The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats

Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive pr...
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Gespeichert in:

Autor*in:	Goorani, Samaneh [verfasserIn] Zhaleh, Mohsen [verfasserIn] Zangeneh, Akram [verfasserIn] Koohi, Mohammad Kazem [verfasserIn] Rashidi, Khodabakhsh [verfasserIn] Moradi, Rohallah [verfasserIn] Zangeneh, Mohammad Mahdi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Hepatoprotective Nephroprotective Hematoprotective Immunoprotective Gastroduodenal protective

Übergeordnetes Werk:	Enthalten in: Comparative haematology international - London : Springer, 1991, 28(2018), 2 vom: 07. Nov., Seite 339-347
Übergeordnetes Werk:	volume:28 ; year:2018 ; number:2 ; day:07 ; month:11 ; pages:339-347

Links:	Volltext

DOI / URN:	10.1007/s00580-018-2852-9

Katalog-ID:	SPR007257325

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allfields	10.1007/s00580-018-2852-9 doi (DE-627)SPR007257325 (SPR)s00580-018-2852-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Goorani, Samaneh verfasserin aut The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract. Hepatoprotective (dpeaa)DE-He213 Nephroprotective (dpeaa)DE-He213 Hematoprotective (dpeaa)DE-He213 Immunoprotective (dpeaa)DE-He213 Gastroduodenal protective (dpeaa)DE-He213 Zhaleh, Mohsen verfasserin aut Zangeneh, Akram verfasserin aut Koohi, Mohammad Kazem verfasserin aut Rashidi, Khodabakhsh verfasserin aut Moradi, Rohallah verfasserin aut Zangeneh, Mohammad Mahdi verfasserin aut Enthalten in Comparative haematology international London : Springer, 1991 28(2018), 2 vom: 07. Nov., Seite 339-347 (DE-627)559430590 (DE-600)2413027-8 1433-2973 nnns volume:28 year:2018 number:2 day:07 month:11 pages:339-347 https://dx.doi.org/10.1007/s00580-018-2852-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2018 2 07 11 339-347
spelling	10.1007/s00580-018-2852-9 doi (DE-627)SPR007257325 (SPR)s00580-018-2852-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Goorani, Samaneh verfasserin aut The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract. Hepatoprotective (dpeaa)DE-He213 Nephroprotective (dpeaa)DE-He213 Hematoprotective (dpeaa)DE-He213 Immunoprotective (dpeaa)DE-He213 Gastroduodenal protective (dpeaa)DE-He213 Zhaleh, Mohsen verfasserin aut Zangeneh, Akram verfasserin aut Koohi, Mohammad Kazem verfasserin aut Rashidi, Khodabakhsh verfasserin aut Moradi, Rohallah verfasserin aut Zangeneh, Mohammad Mahdi verfasserin aut Enthalten in Comparative haematology international London : Springer, 1991 28(2018), 2 vom: 07. Nov., Seite 339-347 (DE-627)559430590 (DE-600)2413027-8 1433-2973 nnns volume:28 year:2018 number:2 day:07 month:11 pages:339-347 https://dx.doi.org/10.1007/s00580-018-2852-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2018 2 07 11 339-347
allfields_unstemmed	10.1007/s00580-018-2852-9 doi (DE-627)SPR007257325 (SPR)s00580-018-2852-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Goorani, Samaneh verfasserin aut The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract. Hepatoprotective (dpeaa)DE-He213 Nephroprotective (dpeaa)DE-He213 Hematoprotective (dpeaa)DE-He213 Immunoprotective (dpeaa)DE-He213 Gastroduodenal protective (dpeaa)DE-He213 Zhaleh, Mohsen verfasserin aut Zangeneh, Akram verfasserin aut Koohi, Mohammad Kazem verfasserin aut Rashidi, Khodabakhsh verfasserin aut Moradi, Rohallah verfasserin aut Zangeneh, Mohammad Mahdi verfasserin aut Enthalten in Comparative haematology international London : Springer, 1991 28(2018), 2 vom: 07. Nov., Seite 339-347 (DE-627)559430590 (DE-600)2413027-8 1433-2973 nnns volume:28 year:2018 number:2 day:07 month:11 pages:339-347 https://dx.doi.org/10.1007/s00580-018-2852-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2018 2 07 11 339-347
allfieldsGer	10.1007/s00580-018-2852-9 doi (DE-627)SPR007257325 (SPR)s00580-018-2852-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Goorani, Samaneh verfasserin aut The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract. Hepatoprotective (dpeaa)DE-He213 Nephroprotective (dpeaa)DE-He213 Hematoprotective (dpeaa)DE-He213 Immunoprotective (dpeaa)DE-He213 Gastroduodenal protective (dpeaa)DE-He213 Zhaleh, Mohsen verfasserin aut Zangeneh, Akram verfasserin aut Koohi, Mohammad Kazem verfasserin aut Rashidi, Khodabakhsh verfasserin aut Moradi, Rohallah verfasserin aut Zangeneh, Mohammad Mahdi verfasserin aut Enthalten in Comparative haematology international London : Springer, 1991 28(2018), 2 vom: 07. Nov., Seite 339-347 (DE-627)559430590 (DE-600)2413027-8 1433-2973 nnns volume:28 year:2018 number:2 day:07 month:11 pages:339-347 https://dx.doi.org/10.1007/s00580-018-2852-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2018 2 07 11 339-347
