Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes
Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA r...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ciccacci, Cinzia [verfasserIn] Morganti, Roberto [verfasserIn] Di Fusco, Davide [verfasserIn] D’Amato, Cinzia [verfasserIn] Cacciotti, Laura [verfasserIn] Greco, Carla [verfasserIn] Rufini, Sara [verfasserIn] Novelli, Giuseppe [verfasserIn] Sangiuolo, Federica [verfasserIn] Marfia, Girolama A. [verfasserIn] Borgiani, Paola [verfasserIn] Spallone, Vincenza [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Acta diabetologica - Mailand : Springer, 1964, 51(2014), 4 vom: 30. März, Seite 663-671 |
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| Übergeordnetes Werk: |
volume:51 ; year:2014 ; number:4 ; day:30 ; month:03 ; pages:663-671 |
| Links: |
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| DOI / URN: |
10.1007/s00592-014-0582-2 |
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| Katalog-ID: |
SPR006995616 |
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| 245 | 1 | 0 | |a Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes |
| 264 | 1 | |c 2014 | |
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| 520 | |a Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. | ||
| 650 | 4 | |a Type 2 diabetes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a microRNAs |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Single nucleotide polymorphisms (SNPs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Autonomic neuropathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diabetic neuropathy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Morganti, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Di Fusco, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a D’Amato, Cinzia |e verfasserin |4 aut | |
| 700 | 1 | |a Cacciotti, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Greco, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Rufini, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Novelli, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Sangiuolo, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Marfia, Girolama A. |e verfasserin |4 aut | |
| 700 | 1 | |a Borgiani, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Spallone, Vincenza |e verfasserin |4 aut | |
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10.1007/s00592-014-0582-2 doi (DE-627)SPR006995616 (SPR)s00592-014-0582-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Ciccacci, Cinzia verfasserin aut Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. Type 2 diabetes (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 Single nucleotide polymorphisms (SNPs) (dpeaa)DE-He213 Autonomic neuropathy (dpeaa)DE-He213 Diabetic neuropathy (dpeaa)DE-He213 Morganti, Roberto verfasserin aut Di Fusco, Davide verfasserin aut D’Amato, Cinzia verfasserin aut Cacciotti, Laura verfasserin aut Greco, Carla verfasserin aut Rufini, Sara verfasserin aut Novelli, Giuseppe verfasserin aut Sangiuolo, Federica verfasserin aut Marfia, Girolama A. verfasserin aut Borgiani, Paola verfasserin aut Spallone, Vincenza verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 51(2014), 4 vom: 30. März, Seite 663-671 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:51 year:2014 number:4 day:30 month:03 pages:663-671 https://dx.doi.org/10.1007/s00592-014-0582-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 51 2014 4 30 03 663-671 |
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10.1007/s00592-014-0582-2 doi (DE-627)SPR006995616 (SPR)s00592-014-0582-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Ciccacci, Cinzia verfasserin aut Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. Type 2 diabetes (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 Single nucleotide polymorphisms (SNPs) (dpeaa)DE-He213 Autonomic neuropathy (dpeaa)DE-He213 Diabetic neuropathy (dpeaa)DE-He213 Morganti, Roberto verfasserin aut Di Fusco, Davide verfasserin aut D’Amato, Cinzia verfasserin aut Cacciotti, Laura verfasserin aut Greco, Carla verfasserin aut Rufini, Sara verfasserin aut Novelli, Giuseppe verfasserin aut Sangiuolo, Federica verfasserin aut Marfia, Girolama A. verfasserin aut Borgiani, Paola verfasserin aut Spallone, Vincenza verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 51(2014), 4 vom: 30. März, Seite 663-671 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:51 year:2014 number:4 day:30 month:03 pages:663-671 https://dx.doi.org/10.1007/s00592-014-0582-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 51 2014 4 30 03 663-671 |
| allfields_unstemmed |
