Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer
Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tominaga, Tetsuro [verfasserIn] Nagasaki, Toshiya [verfasserIn] Akiyoshi, Takashi [verfasserIn] Fukunaga, Yosuke [verfasserIn] Fujimoto, Yoshiya [verfasserIn] Yamaguchi, Tomohiro [verfasserIn] Konishi, Tsuyoshi [verfasserIn] Nagayama, Satoshi [verfasserIn] Ueno, Masashi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Surgery today - Tokyo : Springer, 1971, 49(2019), 8 vom: 01. Apr., Seite 694-703 |
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| Übergeordnetes Werk: |
volume:49 ; year:2019 ; number:8 ; day:01 ; month:04 ; pages:694-703 |
| Links: |
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| DOI / URN: |
10.1007/s00595-019-01801-0 |
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SPR00703900X |
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| 245 | 1 | 0 | |a Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer |
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| 520 | |a Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. | ||
| 650 | 4 | |a Rectal cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Elderly patients |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chemoradiotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neoadjuvant therapy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Nagasaki, Toshiya |e verfasserin |4 aut | |
| 700 | 1 | |a Akiyoshi, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Fukunaga, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimoto, Yoshiya |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Konishi, Tsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Nagayama, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Masashi |e verfasserin |4 aut | |
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10.1007/s00595-019-01801-0 doi (DE-627)SPR00703900X (SPR)s00595-019-01801-0-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Tominaga, Tetsuro verfasserin aut Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. Rectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Chemoradiotherapy (dpeaa)DE-He213 Neoadjuvant therapy (dpeaa)DE-He213 Nagasaki, Toshiya verfasserin aut Akiyoshi, Takashi verfasserin aut Fukunaga, Yosuke verfasserin aut Fujimoto, Yoshiya verfasserin aut Yamaguchi, Tomohiro verfasserin aut Konishi, Tsuyoshi verfasserin aut Nagayama, Satoshi verfasserin aut Ueno, Masashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 49(2019), 8 vom: 01. Apr., Seite 694-703 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:49 year:2019 number:8 day:01 month:04 pages:694-703 https://dx.doi.org/10.1007/s00595-019-01801-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 49 2019 8 01 04 694-703 |
| spelling |
10.1007/s00595-019-01801-0 doi (DE-627)SPR00703900X (SPR)s00595-019-01801-0-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Tominaga, Tetsuro verfasserin aut Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. Rectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Chemoradiotherapy (dpeaa)DE-He213 Neoadjuvant therapy (dpeaa)DE-He213 Nagasaki, Toshiya verfasserin aut Akiyoshi, Takashi verfasserin aut Fukunaga, Yosuke verfasserin aut Fujimoto, Yoshiya verfasserin aut Yamaguchi, Tomohiro verfasserin aut Konishi, Tsuyoshi verfasserin aut Nagayama, Satoshi verfasserin aut Ueno, Masashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 49(2019), 8 vom: 01. Apr., Seite 694-703 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:49 year:2019 number:8 day:01 month:04 pages:694-703 https://dx.doi.org/10.1007/s00595-019-01801-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 49 2019 8 01 04 694-703 |
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10.1007/s00595-019-01801-0 doi (DE-627)SPR00703900X (SPR)s00595-019-01801-0-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Tominaga, Tetsuro verfasserin aut Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. Rectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Chemoradiotherapy (dpeaa)DE-He213 Neoadjuvant therapy (dpeaa)DE-He213 Nagasaki, Toshiya verfasserin aut Akiyoshi, Takashi verfasserin aut Fukunaga, Yosuke verfasserin aut Fujimoto, Yoshiya verfasserin aut Yamaguchi, Tomohiro verfasserin aut Konishi, Tsuyoshi verfasserin aut Nagayama, Satoshi verfasserin aut Ueno, Masashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 49(2019), 8 vom: 01. Apr., Seite 694-703 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:49 year:2019 number:8 day:01 month:04 pages:694-703 https://dx.doi.org/10.1007/s00595-019-01801-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 49 2019 8 01 04 694-703 |
