Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections
Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephriti...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Georgitsi, M. D. [verfasserIn] Vitoros, V. [verfasserIn] Panou, C. [verfasserIn] Tsangaris, I. [verfasserIn] Aimoniotou, E. [verfasserIn] Gatselis, N. K. [verfasserIn] Chasou, E. [verfasserIn] Kouliatsis, G. [verfasserIn] Leventogiannis, K. [verfasserIn] Velissaris, D. [verfasserIn] Belesiotou, E. [verfasserIn] Dioritou-Aggaliadou, O. [verfasserIn] Giannitsioti, E. [verfasserIn] Netea, M. G. [verfasserIn] Giamarellos-Bourboulis, E. J. [verfasserIn] Giannikopoulos, G. [verfasserIn] Alexiou, Z. [verfasserIn] Voloudakis, N. [verfasserIn] Koutsoukou, A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
Single Nucleotide Polymorphism |
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| Übergeordnetes Werk: |
Enthalten in: European journal of clinical microbiology & infectious diseases - Berlin : Springer, 1982, 35(2016), 4 vom: 14. Jan., Seite 563-570 |
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| Übergeordnetes Werk: |
volume:35 ; year:2016 ; number:4 ; day:14 ; month:01 ; pages:563-570 |
| Links: |
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| DOI / URN: |
10.1007/s10096-015-2571-y |
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| Katalog-ID: |
SPR008699232 |
|---|
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| 024 | 7 | |a 10.1007/s10096-015-2571-y |2 doi | |
| 035 | |a (DE-627)SPR008699232 | ||
| 035 | |a (SPR)s10096-015-2571-y-e | ||
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| 084 | |a 44.75 |2 bkl | ||
| 100 | 1 | |a Georgitsi, M. D. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. | ||
| 650 | 4 | |a Single Nucleotide Polymorphism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Septic Shock |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Severe Sepsis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Systemic Inflammatory Response Syndrome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Rs4073 Single Nucleotide Polymorphism |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Vitoros, V. |e verfasserin |4 aut | |
| 700 | 1 | |a Panou, C. |e verfasserin |4 aut | |
| 700 | 1 | |a Tsangaris, I. |e verfasserin |4 aut | |
| 700 | 1 | |a Aimoniotou, E. |e verfasserin |4 aut | |
| 700 | 1 | |a Gatselis, N. K. |e verfasserin |4 aut | |
| 700 | 1 | |a Chasou, E. |e verfasserin |4 aut | |
| 700 | 1 | |a Kouliatsis, G. |e verfasserin |4 aut | |
| 700 | 1 | |a Leventogiannis, K. |e verfasserin |4 aut | |
| 700 | 1 | |a Velissaris, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Belesiotou, E. |e verfasserin |4 aut | |
| 700 | 1 | |a Dioritou-Aggaliadou, O. |e verfasserin |4 aut | |
| 700 | 1 | |a Giannitsioti, E. |e verfasserin |4 aut | |
| 700 | 1 | |a Netea, M. G. |e verfasserin |4 aut | |
| 700 | 1 | |a Giamarellos-Bourboulis, E. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Giannikopoulos, G. |e verfasserin |4 aut | |
| 700 | 1 | |a Alexiou, Z. |e verfasserin |4 aut | |
| 700 | 1 | |a Voloudakis, N. |e verfasserin |4 aut | |
| 700 | 1 | |a Koutsoukou, A. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of clinical microbiology & infectious diseases |d Berlin : Springer, 1982 |g 35(2016), 4 vom: 14. Jan., Seite 563-570 |w (DE-627)25372273X |w (DE-600)1459049-9 |x 1435-4373 |7 nnns |
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| 912 | |a GBV_ILN_90 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_100 | ||
| 912 | |a GBV_ILN_101 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_120 | ||
| 912 | |a GBV_ILN_138 | ||
| 912 | |a GBV_ILN_150 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_152 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_171 | ||
| 912 | |a GBV_ILN_187 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_224 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_250 | ||
| 912 | |a GBV_ILN_267 | ||
| 912 | |a GBV_ILN_281 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_636 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2008 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2116 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2144 | ||
| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2188 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2446 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2472 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
