Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers
Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to ina...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Estes, Anne-Marie [verfasserIn] McAllen, Kathleen [verfasserIn] Parker, Michael S. [verfasserIn] Sah, Renu [verfasserIn] Sweatman, Trevor [verfasserIn] Park, Edwards A. [verfasserIn] Balasubramaniam, Ambikaipakan [verfasserIn] Sallee, Floyd R. [verfasserIn] Walker, Mary W. [verfasserIn] Parker, Steven L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Amino acids - Wien [u.a.] : Springer, 1991, 40(2010), 2 vom: 25. Juni, Seite 371-380 |
|---|---|
| Übergeordnetes Werk: |
volume:40 ; year:2010 ; number:2 ; day:25 ; month:06 ; pages:371-380 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00726-010-0642-z |
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| Katalog-ID: |
SPR007624662 |
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| 100 | 1 | |a Estes, Anne-Marie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers |
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| 520 | |a Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). | ||
| 650 | 4 | |a G-protein coupling receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neuropeptide Y |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Receptor dimer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Receptor heteropentamer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Y1 receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Y2 receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Y4 receptor |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a McAllen, Kathleen |e verfasserin |4 aut | |
| 700 | 1 | |a Parker, Michael S. |e verfasserin |4 aut | |
| 700 | 1 | |a Sah, Renu |e verfasserin |4 aut | |
| 700 | 1 | |a Sweatman, Trevor |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Edwards A. |e verfasserin |4 aut | |
| 700 | 1 | |a Balasubramaniam, Ambikaipakan |e verfasserin |4 aut | |
| 700 | 1 | |a Sallee, Floyd R. |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Mary W. |e verfasserin |4 aut | |
| 700 | 1 | |a Parker, Steven L. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Amino acids |d Wien [u.a.] : Springer, 1991 |g 40(2010), 2 vom: 25. Juni, Seite 371-380 |w (DE-627)271596570 |w (DE-600)1480643-5 |x 1438-2199 |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2010 |g number:2 |g day:25 |g month:06 |g pages:371-380 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00726-010-0642-z |z lizenzpflichtig |3 Volltext |
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| 912 | |a GBV_ILN_100 | ||
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| 912 | |a GBV_ILN_230 | ||
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| 912 | |a GBV_ILN_267 | ||
| 912 | |a GBV_ILN_281 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_636 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2008 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2116 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2144 | ||
| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2188 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2446 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2472 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4046 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4246 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4335 | ||
| 912 | |a GBV_ILN_4336 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
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| allfields |
10.1007/s00726-010-0642-z doi (DE-627)SPR007624662 (SPR)s00726-010-0642-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.76 bkl Estes, Anne-Marie verfasserin aut Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). G-protein coupling receptor (dpeaa)DE-He213 Neuropeptide Y (dpeaa)DE-He213 Receptor dimer (dpeaa)DE-He213 Receptor heteropentamer (dpeaa)DE-He213 Y1 receptor (dpeaa)DE-He213 Y2 receptor (dpeaa)DE-He213 Y4 receptor (dpeaa)DE-He213 McAllen, Kathleen verfasserin aut Parker, Michael S. verfasserin aut Sah, Renu verfasserin aut Sweatman, Trevor verfasserin aut Park, Edwards A. verfasserin aut Balasubramaniam, Ambikaipakan verfasserin aut Sallee, Floyd R. verfasserin aut Walker, Mary W. verfasserin aut Parker, Steven L. verfasserin aut Enthalten in Amino acids Wien [u.a.] : Springer, 1991 40(2010), 2 vom: 25. Juni, Seite 371-380 (DE-627)271596570 (DE-600)1480643-5 1438-2199 nnns volume:40 year:2010 number:2 day:25 month:06 pages:371-380 https://dx.doi.org/10.1007/s00726-010-0642-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.76 ASE AR 40 2010 2 25 06 371-380 |
| spelling |
