allfieldsSound |
10.1007/s00535-015-1129-1 doi (DE-627)SPR006772722 (SPR)s00535-015-1129-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Tokushige, Katsutoshi verfasserin aut Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. Alcoholic liver disease (dpeaa)DE-He213 Nonalcoholic fatty liver disease (dpeaa)DE-He213 Hepatocellular carcinoma (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Hyogo, Hideyuki verfasserin aut Nakajima, Tomoaki verfasserin aut Ono, Masafumi verfasserin aut Kawaguchi, Takumi verfasserin aut Honda, Koichi verfasserin aut Eguchi, Yuichiro verfasserin aut Nozaki, Yuichi verfasserin aut Kawanaka, Miwa verfasserin aut Tanaka, Saiyu verfasserin aut Imajo, Kento verfasserin aut Sumida, Yoshio verfasserin aut Kamada, Yoshihiro verfasserin aut Fujii, Hideki verfasserin aut Suzuki, Yasuaki verfasserin aut Kogiso, Tomomi verfasserin aut Karino, Yoshiyasu verfasserin aut Munekage, Kensuke verfasserin aut Kuromatsu, Ryoko verfasserin aut Oeda, Satoshi verfasserin aut Yanase, Mikio verfasserin aut Mori, Kohjiro verfasserin aut Ogawa, Yuji verfasserin aut Seko, Yuya verfasserin aut Takehara, Tetsuo verfasserin aut Itoh, Yoshito verfasserin aut Nakajima, Atsushi verfasserin aut Kanemasa, Kazuyuki verfasserin aut Nishino, Ken verfasserin aut Masaki, Naohiko verfasserin aut Takahashi, Hirokazu verfasserin aut Seike, Masataka verfasserin aut Torimura, Takuji verfasserin aut Saibara, Toshiji verfasserin aut Toyota, Joji verfasserin aut Chayama, Kazuaki verfasserin aut Hashimoto, Etsuko verfasserin aut Enthalten in Journal of gastroenterology Tokyo : Springer, 1994 51(2015), 6 vom: 11. Okt., Seite 586-596 (DE-627)268761671 (DE-600)1473159-9 1435-5922 nnns volume:51 year:2015 number:6 day:11 month:10 pages:586-596 https://dx.doi.org/10.1007/s00535-015-1129-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 51 2015 6 11 10 586-596 |
| language |
English |
| source |
Enthalten in Journal of gastroenterology 51(2015), 6 vom: 11. Okt., Seite 586-596 volume:51 year:2015 number:6 day:11 month:10 pages:586-596 |
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Enthalten in Journal of gastroenterology 51(2015), 6 vom: 11. Okt., Seite 586-596 volume:51 year:2015 number:6 day:11 month:10 pages:586-596 |
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Article |
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findex.gbv.de |
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Alcoholic liver disease Nonalcoholic fatty liver disease Hepatocellular carcinoma Survival Recurrence |
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false |
| container_title |
Journal of gastroenterology |
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Tokushige, Katsutoshi @@aut@@ Hyogo, Hideyuki @@aut@@ Nakajima, Tomoaki @@aut@@ Ono, Masafumi @@aut@@ Kawaguchi, Takumi @@aut@@ Honda, Koichi @@aut@@ Eguchi, Yuichiro @@aut@@ Nozaki, Yuichi @@aut@@ Kawanaka, Miwa @@aut@@ Tanaka, Saiyu @@aut@@ Imajo, Kento @@aut@@ Sumida, Yoshio @@aut@@ Kamada, Yoshihiro @@aut@@ Fujii, Hideki @@aut@@ Suzuki, Yasuaki @@aut@@ Kogiso, Tomomi @@aut@@ Karino, Yoshiyasu @@aut@@ Munekage, Kensuke @@aut@@ Kuromatsu, Ryoko @@aut@@ Oeda, Satoshi @@aut@@ Yanase, Mikio @@aut@@ Mori, Kohjiro @@aut@@ Ogawa, Yuji @@aut@@ Seko, Yuya @@aut@@ Takehara, Tetsuo @@aut@@ Itoh, Yoshito @@aut@@ Nakajima, Atsushi @@aut@@ Kanemasa, Kazuyuki @@aut@@ Nishino, Ken @@aut@@ Masaki, Naohiko @@aut@@ Takahashi, Hirokazu @@aut@@ Seike, Masataka @@aut@@ Torimura, Takuji @@aut@@ Saibara, Toshiji @@aut@@ Toyota, Joji @@aut@@ Chayama, Kazuaki @@aut@@ Hashimoto, Etsuko @@aut@@ |
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2015-10-11T00:00:00Z |
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3610 |
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SPR006772722 |
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englisch |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR006772722</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519135226.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00535-015-1129-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR006772722</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00535-015-1129-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.87</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Tokushige, Katsutoshi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. 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| author |
Tokushige, Katsutoshi |
| spellingShingle |
Tokushige, Katsutoshi ddc 610 bkl 44.87 misc Alcoholic liver disease misc Nonalcoholic fatty liver disease misc Hepatocellular carcinoma misc Survival misc Recurrence Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
