Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood
Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 he...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Santilli, Veronica [verfasserIn] Cagigi, Alberto [verfasserIn] Guzzo, Isabella [verfasserIn] Rinaldi, Stefano [verfasserIn] Mora, Nadia [verfasserIn] Zotta, Federica [verfasserIn] Piazza, Antonina [verfasserIn] Rossi, Paolo [verfasserIn] Emma, Francesco [verfasserIn] Dello Strologo, Luca [verfasserIn] Palma, Paolo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Pediatric nephrology - Berlin : Springer, 1987, 31(2015), 6 vom: 21. Dez., Seite 1001-1010 |
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| Übergeordnetes Werk: |
volume:31 ; year:2015 ; number:6 ; day:21 ; month:12 ; pages:1001-1010 |
| Links: |
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| DOI / URN: |
10.1007/s00467-015-3274-4 |
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| Katalog-ID: |
SPR006864228 |
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| 245 | 1 | 0 | |a Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood |
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| 520 | |a Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. | ||
| 650 | 4 | |a Kidney transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Humoral allograft rejection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Predictive biomarkers |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lymphocyte subpopulations |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cagigi, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Guzzo, Isabella |e verfasserin |4 aut | |
| 700 | 1 | |a Rinaldi, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Mora, Nadia |e verfasserin |4 aut | |
| 700 | 1 | |a Zotta, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Piazza, Antonina |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Emma, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Dello Strologo, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Palma, Paolo |e verfasserin |4 aut | |
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10.1007/s00467-015-3274-4 doi (DE-627)SPR006864228 (SPR)s00467-015-3274-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Santilli, Veronica verfasserin aut Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. Kidney transplantation (dpeaa)DE-He213 Humoral allograft rejection (dpeaa)DE-He213 Predictive biomarkers (dpeaa)DE-He213 Lymphocyte subpopulations (dpeaa)DE-He213 Cagigi, Alberto verfasserin aut Guzzo, Isabella verfasserin aut Rinaldi, Stefano verfasserin aut Mora, Nadia verfasserin aut Zotta, Federica verfasserin aut Piazza, Antonina verfasserin aut Rossi, Paolo verfasserin aut Emma, Francesco verfasserin aut Dello Strologo, Luca verfasserin aut Palma, Paolo verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 31(2015), 6 vom: 21. Dez., Seite 1001-1010 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 https://dx.doi.org/10.1007/s00467-015-3274-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 31 2015 6 21 12 1001-1010 |
| spelling |
10.1007/s00467-015-3274-4 doi (DE-627)SPR006864228 (SPR)s00467-015-3274-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Santilli, Veronica verfasserin aut Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. Kidney transplantation (dpeaa)DE-He213 Humoral allograft rejection (dpeaa)DE-He213 Predictive biomarkers (dpeaa)DE-He213 Lymphocyte subpopulations (dpeaa)DE-He213 Cagigi, Alberto verfasserin aut Guzzo, Isabella verfasserin aut Rinaldi, Stefano verfasserin aut Mora, Nadia verfasserin aut Zotta, Federica verfasserin aut Piazza, Antonina verfasserin aut Rossi, Paolo verfasserin aut Emma, Francesco verfasserin aut Dello Strologo, Luca verfasserin aut Palma, Paolo verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 31(2015), 6 vom: 21. Dez., Seite 1001-1010 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 https://dx.doi.org/10.1007/s00467-015-3274-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 31 2015 6 21 12 1001-1010 |
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10.1007/s00467-015-3274-4 doi (DE-627)SPR006864228 (SPR)s00467-015-3274-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Santilli, Veronica verfasserin aut Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. Kidney transplantation (dpeaa)DE-He213 Humoral allograft rejection (dpeaa)DE-He213 Predictive biomarkers (dpeaa)DE-He213 Lymphocyte subpopulations (dpeaa)DE-He213 Cagigi, Alberto verfasserin aut Guzzo, Isabella verfasserin aut Rinaldi, Stefano verfasserin aut Mora, Nadia verfasserin aut Zotta, Federica verfasserin aut Piazza, Antonina verfasserin aut Rossi, Paolo verfasserin aut Emma, Francesco verfasserin aut Dello Strologo, Luca verfasserin aut Palma, Paolo verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 31(2015), 6 vom: 21. Dez., Seite 1001-1010 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 https://dx.doi.org/10.1007/s00467-015-3274-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 31 2015 6 21 12 1001-1010 |
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10.1007/s00467-015-3274-4 doi (DE-627)SPR006864228 (SPR)s00467-015-3274-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Santilli, Veronica verfasserin aut Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. Kidney transplantation (dpeaa)DE-He213 Humoral allograft rejection (dpeaa)DE-He213 Predictive biomarkers (dpeaa)DE-He213 Lymphocyte subpopulations (dpeaa)DE-He213 Cagigi, Alberto verfasserin aut Guzzo, Isabella verfasserin aut Rinaldi, Stefano verfasserin aut Mora, Nadia verfasserin aut Zotta, Federica verfasserin aut Piazza, Antonina verfasserin aut Rossi, Paolo verfasserin aut Emma, Francesco verfasserin aut Dello Strologo, Luca verfasserin aut Palma, Paolo verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 31(2015), 6 vom: 21. Dez., Seite 1001-1010 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 https://dx.doi.org/10.1007/s00467-015-3274-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 31 2015 6 21 12 1001-1010 |
