A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy
Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosp...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Takahashi, Tsutomu [verfasserIn] Okada, Takahiro [verfasserIn] Ikejiri, Fumiyoshi [verfasserIn] Ito, Shunsuke [verfasserIn] Okada, Yusuke [verfasserIn] Takahashi, Fumimasa [verfasserIn] Kumanomido, Satoshi [verfasserIn] Jo, Yumi [verfasserIn] Adachi, Koji [verfasserIn] Onishi, Chie [verfasserIn] Kawakami, Koshi [verfasserIn] Miyake, Takaaki [verfasserIn] Inoue, Masaya [verfasserIn] Suzuki, Ritsuro [verfasserIn] Suzumiya, Junji [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of clinical oncology - Tokyo : Springer, 1996, 23(2017), 1 vom: 19. Aug., Seite 189-194 |
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| Übergeordnetes Werk: |
volume:23 ; year:2017 ; number:1 ; day:19 ; month:08 ; pages:189-194 |
| Links: |
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| DOI / URN: |
10.1007/s10147-017-1173-3 |
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| Katalog-ID: |
SPR008912882 |
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| 100 | 1 | |a Takahashi, Tsutomu |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
| 264 | 1 | |c 2017 | |
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| 520 | |a Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. | ||
| 650 | 4 | |a Chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nausea |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Vomiting |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lymphoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Palonosetron |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Okada, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ikejiri, Fumiyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Shunsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Fumimasa |e verfasserin |4 aut | |
| 700 | 1 | |a Kumanomido, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Jo, Yumi |e verfasserin |4 aut | |
| 700 | 1 | |a Adachi, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Onishi, Chie |e verfasserin |4 aut | |
| 700 | 1 | |a Kawakami, Koshi |e verfasserin |4 aut | |
| 700 | 1 | |a Miyake, Takaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Masaya |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Ritsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Suzumiya, Junji |e verfasserin |4 aut | |
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10.1007/s10147-017-1173-3 doi (DE-627)SPR008912882 (SPR)s10147-017-1173-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Takahashi, Tsutomu verfasserin aut A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. Chemotherapy (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Palonosetron (dpeaa)DE-He213 Okada, Takahiro verfasserin aut Ikejiri, Fumiyoshi verfasserin aut Ito, Shunsuke verfasserin aut Okada, Yusuke verfasserin aut Takahashi, Fumimasa verfasserin aut Kumanomido, Satoshi verfasserin aut Jo, Yumi verfasserin aut Adachi, Koji verfasserin aut Onishi, Chie verfasserin aut Kawakami, Koshi verfasserin aut Miyake, Takaaki verfasserin aut Inoue, Masaya verfasserin aut Suzuki, Ritsuro verfasserin aut Suzumiya, Junji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 23(2017), 1 vom: 19. Aug., Seite 189-194 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:23 year:2017 number:1 day:19 month:08 pages:189-194 https://dx.doi.org/10.1007/s10147-017-1173-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 23 2017 1 19 08 189-194 |
| spelling |
10.1007/s10147-017-1173-3 doi (DE-627)SPR008912882 (SPR)s10147-017-1173-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Takahashi, Tsutomu verfasserin aut A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. Chemotherapy (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Palonosetron (dpeaa)DE-He213 Okada, Takahiro verfasserin aut Ikejiri, Fumiyoshi verfasserin aut Ito, Shunsuke verfasserin aut Okada, Yusuke verfasserin aut Takahashi, Fumimasa verfasserin aut Kumanomido, Satoshi verfasserin aut Jo, Yumi verfasserin aut Adachi, Koji verfasserin aut Onishi, Chie verfasserin aut Kawakami, Koshi verfasserin aut Miyake, Takaaki verfasserin aut Inoue, Masaya verfasserin aut Suzuki, Ritsuro verfasserin aut Suzumiya, Junji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 23(2017), 1 vom: 19. Aug., Seite 189-194 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:23 year:2017 number:1 day:19 month:08 pages:189-194 https://dx.doi.org/10.1007/s10147-017-1173-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 23 2017 1 19 08 189-194 |
| allfields_unstemmed |