allfieldsSound	10.1007/s00580-018-2852-9 doi (DE-627)SPR007257325 (SPR)s00580-018-2852-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE Goorani, Samaneh verfasserin aut The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract. Hepatoprotective (dpeaa)DE-He213 Nephroprotective (dpeaa)DE-He213 Hematoprotective (dpeaa)DE-He213 Immunoprotective (dpeaa)DE-He213 Gastroduodenal protective (dpeaa)DE-He213 Zhaleh, Mohsen verfasserin aut Zangeneh, Akram verfasserin aut Koohi, Mohammad Kazem verfasserin aut Rashidi, Khodabakhsh verfasserin aut Moradi, Rohallah verfasserin aut Zangeneh, Mohammad Mahdi verfasserin aut Enthalten in Comparative haematology international London : Springer, 1991 28(2018), 2 vom: 07. Nov., Seite 339-347 (DE-627)559430590 (DE-600)2413027-8 1433-2973 nnns volume:28 year:2018 number:2 day:07 month:11 pages:339-347 https://dx.doi.org/10.1007/s00580-018-2852-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2018 2 07 11 339-347
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source	Enthalten in Comparative haematology international 28(2018), 2 vom: 07. Nov., Seite 339-347 volume:28 year:2018 number:2 day:07 month:11 pages:339-347
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topic_facet	Hepatoprotective Nephroprotective Hematoprotective Immunoprotective Gastroduodenal protective
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authorswithroles_txt_mv	Goorani, Samaneh @@aut@@ Zhaleh, Mohsen @@aut@@ Zangeneh, Akram @@aut@@ Koohi, Mohammad Kazem @@aut@@ Rashidi, Khodabakhsh @@aut@@ Moradi, Rohallah @@aut@@ Zangeneh, Mohammad Mahdi @@aut@@
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author	Goorani, Samaneh
spellingShingle	Goorani, Samaneh ddc 610 misc Hepatoprotective misc Nephroprotective misc Hematoprotective misc Immunoprotective misc Gastroduodenal protective The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats
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topic_title	610 ASE The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats Hepatoprotective (dpeaa)DE-He213 Nephroprotective (dpeaa)DE-He213 Hematoprotective (dpeaa)DE-He213 Immunoprotective (dpeaa)DE-He213 Gastroduodenal protective (dpeaa)DE-He213
topic	ddc 610 misc Hepatoprotective misc Nephroprotective misc Hematoprotective misc Immunoprotective misc Gastroduodenal protective
topic_unstemmed	ddc 610 misc Hepatoprotective misc Nephroprotective misc Hematoprotective misc Immunoprotective misc Gastroduodenal protective
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title	The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats
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title_full	The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats
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author_browse	Goorani, Samaneh Zhaleh, Mohsen Zangeneh, Akram Koohi, Mohammad Kazem Rashidi, Khodabakhsh Moradi, Rohallah Zangeneh, Mohammad Mahdi
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title_sort	aqueous extract of glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on wistar rats
title_auth	The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats
abstract	Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract.
abstractGer	Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract.
abstract_unstemmed	Abstract The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract.
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title_short	The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats
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author2	Zhaleh, Mohsen Zangeneh, Akram Koohi, Mohammad Kazem Rashidi, Khodabakhsh Moradi, Rohallah Zangeneh, Mohammad Mahdi
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Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hepatoprotective</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nephroprotective</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hematoprotective</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunoprotective</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gastroduodenal protective</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhaleh, Mohsen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zangeneh, Akram</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koohi, Mohammad Kazem</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rashidi, Khodabakhsh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Moradi, Rohallah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zangeneh, Mohammad Mahdi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Comparative haematology international</subfield><subfield code="d">London : Springer, 1991</subfield><subfield code="g">28(2018), 2 vom: 07. 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The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats

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