10.1007/s00726-010-0642-z doi (DE-627)SPR007624662 (SPR)s00726-010-0642-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.76 bkl Estes, Anne-Marie verfasserin aut Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). G-protein coupling receptor (dpeaa)DE-He213 Neuropeptide Y (dpeaa)DE-He213 Receptor dimer (dpeaa)DE-He213 Receptor heteropentamer (dpeaa)DE-He213 Y1 receptor (dpeaa)DE-He213 Y2 receptor (dpeaa)DE-He213 Y4 receptor (dpeaa)DE-He213 McAllen, Kathleen verfasserin aut Parker, Michael S. verfasserin aut Sah, Renu verfasserin aut Sweatman, Trevor verfasserin aut Park, Edwards A. verfasserin aut Balasubramaniam, Ambikaipakan verfasserin aut Sallee, Floyd R. verfasserin aut Walker, Mary W. verfasserin aut Parker, Steven L. verfasserin aut Enthalten in Amino acids Wien [u.a.] : Springer, 1991 40(2010), 2 vom: 25. Juni, Seite 371-380 (DE-627)271596570 (DE-600)1480643-5 1438-2199 nnns volume:40 year:2010 number:2 day:25 month:06 pages:371-380 https://dx.doi.org/10.1007/s00726-010-0642-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.76 ASE AR 40 2010 2 25 06 371-380 |
| allfields_unstemmed |
10.1007/s00726-010-0642-z doi (DE-627)SPR007624662 (SPR)s00726-010-0642-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.76 bkl Estes, Anne-Marie verfasserin aut Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). G-protein coupling receptor (dpeaa)DE-He213 Neuropeptide Y (dpeaa)DE-He213 Receptor dimer (dpeaa)DE-He213 Receptor heteropentamer (dpeaa)DE-He213 Y1 receptor (dpeaa)DE-He213 Y2 receptor (dpeaa)DE-He213 Y4 receptor (dpeaa)DE-He213 McAllen, Kathleen verfasserin aut Parker, Michael S. verfasserin aut Sah, Renu verfasserin aut Sweatman, Trevor verfasserin aut Park, Edwards A. verfasserin aut Balasubramaniam, Ambikaipakan verfasserin aut Sallee, Floyd R. verfasserin aut Walker, Mary W. verfasserin aut Parker, Steven L. verfasserin aut Enthalten in Amino acids Wien [u.a.] : Springer, 1991 40(2010), 2 vom: 25. Juni, Seite 371-380 (DE-627)271596570 (DE-600)1480643-5 1438-2199 nnns volume:40 year:2010 number:2 day:25 month:06 pages:371-380 https://dx.doi.org/10.1007/s00726-010-0642-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.76 ASE AR 40 2010 2 25 06 371-380 |
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10.1007/s00726-010-0642-z doi (DE-627)SPR007624662 (SPR)s00726-010-0642-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.76 bkl Estes, Anne-Marie verfasserin aut Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). G-protein coupling receptor (dpeaa)DE-He213 Neuropeptide Y (dpeaa)DE-He213 Receptor dimer (dpeaa)DE-He213 Receptor heteropentamer (dpeaa)DE-He213 Y1 receptor (dpeaa)DE-He213 Y2 receptor (dpeaa)DE-He213 Y4 receptor (dpeaa)DE-He213 McAllen, Kathleen verfasserin aut Parker, Michael S. verfasserin aut Sah, Renu verfasserin aut Sweatman, Trevor verfasserin aut Park, Edwards A. verfasserin aut Balasubramaniam, Ambikaipakan verfasserin aut Sallee, Floyd R. verfasserin aut Walker, Mary W. verfasserin aut Parker, Steven L. verfasserin aut Enthalten in Amino acids Wien [u.a.] : Springer, 1991 40(2010), 2 vom: 25. Juni, Seite 371-380 (DE-627)271596570 (DE-600)1480643-5 1438-2199 nnns volume:40 year:2010 number:2 day:25 month:06 pages:371-380 https://dx.doi.org/10.1007/s00726-010-0642-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.76 ASE AR 40 2010 2 25 06 371-380 |
| allfieldsSound |
10.1007/s00726-010-0642-z doi (DE-627)SPR007624662 (SPR)s00726-010-0642-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.76 bkl Estes, Anne-Marie verfasserin aut Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). G-protein coupling receptor (dpeaa)DE-He213 Neuropeptide Y (dpeaa)DE-He213 Receptor dimer (dpeaa)DE-He213 Receptor heteropentamer (dpeaa)DE-He213 Y1 receptor (dpeaa)DE-He213 Y2 receptor (dpeaa)DE-He213 Y4 receptor (dpeaa)DE-He213 McAllen, Kathleen verfasserin aut Parker, Michael S. verfasserin aut Sah, Renu verfasserin aut Sweatman, Trevor verfasserin aut Park, Edwards A. verfasserin aut Balasubramaniam, Ambikaipakan verfasserin aut Sallee, Floyd R. verfasserin aut Walker, Mary W. verfasserin aut Parker, Steven L. verfasserin aut Enthalten in Amino acids Wien [u.a.] : Springer, 1991 40(2010), 2 vom: 25. Juni, Seite 371-380 (DE-627)271596570 (DE-600)1480643-5 1438-2199 nnns volume:40 year:2010 number:2 day:25 month:06 pages:371-380 https://dx.doi.org/10.1007/s00726-010-0642-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.76 ASE AR 40 2010 2 25 06 371-380 |
| language |
English |
| source |
Enthalten in Amino acids 40(2010), 2 vom: 25. Juni, Seite 371-380 volume:40 year:2010 number:2 day:25 month:06 pages:371-380 |
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Enthalten in Amino acids 40(2010), 2 vom: 25. Juni, Seite 371-380 volume:40 year:2010 number:2 day:25 month:06 pages:371-380 |
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Article |
| institution |
findex.gbv.de |
| topic_facet |
G-protein coupling receptor Neuropeptide Y Receptor dimer Receptor heteropentamer Y1 receptor Y2 receptor Y4 receptor |
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540 |
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false |
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Amino acids |
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Estes, Anne-Marie @@aut@@ McAllen, Kathleen @@aut@@ Parker, Michael S. @@aut@@ Sah, Renu @@aut@@ Sweatman, Trevor @@aut@@ Park, Edwards A. @@aut@@ Balasubramaniam, Ambikaipakan @@aut@@ Sallee, Floyd R. @@aut@@ Walker, Mary W. @@aut@@ Parker, Steven L. @@aut@@ |
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2010-06-25T00:00:00Z |
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271596570 |
