A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age
Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clini...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kajiyama, Hiroaki [verfasserIn] Mizuno, Mika [verfasserIn] Shibata, Kiyosumi [verfasserIn] Umezu, Tomokazu [verfasserIn] Suzuki, Shiro [verfasserIn] Yamamoto, Eiko [verfasserIn] Mitsui, Hiroko [verfasserIn] Sekiya, Ryuichiro [verfasserIn] Niimi, Kaoru [verfasserIn] Kawai, Michiyasu [verfasserIn] Nagasaka, Tetsuro [verfasserIn] Kikkawa, Fumitaka [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of clinical oncology - Tokyo : Springer, 1996, 19(2013), 5 vom: 05. Dez., Seite 921-927 |
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| Übergeordnetes Werk: |
volume:19 ; year:2013 ; number:5 ; day:05 ; month:12 ; pages:921-927 |
| Links: |
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| DOI / URN: |
10.1007/s10147-013-0645-3 |
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| Katalog-ID: |
SPR008907129 |
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| 100 | 1 | |a Kajiyama, Hiroaki |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
| 264 | 1 | |c 2013 | |
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| 520 | |a Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. | ||
| 650 | 4 | |a Clear cell carcinoma of ovary |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reproductive age |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Capsule status |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Recurrence-free survival |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Fertility |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mizuno, Mika |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Kiyosumi |e verfasserin |4 aut | |
| 700 | 1 | |a Umezu, Tomokazu |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Shiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Eiko |e verfasserin |4 aut | |
| 700 | 1 | |a Mitsui, Hiroko |e verfasserin |4 aut | |
| 700 | 1 | |a Sekiya, Ryuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Niimi, Kaoru |e verfasserin |4 aut | |
| 700 | 1 | |a Kawai, Michiyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Nagasaka, Tetsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Kikkawa, Fumitaka |e verfasserin |4 aut | |
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10.1007/s10147-013-0645-3 doi (DE-627)SPR008907129 (SPR)s10147-013-0645-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Kajiyama, Hiroaki verfasserin aut A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. Clear cell carcinoma of ovary (dpeaa)DE-He213 Reproductive age (dpeaa)DE-He213 Capsule status (dpeaa)DE-He213 Recurrence-free survival (dpeaa)DE-He213 Fertility (dpeaa)DE-He213 Mizuno, Mika verfasserin aut Shibata, Kiyosumi verfasserin aut Umezu, Tomokazu verfasserin aut Suzuki, Shiro verfasserin aut Yamamoto, Eiko verfasserin aut Mitsui, Hiroko verfasserin aut Sekiya, Ryuichiro verfasserin aut Niimi, Kaoru verfasserin aut Kawai, Michiyasu verfasserin aut Nagasaka, Tetsuro verfasserin aut Kikkawa, Fumitaka verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 5 vom: 05. Dez., Seite 921-927 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:5 day:05 month:12 pages:921-927 https://dx.doi.org/10.1007/s10147-013-0645-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 5 05 12 921-927 |
| spelling |
10.1007/s10147-013-0645-3 doi (DE-627)SPR008907129 (SPR)s10147-013-0645-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Kajiyama, Hiroaki verfasserin aut A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. Clear cell carcinoma of ovary (dpeaa)DE-He213 Reproductive age (dpeaa)DE-He213 Capsule status (dpeaa)DE-He213 Recurrence-free survival (dpeaa)DE-He213 Fertility (dpeaa)DE-He213 Mizuno, Mika verfasserin aut Shibata, Kiyosumi verfasserin aut Umezu, Tomokazu verfasserin aut Suzuki, Shiro verfasserin aut Yamamoto, Eiko verfasserin aut Mitsui, Hiroko verfasserin aut Sekiya, Ryuichiro verfasserin aut Niimi, Kaoru verfasserin aut Kawai, Michiyasu verfasserin aut Nagasaka, Tetsuro verfasserin aut Kikkawa, Fumitaka verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 5 vom: 05. Dez., Seite 921-927 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:5 day:05 month:12 pages:921-927 https://dx.doi.org/10.1007/s10147-013-0645-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 5 05 12 921-927 |
| allfields_unstemmed |
