Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Guillaume-Jugnot, Perrine [verfasserIn] Badoglio, Manuela [verfasserIn] Labopin, Myriam [verfasserIn] Terriou, Louis [verfasserIn] Yakoub-Agha, Ibrahim [verfasserIn] Martin, Thierry [verfasserIn] Lioure, Bruno [verfasserIn] Marjanovic, Zora [verfasserIn] Blaise, Didier [verfasserIn] Nguyen, Stéphanie [verfasserIn] Pugnet, Gregory [verfasserIn] Huynh, Anne [verfasserIn] Deligny, Christophe [verfasserIn] Seinturier, Christophe [verfasserIn] Garban, Frédéric [verfasserIn] Swiader, Laure [verfasserIn] Bay, Jacques-Olivier [verfasserIn] Braun, Thorsten [verfasserIn] de Latour, Régis Peffault [verfasserIn] Rubio, Marie Thérèse [verfasserIn] Farge, Dominique [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
Enthalten in: Clinical rheumatology - London : Springer, 1982, 38(2019), 5 vom: 21. Jan., Seite 1501-1511 |
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| Übergeordnetes Werk: |
volume:38 ; year:2019 ; number:5 ; day:21 ; month:01 ; pages:1501-1511 |
| Links: |
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| DOI / URN: |
10.1007/s10067-019-04435-2 |
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| Katalog-ID: |
SPR00853487X |
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| 100 | 1 | |a Guillaume-Jugnot, Perrine |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. | ||
| 650 | 4 | |a Adult patients |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Autoimmune disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Autologous |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Haematopoietic stem cell transplantation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Badoglio, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a Labopin, Myriam |e verfasserin |4 aut | |
| 700 | 1 | |a Terriou, Louis |e verfasserin |4 aut | |
| 700 | 1 | |a Yakoub-Agha, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Thierry |e verfasserin |4 aut | |
| 700 | 1 | |a Lioure, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Marjanovic, Zora |e verfasserin |4 aut | |
| 700 | 1 | |a Blaise, Didier |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, Stéphanie |e verfasserin |4 aut | |
| 700 | 1 | |a Pugnet, Gregory |e verfasserin |4 aut | |
| 700 | 1 | |a Huynh, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Deligny, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Seinturier, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Garban, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Swiader, Laure |e verfasserin |4 aut | |
| 700 | 1 | |a Bay, Jacques-Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Braun, Thorsten |e verfasserin |4 aut | |
| 700 | 1 | |a de Latour, Régis Peffault |e verfasserin |4 aut | |
| 700 | 1 | |a Rubio, Marie Thérèse |e verfasserin |4 aut | |
| 700 | 1 | |a Farge, Dominique |e verfasserin |4 aut | |
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10.1007/s10067-019-04435-2 doi (DE-627)SPR00853487X (SPR)s10067-019-04435-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl 44.83 bkl Guillaume-Jugnot, Perrine verfasserin aut Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. Adult patients (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Autologous (dpeaa)DE-He213 Haematopoietic stem cell transplantation (dpeaa)DE-He213 Badoglio, Manuela verfasserin aut Labopin, Myriam verfasserin aut Terriou, Louis verfasserin aut Yakoub-Agha, Ibrahim verfasserin aut Martin, Thierry verfasserin aut Lioure, Bruno verfasserin aut Marjanovic, Zora verfasserin aut Blaise, Didier verfasserin aut Nguyen, Stéphanie verfasserin aut Pugnet, Gregory verfasserin aut Huynh, Anne verfasserin aut Deligny, Christophe verfasserin aut Seinturier, Christophe verfasserin aut Garban, Frédéric verfasserin aut Swiader, Laure verfasserin aut Bay, Jacques-Olivier verfasserin aut Braun, Thorsten verfasserin aut de Latour, Régis Peffault verfasserin aut Rubio, Marie Thérèse verfasserin aut Farge, Dominique verfasserin aut Enthalten in Clinical rheumatology London : Springer, 1982 38(2019), 5 vom: 21. Jan., Seite 1501-1511 (DE-627)27159909X (DE-600)1480901-1 1434-9949 nnns volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 https://dx.doi.org/10.1007/s10067-019-04435-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.83 ASE AR 38 2019 5 21 01 1501-1511 |
| spelling |
10.1007/s10067-019-04435-2 doi (DE-627)SPR00853487X (SPR)s10067-019-04435-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl 44.83 bkl Guillaume-Jugnot, Perrine verfasserin aut Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. Adult patients (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Autologous (dpeaa)DE-He213 Haematopoietic stem cell transplantation (dpeaa)DE-He213 Badoglio, Manuela verfasserin aut Labopin, Myriam verfasserin aut Terriou, Louis verfasserin aut Yakoub-Agha, Ibrahim verfasserin aut Martin, Thierry verfasserin aut Lioure, Bruno verfasserin aut Marjanovic, Zora verfasserin aut Blaise, Didier verfasserin aut Nguyen, Stéphanie verfasserin aut Pugnet, Gregory verfasserin aut Huynh, Anne verfasserin aut Deligny, Christophe verfasserin aut Seinturier, Christophe verfasserin aut Garban, Frédéric verfasserin aut Swiader, Laure verfasserin aut Bay, Jacques-Olivier verfasserin aut Braun, Thorsten verfasserin aut de Latour, Régis Peffault verfasserin aut Rubio, Marie Thérèse verfasserin aut Farge, Dominique verfasserin aut Enthalten in Clinical rheumatology London : Springer, 1982 38(2019), 5 vom: 21. Jan., Seite 1501-1511 (DE-627)27159909X (DE-600)1480901-1 1434-9949 nnns volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 https://dx.doi.org/10.1007/s10067-019-04435-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.83 ASE AR 38 2019 5 21 01 1501-1511 |
