The interplay between bone and vessels in pediatric CKD: lessons from a single-center study

Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patie...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Preka, Evgenia [verfasserIn] Ranchin, Bruno [verfasserIn] Doyon, Anke [verfasserIn] Vierge, Melody [verfasserIn] Ginhoux, Tiphanie [verfasserIn] Kassai, Behrouz [verfasserIn] Bacchetta, Justine [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Chronic kidney disease–mineral bone disorder (CKD-MBD) Vessels Bone HR-pQCT Blood pressure

Übergeordnetes Werk:	Enthalten in: Pediatric nephrology - Berlin : Springer, 1987, 33(2018), 9 vom: 05. Juni, Seite 1565-1575
Übergeordnetes Werk:	volume:33 ; year:2018 ; number:9 ; day:05 ; month:06 ; pages:1565-1575

Links:	Volltext

DOI / URN:	10.1007/s00467-018-3978-3

Katalog-ID:	SPR006871585

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520			\|a Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed.
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publishDate	2018
allfields	10.1007/s00467-018-3978-3 doi (DE-627)SPR006871585 (SPR)s00467-018-3978-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Preka, Evgenia verfasserin aut The interplay between bone and vessels in pediatric CKD: lessons from a single-center study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed. Chronic kidney disease–mineral bone disorder (CKD-MBD) (dpeaa)DE-He213 Vessels (dpeaa)DE-He213 Bone (dpeaa)DE-He213 HR-pQCT (dpeaa)DE-He213 Blood pressure (dpeaa)DE-He213 Ranchin, Bruno verfasserin aut Doyon, Anke verfasserin aut Vierge, Melody verfasserin aut Ginhoux, Tiphanie verfasserin aut Kassai, Behrouz verfasserin aut Bacchetta, Justine verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 33(2018), 9 vom: 05. Juni, Seite 1565-1575 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575 https://dx.doi.org/10.1007/s00467-018-3978-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 33 2018 9 05 06 1565-1575
spelling	10.1007/s00467-018-3978-3 doi (DE-627)SPR006871585 (SPR)s00467-018-3978-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Preka, Evgenia verfasserin aut The interplay between bone and vessels in pediatric CKD: lessons from a single-center study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed. Chronic kidney disease–mineral bone disorder (CKD-MBD) (dpeaa)DE-He213 Vessels (dpeaa)DE-He213 Bone (dpeaa)DE-He213 HR-pQCT (dpeaa)DE-He213 Blood pressure (dpeaa)DE-He213 Ranchin, Bruno verfasserin aut Doyon, Anke verfasserin aut Vierge, Melody verfasserin aut Ginhoux, Tiphanie verfasserin aut Kassai, Behrouz verfasserin aut Bacchetta, Justine verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 33(2018), 9 vom: 05. Juni, Seite 1565-1575 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575 https://dx.doi.org/10.1007/s00467-018-3978-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 33 2018 9 05 06 1565-1575
allfields_unstemmed	10.1007/s00467-018-3978-3 doi (DE-627)SPR006871585 (SPR)s00467-018-3978-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Preka, Evgenia verfasserin aut The interplay between bone and vessels in pediatric CKD: lessons from a single-center study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed. Chronic kidney disease–mineral bone disorder (CKD-MBD) (dpeaa)DE-He213 Vessels (dpeaa)DE-He213 Bone (dpeaa)DE-He213 HR-pQCT (dpeaa)DE-He213 Blood pressure (dpeaa)DE-He213 Ranchin, Bruno verfasserin aut Doyon, Anke verfasserin aut Vierge, Melody verfasserin aut Ginhoux, Tiphanie verfasserin aut Kassai, Behrouz verfasserin aut Bacchetta, Justine verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 33(2018), 9 vom: 05. Juni, Seite 1565-1575 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575 https://dx.doi.org/10.1007/s00467-018-3978-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 33 2018 9 05 06 1565-1575
allfieldsGer	10.1007/s00467-018-3978-3 doi (DE-627)SPR006871585 (SPR)s00467-018-3978-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Preka, Evgenia verfasserin aut The interplay between bone and vessels in pediatric CKD: lessons from a single-center study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed. Chronic kidney disease–mineral bone disorder (CKD-MBD) (dpeaa)DE-He213 Vessels (dpeaa)DE-He213 Bone (dpeaa)DE-He213 HR-pQCT (dpeaa)DE-He213 Blood pressure (dpeaa)DE-He213 Ranchin, Bruno verfasserin aut Doyon, Anke verfasserin aut Vierge, Melody verfasserin aut Ginhoux, Tiphanie verfasserin aut Kassai, Behrouz verfasserin aut Bacchetta, Justine verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 33(2018), 9 vom: 05. Juni, Seite 1565-1575 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575 https://dx.doi.org/10.1007/s00467-018-3978-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 33 2018 9 05 06 1565-1575
