Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients
Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. New...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Michallet, M. [verfasserIn] Bénet, T. [verfasserIn] Sobh, M. [verfasserIn] Kraghel, S. [verfasserIn] El Hamri, M. [verfasserIn] Cannas, G. [verfasserIn] Nicolini, F. E. [verfasserIn] Labussière, H. [verfasserIn] Ducastelle, S. [verfasserIn] Barraco, F. [verfasserIn] Thomas, X. [verfasserIn] Chelghoum, Y. [verfasserIn] Nicolle, M.-C. [verfasserIn] Bienvenu, A.-L. [verfasserIn] Persat, F. [verfasserIn] De Monbrison, F. [verfasserIn] Picot, S. [verfasserIn] Vanhems, P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of clinical microbiology & infectious diseases - Berlin : Springer, 1982, 31(2011), 6 vom: 10. Sept., Seite 991-997 |
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| Übergeordnetes Werk: |
volume:31 ; year:2011 ; number:6 ; day:10 ; month:09 ; pages:991-997 |
| Links: |
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| DOI / URN: |
10.1007/s10096-011-1397-5 |
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| Katalog-ID: |
SPR008686890 |
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| 100 | 1 | |a Michallet, M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients |
| 264 | 1 | |c 2011 | |
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| 520 | |a Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. | ||
| 650 | 4 | |a Acute Myeloid Leukemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hematopoietic Stem Cell Transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Induction Chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Invasive Aspergillosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acute Myeloid Leukemia Patient |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bénet, T. |e verfasserin |4 aut | |
| 700 | 1 | |a Sobh, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Kraghel, S. |e verfasserin |4 aut | |
| 700 | 1 | |a El Hamri, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Cannas, G. |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolini, F. E. |e verfasserin |4 aut | |
| 700 | 1 | |a Labussière, H. |e verfasserin |4 aut | |
| 700 | 1 | |a Ducastelle, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Barraco, F. |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, X. |e verfasserin |4 aut | |
| 700 | 1 | |a Chelghoum, Y. |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolle, M.-C. |e verfasserin |4 aut | |
| 700 | 1 | |a Bienvenu, A.-L. |e verfasserin |4 aut | |
| 700 | 1 | |a Persat, F. |e verfasserin |4 aut | |
| 700 | 1 | |a De Monbrison, F. |e verfasserin |4 aut | |
| 700 | 1 | |a Picot, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Vanhems, P. |e verfasserin |4 aut | |
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10.1007/s10096-011-1397-5 doi (DE-627)SPR008686890 (SPR)s10096-011-1397-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Michallet, M. verfasserin aut Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. Acute Myeloid Leukemia (dpeaa)DE-He213 Hematopoietic Stem Cell Transplantation (dpeaa)DE-He213 Induction Chemotherapy (dpeaa)DE-He213 Invasive Aspergillosis (dpeaa)DE-He213 Acute Myeloid Leukemia Patient (dpeaa)DE-He213 Bénet, T. verfasserin aut Sobh, M. verfasserin aut Kraghel, S. verfasserin aut El Hamri, M. verfasserin aut Cannas, G. verfasserin aut Nicolini, F. E. verfasserin aut Labussière, H. verfasserin aut Ducastelle, S. verfasserin aut Barraco, F. verfasserin aut Thomas, X. verfasserin aut Chelghoum, Y. verfasserin aut Nicolle, M.-C. verfasserin aut Bienvenu, A.-L. verfasserin aut Persat, F. verfasserin aut De Monbrison, F. verfasserin aut Picot, S. verfasserin aut Vanhems, P. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 6 vom: 10. Sept., Seite 991-997 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:6 day:10 month:09 pages:991-997 https://dx.doi.org/10.1007/s10096-011-1397-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 6 10 09 991-997 |
| spelling |
10.1007/s10096-011-1397-5 doi (DE-627)SPR008686890 (SPR)s10096-011-1397-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Michallet, M. verfasserin aut Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. Acute Myeloid Leukemia (dpeaa)DE-He213 Hematopoietic Stem Cell Transplantation (dpeaa)DE-He213 Induction Chemotherapy (dpeaa)DE-He213 Invasive Aspergillosis (dpeaa)DE-He213 Acute Myeloid Leukemia Patient (dpeaa)DE-He213 Bénet, T. verfasserin aut Sobh, M. verfasserin aut Kraghel, S. verfasserin aut El Hamri, M. verfasserin aut Cannas, G. verfasserin aut Nicolini, F. E. verfasserin aut Labussière, H. verfasserin aut Ducastelle, S. verfasserin aut Barraco, F. verfasserin aut Thomas, X. verfasserin aut Chelghoum, Y. verfasserin aut Nicolle, M.-C. verfasserin aut Bienvenu, A.-L. verfasserin aut Persat, F. verfasserin aut De Monbrison, F. verfasserin aut Picot, S. verfasserin aut Vanhems, P. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 6 vom: 10. Sept., Seite 991-997 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:6 day:10 month:09 pages:991-997 https://dx.doi.org/10.1007/s10096-011-1397-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 6 10 09 991-997 |
