Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population

Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees wer...
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Autor*in:	Oberlinner, Christoph [verfasserIn] Zober, Andreas [verfasserIn] Nawroth, Peter P. [verfasserIn] Humpert, Per M. [verfasserIn] Morcos, Michael [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Diabetes-risk Alanine-aminotransferase Diabetes-prediction Worksite-population Screening

Übergeordnetes Werk:	Enthalten in: Acta diabetologica - Mailand : Springer, 1964, 47(2009), 2 vom: 24. Okt., Seite 161-165
Übergeordnetes Werk:	volume:47 ; year:2009 ; number:2 ; day:24 ; month:10 ; pages:161-165

Links:	Volltext

DOI / URN:	10.1007/s00592-009-0148-x

Katalog-ID:	SPR006990967

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520			\|a Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied.
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700	1		\|a Morcos, Michael \|e verfasserin \|4 aut
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Indexfelder

author_variant	c o co a z az p p n pp ppn p m h pm pmh m m mm
matchkey_str	article:14325233:2009----::lnnaiornfrslvlpeitmardlcstlrne
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bklnumber	44.89
publishDate	2009
allfields	10.1007/s00592-009-0148-x doi (DE-627)SPR006990967 (SPR)s00592-009-0148-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Oberlinner, Christoph verfasserin aut Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied. Diabetes-risk (dpeaa)DE-He213 Alanine-aminotransferase (dpeaa)DE-He213 Diabetes-prediction (dpeaa)DE-He213 Worksite-population (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Zober, Andreas verfasserin aut Nawroth, Peter P. verfasserin aut Humpert, Per M. verfasserin aut Morcos, Michael verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 47(2009), 2 vom: 24. Okt., Seite 161-165 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:47 year:2009 number:2 day:24 month:10 pages:161-165 https://dx.doi.org/10.1007/s00592-009-0148-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 47 2009 2 24 10 161-165
spelling	10.1007/s00592-009-0148-x doi (DE-627)SPR006990967 (SPR)s00592-009-0148-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Oberlinner, Christoph verfasserin aut Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied. Diabetes-risk (dpeaa)DE-He213 Alanine-aminotransferase (dpeaa)DE-He213 Diabetes-prediction (dpeaa)DE-He213 Worksite-population (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Zober, Andreas verfasserin aut Nawroth, Peter P. verfasserin aut Humpert, Per M. verfasserin aut Morcos, Michael verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 47(2009), 2 vom: 24. Okt., Seite 161-165 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:47 year:2009 number:2 day:24 month:10 pages:161-165 https://dx.doi.org/10.1007/s00592-009-0148-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 47 2009 2 24 10 161-165
allfields_unstemmed	10.1007/s00592-009-0148-x doi (DE-627)SPR006990967 (SPR)s00592-009-0148-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Oberlinner, Christoph verfasserin aut Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied. Diabetes-risk (dpeaa)DE-He213 Alanine-aminotransferase (dpeaa)DE-He213 Diabetes-prediction (dpeaa)DE-He213 Worksite-population (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Zober, Andreas verfasserin aut Nawroth, Peter P. verfasserin aut Humpert, Per M. verfasserin aut Morcos, Michael verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 47(2009), 2 vom: 24. Okt., Seite 161-165 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:47 year:2009 number:2 day:24 month:10 pages:161-165 https://dx.doi.org/10.1007/s00592-009-0148-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 47 2009 2 24 10 161-165
allfieldsGer	10.1007/s00592-009-0148-x doi (DE-627)SPR006990967 (SPR)s00592-009-0148-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Oberlinner, Christoph verfasserin aut Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied. Diabetes-risk (dpeaa)DE-He213 Alanine-aminotransferase (dpeaa)DE-He213 Diabetes-prediction (dpeaa)DE-He213 Worksite-population (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Zober, Andreas verfasserin aut Nawroth, Peter P. verfasserin aut Humpert, Per M. verfasserin aut Morcos, Michael verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 47(2009), 2 vom: 24. Okt., Seite 161-165 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:47 year:2009 number:2 day:24 month:10 pages:161-165 https://dx.doi.org/10.1007/s00592-009-0148-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 47 2009 2 24 10 161-165
