Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs
Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Buset, Sabrina L. [verfasserIn] Zitzmann, Nicola U. [verfasserIn] Weiger, Roland [verfasserIn] Walter, Clemens [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical Oral Investigations - Springer-Verlag, 2001, 19(2015), 8 vom: 12. Juni, Seite 1763-1775 |
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| Übergeordnetes Werk: |
volume:19 ; year:2015 ; number:8 ; day:12 ; month:06 ; pages:1763-1775 |
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| DOI / URN: |
10.1007/s00784-015-1499-z |
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| 520 | |a Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. | ||
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| 700 | 1 | |a Weiger, Roland |e verfasserin |4 aut | |
| 700 | 1 | |a Walter, Clemens |e verfasserin |4 aut | |
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10.1007/s00784-015-1499-z doi (DE-627)SPR007812000 (SPR)s00784-015-1499-z-e DE-627 ger DE-627 rakwb eng Buset, Sabrina L. verfasserin aut Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. Periodontal debridement (dpeaa)DE-He213 Azithromycin (dpeaa)DE-He213 Aggressive periodontitis (dpeaa)DE-He213 Chronic periodontitis (dpeaa)DE-He213 Zitzmann, Nicola U. verfasserin aut Weiger, Roland verfasserin aut Walter, Clemens verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 19(2015), 8 vom: 12. Juni, Seite 1763-1775 (DE-627)SPR007794231 nnns volume:19 year:2015 number:8 day:12 month:06 pages:1763-1775 https://dx.doi.org/10.1007/s00784-015-1499-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2015 8 12 06 1763-1775 |
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10.1007/s00784-015-1499-z doi (DE-627)SPR007812000 (SPR)s00784-015-1499-z-e DE-627 ger DE-627 rakwb eng Buset, Sabrina L. verfasserin aut Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. Periodontal debridement (dpeaa)DE-He213 Azithromycin (dpeaa)DE-He213 Aggressive periodontitis (dpeaa)DE-He213 Chronic periodontitis (dpeaa)DE-He213 Zitzmann, Nicola U. verfasserin aut Weiger, Roland verfasserin aut Walter, Clemens verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 19(2015), 8 vom: 12. Juni, Seite 1763-1775 (DE-627)SPR007794231 nnns volume:19 year:2015 number:8 day:12 month:06 pages:1763-1775 https://dx.doi.org/10.1007/s00784-015-1499-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2015 8 12 06 1763-1775 |
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10.1007/s00784-015-1499-z doi (DE-627)SPR007812000 (SPR)s00784-015-1499-z-e DE-627 ger DE-627 rakwb eng Buset, Sabrina L. verfasserin aut Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. Periodontal debridement (dpeaa)DE-He213 Azithromycin (dpeaa)DE-He213 Aggressive periodontitis (dpeaa)DE-He213 Chronic periodontitis (dpeaa)DE-He213 Zitzmann, Nicola U. verfasserin aut Weiger, Roland verfasserin aut Walter, Clemens verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 19(2015), 8 vom: 12. Juni, Seite 1763-1775 (DE-627)SPR007794231 nnns volume:19 year:2015 number:8 day:12 month:06 pages:1763-1775 https://dx.doi.org/10.1007/s00784-015-1499-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2015 8 12 06 1763-1775 |
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10.1007/s00784-015-1499-z doi (DE-627)SPR007812000 (SPR)s00784-015-1499-z-e DE-627 ger DE-627 rakwb eng Buset, Sabrina L. verfasserin aut Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. Periodontal debridement (dpeaa)DE-He213 Azithromycin (dpeaa)DE-He213 Aggressive periodontitis (dpeaa)DE-He213 Chronic periodontitis (dpeaa)DE-He213 Zitzmann, Nicola U. verfasserin aut Weiger, Roland verfasserin aut Walter, Clemens verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 19(2015), 8 vom: 12. Juni, Seite 1763-1775 (DE-627)SPR007794231 nnns volume:19 year:2015 number:8 day:12 month:06 pages:1763-1775 https://dx.doi.org/10.1007/s00784-015-1499-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2015 8 12 06 1763-1775 |
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10.1007/s00784-015-1499-z doi (DE-627)SPR007812000 (SPR)s00784-015-1499-z-e DE-627 ger DE-627 rakwb eng Buset, Sabrina L. verfasserin aut Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. Periodontal debridement (dpeaa)DE-He213 Azithromycin (dpeaa)DE-He213 Aggressive periodontitis (dpeaa)DE-He213 Chronic periodontitis (dpeaa)DE-He213 Zitzmann, Nicola U. verfasserin aut Weiger, Roland verfasserin aut Walter, Clemens verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 19(2015), 8 vom: 12. Juni, Seite 1763-1775 (DE-627)SPR007794231 nnns volume:19 year:2015 number:8 day:12 month:06 pages:1763-1775 https://dx.doi.org/10.1007/s00784-015-1499-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2015 8 12 06 1763-1775 |
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Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs |
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Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. |
| abstractGer |
Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. |
| abstract_unstemmed |
Background Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy. Objective This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin. Materials and methods A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion. Results Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes. Conclusion In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients. Clinical relevance When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis. |
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Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs |
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Zitzmann, Nicola U. Weiger, Roland Walter, Clemens |
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2024-07-03T15:23:38.319Z |
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