Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case
Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Matsuda, Masanori [verfasserIn] Amemiya, Hidetake [verfasserIn] Kawaida, Hiromichi [verfasserIn] Okamoto, Hirotaka [verfasserIn] Hosomura, Naohiro [verfasserIn] Asakawa, Masami [verfasserIn] Sano, Katsuhiro [verfasserIn] Motosugi, Utaroh [verfasserIn] Ichikawa, Tomoaki [verfasserIn] Nakazawa, Tadao [verfasserIn] Fujii, Hideki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
Fibrolamellar hepatocellular carcinoma Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI |
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| Übergeordnetes Werk: |
Enthalten in: Surgery today - Tokyo : Springer, 1971, 44(2013), 7 vom: 05. Juli, Seite 1359-1366 |
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| Übergeordnetes Werk: |
volume:44 ; year:2013 ; number:7 ; day:05 ; month:07 ; pages:1359-1366 |
| Links: |
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| DOI / URN: |
10.1007/s00595-013-0653-y |
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| Katalog-ID: |
SPR007027737 |
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| 520 | |a Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. | ||
| 650 | 4 | |a Fibrolamellar hepatocellular carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hepatic resection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunohistological study |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Electron microscopic study |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Amemiya, Hidetake |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaida, Hiromichi |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Hirotaka |e verfasserin |4 aut | |
| 700 | 1 | |a Hosomura, Naohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Asakawa, Masami |e verfasserin |4 aut | |
| 700 | 1 | |a Sano, Katsuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Motosugi, Utaroh |e verfasserin |4 aut | |
| 700 | 1 | |a Ichikawa, Tomoaki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakazawa, Tadao |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Hideki |e verfasserin |4 aut | |
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10.1007/s00595-013-0653-y doi (DE-627)SPR007027737 (SPR)s00595-013-0653-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Matsuda, Masanori verfasserin aut Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. Fibrolamellar hepatocellular carcinoma (dpeaa)DE-He213 Hepatic resection (dpeaa)DE-He213 Immunohistological study (dpeaa)DE-He213 Electron microscopic study (dpeaa)DE-He213 Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI (dpeaa)DE-He213 Amemiya, Hidetake verfasserin aut Kawaida, Hiromichi verfasserin aut Okamoto, Hirotaka verfasserin aut Hosomura, Naohiro verfasserin aut Asakawa, Masami verfasserin aut Sano, Katsuhiro verfasserin aut Motosugi, Utaroh verfasserin aut Ichikawa, Tomoaki verfasserin aut Nakazawa, Tadao verfasserin aut Fujii, Hideki verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 44(2013), 7 vom: 05. Juli, Seite 1359-1366 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:44 year:2013 number:7 day:05 month:07 pages:1359-1366 https://dx.doi.org/10.1007/s00595-013-0653-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 44 2013 7 05 07 1359-1366 |
| spelling |
10.1007/s00595-013-0653-y doi (DE-627)SPR007027737 (SPR)s00595-013-0653-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Matsuda, Masanori verfasserin aut Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. Fibrolamellar hepatocellular carcinoma (dpeaa)DE-He213 Hepatic resection (dpeaa)DE-He213 Immunohistological study (dpeaa)DE-He213 Electron microscopic study (dpeaa)DE-He213 Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI (dpeaa)DE-He213 Amemiya, Hidetake verfasserin aut Kawaida, Hiromichi verfasserin aut Okamoto, Hirotaka verfasserin aut Hosomura, Naohiro verfasserin aut Asakawa, Masami verfasserin aut Sano, Katsuhiro verfasserin aut Motosugi, Utaroh verfasserin aut Ichikawa, Tomoaki verfasserin aut Nakazawa, Tadao verfasserin aut Fujii, Hideki verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 44(2013), 7 vom: 05. Juli, Seite 1359-1366 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:44 year:2013 number:7 day:05 month:07 pages:1359-1366 https://dx.doi.org/10.1007/s00595-013-0653-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 44 2013 7 05 07 1359-1366 |
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10.1007/s00595-013-0653-y doi (DE-627)SPR007027737 (SPR)s00595-013-0653-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Matsuda, Masanori verfasserin aut Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. Fibrolamellar hepatocellular carcinoma (dpeaa)DE-He213 Hepatic resection (dpeaa)DE-He213 Immunohistological study (dpeaa)DE-He213 Electron microscopic study (dpeaa)DE-He213 Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI (dpeaa)DE-He213 Amemiya, Hidetake verfasserin aut Kawaida, Hiromichi verfasserin aut Okamoto, Hirotaka verfasserin aut Hosomura, Naohiro verfasserin aut Asakawa, Masami verfasserin aut Sano, Katsuhiro verfasserin aut Motosugi, Utaroh verfasserin aut Ichikawa, Tomoaki verfasserin aut Nakazawa, Tadao verfasserin aut Fujii, Hideki verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 44(2013), 7 vom: 05. Juli, Seite 1359-1366 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:44 year:2013 number:7 day:05 month:07 pages:1359-1366 https://dx.doi.org/10.1007/s00595-013-0653-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 44 2013 7 05 07 1359-1366 |
