Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China
Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virol...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, X. [verfasserIn] Wang, H. [verfasserIn] He, B. [verfasserIn] Hui, Y. [verfasserIn] Lv, G. [verfasserIn] Li, L. [verfasserIn] Wen, H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
Fluorescent Quantitative Polymerase Chain Reaction |
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| Übergeordnetes Werk: |
Enthalten in: European journal of clinical microbiology & infectious diseases - Berlin : Springer, 1982, 31(2011), 1 vom: 03. Mai, Seite 53-59 |
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| Übergeordnetes Werk: |
volume:31 ; year:2011 ; number:1 ; day:03 ; month:05 ; pages:53-59 |
| Links: |
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| DOI / URN: |
10.1007/s10096-011-1274-2 |
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| Katalog-ID: |
SPR008684278 |
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| 245 | 1 | 0 | |a Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China |
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| 520 | |a Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. | ||
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| 650 | 4 | |a Fluorescent Quantitative Polymerase Chain |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Titer Distribution |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a KSHV Seroprevalence |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Li, L. |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, H. |e verfasserin |4 aut | |
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10.1007/s10096-011-1274-2 doi (DE-627)SPR008684278 (SPR)s10096-011-1274-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Wang, X. verfasserin aut Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. Fluorescent Quantitative Polymerase Chain Reaction (dpeaa)DE-He213 KSHV Infection (dpeaa)DE-He213 Fluorescent Quantitative Polymerase Chain (dpeaa)DE-He213 Titer Distribution (dpeaa)DE-He213 KSHV Seroprevalence (dpeaa)DE-He213 Wang, H. verfasserin aut He, B. verfasserin aut Hui, Y. verfasserin aut Lv, G. verfasserin aut Li, L. verfasserin aut Wen, H. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 1 vom: 03. Mai, Seite 53-59 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:1 day:03 month:05 pages:53-59 https://dx.doi.org/10.1007/s10096-011-1274-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 1 03 05 53-59 |
| spelling |
10.1007/s10096-011-1274-2 doi (DE-627)SPR008684278 (SPR)s10096-011-1274-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Wang, X. verfasserin aut Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. Fluorescent Quantitative Polymerase Chain Reaction (dpeaa)DE-He213 KSHV Infection (dpeaa)DE-He213 Fluorescent Quantitative Polymerase Chain (dpeaa)DE-He213 Titer Distribution (dpeaa)DE-He213 KSHV Seroprevalence (dpeaa)DE-He213 Wang, H. verfasserin aut He, B. verfasserin aut Hui, Y. verfasserin aut Lv, G. verfasserin aut Li, L. verfasserin aut Wen, H. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 1 vom: 03. Mai, Seite 53-59 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:1 day:03 month:05 pages:53-59 https://dx.doi.org/10.1007/s10096-011-1274-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 1 03 05 53-59 |
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10.1007/s10096-011-1274-2 doi (DE-627)SPR008684278 (SPR)s10096-011-1274-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Wang, X. verfasserin aut Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. Fluorescent Quantitative Polymerase Chain Reaction (dpeaa)DE-He213 KSHV Infection (dpeaa)DE-He213 Fluorescent Quantitative Polymerase Chain (dpeaa)DE-He213 Titer Distribution (dpeaa)DE-He213 KSHV Seroprevalence (dpeaa)DE-He213 Wang, H. verfasserin aut He, B. verfasserin aut Hui, Y. verfasserin aut Lv, G. verfasserin aut Li, L. verfasserin aut Wen, H. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 1 vom: 03. Mai, Seite 53-59 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:1 day:03 month:05 pages:53-59 https://dx.doi.org/10.1007/s10096-011-1274-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 1 03 05 53-59 |
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10.1007/s10096-011-1274-2 doi (DE-627)SPR008684278 (SPR)s10096-011-1274-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Wang, X. verfasserin aut Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. Fluorescent Quantitative Polymerase Chain Reaction (dpeaa)DE-He213 KSHV Infection (dpeaa)DE-He213 Fluorescent Quantitative Polymerase Chain (dpeaa)DE-He213 Titer Distribution (dpeaa)DE-He213 KSHV Seroprevalence (dpeaa)DE-He213 Wang, H. verfasserin aut He, B. verfasserin aut Hui, Y. verfasserin aut Lv, G. verfasserin aut Li, L. verfasserin aut Wen, H. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 1 vom: 03. Mai, Seite 53-59 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:1 day:03 month:05 pages:53-59 https://dx.doi.org/10.1007/s10096-011-1274-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 1 03 05 53-59 |
