Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST
Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conse...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
de Azevedo, Carla Rameri Alexandre Silva [verfasserIn] Paiva, Tadeu Ferreira [verfasserIn] Rossi, Benedito Mauro [verfasserIn] Guimarães, Gustavo Cardoso [verfasserIn] de Souza Begnami, Maria Dirlei Ferreira [verfasserIn] Oliveira, Thiago Bueno [verfasserIn] Barros e Silva, Milton José [verfasserIn] Fanelli, Marcello Ferretti [verfasserIn] de Mello, Celso Abdon Lopes [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of clinical oncology - Tokyo : Springer, 1996, 16(2010), 3 vom: 05. Okt., Seite 279-283 |
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| Übergeordnetes Werk: |
volume:16 ; year:2010 ; number:3 ; day:05 ; month:10 ; pages:279-283 |
| Links: |
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| DOI / URN: |
10.1007/s10147-010-0133-y |
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| Katalog-ID: |
SPR008901619 |
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| 245 | 1 | 0 | |a Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST |
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| 520 | |a Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. | ||
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| 650 | 4 | |a Imatinib mesylate |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Unresectable rectal tumor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neoadjuvant |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pathologic complete response |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Paiva, Tadeu Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Benedito Mauro |e verfasserin |4 aut | |
| 700 | 1 | |a Guimarães, Gustavo Cardoso |e verfasserin |4 aut | |
| 700 | 1 | |a de Souza Begnami, Maria Dirlei Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Thiago Bueno |e verfasserin |4 aut | |
| 700 | 1 | |a Barros e Silva, Milton José |e verfasserin |4 aut | |
| 700 | 1 | |a Fanelli, Marcello Ferretti |e verfasserin |4 aut | |
| 700 | 1 | |a de Mello, Celso Abdon Lopes |e verfasserin |4 aut | |
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10.1007/s10147-010-0133-y doi (DE-627)SPR008901619 (SPR)s10147-010-0133-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl de Azevedo, Carla Rameri Alexandre Silva verfasserin aut Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. GIST (dpeaa)DE-He213 Imatinib mesylate (dpeaa)DE-He213 Unresectable rectal tumor (dpeaa)DE-He213 Neoadjuvant (dpeaa)DE-He213 Pathologic complete response (dpeaa)DE-He213 Paiva, Tadeu Ferreira verfasserin aut Rossi, Benedito Mauro verfasserin aut Guimarães, Gustavo Cardoso verfasserin aut de Souza Begnami, Maria Dirlei Ferreira verfasserin aut Oliveira, Thiago Bueno verfasserin aut Barros e Silva, Milton José verfasserin aut Fanelli, Marcello Ferretti verfasserin aut de Mello, Celso Abdon Lopes verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 16(2010), 3 vom: 05. Okt., Seite 279-283 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:16 year:2010 number:3 day:05 month:10 pages:279-283 https://dx.doi.org/10.1007/s10147-010-0133-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 16 2010 3 05 10 279-283 |
| spelling |
10.1007/s10147-010-0133-y doi (DE-627)SPR008901619 (SPR)s10147-010-0133-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl de Azevedo, Carla Rameri Alexandre Silva verfasserin aut Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. GIST (dpeaa)DE-He213 Imatinib mesylate (dpeaa)DE-He213 Unresectable rectal tumor (dpeaa)DE-He213 Neoadjuvant (dpeaa)DE-He213 Pathologic complete response (dpeaa)DE-He213 Paiva, Tadeu Ferreira verfasserin aut Rossi, Benedito Mauro verfasserin aut Guimarães, Gustavo Cardoso verfasserin aut de Souza Begnami, Maria Dirlei Ferreira verfasserin aut Oliveira, Thiago Bueno verfasserin aut Barros e Silva, Milton José verfasserin aut Fanelli, Marcello Ferretti verfasserin aut de Mello, Celso Abdon Lopes verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 16(2010), 3 vom: 05. Okt., Seite 279-283 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:16 year:2010 number:3 day:05 month:10 pages:279-283 https://dx.doi.org/10.1007/s10147-010-0133-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 16 2010 3 05 10 279-283 |
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10.1007/s10147-010-0133-y doi (DE-627)SPR008901619 (SPR)s10147-010-0133-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl de Azevedo, Carla Rameri Alexandre Silva verfasserin aut Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. GIST (dpeaa)DE-He213 Imatinib mesylate (dpeaa)DE-He213 Unresectable rectal tumor (dpeaa)DE-He213 Neoadjuvant (dpeaa)DE-He213 Pathologic complete response (dpeaa)DE-He213 Paiva, Tadeu Ferreira verfasserin aut Rossi, Benedito Mauro verfasserin aut Guimarães, Gustavo Cardoso verfasserin aut de Souza Begnami, Maria Dirlei Ferreira verfasserin aut Oliveira, Thiago Bueno verfasserin aut Barros e Silva, Milton José verfasserin aut Fanelli, Marcello Ferretti verfasserin aut de Mello, Celso Abdon Lopes verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 16(2010), 3 vom: 05. Okt., Seite 279-283 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:16 year:2010 number:3 day:05 month:10 pages:279-283 https://dx.doi.org/10.1007/s10147-010-0133-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 16 2010 3 05 10 279-283 |
