Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer
Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical sample...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ueno, Takayuki [verfasserIn] Masuda, Norikazu [verfasserIn] Yamanaka, Takeharu [verfasserIn] Saji, Shigehira [verfasserIn] Kuroi, Katsumasa [verfasserIn] Sato, Nobuaki [verfasserIn] Takei, Hiroyuki [verfasserIn] Yamamoto, Yutaka [verfasserIn] Ohno, Shinji [verfasserIn] Yamashita, Hiroko [verfasserIn] Hisamatsu, Kazufumi [verfasserIn] Aogi, Kenjiro [verfasserIn] Iwata, Hiroji [verfasserIn] Sasano, Hironobu [verfasserIn] Toi, Masakazu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Übergeordnetes Werk: |
Enthalten in: International journal of clinical oncology - Tokyo : Springer, 1996, 19(2013), 4 vom: 08. Okt., Seite 607-613 |
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| Übergeordnetes Werk: |
volume:19 ; year:2013 ; number:4 ; day:08 ; month:10 ; pages:607-613 |
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| DOI / URN: |
10.1007/s10147-013-0614-x |
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| Katalog-ID: |
SPR008906807 |
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| 100 | 1 | |a Ueno, Takayuki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. | ||
| 650 | 4 | |a Recurrence Score |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neoadjuvant endocrine therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ki-67 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Clinical response |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Breast-conserving surgery rate |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Masuda, Norikazu |e verfasserin |4 aut | |
| 700 | 1 | |a Yamanaka, Takeharu |e verfasserin |4 aut | |
| 700 | 1 | |a Saji, Shigehira |e verfasserin |4 aut | |
| 700 | 1 | |a Kuroi, Katsumasa |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Nobuaki |e verfasserin |4 aut | |
| 700 | 1 | |a Takei, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Ohno, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Hiroko |e verfasserin |4 aut | |
| 700 | 1 | |a Hisamatsu, Kazufumi |e verfasserin |4 aut | |
| 700 | 1 | |a Aogi, Kenjiro |e verfasserin |4 aut | |
| 700 | 1 | |a Iwata, Hiroji |e verfasserin |4 aut | |
| 700 | 1 | |a Sasano, Hironobu |e verfasserin |4 aut | |
| 700 | 1 | |a Toi, Masakazu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of clinical oncology |d Tokyo : Springer, 1996 |g 19(2013), 4 vom: 08. Okt., Seite 607-613 |w (DE-627)300187033 |w (DE-600)1481773-1 |x 1437-7772 |7 nnns |
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10.1007/s10147-013-0614-x doi (DE-627)SPR008906807 (SPR)s10147-013-0614-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Ueno, Takayuki verfasserin aut Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. Recurrence Score (dpeaa)DE-He213 Neoadjuvant endocrine therapy (dpeaa)DE-He213 Ki-67 (dpeaa)DE-He213 Clinical response (dpeaa)DE-He213 Breast-conserving surgery rate (dpeaa)DE-He213 Masuda, Norikazu verfasserin aut Yamanaka, Takeharu verfasserin aut Saji, Shigehira verfasserin aut Kuroi, Katsumasa verfasserin aut Sato, Nobuaki verfasserin aut Takei, Hiroyuki verfasserin aut Yamamoto, Yutaka verfasserin aut Ohno, Shinji verfasserin aut Yamashita, Hiroko verfasserin aut Hisamatsu, Kazufumi verfasserin aut Aogi, Kenjiro verfasserin aut Iwata, Hiroji verfasserin aut Sasano, Hironobu verfasserin aut Toi, Masakazu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 4 vom: 08. Okt., Seite 607-613 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:4 day:08 month:10 pages:607-613 https://dx.doi.org/10.1007/s10147-013-0614-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 4 08 10 607-613 |
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10.1007/s10147-013-0614-x doi (DE-627)SPR008906807 (SPR)s10147-013-0614-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Ueno, Takayuki verfasserin aut Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. Recurrence Score (dpeaa)DE-He213 Neoadjuvant endocrine therapy (dpeaa)DE-He213 Ki-67 (dpeaa)DE-He213 Clinical response (dpeaa)DE-He213 Breast-conserving surgery rate (dpeaa)DE-He213 Masuda, Norikazu verfasserin aut Yamanaka, Takeharu verfasserin aut Saji, Shigehira verfasserin aut Kuroi, Katsumasa verfasserin aut Sato, Nobuaki verfasserin aut Takei, Hiroyuki verfasserin aut Yamamoto, Yutaka verfasserin aut Ohno, Shinji verfasserin aut Yamashita, Hiroko verfasserin aut Hisamatsu, Kazufumi verfasserin aut Aogi, Kenjiro verfasserin aut Iwata, Hiroji verfasserin aut Sasano, Hironobu verfasserin aut Toi, Masakazu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 4 vom: 08. Okt., Seite 607-613 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:4 day:08 month:10 pages:607-613 https://dx.doi.org/10.1007/s10147-013-0614-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 4 08 10 607-613 |
| allfields_unstemmed |
