Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis
Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Folwaczny, Matthias [verfasserIn] Glas, Jürgen [verfasserIn] Tonenchi, Laurean [verfasserIn] Török, Helga-Paula [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
Pattern recognition receptor (PRR) |
|---|
| Übergeordnetes Werk: |
Enthalten in: Clinical Oral Investigations - Springer-Verlag, 2001, 15(2010), 3 vom: 16. März, Seite 435-441 |
|---|---|
| Übergeordnetes Werk: |
volume:15 ; year:2010 ; number:3 ; day:16 ; month:03 ; pages:435-441 |
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| DOI / URN: |
10.1007/s00784-010-0396-8 |
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| 520 | |a Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. | ||
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10.1007/s00784-010-0396-8 doi (DE-627)SPR007800568 (SPR)s00784-010-0396-8-e DE-627 ger DE-627 rakwb eng Folwaczny, Matthias verfasserin aut Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. Periodontitis (dpeaa)DE-He213 TLR2 (dpeaa)DE-He213 Pattern recognition receptor (PRR) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Lipopolysaccharide (dpeaa)DE-He213 Microsatellite (dpeaa)DE-He213 Glas, Jürgen verfasserin aut Tonenchi, Laurean verfasserin aut Török, Helga-Paula verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 15(2010), 3 vom: 16. März, Seite 435-441 (DE-627)SPR007794231 nnns volume:15 year:2010 number:3 day:16 month:03 pages:435-441 https://dx.doi.org/10.1007/s00784-010-0396-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 15 2010 3 16 03 435-441 |
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10.1007/s00784-010-0396-8 doi (DE-627)SPR007800568 (SPR)s00784-010-0396-8-e DE-627 ger DE-627 rakwb eng Folwaczny, Matthias verfasserin aut Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. Periodontitis (dpeaa)DE-He213 TLR2 (dpeaa)DE-He213 Pattern recognition receptor (PRR) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Lipopolysaccharide (dpeaa)DE-He213 Microsatellite (dpeaa)DE-He213 Glas, Jürgen verfasserin aut Tonenchi, Laurean verfasserin aut Török, Helga-Paula verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 15(2010), 3 vom: 16. März, Seite 435-441 (DE-627)SPR007794231 nnns volume:15 year:2010 number:3 day:16 month:03 pages:435-441 https://dx.doi.org/10.1007/s00784-010-0396-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 15 2010 3 16 03 435-441 |
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10.1007/s00784-010-0396-8 doi (DE-627)SPR007800568 (SPR)s00784-010-0396-8-e DE-627 ger DE-627 rakwb eng Folwaczny, Matthias verfasserin aut Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. Periodontitis (dpeaa)DE-He213 TLR2 (dpeaa)DE-He213 Pattern recognition receptor (PRR) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Lipopolysaccharide (dpeaa)DE-He213 Microsatellite (dpeaa)DE-He213 Glas, Jürgen verfasserin aut Tonenchi, Laurean verfasserin aut Török, Helga-Paula verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 15(2010), 3 vom: 16. März, Seite 435-441 (DE-627)SPR007794231 nnns volume:15 year:2010 number:3 day:16 month:03 pages:435-441 https://dx.doi.org/10.1007/s00784-010-0396-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 15 2010 3 16 03 435-441 |
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10.1007/s00784-010-0396-8 doi (DE-627)SPR007800568 (SPR)s00784-010-0396-8-e DE-627 ger DE-627 rakwb eng Folwaczny, Matthias verfasserin aut Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. Periodontitis (dpeaa)DE-He213 TLR2 (dpeaa)DE-He213 Pattern recognition receptor (PRR) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Lipopolysaccharide (dpeaa)DE-He213 Microsatellite (dpeaa)DE-He213 Glas, Jürgen verfasserin aut Tonenchi, Laurean verfasserin aut Török, Helga-Paula verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 15(2010), 3 vom: 16. März, Seite 435-441 (DE-627)SPR007794231 nnns volume:15 year:2010 number:3 day:16 month:03 pages:435-441 https://dx.doi.org/10.1007/s00784-010-0396-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 15 2010 3 16 03 435-441 |
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10.1007/s00784-010-0396-8 doi (DE-627)SPR007800568 (SPR)s00784-010-0396-8-e DE-627 ger DE-627 rakwb eng Folwaczny, Matthias verfasserin aut Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. Periodontitis (dpeaa)DE-He213 TLR2 (dpeaa)DE-He213 Pattern recognition receptor (PRR) (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Lipopolysaccharide (dpeaa)DE-He213 Microsatellite (dpeaa)DE-He213 Glas, Jürgen verfasserin aut Tonenchi, Laurean verfasserin aut Török, Helga-Paula verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 15(2010), 3 vom: 16. März, Seite 435-441 (DE-627)SPR007794231 nnns volume:15 year:2010 number:3 day:16 month:03 pages:435-441 https://dx.doi.org/10.1007/s00784-010-0396-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 15 2010 3 16 03 435-441 |
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microsatellite gt polymorphism in intron 2 of human toll-like receptor (tlr) 2 gene and susceptibility to periodontitis |
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Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis |
| abstract |
Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. |
| abstractGer |
Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. |
| abstract_unstemmed |
Abstract As pattern recognition receptor, Toll-like receptor (TLR) 2 is a signal molecule essential for the cellular response to Porphyromonas gingivalis. A recently described guanine-thymine (GT) repeat microsatellite polymorphism of the human TLR2 gene leads to impaired promotor activity. A total of 380 patients with chronic periodontitis and 590 unrelated healthy control individuals of Caucasian descent were genotyped for the GT repeat microsatellite polymorphism of the TLR2 gene. The mutations were identified with polymerase chain reaction followed by sizing of GT repeat length. The number of GT repeats ranged from 13 to 29 in both study groups. There was no significant difference between periodontitis patients and healthy controls regarding the frequency of GT repeats (p = 0.365). Subclassification of alleles into three subclasses (S allele, M allele, and L allele) revealed no significant association (p = 0.810). Moreover, also the comparison of the summarized prevalence of S and L alleles (high promotor activity) with that of the M allele (low promotor activity) was not significantly different among study groups (p = 0.377). The susceptibility to chronic peridontitis was not associated with the functional effective GT repeat microsatellite polymorphism in the human TLR2 gene. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER |
| container_issue |
3 |
| title_short |
Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis |
| url |
https://dx.doi.org/10.1007/s00784-010-0396-8 |
| remote_bool |
true |
| author2 |
Glas, Jürgen Tonenchi, Laurean Török, Helga-Paula |
| author2Str |
Glas, Jürgen Tonenchi, Laurean Török, Helga-Paula |
| ppnlink |
SPR007794231 |
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c |
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| doi_str |
10.1007/s00784-010-0396-8 |
| up_date |
2024-07-03T15:19:41.818Z |
| _version_ |
1803571672456888320 |
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