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10.1007/s00595-019-01801-0 doi (DE-627)SPR00703900X (SPR)s00595-019-01801-0-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Tominaga, Tetsuro verfasserin aut Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. Rectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Chemoradiotherapy (dpeaa)DE-He213 Neoadjuvant therapy (dpeaa)DE-He213 Nagasaki, Toshiya verfasserin aut Akiyoshi, Takashi verfasserin aut Fukunaga, Yosuke verfasserin aut Fujimoto, Yoshiya verfasserin aut Yamaguchi, Tomohiro verfasserin aut Konishi, Tsuyoshi verfasserin aut Nagayama, Satoshi verfasserin aut Ueno, Masashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 49(2019), 8 vom: 01. Apr., Seite 694-703 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:49 year:2019 number:8 day:01 month:04 pages:694-703 https://dx.doi.org/10.1007/s00595-019-01801-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 49 2019 8 01 04 694-703 |
| allfieldsSound |
10.1007/s00595-019-01801-0 doi (DE-627)SPR00703900X (SPR)s00595-019-01801-0-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl Tominaga, Tetsuro verfasserin aut Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. Rectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Chemoradiotherapy (dpeaa)DE-He213 Neoadjuvant therapy (dpeaa)DE-He213 Nagasaki, Toshiya verfasserin aut Akiyoshi, Takashi verfasserin aut Fukunaga, Yosuke verfasserin aut Fujimoto, Yoshiya verfasserin aut Yamaguchi, Tomohiro verfasserin aut Konishi, Tsuyoshi verfasserin aut Nagayama, Satoshi verfasserin aut Ueno, Masashi verfasserin aut Enthalten in Surgery today Tokyo : Springer, 1971 49(2019), 8 vom: 01. Apr., Seite 694-703 (DE-627)254909604 (DE-600)1463169-6 1436-2813 nnns volume:49 year:2019 number:8 day:01 month:04 pages:694-703 https://dx.doi.org/10.1007/s00595-019-01801-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 49 2019 8 01 04 694-703 |
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Enthalten in Surgery today 49(2019), 8 vom: 01. Apr., Seite 694-703 volume:49 year:2019 number:8 day:01 month:04 pages:694-703 |
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Enthalten in Surgery today 49(2019), 8 vom: 01. Apr., Seite 694-703 volume:49 year:2019 number:8 day:01 month:04 pages:694-703 |
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Rectal cancer Elderly patients Chemoradiotherapy Neoadjuvant therapy |
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Tominaga, Tetsuro @@aut@@ Nagasaki, Toshiya @@aut@@ Akiyoshi, Takashi @@aut@@ Fukunaga, Yosuke @@aut@@ Fujimoto, Yoshiya @@aut@@ Yamaguchi, Tomohiro @@aut@@ Konishi, Tsuyoshi @@aut@@ Nagayama, Satoshi @@aut@@ Ueno, Masashi @@aut@@ |
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Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. 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Tominaga, Tetsuro |
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610 ASE 44.65 bkl Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer Rectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Chemoradiotherapy (dpeaa)DE-He213 Neoadjuvant therapy (dpeaa)DE-He213 |
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feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer |
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Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer |
| abstract |
Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. |
| abstractGer |
Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. |
| abstract_unstemmed |
Purpose The feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well. Methods Between 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years old (elderly group), and 452 were under 75 years old (young group). The patients were divided into sub-groups according to whether they received NAT. Results Nineteen (35.2%) patients from the elderly group and 348 (77.0%) from the young group received NAT. The proportion of patients who received NAT was significantly lower in the elderly group. In the elderly group, the median age and prevalence of co-morbidities were significantly lower in patients with than in those without NAT. The incidence of severe adverse events was similar in the two groups. On multivariate analysis, age was not related to postoperative complications in patients who received NAT. The 5-year local recurrence rate was significantly lower in the elderly patients who received NAT, and similar to that of the young patients who received NAT. Conclusions Neoadjuvant therapy was feasible and should be considered as a treatment option for carefully selected elderly patients with locally advanced low rectal cancer. |
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Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer |
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Nagasaki, Toshiya Akiyoshi, Takashi Fukunaga, Yosuke Fujimoto, Yoshiya Yamaguchi, Tomohiro Konishi, Tsuyoshi Nagayama, Satoshi Ueno, Masashi |
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Nagasaki, Toshiya Akiyoshi, Takashi Fukunaga, Yosuke Fujimoto, Yoshiya Yamaguchi, Tomohiro Konishi, Tsuyoshi Nagayama, Satoshi Ueno, Masashi |
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| score |
7.401025 |