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10.1007/s10096-011-1274-2 doi (DE-627)SPR008684278 (SPR)s10096-011-1274-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Wang, X. verfasserin aut Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. Fluorescent Quantitative Polymerase Chain Reaction (dpeaa)DE-He213 KSHV Infection (dpeaa)DE-He213 Fluorescent Quantitative Polymerase Chain (dpeaa)DE-He213 Titer Distribution (dpeaa)DE-He213 KSHV Seroprevalence (dpeaa)DE-He213 Wang, H. verfasserin aut He, B. verfasserin aut Hui, Y. verfasserin aut Lv, G. verfasserin aut Li, L. verfasserin aut Wen, H. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 1 vom: 03. Mai, Seite 53-59 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:1 day:03 month:05 pages:53-59 https://dx.doi.org/10.1007/s10096-011-1274-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 1 03 05 53-59 |
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Enthalten in European journal of clinical microbiology & infectious diseases 31(2011), 1 vom: 03. Mai, Seite 53-59 volume:31 year:2011 number:1 day:03 month:05 pages:53-59 |
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Fluorescent Quantitative Polymerase Chain Reaction KSHV Infection Fluorescent Quantitative Polymerase Chain Titer Distribution KSHV Seroprevalence |
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Wang, X. @@aut@@ Wang, H. @@aut@@ He, B. @@aut@@ Hui, Y. @@aut@@ Lv, G. @@aut@@ Li, L. @@aut@@ Wen, H. @@aut@@ |
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KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluorescent Quantitative Polymerase Chain Reaction</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">KSHV Infection</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluorescent Quantitative Polymerase Chain</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Titer Distribution</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">KSHV Seroprevalence</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, H.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">He, B.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hui, Y.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lv, G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wen, H.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">European journal of clinical microbiology & infectious diseases</subfield><subfield code="d">Berlin : Springer, 1982</subfield><subfield code="g">31(2011), 1 vom: 03. 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Wang, X. |
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Wang, X. ddc 610 bkl 44.43 bkl 44.75 misc Fluorescent Quantitative Polymerase Chain Reaction misc KSHV Infection misc Fluorescent Quantitative Polymerase Chain misc Titer Distribution misc KSHV Seroprevalence Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China |
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610 ASE 44.43 bkl 44.75 bkl Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China Fluorescent Quantitative Polymerase Chain Reaction (dpeaa)DE-He213 KSHV Infection (dpeaa)DE-He213 Fluorescent Quantitative Polymerase Chain (dpeaa)DE-He213 Titer Distribution (dpeaa)DE-He213 KSHV Seroprevalence (dpeaa)DE-He213 |
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virological and molecular characterization of kaposi’s sarcoma-associated herpesvirus strains from xinjiang, china |
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Virological and molecular characterization of Kaposi’s sarcoma-associated herpesvirus strains from Xinjiang, China |
| abstract |
Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. |
| abstractGer |
Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. |
| abstract_unstemmed |
Abstract Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin. KS-associated herpesvirus (KSHV/HHV-8) is etiologically linked to all epidemiological forms of KS. However, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of KSHV that influence its pathogenesis. We investigated the molecular virological features of KSHV strains from Xinjiang, where KSHV infection is endemic and there is a high incidence of KS. Phylogenetic characterization based on the VR1 region of the KSHV K1 gene for 21 classical and AIDS-KS specimens revealed the Eurasian KSHV genotypes C (n = 18) and A (n = 3), with subtypes A5, C6, and C7 identified for the first time in China. The distribution was closely associated with their unique ethnic origin and evolution. The KSHV viral load in AIDS-KS was substantially lower than in classic KS (p = 0.05), as quantified by real-time fluorescent quantitative polymerase chain reaction (PCR). The results reveal the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain. |
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| score |
7.400566 |