Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart
Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Weiss, Kilian [verfasserIn] Mariotti, Erika [verfasserIn] Hill, Deborah K. [verfasserIn] Orton, Matthew R. [verfasserIn] Dunn, Joel T. [verfasserIn] Medina, Rodolfo A. [verfasserIn] Southworth, Richard [verfasserIn] Kozerke, Sebastian [verfasserIn] Eykyn, Thomas R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Übergeordnetes Werk: |
Enthalten in: Applied magnetic resonance - Wien [u.a.] : Springer, 1990, 43(2012), 1-2 vom: 19. Mai, Seite 275-288 |
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| Übergeordnetes Werk: |
volume:43 ; year:2012 ; number:1-2 ; day:19 ; month:05 ; pages:275-288 |
| Links: |
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| DOI / URN: |
10.1007/s00723-012-0349-2 |
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| Katalog-ID: |
SPR007601174 |
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| 520 | |a Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. | ||
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| 650 | 4 | |a Dynamic Nuclear Polarization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Spectroscopic Imaging |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Perfuse Heart |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Magnetic Resonance Spectroscopic Imaging |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mariotti, Erika |e verfasserin |4 aut | |
| 700 | 1 | |a Hill, Deborah K. |e verfasserin |4 aut | |
| 700 | 1 | |a Orton, Matthew R. |e verfasserin |4 aut | |
| 700 | 1 | |a Dunn, Joel T. |e verfasserin |4 aut | |
| 700 | 1 | |a Medina, Rodolfo A. |e verfasserin |4 aut | |
| 700 | 1 | |a Southworth, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Kozerke, Sebastian |e verfasserin |4 aut | |
| 700 | 1 | |a Eykyn, Thomas R. |e verfasserin |4 aut | |
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10.1007/s00723-012-0349-2 doi (DE-627)SPR007601174 (SPR)s00723-012-0349-2-e DE-627 ger DE-627 rakwb eng 530 620 ASE 33.00 bkl Weiss, Kilian verfasserin aut Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. Pyruvate (dpeaa)DE-He213 Dynamic Nuclear Polarization (dpeaa)DE-He213 Spectroscopic Imaging (dpeaa)DE-He213 Perfuse Heart (dpeaa)DE-He213 Magnetic Resonance Spectroscopic Imaging (dpeaa)DE-He213 Mariotti, Erika verfasserin aut Hill, Deborah K. verfasserin aut Orton, Matthew R. verfasserin aut Dunn, Joel T. verfasserin aut Medina, Rodolfo A. verfasserin aut Southworth, Richard verfasserin aut Kozerke, Sebastian verfasserin aut Eykyn, Thomas R. verfasserin aut Enthalten in Applied magnetic resonance Wien [u.a.] : Springer, 1990 43(2012), 1-2 vom: 19. Mai, Seite 275-288 (DE-627)271596589 (DE-600)1480644-7 1613-7507 nnns volume:43 year:2012 number:1-2 day:19 month:05 pages:275-288 https://dx.doi.org/10.1007/s00723-012-0349-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.00 ASE AR 43 2012 1-2 19 05 275-288 |
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10.1007/s00723-012-0349-2 doi (DE-627)SPR007601174 (SPR)s00723-012-0349-2-e DE-627 ger DE-627 rakwb eng 530 620 ASE 33.00 bkl Weiss, Kilian verfasserin aut Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. Pyruvate (dpeaa)DE-He213 Dynamic Nuclear Polarization (dpeaa)DE-He213 Spectroscopic Imaging (dpeaa)DE-He213 Perfuse Heart (dpeaa)DE-He213 Magnetic Resonance Spectroscopic Imaging (dpeaa)DE-He213 Mariotti, Erika verfasserin aut Hill, Deborah K. verfasserin aut Orton, Matthew R. verfasserin aut Dunn, Joel T. verfasserin aut Medina, Rodolfo A. verfasserin aut Southworth, Richard verfasserin aut Kozerke, Sebastian verfasserin aut Eykyn, Thomas R. verfasserin aut Enthalten in Applied magnetic resonance Wien [u.a.] : Springer, 1990 43(2012), 1-2 vom: 19. Mai, Seite 275-288 (DE-627)271596589 (DE-600)1480644-7 1613-7507 nnns volume:43 year:2012 number:1-2 day:19 month:05 pages:275-288 https://dx.doi.org/10.1007/s00723-012-0349-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.00 ASE AR 43 2012 1-2 19 05 275-288 |