10.1007/s00592-014-0582-2 doi (DE-627)SPR006995616 (SPR)s00592-014-0582-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Ciccacci, Cinzia verfasserin aut Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. Type 2 diabetes (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 Single nucleotide polymorphisms (SNPs) (dpeaa)DE-He213 Autonomic neuropathy (dpeaa)DE-He213 Diabetic neuropathy (dpeaa)DE-He213 Morganti, Roberto verfasserin aut Di Fusco, Davide verfasserin aut D’Amato, Cinzia verfasserin aut Cacciotti, Laura verfasserin aut Greco, Carla verfasserin aut Rufini, Sara verfasserin aut Novelli, Giuseppe verfasserin aut Sangiuolo, Federica verfasserin aut Marfia, Girolama A. verfasserin aut Borgiani, Paola verfasserin aut Spallone, Vincenza verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 51(2014), 4 vom: 30. März, Seite 663-671 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:51 year:2014 number:4 day:30 month:03 pages:663-671 https://dx.doi.org/10.1007/s00592-014-0582-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 51 2014 4 30 03 663-671 |
| allfieldsGer |
10.1007/s00592-014-0582-2 doi (DE-627)SPR006995616 (SPR)s00592-014-0582-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Ciccacci, Cinzia verfasserin aut Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. Type 2 diabetes (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 Single nucleotide polymorphisms (SNPs) (dpeaa)DE-He213 Autonomic neuropathy (dpeaa)DE-He213 Diabetic neuropathy (dpeaa)DE-He213 Morganti, Roberto verfasserin aut Di Fusco, Davide verfasserin aut D’Amato, Cinzia verfasserin aut Cacciotti, Laura verfasserin aut Greco, Carla verfasserin aut Rufini, Sara verfasserin aut Novelli, Giuseppe verfasserin aut Sangiuolo, Federica verfasserin aut Marfia, Girolama A. verfasserin aut Borgiani, Paola verfasserin aut Spallone, Vincenza verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 51(2014), 4 vom: 30. März, Seite 663-671 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:51 year:2014 number:4 day:30 month:03 pages:663-671 https://dx.doi.org/10.1007/s00592-014-0582-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 51 2014 4 30 03 663-671 |
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10.1007/s00592-014-0582-2 doi (DE-627)SPR006995616 (SPR)s00592-014-0582-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.89 bkl Ciccacci, Cinzia verfasserin aut Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. Type 2 diabetes (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 Single nucleotide polymorphisms (SNPs) (dpeaa)DE-He213 Autonomic neuropathy (dpeaa)DE-He213 Diabetic neuropathy (dpeaa)DE-He213 Morganti, Roberto verfasserin aut Di Fusco, Davide verfasserin aut D’Amato, Cinzia verfasserin aut Cacciotti, Laura verfasserin aut Greco, Carla verfasserin aut Rufini, Sara verfasserin aut Novelli, Giuseppe verfasserin aut Sangiuolo, Federica verfasserin aut Marfia, Girolama A. verfasserin aut Borgiani, Paola verfasserin aut Spallone, Vincenza verfasserin aut Enthalten in Acta diabetologica Mailand : Springer, 1964 51(2014), 4 vom: 30. März, Seite 663-671 (DE-627)266886469 (DE-600)1468518-8 1432-5233 nnns volume:51 year:2014 number:4 day:30 month:03 pages:663-671 https://dx.doi.org/10.1007/s00592-014-0582-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 51 2014 4 30 03 663-671 |
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Type 2 diabetes microRNAs Single nucleotide polymorphisms (SNPs) Autonomic neuropathy Diabetic neuropathy |
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Ciccacci, Cinzia @@aut@@ Morganti, Roberto @@aut@@ Di Fusco, Davide @@aut@@ D’Amato, Cinzia @@aut@@ Cacciotti, Laura @@aut@@ Greco, Carla @@aut@@ Rufini, Sara @@aut@@ Novelli, Giuseppe @@aut@@ Sangiuolo, Federica @@aut@@ Marfia, Girolama A. @@aut@@ Borgiani, Paola @@aut@@ Spallone, Vincenza @@aut@@ |
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2014-03-30T00:00:00Z |
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| author |
Ciccacci, Cinzia |
| spellingShingle |
Ciccacci, Cinzia ddc 610 bkl 44.89 misc Type 2 diabetes misc microRNAs misc Single nucleotide polymorphisms (SNPs) misc Autonomic neuropathy misc Diabetic neuropathy Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes |
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Ciccacci, Cinzia |
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1432-5233 |
| topic_title |
610 ASE 44.89 bkl Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes Type 2 diabetes (dpeaa)DE-He213 microRNAs (dpeaa)DE-He213 Single nucleotide polymorphisms (SNPs) (dpeaa)DE-He213 Autonomic neuropathy (dpeaa)DE-He213 Diabetic neuropathy (dpeaa)DE-He213 |
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ddc 610 bkl 44.89 misc Type 2 diabetes misc microRNAs misc Single nucleotide polymorphisms (SNPs) misc Autonomic neuropathy misc Diabetic neuropathy |
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ddc 610 bkl 44.89 misc Type 2 diabetes misc microRNAs misc Single nucleotide polymorphisms (SNPs) misc Autonomic neuropathy misc Diabetic neuropathy |
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ddc 610 bkl 44.89 misc Type 2 diabetes misc microRNAs misc Single nucleotide polymorphisms (SNPs) misc Autonomic neuropathy misc Diabetic neuropathy |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Acta diabetologica |