10.1007/s10147-013-0614-x doi (DE-627)SPR008906807 (SPR)s10147-013-0614-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Ueno, Takayuki verfasserin aut Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. Recurrence Score (dpeaa)DE-He213 Neoadjuvant endocrine therapy (dpeaa)DE-He213 Ki-67 (dpeaa)DE-He213 Clinical response (dpeaa)DE-He213 Breast-conserving surgery rate (dpeaa)DE-He213 Masuda, Norikazu verfasserin aut Yamanaka, Takeharu verfasserin aut Saji, Shigehira verfasserin aut Kuroi, Katsumasa verfasserin aut Sato, Nobuaki verfasserin aut Takei, Hiroyuki verfasserin aut Yamamoto, Yutaka verfasserin aut Ohno, Shinji verfasserin aut Yamashita, Hiroko verfasserin aut Hisamatsu, Kazufumi verfasserin aut Aogi, Kenjiro verfasserin aut Iwata, Hiroji verfasserin aut Sasano, Hironobu verfasserin aut Toi, Masakazu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 4 vom: 08. Okt., Seite 607-613 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:4 day:08 month:10 pages:607-613 https://dx.doi.org/10.1007/s10147-013-0614-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 4 08 10 607-613 |
| allfieldsGer |
10.1007/s10147-013-0614-x doi (DE-627)SPR008906807 (SPR)s10147-013-0614-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Ueno, Takayuki verfasserin aut Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. Recurrence Score (dpeaa)DE-He213 Neoadjuvant endocrine therapy (dpeaa)DE-He213 Ki-67 (dpeaa)DE-He213 Clinical response (dpeaa)DE-He213 Breast-conserving surgery rate (dpeaa)DE-He213 Masuda, Norikazu verfasserin aut Yamanaka, Takeharu verfasserin aut Saji, Shigehira verfasserin aut Kuroi, Katsumasa verfasserin aut Sato, Nobuaki verfasserin aut Takei, Hiroyuki verfasserin aut Yamamoto, Yutaka verfasserin aut Ohno, Shinji verfasserin aut Yamashita, Hiroko verfasserin aut Hisamatsu, Kazufumi verfasserin aut Aogi, Kenjiro verfasserin aut Iwata, Hiroji verfasserin aut Sasano, Hironobu verfasserin aut Toi, Masakazu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 4 vom: 08. Okt., Seite 607-613 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:4 day:08 month:10 pages:607-613 https://dx.doi.org/10.1007/s10147-013-0614-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 4 08 10 607-613 |
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10.1007/s10147-013-0614-x doi (DE-627)SPR008906807 (SPR)s10147-013-0614-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Ueno, Takayuki verfasserin aut Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. Recurrence Score (dpeaa)DE-He213 Neoadjuvant endocrine therapy (dpeaa)DE-He213 Ki-67 (dpeaa)DE-He213 Clinical response (dpeaa)DE-He213 Breast-conserving surgery rate (dpeaa)DE-He213 Masuda, Norikazu verfasserin aut Yamanaka, Takeharu verfasserin aut Saji, Shigehira verfasserin aut Kuroi, Katsumasa verfasserin aut Sato, Nobuaki verfasserin aut Takei, Hiroyuki verfasserin aut Yamamoto, Yutaka verfasserin aut Ohno, Shinji verfasserin aut Yamashita, Hiroko verfasserin aut Hisamatsu, Kazufumi verfasserin aut Aogi, Kenjiro verfasserin aut Iwata, Hiroji verfasserin aut Sasano, Hironobu verfasserin aut Toi, Masakazu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 4 vom: 08. Okt., Seite 607-613 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:4 day:08 month:10 pages:607-613 https://dx.doi.org/10.1007/s10147-013-0614-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 4 08 10 607-613 |
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Enthalten in International journal of clinical oncology 19(2013), 4 vom: 08. Okt., Seite 607-613 volume:19 year:2013 number:4 day:08 month:10 pages:607-613 |
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Enthalten in International journal of clinical oncology 19(2013), 4 vom: 08. Okt., Seite 607-613 volume:19 year:2013 number:4 day:08 month:10 pages:607-613 |
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Recurrence Score Neoadjuvant endocrine therapy Ki-67 Clinical response Breast-conserving surgery rate |
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International journal of clinical oncology |
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Ueno, Takayuki @@aut@@ Masuda, Norikazu @@aut@@ Yamanaka, Takeharu @@aut@@ Saji, Shigehira @@aut@@ Kuroi, Katsumasa @@aut@@ Sato, Nobuaki @@aut@@ Takei, Hiroyuki @@aut@@ Yamamoto, Yutaka @@aut@@ Ohno, Shinji @@aut@@ Yamashita, Hiroko @@aut@@ Hisamatsu, Kazufumi @@aut@@ Aogi, Kenjiro @@aut@@ Iwata, Hiroji @@aut@@ Sasano, Hironobu @@aut@@ Toi, Masakazu @@aut@@ |
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2013-10-08T00:00:00Z |
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Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). 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Ueno, Takayuki |
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Ueno, Takayuki ddc 610 bkl 44.81 misc Recurrence Score misc Neoadjuvant endocrine therapy misc Ki-67 misc Clinical response misc Breast-conserving surgery rate Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