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Tokushige, Katsutoshi |
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1435-5922 |
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610 ASE 44.87 bkl Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey Alcoholic liver disease (dpeaa)DE-He213 Nonalcoholic fatty liver disease (dpeaa)DE-He213 Hepatocellular carcinoma (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 |
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ddc 610 bkl 44.87 misc Alcoholic liver disease misc Nonalcoholic fatty liver disease misc Hepatocellular carcinoma misc Survival misc Recurrence |
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ddc 610 bkl 44.87 misc Alcoholic liver disease misc Nonalcoholic fatty liver disease misc Hepatocellular carcinoma misc Survival misc Recurrence |
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ddc 610 bkl 44.87 misc Alcoholic liver disease misc Nonalcoholic fatty liver disease misc Hepatocellular carcinoma misc Survival misc Recurrence |
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Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
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Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
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Tokushige, Katsutoshi |
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Journal of gastroenterology |
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Tokushige, Katsutoshi Hyogo, Hideyuki Nakajima, Tomoaki Ono, Masafumi Kawaguchi, Takumi Honda, Koichi Eguchi, Yuichiro Nozaki, Yuichi Kawanaka, Miwa Tanaka, Saiyu Imajo, Kento Sumida, Yoshio Kamada, Yoshihiro Fujii, Hideki Suzuki, Yasuaki Kogiso, Tomomi Karino, Yoshiyasu Munekage, Kensuke Kuromatsu, Ryoko Oeda, Satoshi Yanase, Mikio Mori, Kohjiro Ogawa, Yuji Seko, Yuya Takehara, Tetsuo Itoh, Yoshito Nakajima, Atsushi Kanemasa, Kazuyuki Nishino, Ken Masaki, Naohiko Takahashi, Hirokazu Seike, Masataka Torimura, Takuji Saibara, Toshiji Toyota, Joji Chayama, Kazuaki Hashimoto, Etsuko |
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Tokushige, Katsutoshi |
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10.1007/s00535-015-1129-1 |
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610 |
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hepatocellular carcinoma in japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
| title_auth |
Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
| abstract |
Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. |
| abstractGer |
Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. |
| abstract_unstemmed |
Background In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases. |
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Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey |
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Hyogo, Hideyuki Nakajima, Tomoaki Ono, Masafumi Kawaguchi, Takumi Honda, Koichi Eguchi, Yuichiro Nozaki, Yuichi Kawanaka, Miwa Tanaka, Saiyu Imajo, Kento Sumida, Yoshio Kamada, Yoshihiro Fujii, Hideki Suzuki, Yasuaki Kogiso, Tomomi Karino, Yoshiyasu Munekage, Kensuke Kuromatsu, Ryoko Oeda, Satoshi Yanase, Mikio Mori, Kohjiro Ogawa, Yuji Seko, Yuya Takehara, Tetsuo Itoh, Yoshito Nakajima, Atsushi Kanemasa, Kazuyuki Nishino, Ken Masaki, Naohiko Takahashi, Hirokazu Seike, Masataka Torimura, Takuji Saibara, Toshiji Toyota, Joji Chayama, Kazuaki Hashimoto, Etsuko |
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Hyogo, Hideyuki Nakajima, Tomoaki Ono, Masafumi Kawaguchi, Takumi Honda, Koichi Eguchi, Yuichiro Nozaki, Yuichi Kawanaka, Miwa Tanaka, Saiyu Imajo, Kento Sumida, Yoshio Kamada, Yoshihiro Fujii, Hideki Suzuki, Yasuaki Kogiso, Tomomi Karino, Yoshiyasu Munekage, Kensuke Kuromatsu, Ryoko Oeda, Satoshi Yanase, Mikio Mori, Kohjiro Ogawa, Yuji Seko, Yuya Takehara, Tetsuo Itoh, Yoshito Nakajima, Atsushi Kanemasa, Kazuyuki Nishino, Ken Masaki, Naohiko Takahashi, Hirokazu Seike, Masataka Torimura, Takuji Saibara, Toshiji Toyota, Joji Chayama, Kazuaki Hashimoto, Etsuko |
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2024-07-04T00:35:57.854Z |
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Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC. Methods Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013. Results The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC. Conclusions Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. 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| score |
7.399972 |