10.1007/s10147-013-0645-3 doi (DE-627)SPR008907129 (SPR)s10147-013-0645-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Kajiyama, Hiroaki verfasserin aut A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. Clear cell carcinoma of ovary (dpeaa)DE-He213 Reproductive age (dpeaa)DE-He213 Capsule status (dpeaa)DE-He213 Recurrence-free survival (dpeaa)DE-He213 Fertility (dpeaa)DE-He213 Mizuno, Mika verfasserin aut Shibata, Kiyosumi verfasserin aut Umezu, Tomokazu verfasserin aut Suzuki, Shiro verfasserin aut Yamamoto, Eiko verfasserin aut Mitsui, Hiroko verfasserin aut Sekiya, Ryuichiro verfasserin aut Niimi, Kaoru verfasserin aut Kawai, Michiyasu verfasserin aut Nagasaka, Tetsuro verfasserin aut Kikkawa, Fumitaka verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 5 vom: 05. Dez., Seite 921-927 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:5 day:05 month:12 pages:921-927 https://dx.doi.org/10.1007/s10147-013-0645-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 5 05 12 921-927 |
| allfieldsGer |
10.1007/s10147-013-0645-3 doi (DE-627)SPR008907129 (SPR)s10147-013-0645-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Kajiyama, Hiroaki verfasserin aut A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. Clear cell carcinoma of ovary (dpeaa)DE-He213 Reproductive age (dpeaa)DE-He213 Capsule status (dpeaa)DE-He213 Recurrence-free survival (dpeaa)DE-He213 Fertility (dpeaa)DE-He213 Mizuno, Mika verfasserin aut Shibata, Kiyosumi verfasserin aut Umezu, Tomokazu verfasserin aut Suzuki, Shiro verfasserin aut Yamamoto, Eiko verfasserin aut Mitsui, Hiroko verfasserin aut Sekiya, Ryuichiro verfasserin aut Niimi, Kaoru verfasserin aut Kawai, Michiyasu verfasserin aut Nagasaka, Tetsuro verfasserin aut Kikkawa, Fumitaka verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 5 vom: 05. Dez., Seite 921-927 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:5 day:05 month:12 pages:921-927 https://dx.doi.org/10.1007/s10147-013-0645-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 5 05 12 921-927 |
| allfieldsSound |
10.1007/s10147-013-0645-3 doi (DE-627)SPR008907129 (SPR)s10147-013-0645-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Kajiyama, Hiroaki verfasserin aut A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. Clear cell carcinoma of ovary (dpeaa)DE-He213 Reproductive age (dpeaa)DE-He213 Capsule status (dpeaa)DE-He213 Recurrence-free survival (dpeaa)DE-He213 Fertility (dpeaa)DE-He213 Mizuno, Mika verfasserin aut Shibata, Kiyosumi verfasserin aut Umezu, Tomokazu verfasserin aut Suzuki, Shiro verfasserin aut Yamamoto, Eiko verfasserin aut Mitsui, Hiroko verfasserin aut Sekiya, Ryuichiro verfasserin aut Niimi, Kaoru verfasserin aut Kawai, Michiyasu verfasserin aut Nagasaka, Tetsuro verfasserin aut Kikkawa, Fumitaka verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 19(2013), 5 vom: 05. Dez., Seite 921-927 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:19 year:2013 number:5 day:05 month:12 pages:921-927 https://dx.doi.org/10.1007/s10147-013-0645-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2013 5 05 12 921-927 |
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Enthalten in International journal of clinical oncology 19(2013), 5 vom: 05. Dez., Seite 921-927 volume:19 year:2013 number:5 day:05 month:12 pages:921-927 |
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findex.gbv.de |
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Clear cell carcinoma of ovary Reproductive age Capsule status Recurrence-free survival Fertility |
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International journal of clinical oncology |
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Kajiyama, Hiroaki @@aut@@ Mizuno, Mika @@aut@@ Shibata, Kiyosumi @@aut@@ Umezu, Tomokazu @@aut@@ Suzuki, Shiro @@aut@@ Yamamoto, Eiko @@aut@@ Mitsui, Hiroko @@aut@@ Sekiya, Ryuichiro @@aut@@ Niimi, Kaoru @@aut@@ Kawai, Michiyasu @@aut@@ Nagasaka, Tetsuro @@aut@@ Kikkawa, Fumitaka @@aut@@ |
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2013-12-05T00:00:00Z |
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3610 |
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Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). 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| author |
Kajiyama, Hiroaki |
| spellingShingle |
Kajiyama, Hiroaki ddc 610 bkl 44.81 misc Clear cell carcinoma of ovary misc Reproductive age misc Capsule status misc Recurrence-free survival misc Fertility A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
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Kajiyama, Hiroaki |
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1437-7772 |
| topic_title |
610 ASE 44.81 bkl A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age Clear cell carcinoma of ovary (dpeaa)DE-He213 Reproductive age (dpeaa)DE-He213 Capsule status (dpeaa)DE-He213 Recurrence-free survival (dpeaa)DE-He213 Fertility (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.81 misc Clear cell carcinoma of ovary misc Reproductive age misc Capsule status misc Recurrence-free survival misc Fertility |