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610 ASE 44.81 bkl Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer Recurrence Score (dpeaa)DE-He213 Neoadjuvant endocrine therapy (dpeaa)DE-He213 Ki-67 (dpeaa)DE-He213 Clinical response (dpeaa)DE-He213 Breast-conserving surgery rate (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Recurrence Score misc Neoadjuvant endocrine therapy misc Ki-67 misc Clinical response misc Breast-conserving surgery rate |
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ddc 610 bkl 44.81 misc Recurrence Score misc Neoadjuvant endocrine therapy misc Ki-67 misc Clinical response misc Breast-conserving surgery rate |
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ddc 610 bkl 44.81 misc Recurrence Score misc Neoadjuvant endocrine therapy misc Ki-67 misc Clinical response misc Breast-conserving surgery rate |
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International journal of clinical oncology |
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International journal of clinical oncology |
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Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
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(DE-627)SPR008906807 (SPR)s10147-013-0614-x-e |
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Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
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Ueno, Takayuki |
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International journal of clinical oncology |
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International journal of clinical oncology |
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Ueno, Takayuki Masuda, Norikazu Yamanaka, Takeharu Saji, Shigehira Kuroi, Katsumasa Sato, Nobuaki Takei, Hiroyuki Yamamoto, Yutaka Ohno, Shinji Yamashita, Hiroko Hisamatsu, Kazufumi Aogi, Kenjiro Iwata, Hiroji Sasano, Hironobu Toi, Masakazu |
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Ueno, Takayuki |
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10.1007/s10147-013-0614-x |
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610 |
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verfasserin |
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evaluating the 21-gene assay recurrence $ score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
| title_auth |
Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
| abstract |
Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. |
| abstractGer |
Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. |
| abstract_unstemmed |
Background The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Methods Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadjuvant exemestane therapy (JFMC34-0601). The 21-gene assay was performed after appropriate manual microdissection. The estrogen receptor (ER), progesterone receptor, HER2 and Ki-67 were assayed by immunohistochemistry at a central laboratory. Clinical response was assessed based on the RECIST (Response Evaluation Criteria In Solid Tumors) guideline. Results Sixty-four core biopsy samples and 52 resection samples met the RS quality requirements. The clinical response rate in those patients with a low RS result (low RS group; 19/32, 59.4 %) was significantly higher than that in those patients with a high RS result (high RS group; 3/15, 20.0 %) (P = 0.015) and similar to that in patients with an intermediate RS result (intermediate RS group; 10/17, 58.8 %). The rates of breast-conserving surgery (BCS) were 90.6 % (29/32) in the low RS group, 76.5 % (13/17) in the intermediate RS group and 46.7 % (7/15) in the high RS group. The odds ratio for BCS adjusted for continuous baseline Ki-67 was 0.114 [95 % confidence interval (CI) 0.014–0.721; P = 0.028] between the high and low RS groups. RS values in pre-treatment samples were highly correlated with those in post-treatment samples (Spearman correlation coefficient 0.745, 95 % CI 0.592–0.846). Conclusion Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with ER-positive breast cancer. |
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Evaluating the 21-gene assay Recurrence $ Score^{®} $ as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer |
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https://dx.doi.org/10.1007/s10147-013-0614-x |
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Masuda, Norikazu Yamanaka, Takeharu Saji, Shigehira Kuroi, Katsumasa Sato, Nobuaki Takei, Hiroyuki Yamamoto, Yutaka Ohno, Shinji Yamashita, Hiroko Hisamatsu, Kazufumi Aogi, Kenjiro Iwata, Hiroji Sasano, Hironobu Toi, Masakazu |
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Masuda, Norikazu Yamanaka, Takeharu Saji, Shigehira Kuroi, Katsumasa Sato, Nobuaki Takei, Hiroyuki Yamamoto, Yutaka Ohno, Shinji Yamashita, Hiroko Hisamatsu, Kazufumi Aogi, Kenjiro Iwata, Hiroji Sasano, Hironobu Toi, Masakazu |
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10.1007/s10147-013-0614-x |
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2024-07-03T23:48:00.286Z |
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| score |
7.399748 |