| 912 | |a GBV_ILN_2548 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4046 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4246 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4335 | ||
| 912 | |a GBV_ILN_4336 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
| 912 | |a GBV_ILN_4700 | ||
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44.43 44.75 |
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2016 |
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10.1007/s10096-015-2571-y doi (DE-627)SPR008699232 (SPR)s10096-015-2571-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Georgitsi, M. D. verfasserin aut Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. Single Nucleotide Polymorphism (dpeaa)DE-He213 Septic Shock (dpeaa)DE-He213 Severe Sepsis (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Rs4073 Single Nucleotide Polymorphism (dpeaa)DE-He213 Vitoros, V. verfasserin aut Panou, C. verfasserin aut Tsangaris, I. verfasserin aut Aimoniotou, E. verfasserin aut Gatselis, N. K. verfasserin aut Chasou, E. verfasserin aut Kouliatsis, G. verfasserin aut Leventogiannis, K. verfasserin aut Velissaris, D. verfasserin aut Belesiotou, E. verfasserin aut Dioritou-Aggaliadou, O. verfasserin aut Giannitsioti, E. verfasserin aut Netea, M. G. verfasserin aut Giamarellos-Bourboulis, E. J. verfasserin aut Giannikopoulos, G. verfasserin aut Alexiou, Z. verfasserin aut Voloudakis, N. verfasserin aut Koutsoukou, A. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 35(2016), 4 vom: 14. Jan., Seite 563-570 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:35 year:2016 number:4 day:14 month:01 pages:563-570 https://dx.doi.org/10.1007/s10096-015-2571-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 35 2016 4 14 01 563-570 |
| spelling |
10.1007/s10096-015-2571-y doi (DE-627)SPR008699232 (SPR)s10096-015-2571-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Georgitsi, M. D. verfasserin aut Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. Single Nucleotide Polymorphism (dpeaa)DE-He213 Septic Shock (dpeaa)DE-He213 Severe Sepsis (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Rs4073 Single Nucleotide Polymorphism (dpeaa)DE-He213 Vitoros, V. verfasserin aut Panou, C. verfasserin aut Tsangaris, I. verfasserin aut Aimoniotou, E. verfasserin aut Gatselis, N. K. verfasserin aut Chasou, E. verfasserin aut Kouliatsis, G. verfasserin aut Leventogiannis, K. verfasserin aut Velissaris, D. verfasserin aut Belesiotou, E. verfasserin aut Dioritou-Aggaliadou, O. verfasserin aut Giannitsioti, E. verfasserin aut Netea, M. G. verfasserin aut Giamarellos-Bourboulis, E. J. verfasserin aut Giannikopoulos, G. verfasserin aut Alexiou, Z. verfasserin aut Voloudakis, N. verfasserin aut Koutsoukou, A. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 35(2016), 4 vom: 14. Jan., Seite 563-570 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:35 year:2016 number:4 day:14 month:01 pages:563-570 https://dx.doi.org/10.1007/s10096-015-2571-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 35 2016 4 14 01 563-570 |
| allfields_unstemmed |
10.1007/s10096-015-2571-y doi (DE-627)SPR008699232 (SPR)s10096-015-2571-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Georgitsi, M. D. verfasserin aut Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. Single Nucleotide Polymorphism (dpeaa)DE-He213 Septic Shock (dpeaa)DE-He213 Severe Sepsis (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Rs4073 Single Nucleotide Polymorphism (dpeaa)DE-He213 Vitoros, V. verfasserin aut Panou, C. verfasserin aut Tsangaris, I. verfasserin aut Aimoniotou, E. verfasserin aut Gatselis, N. K. verfasserin aut Chasou, E. verfasserin aut Kouliatsis, G. verfasserin aut Leventogiannis, K. verfasserin aut Velissaris, D. verfasserin aut Belesiotou, E. verfasserin aut Dioritou-Aggaliadou, O. verfasserin aut Giannitsioti, E. verfasserin aut Netea, M. G. verfasserin aut Giamarellos-Bourboulis, E. J. verfasserin aut Giannikopoulos, G. verfasserin aut Alexiou, Z. verfasserin aut Voloudakis, N. verfasserin aut Koutsoukou, A. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 35(2016), 4 vom: 14. Jan., Seite 563-570 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:35 year:2016 number:4 day:14 month:01 pages:563-570 https://dx.doi.org/10.1007/s10096-015-2571-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 35 2016 4 14 01 563-570 |
| allfieldsGer |