| topic_unstemmed |
ddc 610 bkl 44.81 misc Clear cell carcinoma of ovary misc Reproductive age misc Capsule status misc Recurrence-free survival misc Fertility |
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ddc 610 bkl 44.81 misc Clear cell carcinoma of ovary misc Reproductive age misc Capsule status misc Recurrence-free survival misc Fertility |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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International journal of clinical oncology |
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300187033 |
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610 - Medicine & health |
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International journal of clinical oncology |
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A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
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(DE-627)SPR008907129 (SPR)s10147-013-0645-3-e |
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A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
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Kajiyama, Hiroaki |
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International journal of clinical oncology |
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International journal of clinical oncology |
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eng |
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600 - Technology |
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2013 |
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Kajiyama, Hiroaki Mizuno, Mika Shibata, Kiyosumi Umezu, Tomokazu Suzuki, Shiro Yamamoto, Eiko Mitsui, Hiroko Sekiya, Ryuichiro Niimi, Kaoru Kawai, Michiyasu Nagasaka, Tetsuro Kikkawa, Fumitaka |
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610 ASE 44.81 bkl |
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Elektronische Aufsätze |
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Kajiyama, Hiroaki |
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10.1007/s10147-013-0645-3 |
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610 |
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verfasserin |
| title_sort |
recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
| title_auth |
A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
| abstract |
Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. |
| abstractGer |
Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. |
| abstract_unstemmed |
Objectives We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. Conclusion We should keep in mind the greater risk of recurrence in patients with stage IC disease or higher, other than those stage IC patients with intraoperative rupture. |
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A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age |
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https://dx.doi.org/10.1007/s10147-013-0645-3 |
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Mizuno, Mika Shibata, Kiyosumi Umezu, Tomokazu Suzuki, Shiro Yamamoto, Eiko Mitsui, Hiroko Sekiya, Ryuichiro Niimi, Kaoru Kawai, Michiyasu Nagasaka, Tetsuro Kikkawa, Fumitaka |
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Mizuno, Mika Shibata, Kiyosumi Umezu, Tomokazu Suzuki, Shiro Yamamoto, Eiko Mitsui, Hiroko Sekiya, Ryuichiro Niimi, Kaoru Kawai, Michiyasu Nagasaka, Tetsuro Kikkawa, Fumitaka |
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Patients and methods Between 1986 and 2011, as a regional population-based study, clinicopathological data on 132 young patients with CCC, collected under the central pathological review system, were subjected to uni- and multivariable analyses to evaluate recurrence-free survival (RFS). Results The median age was 40 (27–45) years. The median follow-up period for surviving patients was 46.4 months. During the observation period, there were 16 recurrences in 87 patients with stage I tumors (18.4 %), 8 in 17 with stage II (47.1 %), and 16 in 28 with III–IV (57.1 %). Subsequently, 35 patients died of the disease. Those with stage I or II did not reach the median RFS. The median RFS of stage III–IV was 21.6 months. When analysis was confined to stage I patients, there was no significant difference in the RFS of CCC patients between IA and IC(r) (intraoperative capsule rupture) (P = 0.7957). In contrast, CCC patients with IC excluding IC(r) [IC(non-r)] showed a poorer RFS than those with IC(r) (P < 0.0001). In multivariable analysis confined to stage I patients, the substage group was only an independent prognostic factor for RFS [IA vs. IC(non-r)] [hazard ratio (HR) = 9.394; 95 % CI, 1.445–61.070; P = 0.0190]. 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