Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice
Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranq...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kimura-Kuroiwa, Kaori [verfasserIn] Adachi, Yushi U. [verfasserIn] Obata, Yukako [verfasserIn] Kawamata, Mikito [verfasserIn] Sato, Shigehito [verfasserIn] Matsuda, Naoyuki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of anesthesia - Tokyo, 1987, 26(2012), 3 vom: 18. Feb., Seite 422-428 |
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| Übergeordnetes Werk: |
volume:26 ; year:2012 ; number:3 ; day:18 ; month:02 ; pages:422-428 |
| Links: |
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| DOI / URN: |
10.1007/s00540-012-1344-3 |
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| Katalog-ID: |
SPR006790607 |
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| 100 | 1 | |a Kimura-Kuroiwa, Kaori |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice |
| 264 | 1 | |c 2012 | |
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| 520 | |a Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. | ||
| 650 | 4 | |a Dexmedetomidine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hydroxyzine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Propofol |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Synergistic |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hypnosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Adachi, Yushi U. |e verfasserin |4 aut | |
| 700 | 1 | |a Obata, Yukako |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamata, Mikito |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Shigehito |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuda, Naoyuki |e verfasserin |4 aut | |
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10.1007/s00540-012-1344-3 doi (DE-627)SPR006790607 (SPR)s00540-012-1344-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.66 bkl Kimura-Kuroiwa, Kaori verfasserin aut Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. Dexmedetomidine (dpeaa)DE-He213 Hydroxyzine (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Synergistic (dpeaa)DE-He213 Hypnosis (dpeaa)DE-He213 Adachi, Yushi U. verfasserin aut Obata, Yukako verfasserin aut Kawamata, Mikito verfasserin aut Sato, Shigehito verfasserin aut Matsuda, Naoyuki verfasserin aut Enthalten in Journal of anesthesia Tokyo, 1987 26(2012), 3 vom: 18. Feb., Seite 422-428 (DE-627)300185065 (DE-600)1481564-3 1438-8359 nnns volume:26 year:2012 number:3 day:18 month:02 pages:422-428 https://dx.doi.org/10.1007/s00540-012-1344-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.66 ASE AR 26 2012 3 18 02 422-428 |
| spelling |
10.1007/s00540-012-1344-3 doi (DE-627)SPR006790607 (SPR)s00540-012-1344-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.66 bkl Kimura-Kuroiwa, Kaori verfasserin aut Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. Dexmedetomidine (dpeaa)DE-He213 Hydroxyzine (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Synergistic (dpeaa)DE-He213 Hypnosis (dpeaa)DE-He213 Adachi, Yushi U. verfasserin aut Obata, Yukako verfasserin aut Kawamata, Mikito verfasserin aut Sato, Shigehito verfasserin aut Matsuda, Naoyuki verfasserin aut Enthalten in Journal of anesthesia Tokyo, 1987 26(2012), 3 vom: 18. Feb., Seite 422-428 (DE-627)300185065 (DE-600)1481564-3 1438-8359 nnns volume:26 year:2012 number:3 day:18 month:02 pages:422-428 https://dx.doi.org/10.1007/s00540-012-1344-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.66 ASE AR 26 2012 3 18 02 422-428 |
| allfields_unstemmed |
10.1007/s00540-012-1344-3 doi (DE-627)SPR006790607 (SPR)s00540-012-1344-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.66 bkl Kimura-Kuroiwa, Kaori verfasserin aut Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. Dexmedetomidine (dpeaa)DE-He213 Hydroxyzine (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Synergistic (dpeaa)DE-He213 Hypnosis (dpeaa)DE-He213 Adachi, Yushi U. verfasserin aut Obata, Yukako verfasserin aut Kawamata, Mikito verfasserin aut Sato, Shigehito verfasserin aut Matsuda, Naoyuki verfasserin aut Enthalten in Journal of anesthesia Tokyo, 1987 26(2012), 3 vom: 18. Feb., Seite 422-428 (DE-627)300185065 (DE-600)1481564-3 1438-8359 nnns volume:26 year:2012 number:3 day:18 month:02 pages:422-428 https://dx.doi.org/10.1007/s00540-012-1344-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.66 ASE AR 26 2012 3 18 02 422-428 |
| allfieldsGer |
10.1007/s00540-012-1344-3 doi (DE-627)SPR006790607 (SPR)s00540-012-1344-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.66 bkl Kimura-Kuroiwa, Kaori verfasserin aut Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. Dexmedetomidine (dpeaa)DE-He213 Hydroxyzine (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Synergistic (dpeaa)DE-He213 Hypnosis (dpeaa)DE-He213 Adachi, Yushi U. verfasserin aut Obata, Yukako verfasserin aut Kawamata, Mikito verfasserin aut Sato, Shigehito verfasserin aut Matsuda, Naoyuki verfasserin aut Enthalten in Journal of anesthesia Tokyo, 1987 26(2012), 3 vom: 18. Feb., Seite 422-428 (DE-627)300185065 (DE-600)1481564-3 1438-8359 nnns volume:26 year:2012 number:3 day:18 month:02 pages:422-428 https://dx.doi.org/10.1007/s00540-012-1344-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.66 ASE AR 26 2012 3 18 02 422-428 |