10.1007/s10096-015-2571-y doi (DE-627)SPR008699232 (SPR)s10096-015-2571-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Georgitsi, M. D. verfasserin aut Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. Single Nucleotide Polymorphism (dpeaa)DE-He213 Septic Shock (dpeaa)DE-He213 Severe Sepsis (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Rs4073 Single Nucleotide Polymorphism (dpeaa)DE-He213 Vitoros, V. verfasserin aut Panou, C. verfasserin aut Tsangaris, I. verfasserin aut Aimoniotou, E. verfasserin aut Gatselis, N. K. verfasserin aut Chasou, E. verfasserin aut Kouliatsis, G. verfasserin aut Leventogiannis, K. verfasserin aut Velissaris, D. verfasserin aut Belesiotou, E. verfasserin aut Dioritou-Aggaliadou, O. verfasserin aut Giannitsioti, E. verfasserin aut Netea, M. G. verfasserin aut Giamarellos-Bourboulis, E. J. verfasserin aut Giannikopoulos, G. verfasserin aut Alexiou, Z. verfasserin aut Voloudakis, N. verfasserin aut Koutsoukou, A. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 35(2016), 4 vom: 14. Jan., Seite 563-570 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:35 year:2016 number:4 day:14 month:01 pages:563-570 https://dx.doi.org/10.1007/s10096-015-2571-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 35 2016 4 14 01 563-570 |
| allfieldsSound |
10.1007/s10096-015-2571-y doi (DE-627)SPR008699232 (SPR)s10096-015-2571-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.43 bkl 44.75 bkl Georgitsi, M. D. verfasserin aut Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. Single Nucleotide Polymorphism (dpeaa)DE-He213 Septic Shock (dpeaa)DE-He213 Severe Sepsis (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Rs4073 Single Nucleotide Polymorphism (dpeaa)DE-He213 Vitoros, V. verfasserin aut Panou, C. verfasserin aut Tsangaris, I. verfasserin aut Aimoniotou, E. verfasserin aut Gatselis, N. K. verfasserin aut Chasou, E. verfasserin aut Kouliatsis, G. verfasserin aut Leventogiannis, K. verfasserin aut Velissaris, D. verfasserin aut Belesiotou, E. verfasserin aut Dioritou-Aggaliadou, O. verfasserin aut Giannitsioti, E. verfasserin aut Netea, M. G. verfasserin aut Giamarellos-Bourboulis, E. J. verfasserin aut Giannikopoulos, G. verfasserin aut Alexiou, Z. verfasserin aut Voloudakis, N. verfasserin aut Koutsoukou, A. verfasserin aut Enthalten in European journal of clinical microbiology & infectious diseases Berlin : Springer, 1982 35(2016), 4 vom: 14. Jan., Seite 563-570 (DE-627)25372273X (DE-600)1459049-9 1435-4373 nnns volume:35 year:2016 number:4 day:14 month:01 pages:563-570 https://dx.doi.org/10.1007/s10096-015-2571-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 ASE 44.75 ASE AR 35 2016 4 14 01 563-570 |
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Enthalten in European journal of clinical microbiology & infectious diseases 35(2016), 4 vom: 14. Jan., Seite 563-570 volume:35 year:2016 number:4 day:14 month:01 pages:563-570 |
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Single Nucleotide Polymorphism Septic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Rs4073 Single Nucleotide Polymorphism |
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Georgitsi, M. D. @@aut@@ Vitoros, V. @@aut@@ Panou, C. @@aut@@ Tsangaris, I. @@aut@@ Aimoniotou, E. @@aut@@ Gatselis, N. K. @@aut@@ Chasou, E. @@aut@@ Kouliatsis, G. @@aut@@ Leventogiannis, K. @@aut@@ Velissaris, D. @@aut@@ Belesiotou, E. @@aut@@ Dioritou-Aggaliadou, O. @@aut@@ Giannitsioti, E. @@aut@@ Netea, M. G. @@aut@@ Giamarellos-Bourboulis, E. J. @@aut@@ Giannikopoulos, G. @@aut@@ Alexiou, Z. @@aut@@ Voloudakis, N. @@aut@@ Koutsoukou, A. @@aut@@ |
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2016-01-14T00:00:00Z |
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|
| author |
Georgitsi, M. D. |
| spellingShingle |
Georgitsi, M. D. ddc 610 bkl 44.43 bkl 44.75 misc Single Nucleotide Polymorphism misc Septic Shock misc Severe Sepsis misc Systemic Inflammatory Response Syndrome misc Rs4073 Single Nucleotide Polymorphism Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections |
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Georgitsi, M. D. |
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610 - Medicine & health |
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1435-4373 |
| topic_title |