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Acta diabetologica |
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(DE-627)266886469 (DE-600)1468518-8 |
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Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes |
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(DE-627)SPR006995616 (SPR)s00592-014-0582-2-e |
| title_full |
Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes |
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Ciccacci, Cinzia |
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Acta diabetologica |
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Acta diabetologica |
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eng |
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600 - Technology |
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2014 |
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Ciccacci, Cinzia Morganti, Roberto Di Fusco, Davide D’Amato, Cinzia Cacciotti, Laura Greco, Carla Rufini, Sara Novelli, Giuseppe Sangiuolo, Federica Marfia, Girolama A. Borgiani, Paola Spallone, Vincenza |
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610 ASE 44.89 bkl |
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Elektronische Aufsätze |
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Ciccacci, Cinzia |
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10.1007/s00592-014-0582-2 |
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610 |
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verfasserin |
| title_sort |
common polymorphisms in mir146a, mir128a and mir27a genes contribute to neuropathy susceptibility in type 2 diabetes |
| title_auth |
Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes |
| abstract |
Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. |
| abstractGer |
Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. |
| abstract_unstemmed |
Abstract Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) are common type 2 diabetes complications with a large inter-individual variability in terms of clinical manifestations and severity. Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. This is the first study showing that genetic variability in miRNA genes could be involved in diabetic neuropathies susceptibility. |
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| title_short |
Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes |
| url |
https://dx.doi.org/10.1007/s00592-014-0582-2 |
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| author2 |
Morganti, Roberto Di Fusco, Davide D’Amato, Cinzia Cacciotti, Laura Greco, Carla Rufini, Sara Novelli, Giuseppe Sangiuolo, Federica Marfia, Girolama A. Borgiani, Paola Spallone, Vincenza |
| author2Str |
Morganti, Roberto Di Fusco, Davide D’Amato, Cinzia Cacciotti, Laura Greco, Carla Rufini, Sara Novelli, Giuseppe Sangiuolo, Federica Marfia, Girolama A. Borgiani, Paola Spallone, Vincenza |
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266886469 |
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c |
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false |
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false |
| doi_str |
10.1007/s00592-014-0582-2 |
| up_date |
2024-07-04T01:36:27.590Z |
| _version_ |
1803610475823366144 |
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Our aim was to evaluate a possible involvement of genetic polymorphisms in miRNA regions in the susceptibility to DPN and CAN. Nine polymorphisms in miRNA genes were studied in a sample of 132 type 2 diabetes patients (T2D) analysed for DPN and 128 T2D patients analysed for CAN. A genotype–phenotype correlation analysis was performed. The T allele of rs11888095 single nucleotide polymorphism (SNP) in MIR128a was significantly associated with a higher risk ($ OR_{adj} $ = 4.89, Padj = 0.02), whereas the C allele of rs2910164 SNP in MIR146a was associated with a lower risk to develop DPN ($ OR_{adj} $ = 0.49, Padj = 0.09), respectively. A multivariate logistic regression analysis confirmed that both SNPs contribute to DPN (p < 0.001 and p = 0.01 for MIR128a and MIR146a, respectively). MIR128a SNP significantly contributed also to DPN score (p = 0.026). Rs895819 SNP in MIR27a was significantly associated with a higher risk to develop early CAN (Padj = 0.023 and $ OR_{adj} $ = 3.43). The rs2910164 SNP in MIR146a showed a protective effect respect to early CAN (Padj = 0.052, $ OR_{adj} $ = 0.32) and to confirmed CAN (Padj = 0.041, $ OR_{adj} $ = 0.13). The same SNP resulted significantly associated with a lower CAN score and a higher E/I (p = 0.002 and p = 0.003, respectively). In conclusion, we described associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility. 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| score |
7.4020243 |