| allfields_unstemmed |
10.1007/s10096-011-1397-5 doi (DE-627)SPR008686890 (SPR)s10096-011-1397-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Michallet, M. verfasserin aut Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. Acute Myeloid Leukemia (dpeaa)DE-He213 Hematopoietic Stem Cell Transplantation (dpeaa)DE-He213 Induction Chemotherapy (dpeaa)DE-He213 Invasive Aspergillosis (dpeaa)DE-He213 Acute Myeloid Leukemia Patient (dpeaa)DE-He213 Bénet, T. verfasserin aut Sobh, M. verfasserin aut Kraghel, S. verfasserin aut El Hamri, M. verfasserin aut Cannas, G. verfasserin aut Nicolini, F. E. verfasserin aut Labussière, H. verfasserin aut Ducastelle, S. verfasserin aut Barraco, F. verfasserin aut Thomas, X. verfasserin aut Chelghoum, Y. verfasserin aut Nicolle, M.-C. verfasserin aut Bienvenu, A.-L. verfasserin aut Persat, F. verfasserin aut De Monbrison, F. verfasserin aut Picot, S. verfasserin aut Vanhems, P. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 6 vom: 10. Sept., Seite 991-997 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:6 day:10 month:09 pages:991-997 https://dx.doi.org/10.1007/s10096-011-1397-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 6 10 09 991-997 |
| allfieldsGer |
10.1007/s10096-011-1397-5 doi (DE-627)SPR008686890 (SPR)s10096-011-1397-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Michallet, M. verfasserin aut Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. Acute Myeloid Leukemia (dpeaa)DE-He213 Hematopoietic Stem Cell Transplantation (dpeaa)DE-He213 Induction Chemotherapy (dpeaa)DE-He213 Invasive Aspergillosis (dpeaa)DE-He213 Acute Myeloid Leukemia Patient (dpeaa)DE-He213 Bénet, T. verfasserin aut Sobh, M. verfasserin aut Kraghel, S. verfasserin aut El Hamri, M. verfasserin aut Cannas, G. verfasserin aut Nicolini, F. E. verfasserin aut Labussière, H. verfasserin aut Ducastelle, S. verfasserin aut Barraco, F. verfasserin aut Thomas, X. verfasserin aut Chelghoum, Y. verfasserin aut Nicolle, M.-C. verfasserin aut Bienvenu, A.-L. verfasserin aut Persat, F. verfasserin aut De Monbrison, F. verfasserin aut Picot, S. verfasserin aut Vanhems, P. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 6 vom: 10. Sept., Seite 991-997 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:6 day:10 month:09 pages:991-997 https://dx.doi.org/10.1007/s10096-011-1397-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 6 10 09 991-997 |
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10.1007/s10096-011-1397-5 doi (DE-627)SPR008686890 (SPR)s10096-011-1397-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Michallet, M. verfasserin aut Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. Acute Myeloid Leukemia (dpeaa)DE-He213 Hematopoietic Stem Cell Transplantation (dpeaa)DE-He213 Induction Chemotherapy (dpeaa)DE-He213 Invasive Aspergillosis (dpeaa)DE-He213 Acute Myeloid Leukemia Patient (dpeaa)DE-He213 Bénet, T. verfasserin aut Sobh, M. verfasserin aut Kraghel, S. verfasserin aut El Hamri, M. verfasserin aut Cannas, G. verfasserin aut Nicolini, F. E. verfasserin aut Labussière, H. verfasserin aut Ducastelle, S. verfasserin aut Barraco, F. verfasserin aut Thomas, X. verfasserin aut Chelghoum, Y. verfasserin aut Nicolle, M.-C. verfasserin aut Bienvenu, A.-L. verfasserin aut Persat, F. verfasserin aut De Monbrison, F. verfasserin aut Picot, S. verfasserin aut Vanhems, P. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 31(2011), 6 vom: 10. Sept., Seite 991-997 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:31 year:2011 number:6 day:10 month:09 pages:991-997 https://dx.doi.org/10.1007/s10096-011-1397-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 31 2011 6 10 09 991-997 |
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Enthalten in European journal of clinical microbiology & infectious diseases 31(2011), 6 vom: 10. Sept., Seite 991-997 volume:31 year:2011 number:6 day:10 month:09 pages:991-997 |
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Acute Myeloid Leukemia Hematopoietic Stem Cell Transplantation Induction Chemotherapy Invasive Aspergillosis Acute Myeloid Leukemia Patient |
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Michallet, M. @@aut@@ Bénet, T. @@aut@@ Sobh, M. @@aut@@ Kraghel, S. @@aut@@ El Hamri, M. @@aut@@ Cannas, G. @@aut@@ Nicolini, F. E. @@aut@@ Labussière, H. @@aut@@ Ducastelle, S. @@aut@@ Barraco, F. @@aut@@ Thomas, X. @@aut@@ Chelghoum, Y. @@aut@@ Nicolle, M.-C. @@aut@@ Bienvenu, A.-L. @@aut@@ Persat, F. @@aut@@ De Monbrison, F. @@aut@@ Picot, S. @@aut@@ Vanhems, P. @@aut@@ |
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2011-09-10T00:00:00Z |
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3610 |
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|
| author |
Michallet, M. |
| spellingShingle |
Michallet, M. ddc 610 bkl 44.43 bkl 44.75 misc Acute Myeloid Leukemia misc Hematopoietic Stem Cell Transplantation misc Induction Chemotherapy misc Invasive Aspergillosis misc Acute Myeloid Leukemia Patient Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients |
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Michallet, M. |