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10.1007/s00723-012-0349-2 doi (DE-627)SPR007601174 (SPR)s00723-012-0349-2-e DE-627 ger DE-627 rakwb eng 530 620 ASE 33.00 bkl Weiss, Kilian verfasserin aut Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. Pyruvate (dpeaa)DE-He213 Dynamic Nuclear Polarization (dpeaa)DE-He213 Spectroscopic Imaging (dpeaa)DE-He213 Perfuse Heart (dpeaa)DE-He213 Magnetic Resonance Spectroscopic Imaging (dpeaa)DE-He213 Mariotti, Erika verfasserin aut Hill, Deborah K. verfasserin aut Orton, Matthew R. verfasserin aut Dunn, Joel T. verfasserin aut Medina, Rodolfo A. verfasserin aut Southworth, Richard verfasserin aut Kozerke, Sebastian verfasserin aut Eykyn, Thomas R. verfasserin aut Enthalten in Applied magnetic resonance Wien [u.a.] : Springer, 1990 43(2012), 1-2 vom: 19. Mai, Seite 275-288 (DE-627)271596589 (DE-600)1480644-7 1613-7507 nnns volume:43 year:2012 number:1-2 day:19 month:05 pages:275-288 https://dx.doi.org/10.1007/s00723-012-0349-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.00 ASE AR 43 2012 1-2 19 05 275-288 |
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10.1007/s00723-012-0349-2 doi (DE-627)SPR007601174 (SPR)s00723-012-0349-2-e DE-627 ger DE-627 rakwb eng 530 620 ASE 33.00 bkl Weiss, Kilian verfasserin aut Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. Pyruvate (dpeaa)DE-He213 Dynamic Nuclear Polarization (dpeaa)DE-He213 Spectroscopic Imaging (dpeaa)DE-He213 Perfuse Heart (dpeaa)DE-He213 Magnetic Resonance Spectroscopic Imaging (dpeaa)DE-He213 Mariotti, Erika verfasserin aut Hill, Deborah K. verfasserin aut Orton, Matthew R. verfasserin aut Dunn, Joel T. verfasserin aut Medina, Rodolfo A. verfasserin aut Southworth, Richard verfasserin aut Kozerke, Sebastian verfasserin aut Eykyn, Thomas R. verfasserin aut Enthalten in Applied magnetic resonance Wien [u.a.] : Springer, 1990 43(2012), 1-2 vom: 19. Mai, Seite 275-288 (DE-627)271596589 (DE-600)1480644-7 1613-7507 nnns volume:43 year:2012 number:1-2 day:19 month:05 pages:275-288 https://dx.doi.org/10.1007/s00723-012-0349-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.00 ASE AR 43 2012 1-2 19 05 275-288 |
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10.1007/s00723-012-0349-2 doi (DE-627)SPR007601174 (SPR)s00723-012-0349-2-e DE-627 ger DE-627 rakwb eng 530 620 ASE 33.00 bkl Weiss, Kilian verfasserin aut Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. Pyruvate (dpeaa)DE-He213 Dynamic Nuclear Polarization (dpeaa)DE-He213 Spectroscopic Imaging (dpeaa)DE-He213 Perfuse Heart (dpeaa)DE-He213 Magnetic Resonance Spectroscopic Imaging (dpeaa)DE-He213 Mariotti, Erika verfasserin aut Hill, Deborah K. verfasserin aut Orton, Matthew R. verfasserin aut Dunn, Joel T. verfasserin aut Medina, Rodolfo A. verfasserin aut Southworth, Richard verfasserin aut Kozerke, Sebastian verfasserin aut Eykyn, Thomas R. verfasserin aut Enthalten in Applied magnetic resonance Wien [u.a.] : Springer, 1990 43(2012), 1-2 vom: 19. Mai, Seite 275-288 (DE-627)271596589 (DE-600)1480644-7 1613-7507 nnns volume:43 year:2012 number:1-2 day:19 month:05 pages:275-288 https://dx.doi.org/10.1007/s00723-012-0349-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.00 ASE AR 43 2012 1-2 19 05 275-288 |