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10.1007/s10147-010-0133-y doi (DE-627)SPR008901619 (SPR)s10147-010-0133-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl de Azevedo, Carla Rameri Alexandre Silva verfasserin aut Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. GIST (dpeaa)DE-He213 Imatinib mesylate (dpeaa)DE-He213 Unresectable rectal tumor (dpeaa)DE-He213 Neoadjuvant (dpeaa)DE-He213 Pathologic complete response (dpeaa)DE-He213 Paiva, Tadeu Ferreira verfasserin aut Rossi, Benedito Mauro verfasserin aut Guimarães, Gustavo Cardoso verfasserin aut de Souza Begnami, Maria Dirlei Ferreira verfasserin aut Oliveira, Thiago Bueno verfasserin aut Barros e Silva, Milton José verfasserin aut Fanelli, Marcello Ferretti verfasserin aut de Mello, Celso Abdon Lopes verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 16(2010), 3 vom: 05. Okt., Seite 279-283 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:16 year:2010 number:3 day:05 month:10 pages:279-283 https://dx.doi.org/10.1007/s10147-010-0133-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 16 2010 3 05 10 279-283 |
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10.1007/s10147-010-0133-y doi (DE-627)SPR008901619 (SPR)s10147-010-0133-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl de Azevedo, Carla Rameri Alexandre Silva verfasserin aut Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. GIST (dpeaa)DE-He213 Imatinib mesylate (dpeaa)DE-He213 Unresectable rectal tumor (dpeaa)DE-He213 Neoadjuvant (dpeaa)DE-He213 Pathologic complete response (dpeaa)DE-He213 Paiva, Tadeu Ferreira verfasserin aut Rossi, Benedito Mauro verfasserin aut Guimarães, Gustavo Cardoso verfasserin aut de Souza Begnami, Maria Dirlei Ferreira verfasserin aut Oliveira, Thiago Bueno verfasserin aut Barros e Silva, Milton José verfasserin aut Fanelli, Marcello Ferretti verfasserin aut de Mello, Celso Abdon Lopes verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 16(2010), 3 vom: 05. Okt., Seite 279-283 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:16 year:2010 number:3 day:05 month:10 pages:279-283 https://dx.doi.org/10.1007/s10147-010-0133-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 16 2010 3 05 10 279-283 |
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English |
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Enthalten in International journal of clinical oncology 16(2010), 3 vom: 05. Okt., Seite 279-283 volume:16 year:2010 number:3 day:05 month:10 pages:279-283 |
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Enthalten in International journal of clinical oncology 16(2010), 3 vom: 05. Okt., Seite 279-283 volume:16 year:2010 number:3 day:05 month:10 pages:279-283 |
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GIST Imatinib mesylate Unresectable rectal tumor Neoadjuvant Pathologic complete response |
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International journal of clinical oncology |
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de Azevedo, Carla Rameri Alexandre Silva @@aut@@ Paiva, Tadeu Ferreira @@aut@@ Rossi, Benedito Mauro @@aut@@ Guimarães, Gustavo Cardoso @@aut@@ de Souza Begnami, Maria Dirlei Ferreira @@aut@@ Oliveira, Thiago Bueno @@aut@@ Barros e Silva, Milton José @@aut@@ Fanelli, Marcello Ferretti @@aut@@ de Mello, Celso Abdon Lopes @@aut@@ |
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2010-10-05T00:00:00Z |
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We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. 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de Azevedo, Carla Rameri Alexandre Silva |
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de Azevedo, Carla Rameri Alexandre Silva ddc 610 bkl 44.81 misc GIST misc Imatinib mesylate misc Unresectable rectal tumor misc Neoadjuvant misc Pathologic complete response Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST |
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610 ASE 44.81 bkl Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST GIST (dpeaa)DE-He213 Imatinib mesylate (dpeaa)DE-He213 Unresectable rectal tumor (dpeaa)DE-He213 Neoadjuvant (dpeaa)DE-He213 Pathologic complete response (dpeaa)DE-He213 |
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de Azevedo, Carla Rameri Alexandre Silva Paiva, Tadeu Ferreira Rossi, Benedito Mauro Guimarães, Gustavo Cardoso de Souza Begnami, Maria Dirlei Ferreira Oliveira, Thiago Bueno Barros e Silva, Milton José Fanelli, Marcello Ferretti de Mello, Celso Abdon Lopes |
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de Azevedo, Carla Rameri Alexandre Silva |
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pathologic complete response with neoadjuvant imatinib for locally advanced pelvic gist |
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Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST |
| abstract |
Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. |
| abstractGer |
Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. |
| abstract_unstemmed |
Abstract There are few data that show pathologic complete response (pCR) to imatinib treatment in gastrointestinal stromal tumors (GISTs). We describe a case of a patient with pCR of a pelvic, locally advanced, high-risk GIST who was treated with neoadjuvant imatinib and ultimately underwent a conservative procedure. A 48-year-old male presented with a pelvic mass 10 cm in diameter. Biopsy revealed a gastrointestinal stromal tumor of rectal origin. Although it was considered initially resectable, an extensive procedure would have been necessary for complete resection. Treatment with imatinib was initiated, resulting in partial response. The patient remained on imatinib for over 15 months, maintaining stable disease. Radical prostatectomy with anal sphincter preservation was performed. Pathological report revealed no viable neoplastic cells. The use of imatinib was held for 6 months after the surgery. At a follow-up 15 months after surgery, the patient had no evidence of disease. Our report may help to guide future studies of neoadjuvant imatinib for large pelvic or rectum GISTs that are initially considered unresectable. |
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| score |
7.397977 |