allfieldsSound	10.1007/s00592-009-0148-x doi (DE-627)SPR006990967 (SPR)s00592-009-0148-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Oberlinner, Christoph verfasserin aut Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied. Diabetes-risk (dpeaa)DE-He213 Alanine-aminotransferase (dpeaa)DE-He213 Diabetes-prediction (dpeaa)DE-He213 Worksite-population (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Zober, Andreas verfasserin aut Nawroth, Peter P. verfasserin aut Humpert, Per M. verfasserin aut Morcos, Michael verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 47(2009), 2 vom: 24. Okt., Seite 161-165 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:47 year:2009 number:2 day:24 month:10 pages:161-165 https://dx.doi.org/10.1007/s00592-009-0148-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 47 2009 2 24 10 161-165
language	English
source	Enthalten in Acta diabetologica 47(2009), 2 vom: 24. Okt., Seite 161-165 volume:47 year:2009 number:2 day:24 month:10 pages:161-165
sourceStr	Enthalten in Acta diabetologica 47(2009), 2 vom: 24. Okt., Seite 161-165 volume:47 year:2009 number:2 day:24 month:10 pages:161-165
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diabetes-risk Alanine-aminotransferase Diabetes-prediction Worksite-population Screening
dewey-raw	610
isfreeaccess_bool	false
container_title	Acta diabetologica
authorswithroles_txt_mv	Oberlinner, Christoph @@aut@@ Zober, Andreas @@aut@@ Nawroth, Peter P. @@aut@@ Humpert, Per M. @@aut@@ Morcos, Michael @@aut@@
publishDateDaySort_date	2009-10-24T00:00:00Z
hierarchy_top_id	266886469
dewey-sort	3610
id	SPR006990967
language_de	englisch
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author	Oberlinner, Christoph
spellingShingle	Oberlinner, Christoph ddc 610 bkl 44.89 misc Diabetes-risk misc Alanine-aminotransferase misc Diabetes-prediction misc Worksite-population misc Screening Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
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topic_title	610 ASE 44.89 bkl Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population Diabetes-risk (dpeaa)DE-He213 Alanine-aminotransferase (dpeaa)DE-He213 Diabetes-prediction (dpeaa)DE-He213 Worksite-population (dpeaa)DE-He213 Screening (dpeaa)DE-He213
topic	ddc 610 bkl 44.89 misc Diabetes-risk misc Alanine-aminotransferase misc Diabetes-prediction misc Worksite-population misc Screening
topic_unstemmed	ddc 610 bkl 44.89 misc Diabetes-risk misc Alanine-aminotransferase misc Diabetes-prediction misc Worksite-population misc Screening
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title	Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
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title_full	Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
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author_browse	Oberlinner, Christoph Zober, Andreas Nawroth, Peter P. Humpert, Per M. Morcos, Michael
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title_sort	alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
title_auth	Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
abstract	Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied.
abstractGer	Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied.
abstract_unstemmed	Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals with normal glucose tolerance and impaired glucose tolerance differed significantly with respect to fasting glucose (97 ± 8 vs. 103 ± 10 mg/dl, P < 0.01), HbA1c (5.5 ± 0.3 vs. 5.7 ± 0.4%, P < 0.01), and alanine-aminotransferase (ALT) (28 ± 15 vs. 36 ± 18 U/I, P < 0.05). In binary logistic regression analysis adjusted for age and gender, fasting glucose and ALT were the only independent predictors of impaired glucose tolerance (OR 4.8 [1.24–24.8] and OR 5.5 [1.2–24.8]), while age and HbA1c had only borderline significance (OR 3.9 [0.94–15.92] and OR 2.8 [0.94–8.67]). Waist circumference, BMI, triglycerides, and HDL as central components of the MS had no predictive value for impaired glucose tolerance. In summary, in this particular sample population, fasting glucose and ALT were the only significant predictors of IGT. These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied.
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container_issue	2
title_short	Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
url	https://dx.doi.org/10.1007/s00592-009-0148-x
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author2	Zober, Andreas Nawroth, Peter P. Humpert, Per M. Morcos, Michael
author2Str	Zober, Andreas Nawroth, Peter P. Humpert, Per M. Morcos, Michael
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doi_str	10.1007/s00592-009-0148-x
up_date	2024-07-04T01:35:00.820Z
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Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population

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