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10.1007/s00595-013-0653-y doi (DE-627)SPR007027737 (SPR)s00595-013-0653-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Matsuda, Masanori verfasserin aut Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. Fibrolamellar hepatocellular carcinoma (dpeaa)DE-He213 Hepatic resection (dpeaa)DE-He213 Immunohistological study (dpeaa)DE-He213 Electron microscopic study (dpeaa)DE-He213 Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI (dpeaa)DE-He213 Amemiya, Hidetake verfasserin aut Kawaida, Hiromichi verfasserin aut Okamoto, Hirotaka verfasserin aut Hosomura, Naohiro verfasserin aut Asakawa, Masami verfasserin aut Sano, Katsuhiro verfasserin aut Motosugi, Utaroh verfasserin aut Ichikawa, Tomoaki verfasserin aut Nakazawa, Tadao verfasserin aut Fujii, Hideki verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 44(2013), 7 vom: 05. Juli, Seite 1359-1366 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:44 year:2013 number:7 day:05 month:07 pages:1359-1366 https://dx.doi.org/10.1007/s00595-013-0653-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 44 2013 7 05 07 1359-1366 |
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10.1007/s00595-013-0653-y doi (DE-627)SPR007027737 (SPR)s00595-013-0653-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Matsuda, Masanori verfasserin aut Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. Fibrolamellar hepatocellular carcinoma (dpeaa)DE-He213 Hepatic resection (dpeaa)DE-He213 Immunohistological study (dpeaa)DE-He213 Electron microscopic study (dpeaa)DE-He213 Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI (dpeaa)DE-He213 Amemiya, Hidetake verfasserin aut Kawaida, Hiromichi verfasserin aut Okamoto, Hirotaka verfasserin aut Hosomura, Naohiro verfasserin aut Asakawa, Masami verfasserin aut Sano, Katsuhiro verfasserin aut Motosugi, Utaroh verfasserin aut Ichikawa, Tomoaki verfasserin aut Nakazawa, Tadao verfasserin aut Fujii, Hideki verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 44(2013), 7 vom: 05. Juli, Seite 1359-1366 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:44 year:2013 number:7 day:05 month:07 pages:1359-1366 https://dx.doi.org/10.1007/s00595-013-0653-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 44 2013 7 05 07 1359-1366 |
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Enthalten in Surgery today 44(2013), 7 vom: 05. Juli, Seite 1359-1366 volume:44 year:2013 number:7 day:05 month:07 pages:1359-1366 |
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Fibrolamellar hepatocellular carcinoma Hepatic resection Immunohistological study Electron microscopic study Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI |
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Matsuda, Masanori @@aut@@ Amemiya, Hidetake @@aut@@ Kawaida, Hiromichi @@aut@@ Okamoto, Hirotaka @@aut@@ Hosomura, Naohiro @@aut@@ Asakawa, Masami @@aut@@ Sano, Katsuhiro @@aut@@ Motosugi, Utaroh @@aut@@ Ichikawa, Tomoaki @@aut@@ Nakazawa, Tadao @@aut@@ Fujii, Hideki @@aut@@ |
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2013-07-05T00:00:00Z |
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This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. 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Matsuda, Masanori |
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Matsuda, Masanori ddc 610 bkl 44.65 misc Fibrolamellar hepatocellular carcinoma misc Hepatic resection misc Immunohistological study misc Electron microscopic study misc Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case |
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Matsuda, Masanori |
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610 ASE 44.65 bkl Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case Fibrolamellar hepatocellular carcinoma (dpeaa)DE-He213 Hepatic resection (dpeaa)DE-He213 Immunohistological study (dpeaa)DE-He213 Electron microscopic study (dpeaa)DE-He213 Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI (dpeaa)DE-He213 |
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ddc 610 bkl 44.65 misc Fibrolamellar hepatocellular carcinoma misc Hepatic resection misc Immunohistological study misc Electron microscopic study misc Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI |
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ddc 610 bkl 44.65 misc Fibrolamellar hepatocellular carcinoma misc Hepatic resection misc Immunohistological study misc Electron microscopic study misc Gadolinium ethoxybenzyl diethylenetriaminepentaacetic-enhanced MRI |
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Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case |
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Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case |
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Matsuda, Masanori Amemiya, Hidetake Kawaida, Hiromichi Okamoto, Hirotaka Hosomura, Naohiro Asakawa, Masami Sano, Katsuhiro Motosugi, Utaroh Ichikawa, Tomoaki Nakazawa, Tadao Fujii, Hideki |
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typical fibrolamellar hepatocellular carcinoma in a japanese boy: report of a case |
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Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case |
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Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. |
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Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. |
| abstract_unstemmed |
Abstract We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. |
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Amemiya, Hidetake Kawaida, Hiromichi Okamoto, Hirotaka Hosomura, Naohiro Asakawa, Masami Sano, Katsuhiro Motosugi, Utaroh Ichikawa, Tomoaki Nakazawa, Tadao Fujii, Hideki |
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| score |
7.4003134 |