Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia

Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine recepto...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Solís, Oscar [verfasserIn] Moratalla, Rosario [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Parkinson disease Abnormal involuntary movements Dopamine D1 receptor Dopamine D3 receptor Striatum

Übergeordnetes Werk:	Enthalten in: Journal of neural transmission - Wien [u.a.] : Springer, 1950, 125(2018), 8 vom: 07. Feb., Seite 1187-1194
Übergeordnetes Werk:	volume:125 ; year:2018 ; number:8 ; day:07 ; month:02 ; pages:1187-1194

Links:	Volltext

DOI / URN:	10.1007/s00702-018-1852-x

Katalog-ID:	SPR00770819X

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520			\|a Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID.
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matchkey_str	article:14351463:2018----::oaieeetrhmmrcnhtrmrcopeeilo
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bklnumber	44.90
publishDate	2018
allfields	10.1007/s00702-018-1852-x doi (DE-627)SPR00770819X (SPR)s00702-018-1852-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Solís, Oscar verfasserin aut Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID. Parkinson disease (dpeaa)DE-He213 Abnormal involuntary movements (dpeaa)DE-He213 Dopamine D1 receptor (dpeaa)DE-He213 Dopamine D3 receptor (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Moratalla, Rosario verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 125(2018), 8 vom: 07. Feb., Seite 1187-1194 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194 https://dx.doi.org/10.1007/s00702-018-1852-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 125 2018 8 07 02 1187-1194
spelling	10.1007/s00702-018-1852-x doi (DE-627)SPR00770819X (SPR)s00702-018-1852-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Solís, Oscar verfasserin aut Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID. Parkinson disease (dpeaa)DE-He213 Abnormal involuntary movements (dpeaa)DE-He213 Dopamine D1 receptor (dpeaa)DE-He213 Dopamine D3 receptor (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Moratalla, Rosario verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 125(2018), 8 vom: 07. Feb., Seite 1187-1194 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194 https://dx.doi.org/10.1007/s00702-018-1852-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 125 2018 8 07 02 1187-1194
allfields_unstemmed	10.1007/s00702-018-1852-x doi (DE-627)SPR00770819X (SPR)s00702-018-1852-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Solís, Oscar verfasserin aut Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID. Parkinson disease (dpeaa)DE-He213 Abnormal involuntary movements (dpeaa)DE-He213 Dopamine D1 receptor (dpeaa)DE-He213 Dopamine D3 receptor (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Moratalla, Rosario verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 125(2018), 8 vom: 07. Feb., Seite 1187-1194 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194 https://dx.doi.org/10.1007/s00702-018-1852-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 125 2018 8 07 02 1187-1194
allfieldsGer	10.1007/s00702-018-1852-x doi (DE-627)SPR00770819X (SPR)s00702-018-1852-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Solís, Oscar verfasserin aut Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID. Parkinson disease (dpeaa)DE-He213 Abnormal involuntary movements (dpeaa)DE-He213 Dopamine D1 receptor (dpeaa)DE-He213 Dopamine D3 receptor (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Moratalla, Rosario verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 125(2018), 8 vom: 07. Feb., Seite 1187-1194 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194 https://dx.doi.org/10.1007/s00702-018-1852-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 125 2018 8 07 02 1187-1194
allfieldsSound	10.1007/s00702-018-1852-x doi (DE-627)SPR00770819X (SPR)s00702-018-1852-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Solís, Oscar verfasserin aut Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID. Parkinson disease (dpeaa)DE-He213 Abnormal involuntary movements (dpeaa)DE-He213 Dopamine D1 receptor (dpeaa)DE-He213 Dopamine D3 receptor (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Moratalla, Rosario verfasserin aut Enthalten in Journal of neural transmission Wien [u.a.] : Springer, 1950 125(2018), 8 vom: 07. Feb., Seite 1187-1194 (DE-627)300185901 (DE-600)1481655-6 1435-1463 nnns volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194 https://dx.doi.org/10.1007/s00702-018-1852-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 125 2018 8 07 02 1187-1194
language	English
source	Enthalten in Journal of neural transmission 125(2018), 8 vom: 07. Feb., Seite 1187-1194 volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194
sourceStr	Enthalten in Journal of neural transmission 125(2018), 8 vom: 07. Feb., Seite 1187-1194 volume:125 year:2018 number:8 day:07 month:02 pages:1187-1194
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Parkinson disease Abnormal involuntary movements Dopamine D1 receptor Dopamine D3 receptor Striatum
dewey-raw	610
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container_title	Journal of neural transmission
authorswithroles_txt_mv	Solís, Oscar @@aut@@ Moratalla, Rosario @@aut@@
publishDateDaySort_date	2018-02-07T00:00:00Z
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language_de	englisch
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However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. 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author	Solís, Oscar
spellingShingle	Solís, Oscar ddc 610 bkl 44.90 misc Parkinson disease misc Abnormal involuntary movements misc Dopamine D1 receptor misc Dopamine D3 receptor misc Striatum Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
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topic_title	610 ASE 44.90 bkl Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia Parkinson disease (dpeaa)DE-He213 Abnormal involuntary movements (dpeaa)DE-He213 Dopamine D1 receptor (dpeaa)DE-He213 Dopamine D3 receptor (dpeaa)DE-He213 Striatum (dpeaa)DE-He213
topic	ddc 610 bkl 44.90 misc Parkinson disease misc Abnormal involuntary movements misc Dopamine D1 receptor misc Dopamine D3 receptor misc Striatum
topic_unstemmed	ddc 610 bkl 44.90 misc Parkinson disease misc Abnormal involuntary movements misc Dopamine D1 receptor misc Dopamine D3 receptor misc Striatum
topic_browse	ddc 610 bkl 44.90 misc Parkinson disease misc Abnormal involuntary movements misc Dopamine D1 receptor misc Dopamine D3 receptor misc Striatum
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title	Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
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title_full	Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
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title_sort	dopamine receptors: homomeric and heteromeric complexes in l-dopa-induced dyskinesia
title_auth	Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
abstract	Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID.
abstractGer	Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID.
abstract_unstemmed	Abstract The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID.
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container_issue	8
title_short	Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
url	https://dx.doi.org/10.1007/s00702-018-1852-x
remote_bool	true
author2	Moratalla, Rosario
author2Str	Moratalla, Rosario
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doi_str	10.1007/s00702-018-1852-x
up_date	2024-07-03T14:41:04Z
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Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia

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