allfieldsSound	10.1007/s00467-018-3978-3 doi (DE-627)SPR006871585 (SPR)s00467-018-3978-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl 44.67 bkl Preka, Evgenia verfasserin aut The interplay between bone and vessels in pediatric CKD: lessons from a single-center study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed. Chronic kidney disease–mineral bone disorder (CKD-MBD) (dpeaa)DE-He213 Vessels (dpeaa)DE-He213 Bone (dpeaa)DE-He213 HR-pQCT (dpeaa)DE-He213 Blood pressure (dpeaa)DE-He213 Ranchin, Bruno verfasserin aut Doyon, Anke verfasserin aut Vierge, Melody verfasserin aut Ginhoux, Tiphanie verfasserin aut Kassai, Behrouz verfasserin aut Bacchetta, Justine verfasserin aut Enthalten in Pediatric nephrology Berlin : Springer, 1987 33(2018), 9 vom: 05. Juni, Seite 1565-1575 (DE-627)254638872 (DE-600)1463004-7 1432-198X nnns volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575 https://dx.doi.org/10.1007/s00467-018-3978-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE 44.67 ASE AR 33 2018 9 05 06 1565-1575
language	English
source	Enthalten in Pediatric nephrology 33(2018), 9 vom: 05. Juni, Seite 1565-1575 volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575
sourceStr	Enthalten in Pediatric nephrology 33(2018), 9 vom: 05. Juni, Seite 1565-1575 volume:33 year:2018 number:9 day:05 month:06 pages:1565-1575
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic kidney disease–mineral bone disorder (CKD-MBD) Vessels Bone HR-pQCT Blood pressure
dewey-raw	610
isfreeaccess_bool	false
container_title	Pediatric nephrology
authorswithroles_txt_mv	Preka, Evgenia @@aut@@ Ranchin, Bruno @@aut@@ Doyon, Anke @@aut@@ Vierge, Melody @@aut@@ Ginhoux, Tiphanie @@aut@@ Kassai, Behrouz @@aut@@ Bacchetta, Justine @@aut@@
publishDateDaySort_date	2018-06-05T00:00:00Z
hierarchy_top_id	254638872
dewey-sort	3610
id	SPR006871585
language_de	englisch
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Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. 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author	Preka, Evgenia
spellingShingle	Preka, Evgenia ddc 610 bkl 44.88 bkl 44.67 misc Chronic kidney disease–mineral bone disorder (CKD-MBD) misc Vessels misc Bone misc HR-pQCT misc Blood pressure The interplay between bone and vessels in pediatric CKD: lessons from a single-center study
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topic_title	610 ASE 44.88 bkl 44.67 bkl The interplay between bone and vessels in pediatric CKD: lessons from a single-center study Chronic kidney disease–mineral bone disorder (CKD-MBD) (dpeaa)DE-He213 Vessels (dpeaa)DE-He213 Bone (dpeaa)DE-He213 HR-pQCT (dpeaa)DE-He213 Blood pressure (dpeaa)DE-He213
topic	ddc 610 bkl 44.88 bkl 44.67 misc Chronic kidney disease–mineral bone disorder (CKD-MBD) misc Vessels misc Bone misc HR-pQCT misc Blood pressure
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title	The interplay between bone and vessels in pediatric CKD: lessons from a single-center study
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title_full	The interplay between bone and vessels in pediatric CKD: lessons from a single-center study
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author_browse	Preka, Evgenia Ranchin, Bruno Doyon, Anke Vierge, Melody Ginhoux, Tiphanie Kassai, Behrouz Bacchetta, Justine
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title_sort	interplay between bone and vessels in pediatric ckd: lessons from a single-center study
title_auth	The interplay between bone and vessels in pediatric CKD: lessons from a single-center study
abstract	Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed.
abstractGer	Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed.
abstract_unstemmed	Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the greater the serum levels of calcium, the greater the (diastolic and mean) blood pressure; moreover, the greater the Tb. Th, the greater the (diastolic and mean) blood pressure. The role of calcium supplements to explain such findings in early pediatric CKD can be discussed.
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container_issue	9
title_short	The interplay between bone and vessels in pediatric CKD: lessons from a single-center study
url	https://dx.doi.org/10.1007/s00467-018-3978-3
remote_bool	true
author2	Ranchin, Bruno Doyon, Anke Vierge, Melody Ginhoux, Tiphanie Kassai, Behrouz Bacchetta, Justine
author2Str	Ranchin, Bruno Doyon, Anke Vierge, Melody Ginhoux, Tiphanie Kassai, Behrouz Bacchetta, Justine
ppnlink	254638872
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isOA_txt	false
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doi_str	10.1007/s00467-018-3978-3
up_date	2024-07-04T01:03:17.237Z
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Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.$ 73m^{2} $ (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32–116), respectively. 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The interplay between bone and vessels in pediatric CKD: lessons from a single-center study

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