| allfieldsSound |
10.1007/s00540-012-1344-3 doi (DE-627)SPR006790607 (SPR)s00540-012-1344-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.66 bkl Kimura-Kuroiwa, Kaori verfasserin aut Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. Dexmedetomidine (dpeaa)DE-He213 Hydroxyzine (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Synergistic (dpeaa)DE-He213 Hypnosis (dpeaa)DE-He213 Adachi, Yushi U. verfasserin aut Obata, Yukako verfasserin aut Kawamata, Mikito verfasserin aut Sato, Shigehito verfasserin aut Matsuda, Naoyuki verfasserin aut Enthalten in Journal of anesthesia Tokyo, 1987 26(2012), 3 vom: 18. Feb., Seite 422-428 (DE-627)300185065 (DE-600)1481564-3 1438-8359 nnns volume:26 year:2012 number:3 day:18 month:02 pages:422-428 https://dx.doi.org/10.1007/s00540-012-1344-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.66 ASE AR 26 2012 3 18 02 422-428 |
| language |
English |
| source |
Enthalten in Journal of anesthesia 26(2012), 3 vom: 18. Feb., Seite 422-428 volume:26 year:2012 number:3 day:18 month:02 pages:422-428 |
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Enthalten in Journal of anesthesia 26(2012), 3 vom: 18. Feb., Seite 422-428 volume:26 year:2012 number:3 day:18 month:02 pages:422-428 |
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Article |
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findex.gbv.de |
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Dexmedetomidine Hydroxyzine Propofol Synergistic Hypnosis |
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610 |
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false |
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Journal of anesthesia |
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Kimura-Kuroiwa, Kaori @@aut@@ Adachi, Yushi U. @@aut@@ Obata, Yukako @@aut@@ Kawamata, Mikito @@aut@@ Sato, Shigehito @@aut@@ Matsuda, Naoyuki @@aut@@ |
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2012-02-18T00:00:00Z |
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Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. 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Kimura-Kuroiwa, Kaori |
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Kimura-Kuroiwa, Kaori ddc 610 bkl 44.66 misc Dexmedetomidine misc Hydroxyzine misc Propofol misc Synergistic misc Hypnosis Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice |
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610 ASE 44.66 bkl Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice Dexmedetomidine (dpeaa)DE-He213 Hydroxyzine (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Synergistic (dpeaa)DE-He213 Hypnosis (dpeaa)DE-He213 |
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Kimura-Kuroiwa, Kaori Adachi, Yushi U. Obata, Yukako Kawamata, Mikito Sato, Shigehito Matsuda, Naoyuki |
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Kimura-Kuroiwa, Kaori |
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10.1007/s00540-012-1344-3 |
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dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice |
| title_auth |
Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice |
| abstract |
Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. |
| abstractGer |
Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. |
| abstract_unstemmed |
Purpose Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an $ α_{2} $-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol. Thus, we studied their combined effect with a hypnotic dose of propofol in ddY mice. Methods Male adult mice were intravenously administered either dexmedetomidine (30 μg/kg) or hydroxyzine (5 mg/kg) with propofol (3.75–10 mg/kg) to induce hypnosis, defined as a loss of the righting reflex (LRR). Other mice were intravenously administered propofol, dexmedetomidine (300 μg/kg), or hydroxyzine (50 mg/kg) alone, and subsequent behavioral changes were observed. The 50% effective dose ($ ED_{50} $) for LRR was calculated, and the duration of LRR was determined. Results The hypnotic dose of propofol was 9.95 ± 1.04 mg/kg ($ ED_{50} $ ± SEM) without combination. Dexmedetomidine and hydroxyzine reduced the $ ED_{50} $ of propofol to 5.32 ± 0.57 and 5.63 ± 0.57 mg/kg, respectively. Coadministration of dexmedetomidine significantly extended LRR duration compared with propofol alone, whereas hydroxyzine significantly shortened LRR duration. A maximal dose of dexmedetomidine or hydroxyzine alone did not induce hypnosis. Conclusions Dexmedetomidine and hydroxyzine demonstrated no hypnotic action alone; however, their coadministration potentiated the hypnotic activity of propofol. Although reduction in the dose of propofol was similar, only dexmedetomidine prolonged the duration of hypnosis. |
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Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice |
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Adachi, Yushi U. Obata, Yukako Kawamata, Mikito Sato, Shigehito Matsuda, Naoyuki |
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| score |
7.402815 |