Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study
Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 7...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Miclotte, Isabel [verfasserIn] Vanhaverbeke, Maarten [verfasserIn] Agbaje, Jimoh Olubanwo [verfasserIn] Legrand, Paul [verfasserIn] Vanassche, Thomas [verfasserIn] Verhamme, Peter [verfasserIn] Politis, Constantinus [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical Oral Investigations - Springer-Verlag, 2001, 21(2016), 7 vom: 28. Nov., Seite 2183-2188 |
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| Übergeordnetes Werk: |
volume:21 ; year:2016 ; number:7 ; day:28 ; month:11 ; pages:2183-2188 |
| Links: |
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| DOI / URN: |
10.1007/s00784-016-2010-1 |
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| Katalog-ID: |
SPR007818068 |
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| 520 | |a Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. | ||
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| 700 | 1 | |a Verhamme, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Politis, Constantinus |e verfasserin |4 aut | |
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10.1007/s00784-016-2010-1 doi (DE-627)SPR007818068 (SPR)s00784-016-2010-1-e DE-627 ger DE-627 rakwb eng Miclotte, Isabel verfasserin aut Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. Tooth extraction (dpeaa)DE-He213 Anticoagulants (dpeaa)DE-He213 New oral anticoagulants (NOACs) (dpeaa)DE-He213 Interruption (dpeaa)DE-He213 Bleeding (dpeaa)DE-He213 Vanhaverbeke, Maarten verfasserin aut Agbaje, Jimoh Olubanwo verfasserin aut Legrand, Paul verfasserin aut Vanassche, Thomas verfasserin aut Verhamme, Peter verfasserin aut Politis, Constantinus verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 21(2016), 7 vom: 28. Nov., Seite 2183-2188 (DE-627)SPR007794231 nnns volume:21 year:2016 number:7 day:28 month:11 pages:2183-2188 https://dx.doi.org/10.1007/s00784-016-2010-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 21 2016 7 28 11 2183-2188 |
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10.1007/s00784-016-2010-1 doi (DE-627)SPR007818068 (SPR)s00784-016-2010-1-e DE-627 ger DE-627 rakwb eng Miclotte, Isabel verfasserin aut Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. Tooth extraction (dpeaa)DE-He213 Anticoagulants (dpeaa)DE-He213 New oral anticoagulants (NOACs) (dpeaa)DE-He213 Interruption (dpeaa)DE-He213 Bleeding (dpeaa)DE-He213 Vanhaverbeke, Maarten verfasserin aut Agbaje, Jimoh Olubanwo verfasserin aut Legrand, Paul verfasserin aut Vanassche, Thomas verfasserin aut Verhamme, Peter verfasserin aut Politis, Constantinus verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 21(2016), 7 vom: 28. Nov., Seite 2183-2188 (DE-627)SPR007794231 nnns volume:21 year:2016 number:7 day:28 month:11 pages:2183-2188 https://dx.doi.org/10.1007/s00784-016-2010-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 21 2016 7 28 11 2183-2188 |
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10.1007/s00784-016-2010-1 doi (DE-627)SPR007818068 (SPR)s00784-016-2010-1-e DE-627 ger DE-627 rakwb eng Miclotte, Isabel verfasserin aut Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. Tooth extraction (dpeaa)DE-He213 Anticoagulants (dpeaa)DE-He213 New oral anticoagulants (NOACs) (dpeaa)DE-He213 Interruption (dpeaa)DE-He213 Bleeding (dpeaa)DE-He213 Vanhaverbeke, Maarten verfasserin aut Agbaje, Jimoh Olubanwo verfasserin aut Legrand, Paul verfasserin aut Vanassche, Thomas verfasserin aut Verhamme, Peter verfasserin aut Politis, Constantinus verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 21(2016), 7 vom: 28. Nov., Seite 2183-2188 (DE-627)SPR007794231 nnns volume:21 year:2016 number:7 day:28 month:11 pages:2183-2188 https://dx.doi.org/10.1007/s00784-016-2010-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 21 2016 7 28 11 2183-2188 |
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10.1007/s00784-016-2010-1 doi (DE-627)SPR007818068 (SPR)s00784-016-2010-1-e DE-627 ger DE-627 rakwb eng Miclotte, Isabel verfasserin aut Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. Tooth extraction (dpeaa)DE-He213 Anticoagulants (dpeaa)DE-He213 New oral anticoagulants (NOACs) (dpeaa)DE-He213 Interruption (dpeaa)DE-He213 Bleeding (dpeaa)DE-He213 Vanhaverbeke, Maarten verfasserin aut Agbaje, Jimoh Olubanwo verfasserin aut Legrand, Paul verfasserin aut Vanassche, Thomas verfasserin aut Verhamme, Peter verfasserin aut Politis, Constantinus verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 21(2016), 7 vom: 28. Nov., Seite 2183-2188 (DE-627)SPR007794231 nnns volume:21 year:2016 number:7 day:28 month:11 pages:2183-2188 https://dx.doi.org/10.1007/s00784-016-2010-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 21 2016 7 28 11 2183-2188 |
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10.1007/s00784-016-2010-1 doi (DE-627)SPR007818068 (SPR)s00784-016-2010-1-e DE-627 ger DE-627 rakwb eng Miclotte, Isabel verfasserin aut Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. Tooth extraction (dpeaa)DE-He213 Anticoagulants (dpeaa)DE-He213 New oral anticoagulants (NOACs) (dpeaa)DE-He213 Interruption (dpeaa)DE-He213 Bleeding (dpeaa)DE-He213 Vanhaverbeke, Maarten verfasserin aut Agbaje, Jimoh Olubanwo verfasserin aut Legrand, Paul verfasserin aut Vanassche, Thomas verfasserin aut Verhamme, Peter verfasserin aut Politis, Constantinus verfasserin aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 21(2016), 7 vom: 28. Nov., Seite 2183-2188 (DE-627)SPR007794231 nnns volume:21 year:2016 number:7 day:28 month:11 pages:2183-2188 https://dx.doi.org/10.1007/s00784-016-2010-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 21 2016 7 28 11 2183-2188 |
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Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study |
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Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study |
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Miclotte, Isabel |
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Clinical Oral Investigations |
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Miclotte, Isabel Vanhaverbeke, Maarten Agbaje, Jimoh Olubanwo Legrand, Paul Vanassche, Thomas Verhamme, Peter Politis, Constantinus |
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Miclotte, Isabel |
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10.1007/s00784-016-2010-1 |
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pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study |
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Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study |
| abstract |
Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. |
| abstractGer |
Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. |
| abstract_unstemmed |
Objectives The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. Materials and methods This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug. Results There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01). Conclusions Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management. Clinical relevance This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk. |
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Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study |
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Vanhaverbeke, Maarten Agbaje, Jimoh Olubanwo Legrand, Paul Vanassche, Thomas Verhamme, Peter Politis, Constantinus |
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