Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy
Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for E...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Okumura, Hiroshi [verfasserIn] Uchikado, Yasuto [verfasserIn] Matsumoto, Masataka [verfasserIn] Owaki, Tetsuhiro [verfasserIn] Kita, Yoshiaki [verfasserIn] Omoto, Itaru [verfasserIn] Sasaki, Ken [verfasserIn] Sakurai, Toshihide [verfasserIn] Setoyama, Tetsuro [verfasserIn] Nabeki, Bunpei [verfasserIn] Matsushita, Daisuke [verfasserIn] Ishigami, Sumiya [verfasserIn] Hiraki, Yoshiyuki [verfasserIn] Nakajo, Masayuki [verfasserIn] Natsugoe, Shoji [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Übergeordnetes Werk: |
Enthalten in: International journal of clinical oncology - Tokyo : Springer, 1996, 18(2012), 2 vom: 18. Feb., Seite 329-334 |
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| Übergeordnetes Werk: |
volume:18 ; year:2012 ; number:2 ; day:18 ; month:02 ; pages:329-334 |
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| DOI / URN: |
10.1007/s10147-012-0383-y |
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| Katalog-ID: |
SPR008904278 |
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| 245 | 1 | 0 | |a Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
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| 520 | |a Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. | ||
| 650 | 4 | |a Esophageal SCC |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chemoradiation therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognostic factor |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Uchikado, Yasuto |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Masataka |e verfasserin |4 aut | |
| 700 | 1 | |a Owaki, Tetsuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kita, Yoshiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Omoto, Itaru |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurai, Toshihide |e verfasserin |4 aut | |
| 700 | 1 | |a Setoyama, Tetsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Nabeki, Bunpei |e verfasserin |4 aut | |
| 700 | 1 | |a Matsushita, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ishigami, Sumiya |e verfasserin |4 aut | |
| 700 | 1 | |a Hiraki, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajo, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Natsugoe, Shoji |e verfasserin |4 aut | |
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10.1007/s10147-012-0383-y doi (DE-627)SPR008904278 (SPR)s10147-012-0383-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Okumura, Hiroshi verfasserin aut Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. Esophageal SCC (dpeaa)DE-He213 Chemoradiation therapy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Uchikado, Yasuto verfasserin aut Matsumoto, Masataka verfasserin aut Owaki, Tetsuhiro verfasserin aut Kita, Yoshiaki verfasserin aut Omoto, Itaru verfasserin aut Sasaki, Ken verfasserin aut Sakurai, Toshihide verfasserin aut Setoyama, Tetsuro verfasserin aut Nabeki, Bunpei verfasserin aut Matsushita, Daisuke verfasserin aut Ishigami, Sumiya verfasserin aut Hiraki, Yoshiyuki verfasserin aut Nakajo, Masayuki verfasserin aut Natsugoe, Shoji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 18(2012), 2 vom: 18. Feb., Seite 329-334 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:18 year:2012 number:2 day:18 month:02 pages:329-334 https://dx.doi.org/10.1007/s10147-012-0383-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 18 2012 2 18 02 329-334 |
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10.1007/s10147-012-0383-y doi (DE-627)SPR008904278 (SPR)s10147-012-0383-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Okumura, Hiroshi verfasserin aut Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. Esophageal SCC (dpeaa)DE-He213 Chemoradiation therapy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Uchikado, Yasuto verfasserin aut Matsumoto, Masataka verfasserin aut Owaki, Tetsuhiro verfasserin aut Kita, Yoshiaki verfasserin aut Omoto, Itaru verfasserin aut Sasaki, Ken verfasserin aut Sakurai, Toshihide verfasserin aut Setoyama, Tetsuro verfasserin aut Nabeki, Bunpei verfasserin aut Matsushita, Daisuke verfasserin aut Ishigami, Sumiya verfasserin aut Hiraki, Yoshiyuki verfasserin aut Nakajo, Masayuki verfasserin aut Natsugoe, Shoji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 18(2012), 2 vom: 18. Feb., Seite 329-334 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:18 year:2012 number:2 day:18 month:02 pages:329-334 https://dx.doi.org/10.1007/s10147-012-0383-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 18 2012 2 18 02 329-334 |
