Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells
Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impac...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Walter, C. [verfasserIn] Klein, M. O. [verfasserIn] Pabst, A. [verfasserIn] Al-Nawas, B. [verfasserIn] Duschner, H. [verfasserIn] Ziebart, T. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical Oral Investigations - Springer-Verlag, 2001, 14(2009), 1 vom: 18. März, Seite 35-41 |
|---|---|
| Übergeordnetes Werk: |
volume:14 ; year:2009 ; number:1 ; day:18 ; month:03 ; pages:35-41 |
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| DOI / URN: |
10.1007/s00784-009-0266-4 |
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| 520 | |a Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. | ||
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10.1007/s00784-009-0266-4 doi (DE-627)SPR007799098 (SPR)s00784-009-0266-4-e DE-627 ger DE-627 rakwb eng Walter, C. verfasserin aut Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. Bisphosphonates (dpeaa)DE-He213 Bisphosphonate-associated osteonecrosis of the jaws (dpeaa)DE-He213 Osteogenic cells (dpeaa)DE-He213 HUVEC (dpeaa)DE-He213 Fibroblasts (dpeaa)DE-He213 Klein, M. O. verfasserin aut Pabst, A. verfasserin aut Al-Nawas, B. verfasserin aut Duschner, H. verfasserin aut Ziebart, T. verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 14(2009), 1 vom: 18. März, Seite 35-41 (DE-627)SPR007794231 nnns volume:14 year:2009 number:1 day:18 month:03 pages:35-41 https://dx.doi.org/10.1007/s00784-009-0266-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 14 2009 1 18 03 35-41 |
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10.1007/s00784-009-0266-4 doi (DE-627)SPR007799098 (SPR)s00784-009-0266-4-e DE-627 ger DE-627 rakwb eng Walter, C. verfasserin aut Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. Bisphosphonates (dpeaa)DE-He213 Bisphosphonate-associated osteonecrosis of the jaws (dpeaa)DE-He213 Osteogenic cells (dpeaa)DE-He213 HUVEC (dpeaa)DE-He213 Fibroblasts (dpeaa)DE-He213 Klein, M. O. verfasserin aut Pabst, A. verfasserin aut Al-Nawas, B. verfasserin aut Duschner, H. verfasserin aut Ziebart, T. verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 14(2009), 1 vom: 18. März, Seite 35-41 (DE-627)SPR007794231 nnns volume:14 year:2009 number:1 day:18 month:03 pages:35-41 https://dx.doi.org/10.1007/s00784-009-0266-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 14 2009 1 18 03 35-41 |
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10.1007/s00784-009-0266-4 doi (DE-627)SPR007799098 (SPR)s00784-009-0266-4-e DE-627 ger DE-627 rakwb eng Walter, C. verfasserin aut Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. Bisphosphonates (dpeaa)DE-He213 Bisphosphonate-associated osteonecrosis of the jaws (dpeaa)DE-He213 Osteogenic cells (dpeaa)DE-He213 HUVEC (dpeaa)DE-He213 Fibroblasts (dpeaa)DE-He213 Klein, M. O. verfasserin aut Pabst, A. verfasserin aut Al-Nawas, B. verfasserin aut Duschner, H. verfasserin aut Ziebart, T. verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 14(2009), 1 vom: 18. März, Seite 35-41 (DE-627)SPR007794231 nnns volume:14 year:2009 number:1 day:18 month:03 pages:35-41 https://dx.doi.org/10.1007/s00784-009-0266-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 14 2009 1 18 03 35-41 |
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10.1007/s00784-009-0266-4 doi (DE-627)SPR007799098 (SPR)s00784-009-0266-4-e DE-627 ger DE-627 rakwb eng Walter, C. verfasserin aut Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. Bisphosphonates (dpeaa)DE-He213 Bisphosphonate-associated osteonecrosis of the jaws (dpeaa)DE-He213 Osteogenic cells (dpeaa)DE-He213 HUVEC (dpeaa)DE-He213 Fibroblasts (dpeaa)DE-He213 Klein, M. O. verfasserin aut Pabst, A. verfasserin aut Al-Nawas, B. verfasserin aut Duschner, H. verfasserin aut Ziebart, T. verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 14(2009), 1 vom: 18. März, Seite 35-41 (DE-627)SPR007794231 nnns volume:14 year:2009 number:1 day:18 month:03 pages:35-41 https://dx.doi.org/10.1007/s00784-009-0266-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 14 2009 1 18 03 35-41 |
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10.1007/s00784-009-0266-4 doi (DE-627)SPR007799098 (SPR)s00784-009-0266-4-e DE-627 ger DE-627 rakwb eng Walter, C. verfasserin aut Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. Bisphosphonates (dpeaa)DE-He213 Bisphosphonate-associated osteonecrosis of the jaws (dpeaa)DE-He213 Osteogenic cells (dpeaa)DE-He213 HUVEC (dpeaa)DE-He213 Fibroblasts (dpeaa)DE-He213 Klein, M. O. verfasserin aut Pabst, A. verfasserin aut Al-Nawas, B. verfasserin aut Duschner, H. verfasserin aut Ziebart, T. verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 14(2009), 1 vom: 18. März, Seite 35-41 (DE-627)SPR007794231 nnns volume:14 year:2009 number:1 day:18 month:03 pages:35-41 https://dx.doi.org/10.1007/s00784-009-0266-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 14 2009 1 18 03 35-41 |
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Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells |
| abstract |
Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. |
| abstractGer |
Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. |
| abstract_unstemmed |
Abstract Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is a side effect primarily in patients receiving highly potent nitrogen-containing bisphosphonates. The exact etiopathology is unknown. In addition to reduced bone remodeling, there may also be an impact on soft tissues. The impact of nitrogen- (ibandronate, pamidronate, zoledronate) and non-nitrogen-containing bisphosphonates (clodronate) on human umbilicord vein endothelial cells (HUVEC), fibroblasts and osteogenic cells was analyzed employing cell viability testing and a scratch wound assay. The impact on the cell morphology of vital-stained osteogenic cells was investigated by cell visualization (confocal laser scanning microscopy). Pamidronate and zoledronate had the greatest negative impact on all cell lines, whereas the impact of ibandronate and clodronate was less distinct. The effect of clodronate on HUVEC and fibroblasts was particularly marginal. BP-ONJ could be a multifactorial event with multicellular impairments. This might result in altered wound healing. The increased impact of the highly potent bisphosphonates, particularly on non-bone cells, may explain the higher occurrence of BP-ONJ. |
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| title_short |
Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells |
| url |
https://dx.doi.org/10.1007/s00784-009-0266-4 |
| remote_bool |
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| author2 |
Klein, M. O. Pabst, A. Al-Nawas, B. Duschner, H. Ziebart, T. |
| author2Str |
Klein, M. O. Pabst, A. Al-Nawas, B. Duschner, H. Ziebart, T. |
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| doi_str |
10.1007/s00784-009-0266-4 |
| up_date |
2024-07-03T15:19:09.870Z |
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