| allfields_unstemmed |
10.1007/s10067-019-04435-2 doi (DE-627)SPR00853487X (SPR)s10067-019-04435-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl 44.83 bkl Guillaume-Jugnot, Perrine verfasserin aut Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. Adult patients (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Autologous (dpeaa)DE-He213 Haematopoietic stem cell transplantation (dpeaa)DE-He213 Badoglio, Manuela verfasserin aut Labopin, Myriam verfasserin aut Terriou, Louis verfasserin aut Yakoub-Agha, Ibrahim verfasserin aut Martin, Thierry verfasserin aut Lioure, Bruno verfasserin aut Marjanovic, Zora verfasserin aut Blaise, Didier verfasserin aut Nguyen, Stéphanie verfasserin aut Pugnet, Gregory verfasserin aut Huynh, Anne verfasserin aut Deligny, Christophe verfasserin aut Seinturier, Christophe verfasserin aut Garban, Frédéric verfasserin aut Swiader, Laure verfasserin aut Bay, Jacques-Olivier verfasserin aut Braun, Thorsten verfasserin aut de Latour, Régis Peffault verfasserin aut Rubio, Marie Thérèse verfasserin aut Farge, Dominique verfasserin aut Enthalten in Clinical rheumatology London : Springer, 1982 38(2019), 5 vom: 21. Jan., Seite 1501-1511 (DE-627)27159909X (DE-600)1480901-1 1434-9949 nnns volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 https://dx.doi.org/10.1007/s10067-019-04435-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.83 ASE AR 38 2019 5 21 01 1501-1511 |
| allfieldsGer |
10.1007/s10067-019-04435-2 doi (DE-627)SPR00853487X (SPR)s10067-019-04435-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl 44.83 bkl Guillaume-Jugnot, Perrine verfasserin aut Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. Adult patients (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Autologous (dpeaa)DE-He213 Haematopoietic stem cell transplantation (dpeaa)DE-He213 Badoglio, Manuela verfasserin aut Labopin, Myriam verfasserin aut Terriou, Louis verfasserin aut Yakoub-Agha, Ibrahim verfasserin aut Martin, Thierry verfasserin aut Lioure, Bruno verfasserin aut Marjanovic, Zora verfasserin aut Blaise, Didier verfasserin aut Nguyen, Stéphanie verfasserin aut Pugnet, Gregory verfasserin aut Huynh, Anne verfasserin aut Deligny, Christophe verfasserin aut Seinturier, Christophe verfasserin aut Garban, Frédéric verfasserin aut Swiader, Laure verfasserin aut Bay, Jacques-Olivier verfasserin aut Braun, Thorsten verfasserin aut de Latour, Régis Peffault verfasserin aut Rubio, Marie Thérèse verfasserin aut Farge, Dominique verfasserin aut Enthalten in Clinical rheumatology London : Springer, 1982 38(2019), 5 vom: 21. Jan., Seite 1501-1511 (DE-627)27159909X (DE-600)1480901-1 1434-9949 nnns volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 https://dx.doi.org/10.1007/s10067-019-04435-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.83 ASE AR 38 2019 5 21 01 1501-1511 |
| allfieldsSound |
10.1007/s10067-019-04435-2 doi (DE-627)SPR00853487X (SPR)s10067-019-04435-2-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.00 bkl 44.83 bkl Guillaume-Jugnot, Perrine verfasserin aut Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. Adult patients (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Autologous (dpeaa)DE-He213 Haematopoietic stem cell transplantation (dpeaa)DE-He213 Badoglio, Manuela verfasserin aut Labopin, Myriam verfasserin aut Terriou, Louis verfasserin aut Yakoub-Agha, Ibrahim verfasserin aut Martin, Thierry verfasserin aut Lioure, Bruno verfasserin aut Marjanovic, Zora verfasserin aut Blaise, Didier verfasserin aut Nguyen, Stéphanie verfasserin aut Pugnet, Gregory verfasserin aut Huynh, Anne verfasserin aut Deligny, Christophe verfasserin aut Seinturier, Christophe verfasserin aut Garban, Frédéric verfasserin aut Swiader, Laure verfasserin aut Bay, Jacques-Olivier verfasserin aut Braun, Thorsten verfasserin aut de Latour, Régis Peffault verfasserin aut Rubio, Marie Thérèse verfasserin aut Farge, Dominique verfasserin aut Enthalten in Clinical rheumatology London : Springer, 1982 38(2019), 5 vom: 21. Jan., Seite 1501-1511 (DE-627)27159909X (DE-600)1480901-1 1434-9949 nnns volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 https://dx.doi.org/10.1007/s10067-019-04435-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.83 ASE AR 38 2019 5 21 01 1501-1511 |
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Enthalten in Clinical rheumatology 38(2019), 5 vom: 21. Jan., Seite 1501-1511 volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 |
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Enthalten in Clinical rheumatology 38(2019), 5 vom: 21. Jan., Seite 1501-1511 volume:38 year:2019 number:5 day:21 month:01 pages:1501-1511 |