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Enthalten in Applied magnetic resonance 43(2012), 1-2 vom: 19. Mai, Seite 275-288 volume:43 year:2012 number:1-2 day:19 month:05 pages:275-288 |
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Pyruvate Dynamic Nuclear Polarization Spectroscopic Imaging Perfuse Heart Magnetic Resonance Spectroscopic Imaging |
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Weiss, Kilian @@aut@@ Mariotti, Erika @@aut@@ Hill, Deborah K. @@aut@@ Orton, Matthew R. @@aut@@ Dunn, Joel T. @@aut@@ Medina, Rodolfo A. @@aut@@ Southworth, Richard @@aut@@ Kozerke, Sebastian @@aut@@ Eykyn, Thomas R. @@aut@@ |
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Weiss, Kilian |
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Weiss, Kilian ddc 530 bkl 33.00 misc Pyruvate misc Dynamic Nuclear Polarization misc Spectroscopic Imaging misc Perfuse Heart misc Magnetic Resonance Spectroscopic Imaging Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart |
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530 620 ASE 33.00 bkl Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart Pyruvate (dpeaa)DE-He213 Dynamic Nuclear Polarization (dpeaa)DE-He213 Spectroscopic Imaging (dpeaa)DE-He213 Perfuse Heart (dpeaa)DE-He213 Magnetic Resonance Spectroscopic Imaging (dpeaa)DE-He213 |
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Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart |
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Weiss, Kilian Mariotti, Erika Hill, Deborah K. Orton, Matthew R. Dunn, Joel T. Medina, Rodolfo A. Southworth, Richard Kozerke, Sebastian Eykyn, Thomas R. |
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developing hyperpolarized 13c spectroscopy and imaging for metabolic studies in the isolated perfused rat heart |
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Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart |
| abstract |
Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. |
| abstractGer |
Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. |
| abstract_unstemmed |
Abstract Hyperpolarized 13C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time hyperpolarized 13C investigation of Langendorff-perfused rat hearts using both non-selective non-localized spectroscopy and fast spectroscopic imaging. Following [1-13C] pyruvate infusion, we observed both catabolic and anaplerotic metabolic processes resulting in a number of metabolites, including bicarbonate, carbon dioxide, lactate, alanine and aspartate. Employing fast spectroscopic imaging, we were able to observe regional variations in pyruvate perfusion as well as in lactate and bicarbonate production. |
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| container_issue |
1-2 |
| title_short |
Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart |
| url |
https://dx.doi.org/10.1007/s00723-012-0349-2 |
| remote_bool |
true |
| author2 |
Mariotti, Erika Hill, Deborah K. Orton, Matthew R. Dunn, Joel T. Medina, Rodolfo A. Southworth, Richard Kozerke, Sebastian Eykyn, Thomas R. |
| author2Str |
Mariotti, Erika Hill, Deborah K. Orton, Matthew R. Dunn, Joel T. Medina, Rodolfo A. Southworth, Richard Kozerke, Sebastian Eykyn, Thomas R. |
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false |
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| doi_str |
10.1007/s00723-012-0349-2 |
| up_date |
2024-07-03T13:58:54.460Z |
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|
| score |
7.402011 |