| allfieldsSound |
10.1007/s00467-015-3274-4 doi (DE-627)SPR006864228 (SPR)s00467-015-3274-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Santilli, Veronica verfasserin aut Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. Kidney transplantation (dpeaa)DE-He213 Humoral allograft rejection (dpeaa)DE-He213 Predictive biomarkers (dpeaa)DE-He213 Lymphocyte subpopulations (dpeaa)DE-He213 Cagigi, Alberto verfasserin aut Guzzo, Isabella verfasserin aut Rinaldi, Stefano verfasserin aut Mora, Nadia verfasserin aut Zotta, Federica verfasserin aut Piazza, Antonina verfasserin aut Rossi, Paolo verfasserin aut Emma, Francesco verfasserin aut Dello Strologo, Luca verfasserin aut Palma, Paolo verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 31(2015), 6 vom: 21. Dez., Seite 1001-1010 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 https://dx.doi.org/10.1007/s00467-015-3274-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 31 2015 6 21 12 1001-1010 |
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English |
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Enthalten in Pediatric nephrology 31(2015), 6 vom: 21. Dez., Seite 1001-1010 volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 |
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Enthalten in Pediatric nephrology 31(2015), 6 vom: 21. Dez., Seite 1001-1010 volume:31 year:2015 number:6 day:21 month:12 pages:1001-1010 |
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Kidney transplantation Humoral allograft rejection Predictive biomarkers Lymphocyte subpopulations |
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Pediatric nephrology |
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Santilli, Veronica @@aut@@ Cagigi, Alberto @@aut@@ Guzzo, Isabella @@aut@@ Rinaldi, Stefano @@aut@@ Mora, Nadia @@aut@@ Zotta, Federica @@aut@@ Piazza, Antonina @@aut@@ Rossi, Paolo @@aut@@ Emma, Francesco @@aut@@ Dello Strologo, Luca @@aut@@ Palma, Paolo @@aut@@ |
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2015-12-21T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR006864228</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520001401.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00467-015-3274-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR006864228</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00467-015-3274-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.88</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.67</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Santilli, Veronica</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. 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Santilli, Veronica |
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Santilli, Veronica ddc 610 bkl 44.88 bkl 44.67 misc Kidney transplantation misc Humoral allograft rejection misc Predictive biomarkers misc Lymphocyte subpopulations Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood |
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610 ASE 44.88 bkl 44.67 bkl Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood Kidney transplantation (dpeaa)DE-He213 Humoral allograft rejection (dpeaa)DE-He213 Predictive biomarkers (dpeaa)DE-He213 Lymphocyte subpopulations (dpeaa)DE-He213 |
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ddc 610 bkl 44.88 bkl 44.67 misc Kidney transplantation misc Humoral allograft rejection misc Predictive biomarkers misc Lymphocyte subpopulations |
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ddc 610 bkl 44.88 bkl 44.67 misc Kidney transplantation misc Humoral allograft rejection misc Predictive biomarkers misc Lymphocyte subpopulations |
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Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood |
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Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood |
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Santilli, Veronica |
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Pediatric nephrology |
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Santilli, Veronica Cagigi, Alberto Guzzo, Isabella Rinaldi, Stefano Mora, Nadia Zotta, Federica Piazza, Antonina Rossi, Paolo Emma, Francesco Dello Strologo, Luca Palma, Paolo |
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cellular immune profile of kidney transplant patients developing anti-hla antibodies during childhood |
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Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood |
| abstract |
Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. |
| abstractGer |
Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. |
| abstract_unstemmed |
Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response. |
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Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood |
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Cagigi, Alberto Guzzo, Isabella Rinaldi, Stefano Mora, Nadia Zotta, Federica Piazza, Antonina Rossi, Paolo Emma, Francesco Dello Strologo, Luca Palma, Paolo |
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| score |
7.4017563 |