610 ASE 44.43 bkl 44.75 bkl Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections Single Nucleotide Polymorphism (dpeaa)DE-He213 Septic Shock (dpeaa)DE-He213 Severe Sepsis (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Rs4073 Single Nucleotide Polymorphism (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.43 bkl 44.75 misc Single Nucleotide Polymorphism misc Septic Shock misc Severe Sepsis misc Systemic Inflammatory Response Syndrome misc Rs4073 Single Nucleotide Polymorphism |
| topic_unstemmed |
ddc 610 bkl 44.43 bkl 44.75 misc Single Nucleotide Polymorphism misc Septic Shock misc Severe Sepsis misc Systemic Inflammatory Response Syndrome misc Rs4073 Single Nucleotide Polymorphism |
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ddc 610 bkl 44.43 bkl 44.75 misc Single Nucleotide Polymorphism misc Septic Shock misc Severe Sepsis misc Systemic Inflammatory Response Syndrome misc Rs4073 Single Nucleotide Polymorphism |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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European journal of clinical microbiology & infectious diseases |
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25372273X |
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610 - Medicine & health |
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European journal of clinical microbiology & infectious diseases |
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| title |
Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections |
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(DE-627)SPR008699232 (SPR)s10096-015-2571-y-e |
| title_full |
Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections |
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Georgitsi, M. D. |
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European journal of clinical microbiology & infectious diseases |
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European journal of clinical microbiology & infectious diseases |
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eng |
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600 - Technology |
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2016 |
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txt |
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563 |
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Georgitsi, M. D. Vitoros, V. Panou, C. Tsangaris, I. Aimoniotou, E. Gatselis, N. K. Chasou, E. Kouliatsis, G. Leventogiannis, K. Velissaris, D. Belesiotou, E. Dioritou-Aggaliadou, O. Giannitsioti, E. Netea, M. G. Giamarellos-Bourboulis, E. J. Giannikopoulos, G. Alexiou, Z. Voloudakis, N. Koutsoukou, A. |
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35 |
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610 ASE 44.43 bkl 44.75 bkl |
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Elektronische Aufsätze |
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Georgitsi, M. D. |
| doi_str_mv |
10.1007/s10096-015-2571-y |
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610 |
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verfasserin |
| title_sort |
individualized significance of the −251 a/t single nucleotide polymorphism of interleukin-8 in severe infections |
| title_auth |
Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections |
| abstract |
Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. |
| abstractGer |
Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. |
| abstract_unstemmed |
Abstract Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. |
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Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections |
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Vitoros, V. Panou, C. Tsangaris, I. Aimoniotou, E. Gatselis, N. K. Chasou, E. Kouliatsis, G. Leventogiannis, K. Velissaris, D. Belesiotou, E. Dioritou-Aggaliadou, O. Giannitsioti, E. Netea, M. G. Giamarellos-Bourboulis, E. J. Giannikopoulos, G. Alexiou, Z. Voloudakis, N. Koutsoukou, A. |
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Vitoros, V. Panou, C. Tsangaris, I. Aimoniotou, E. Gatselis, N. K. Chasou, E. Kouliatsis, G. Leventogiannis, K. Velissaris, D. Belesiotou, E. Dioritou-Aggaliadou, O. Giannitsioti, E. Netea, M. G. Giamarellos-Bourboulis, E. J. Giannikopoulos, G. Alexiou, Z. Voloudakis, N. Koutsoukou, A. |
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10.1007/s10096-015-2571-y |
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2024-07-03T22:40:12.557Z |
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| score |
7.3995323 |