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Adult patients Autoimmune disease Autologous Haematopoietic stem cell transplantation |
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Guillaume-Jugnot, Perrine @@aut@@ Badoglio, Manuela @@aut@@ Labopin, Myriam @@aut@@ Terriou, Louis @@aut@@ Yakoub-Agha, Ibrahim @@aut@@ Martin, Thierry @@aut@@ Lioure, Bruno @@aut@@ Marjanovic, Zora @@aut@@ Blaise, Didier @@aut@@ Nguyen, Stéphanie @@aut@@ Pugnet, Gregory @@aut@@ Huynh, Anne @@aut@@ Deligny, Christophe @@aut@@ Seinturier, Christophe @@aut@@ Garban, Frédéric @@aut@@ Swiader, Laure @@aut@@ Bay, Jacques-Olivier @@aut@@ Braun, Thorsten @@aut@@ de Latour, Régis Peffault @@aut@@ Rubio, Marie Thérèse @@aut@@ Farge, Dominique @@aut@@ |
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We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. 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|
| author |
Guillaume-Jugnot, Perrine |
| spellingShingle |
Guillaume-Jugnot, Perrine ddc 610 bkl 44.00 bkl 44.83 misc Adult patients misc Autoimmune disease misc Autologous misc Haematopoietic stem cell transplantation Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) |
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1434-9949 |
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610 ASE 44.00 bkl 44.83 bkl Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) Adult patients (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Autologous (dpeaa)DE-He213 Haematopoietic stem cell transplantation (dpeaa)DE-He213 |
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ddc 610 bkl 44.00 bkl 44.83 misc Adult patients misc Autoimmune disease misc Autologous misc Haematopoietic stem cell transplantation |
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ddc 610 bkl 44.00 bkl 44.83 misc Adult patients misc Autoimmune disease misc Autologous misc Haematopoietic stem cell transplantation |
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ddc 610 bkl 44.00 bkl 44.83 misc Adult patients misc Autoimmune disease misc Autologous misc Haematopoietic stem cell transplantation |
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Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) |
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(DE-627)SPR00853487X (SPR)s10067-019-04435-2-e |
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Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) |
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Guillaume-Jugnot, Perrine |
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Guillaume-Jugnot, Perrine Badoglio, Manuela Labopin, Myriam Terriou, Louis Yakoub-Agha, Ibrahim Martin, Thierry Lioure, Bruno Marjanovic, Zora Blaise, Didier Nguyen, Stéphanie Pugnet, Gregory Huynh, Anne Deligny, Christophe Seinturier, Christophe Garban, Frédéric Swiader, Laure Bay, Jacques-Olivier Braun, Thorsten de Latour, Régis Peffault Rubio, Marie Thérèse Farge, Dominique |
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Guillaume-Jugnot, Perrine |
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10.1007/s10067-019-04435-2 |
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610 |
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verfasserin |
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autologous haematopoietic stem cell transplantation (ahsct) in autoimmune disease adult patients in france: analysis of the long-term outcome from the french society for bone marrow transplantation and cellular therapy (sfgm-tc) |
| title_auth |
Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) |
| abstract |
Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. |
| abstractGer |
Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. |
| abstract_unstemmed |
Introduction The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Method All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM). Results Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years. Conclusions This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity. |
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Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) |
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https://dx.doi.org/10.1007/s10067-019-04435-2 |
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Badoglio, Manuela Labopin, Myriam Terriou, Louis Yakoub-Agha, Ibrahim Martin, Thierry Lioure, Bruno Marjanovic, Zora Blaise, Didier Nguyen, Stéphanie Pugnet, Gregory Huynh, Anne Deligny, Christophe Seinturier, Christophe Garban, Frédéric Swiader, Laure Bay, Jacques-Olivier Braun, Thorsten de Latour, Régis Peffault Rubio, Marie Thérèse Farge, Dominique |
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Badoglio, Manuela Labopin, Myriam Terriou, Louis Yakoub-Agha, Ibrahim Martin, Thierry Lioure, Bruno Marjanovic, Zora Blaise, Didier Nguyen, Stéphanie Pugnet, Gregory Huynh, Anne Deligny, Christophe Seinturier, Christophe Garban, Frédéric Swiader, Laure Bay, Jacques-Olivier Braun, Thorsten de Latour, Régis Peffault Rubio, Marie Thérèse Farge, Dominique |
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10.1007/s10067-019-04435-2 |
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2024-07-03T21:40:41.843Z |
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| score |
7.401267 |