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3540 |
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SPR007624662 |
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englisch |
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| author |
Estes, Anne-Marie |
| spellingShingle |
Estes, Anne-Marie ddc 540 bkl 35.76 misc G-protein coupling receptor misc Neuropeptide Y misc Receptor dimer misc Receptor heteropentamer misc Y1 receptor misc Y2 receptor misc Y4 receptor Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers |
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540 ASE 35.76 bkl Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers G-protein coupling receptor (dpeaa)DE-He213 Neuropeptide Y (dpeaa)DE-He213 Receptor dimer (dpeaa)DE-He213 Receptor heteropentamer (dpeaa)DE-He213 Y1 receptor (dpeaa)DE-He213 Y2 receptor (dpeaa)DE-He213 Y4 receptor (dpeaa)DE-He213 |
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ddc 540 bkl 35.76 misc G-protein coupling receptor misc Neuropeptide Y misc Receptor dimer misc Receptor heteropentamer misc Y1 receptor misc Y2 receptor misc Y4 receptor |
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ddc 540 bkl 35.76 misc G-protein coupling receptor misc Neuropeptide Y misc Receptor dimer misc Receptor heteropentamer misc Y1 receptor misc Y2 receptor misc Y4 receptor |
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ddc 540 bkl 35.76 misc G-protein coupling receptor misc Neuropeptide Y misc Receptor dimer misc Receptor heteropentamer misc Y1 receptor misc Y2 receptor misc Y4 receptor |
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Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers |
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Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers |
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Estes, Anne-Marie |
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Amino acids |
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Amino acids |
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eng |
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500 - Science |
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marc |
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2010 |
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txt |
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371 |
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Estes, Anne-Marie McAllen, Kathleen Parker, Michael S. Sah, Renu Sweatman, Trevor Park, Edwards A. Balasubramaniam, Ambikaipakan Sallee, Floyd R. Walker, Mary W. Parker, Steven L. |
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Elektronische Aufsätze |
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Estes, Anne-Marie |
| doi_str_mv |
10.1007/s00726-010-0642-z |
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540 |
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verfasserin |
| title_sort |
maintenance of y receptor dimers in epithelial cells depends on interaction with g-protein heterotrimers |
| title_auth |
Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers |
| abstract |
Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). |
| abstractGer |
Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). |
| abstract_unstemmed |
Abstract Treatment of CHO cells expressing human Y receptors ($ Y_{1} $, $ Y_{2} $ or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a preferential loss of heteropentameric assemblies of receptor dimers and G-protein trimers. This occurs in parallel to inactivation of the nucleotide site of Gi α subunits, with a half period of about 4 h. The loss could be mainly due to proteolysis at the level of recycling/perinuclear endosomes, and of receptor completion in the ER, since it is reduced by co-treatment with ammonium chloride, an inhibitor of particulate proteinases. Antagonists do not strongly decrease the heteropentameric fraction. These findings indicate that the upkeep of Y receptor dimers in epithelial cell lines depends on the association of receptor oligomers with functional Gi α subunits. This interaction could use the juxtamembrane helix 8 in the fourth intracellular domain, and could also be supported by the C-terminal helix of the third intracellular loop, as outlined in the companion review (Parker et al., Amino Acids, doi:10.1007/s00726-010-0616-1, 2010). |
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2 |
| title_short |
Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers |
| url |
https://dx.doi.org/10.1007/s00726-010-0642-z |
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McAllen, Kathleen Parker, Michael S. Sah, Renu Sweatman, Trevor Park, Edwards A. Balasubramaniam, Ambikaipakan Sallee, Floyd R. Walker, Mary W. Parker, Steven L. |
| author2Str |
McAllen, Kathleen Parker, Michael S. Sah, Renu Sweatman, Trevor Park, Edwards A. Balasubramaniam, Ambikaipakan Sallee, Floyd R. Walker, Mary W. Parker, Steven L. |
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10.1007/s00726-010-0642-z |
| up_date |
2024-07-03T14:08:59.506Z |
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| score |
7.3982754 |