| allfields_unstemmed |
10.1007/s10147-012-0383-y doi (DE-627)SPR008904278 (SPR)s10147-012-0383-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Okumura, Hiroshi verfasserin aut Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. Esophageal SCC (dpeaa)DE-He213 Chemoradiation therapy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Uchikado, Yasuto verfasserin aut Matsumoto, Masataka verfasserin aut Owaki, Tetsuhiro verfasserin aut Kita, Yoshiaki verfasserin aut Omoto, Itaru verfasserin aut Sasaki, Ken verfasserin aut Sakurai, Toshihide verfasserin aut Setoyama, Tetsuro verfasserin aut Nabeki, Bunpei verfasserin aut Matsushita, Daisuke verfasserin aut Ishigami, Sumiya verfasserin aut Hiraki, Yoshiyuki verfasserin aut Nakajo, Masayuki verfasserin aut Natsugoe, Shoji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 18(2012), 2 vom: 18. Feb., Seite 329-334 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:18 year:2012 number:2 day:18 month:02 pages:329-334 https://dx.doi.org/10.1007/s10147-012-0383-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 18 2012 2 18 02 329-334 |
| allfieldsGer |
10.1007/s10147-012-0383-y doi (DE-627)SPR008904278 (SPR)s10147-012-0383-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Okumura, Hiroshi verfasserin aut Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. Esophageal SCC (dpeaa)DE-He213 Chemoradiation therapy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Uchikado, Yasuto verfasserin aut Matsumoto, Masataka verfasserin aut Owaki, Tetsuhiro verfasserin aut Kita, Yoshiaki verfasserin aut Omoto, Itaru verfasserin aut Sasaki, Ken verfasserin aut Sakurai, Toshihide verfasserin aut Setoyama, Tetsuro verfasserin aut Nabeki, Bunpei verfasserin aut Matsushita, Daisuke verfasserin aut Ishigami, Sumiya verfasserin aut Hiraki, Yoshiyuki verfasserin aut Nakajo, Masayuki verfasserin aut Natsugoe, Shoji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 18(2012), 2 vom: 18. Feb., Seite 329-334 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:18 year:2012 number:2 day:18 month:02 pages:329-334 https://dx.doi.org/10.1007/s10147-012-0383-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 18 2012 2 18 02 329-334 |
| allfieldsSound |
10.1007/s10147-012-0383-y doi (DE-627)SPR008904278 (SPR)s10147-012-0383-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Okumura, Hiroshi verfasserin aut Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. Esophageal SCC (dpeaa)DE-He213 Chemoradiation therapy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Uchikado, Yasuto verfasserin aut Matsumoto, Masataka verfasserin aut Owaki, Tetsuhiro verfasserin aut Kita, Yoshiaki verfasserin aut Omoto, Itaru verfasserin aut Sasaki, Ken verfasserin aut Sakurai, Toshihide verfasserin aut Setoyama, Tetsuro verfasserin aut Nabeki, Bunpei verfasserin aut Matsushita, Daisuke verfasserin aut Ishigami, Sumiya verfasserin aut Hiraki, Yoshiyuki verfasserin aut Nakajo, Masayuki verfasserin aut Natsugoe, Shoji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 18(2012), 2 vom: 18. Feb., Seite 329-334 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:18 year:2012 number:2 day:18 month:02 pages:329-334 https://dx.doi.org/10.1007/s10147-012-0383-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 18 2012 2 18 02 329-334 |
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Enthalten in International journal of clinical oncology 18(2012), 2 vom: 18. Feb., Seite 329-334 volume:18 year:2012 number:2 day:18 month:02 pages:329-334 |
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Enthalten in International journal of clinical oncology 18(2012), 2 vom: 18. Feb., Seite 329-334 volume:18 year:2012 number:2 day:18 month:02 pages:329-334 |
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Esophageal SCC Chemoradiation therapy Prognostic factor |
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International journal of clinical oncology |
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Okumura, Hiroshi @@aut@@ Uchikado, Yasuto @@aut@@ Matsumoto, Masataka @@aut@@ Owaki, Tetsuhiro @@aut@@ Kita, Yoshiaki @@aut@@ Omoto, Itaru @@aut@@ Sasaki, Ken @@aut@@ Sakurai, Toshihide @@aut@@ Setoyama, Tetsuro @@aut@@ Nabeki, Bunpei @@aut@@ Matsushita, Daisuke @@aut@@ Ishigami, Sumiya @@aut@@ Hiraki, Yoshiyuki @@aut@@ Nakajo, Masayuki @@aut@@ Natsugoe, Shoji @@aut@@ |