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1435-4373 |
| topic_title |
610 ASE 44.43 bkl 44.75 bkl Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients Acute Myeloid Leukemia (dpeaa)DE-He213 Hematopoietic Stem Cell Transplantation (dpeaa)DE-He213 Induction Chemotherapy (dpeaa)DE-He213 Invasive Aspergillosis (dpeaa)DE-He213 Acute Myeloid Leukemia Patient (dpeaa)DE-He213 |
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ddc 610 bkl 44.43 bkl 44.75 misc Acute Myeloid Leukemia misc Hematopoietic Stem Cell Transplantation misc Induction Chemotherapy misc Invasive Aspergillosis misc Acute Myeloid Leukemia Patient |
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ddc 610 bkl 44.43 bkl 44.75 misc Acute Myeloid Leukemia misc Hematopoietic Stem Cell Transplantation misc Induction Chemotherapy misc Invasive Aspergillosis misc Acute Myeloid Leukemia Patient |
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European journal of clinical microbiology & infectious diseases |
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610 - Medicine & health |
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European journal of clinical microbiology & infectious diseases |
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(DE-627)25372273X (DE-600)1459049-9 |
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Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients |
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(DE-627)SPR008686890 (SPR)s10096-011-1397-5-e |
| title_full |
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients |
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Michallet, M. |
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European journal of clinical microbiology & infectious diseases |
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European journal of clinical microbiology & infectious diseases |
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eng |
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600 - Technology |
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2011 |
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Michallet, M. Bénet, T. Sobh, M. Kraghel, S. El Hamri, M. Cannas, G. Nicolini, F. E. Labussière, H. Ducastelle, S. Barraco, F. Thomas, X. Chelghoum, Y. Nicolle, M.-C. Bienvenu, A.-L. Persat, F. De Monbrison, F. Picot, S. Vanhems, P. |
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Michallet, M. |
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10.1007/s10096-011-1397-5 |
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610 |
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verfasserin |
| title_sort |
invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (aml) patients |
| title_auth |
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients |
| abstract |
Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. |
| abstractGer |
Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. |
| abstract_unstemmed |
Abstract Invasive aspergillosis (IA) during induction chemotherapy of acute myeloid leukemia (AML) could worsen the prognosis. Our objective was to study how the development of IA during AML interferes with the therapeutic strategy and to evaluate its impact on the short- and long-term survival. Newly diagnosed AML patients between the years 2004 and 2007 were retrospectively analyzed. The outcome was death of the patient. A Cox proportional hazards model with the diagnosis of IA and post-induction response evaluation as the main exposure was fitted. Overall, 262 patients were analyzed and 58 IA were observed. The 2-year survival of patients having had remission of AML was 54% and, for patients with failure of chemotherapy, it was 5% (p < 0.001). The 2-year survival of patients having had IA was 14%, and without IA, it was 32% (p = 0.01). Multivariate analysis showed that IA was associated with a higher risk of death in case of remission compared to no IA (hazard ratio [HR] = 1.66 [1.05–2.65], p = 0.031) and also in case of failure (HR = 6.43, p < 0.001). IA was associated with an increased risk of death for patients if they were either in remission or in failure after induction chemotherapy. |
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Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients |
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https://dx.doi.org/10.1007/s10096-011-1397-5 |
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Bénet, T. Sobh, M. Kraghel, S. El Hamri, M. Cannas, G. Nicolini, F. E. Labussière, H. Ducastelle, S. Barraco, F. Thomas, X. Chelghoum, Y. Nicolle, M.-C. Bienvenu, A.-L. Persat, F. De Monbrison, F. Picot, S. Vanhems, P. |
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Bénet, T. Sobh, M. Kraghel, S. El Hamri, M. Cannas, G. Nicolini, F. E. Labussière, H. Ducastelle, S. Barraco, F. Thomas, X. Chelghoum, Y. Nicolle, M.-C. Bienvenu, A.-L. Persat, F. De Monbrison, F. Picot, S. Vanhems, P. |
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10.1007/s10096-011-1397-5 |
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2024-07-03T22:35:12.590Z |
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| score |
7.4018383 |