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2012-02-18T00:00:00Z |
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In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. 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Okumura, Hiroshi |
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Okumura, Hiroshi ddc 610 bkl 44.81 misc Esophageal SCC misc Chemoradiation therapy misc Prognostic factor Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
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610 ASE 44.81 bkl Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy Esophageal SCC (dpeaa)DE-He213 Chemoradiation therapy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Esophageal SCC misc Chemoradiation therapy misc Prognostic factor |
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ddc 610 bkl 44.81 misc Esophageal SCC misc Chemoradiation therapy misc Prognostic factor |
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International journal of clinical oncology |
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Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
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Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
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Okumura, Hiroshi |
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International journal of clinical oncology |
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Okumura, Hiroshi Uchikado, Yasuto Matsumoto, Masataka Owaki, Tetsuhiro Kita, Yoshiaki Omoto, Itaru Sasaki, Ken Sakurai, Toshihide Setoyama, Tetsuro Nabeki, Bunpei Matsushita, Daisuke Ishigami, Sumiya Hiraki, Yoshiyuki Nakajo, Masayuki Natsugoe, Shoji |
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Okumura, Hiroshi |
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prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
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Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
| abstract |
Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. |
| abstractGer |
Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. |
| abstract_unstemmed |
Background Definitive evaluation of surgical specimens obtained after neoadjuvant chemoradiation therapy (CRT) is important for assessing additional treatment or prognosis in patients with esophageal squamous cell carcinoma (ESCC). In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. Conclusion The evaluation method using both pN status and T-effect is useful for assessing prognosis of ESCC patients treated with neoadjuvant CRT. |
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Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy |
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Uchikado, Yasuto Matsumoto, Masataka Owaki, Tetsuhiro Kita, Yoshiaki Omoto, Itaru Sasaki, Ken Sakurai, Toshihide Setoyama, Tetsuro Nabeki, Bunpei Matsushita, Daisuke Ishigami, Sumiya Hiraki, Yoshiyuki Nakajo, Masayuki Natsugoe, Shoji |
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In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation. Patients and methods The present study involved 38 consecutive ESCC patients who underwent CRT followed by curative operation. CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. We examined histological variables as follows: CRT effect on primary tumor (T-effect: T-effective/T-ineffective), tumor depth (pT), lymph node metastases (pN: pN0/N1), number of lymph node metastases (number-pN), lymphatic invasion, and venous invasion. Univariate and multivariate analyses were performed to examine the independent prognostic factors. Survivals and mode of recurrence were then evaluated according to the independent prognostic factors. Results In the univariate analyses, T-effect, pN, number-pN, lymphatic invasion, and venous invasion were found to be prognostic factors with p < 0.01, and pT was a factor with p < 0.05. In the multivariate analysis, pN and T-effect were independent prognostic factors. The five-year survival rate of pN0 patients was more than 75%, even though the T-effect was poor. The 5-year survival rate of patients judged as pN1/T-effective was 50%, whereas all of the pN1/T-ineffective patients died within 2 years with relapse disease. 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