10.1007/s10147-017-1173-3 doi (DE-627)SPR008912882 (SPR)s10147-017-1173-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Takahashi, Tsutomu verfasserin aut A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. Chemotherapy (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Palonosetron (dpeaa)DE-He213 Okada, Takahiro verfasserin aut Ikejiri, Fumiyoshi verfasserin aut Ito, Shunsuke verfasserin aut Okada, Yusuke verfasserin aut Takahashi, Fumimasa verfasserin aut Kumanomido, Satoshi verfasserin aut Jo, Yumi verfasserin aut Adachi, Koji verfasserin aut Onishi, Chie verfasserin aut Kawakami, Koshi verfasserin aut Miyake, Takaaki verfasserin aut Inoue, Masaya verfasserin aut Suzuki, Ritsuro verfasserin aut Suzumiya, Junji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 23(2017), 1 vom: 19. Aug., Seite 189-194 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:23 year:2017 number:1 day:19 month:08 pages:189-194 https://dx.doi.org/10.1007/s10147-017-1173-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 23 2017 1 19 08 189-194 |
| allfieldsGer |
10.1007/s10147-017-1173-3 doi (DE-627)SPR008912882 (SPR)s10147-017-1173-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Takahashi, Tsutomu verfasserin aut A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. Chemotherapy (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Palonosetron (dpeaa)DE-He213 Okada, Takahiro verfasserin aut Ikejiri, Fumiyoshi verfasserin aut Ito, Shunsuke verfasserin aut Okada, Yusuke verfasserin aut Takahashi, Fumimasa verfasserin aut Kumanomido, Satoshi verfasserin aut Jo, Yumi verfasserin aut Adachi, Koji verfasserin aut Onishi, Chie verfasserin aut Kawakami, Koshi verfasserin aut Miyake, Takaaki verfasserin aut Inoue, Masaya verfasserin aut Suzuki, Ritsuro verfasserin aut Suzumiya, Junji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 23(2017), 1 vom: 19. Aug., Seite 189-194 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:23 year:2017 number:1 day:19 month:08 pages:189-194 https://dx.doi.org/10.1007/s10147-017-1173-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 23 2017 1 19 08 189-194 |
| allfieldsSound |
10.1007/s10147-017-1173-3 doi (DE-627)SPR008912882 (SPR)s10147-017-1173-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Takahashi, Tsutomu verfasserin aut A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. Chemotherapy (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Palonosetron (dpeaa)DE-He213 Okada, Takahiro verfasserin aut Ikejiri, Fumiyoshi verfasserin aut Ito, Shunsuke verfasserin aut Okada, Yusuke verfasserin aut Takahashi, Fumimasa verfasserin aut Kumanomido, Satoshi verfasserin aut Jo, Yumi verfasserin aut Adachi, Koji verfasserin aut Onishi, Chie verfasserin aut Kawakami, Koshi verfasserin aut Miyake, Takaaki verfasserin aut Inoue, Masaya verfasserin aut Suzuki, Ritsuro verfasserin aut Suzumiya, Junji verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 23(2017), 1 vom: 19. Aug., Seite 189-194 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:23 year:2017 number:1 day:19 month:08 pages:189-194 https://dx.doi.org/10.1007/s10147-017-1173-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 23 2017 1 19 08 189-194 |
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Enthalten in International journal of clinical oncology 23(2017), 1 vom: 19. Aug., Seite 189-194 volume:23 year:2017 number:1 day:19 month:08 pages:189-194 |
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Chemotherapy Nausea Vomiting Lymphoma Palonosetron |
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International journal of clinical oncology |
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Takahashi, Tsutomu @@aut@@ Okada, Takahiro @@aut@@ Ikejiri, Fumiyoshi @@aut@@ Ito, Shunsuke @@aut@@ Okada, Yusuke @@aut@@ Takahashi, Fumimasa @@aut@@ Kumanomido, Satoshi @@aut@@ Jo, Yumi @@aut@@ Adachi, Koji @@aut@@ Onishi, Chie @@aut@@ Kawakami, Koshi @@aut@@ Miyake, Takaaki @@aut@@ Inoue, Masaya @@aut@@ Suzuki, Ritsuro @@aut@@ Suzumiya, Junji @@aut@@ |
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2017-08-19T00:00:00Z |
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A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. 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| author |
Takahashi, Tsutomu |
| spellingShingle |
Takahashi, Tsutomu ddc 610 bkl 44.81 misc Chemotherapy misc Nausea misc Vomiting misc Lymphoma misc Palonosetron A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
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Takahashi, Tsutomu |
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1437-7772 |
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610 ASE 44.81 bkl A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy Chemotherapy (dpeaa)DE-He213 Nausea (dpeaa)DE-He213 Vomiting (dpeaa)DE-He213 Lymphoma (dpeaa)DE-He213 Palonosetron (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Chemotherapy misc Nausea misc Vomiting misc Lymphoma misc Palonosetron |
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ddc 610 bkl 44.81 misc Chemotherapy misc Nausea misc Vomiting misc Lymphoma misc Palonosetron |
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ddc 610 bkl 44.81 misc Chemotherapy misc Nausea misc Vomiting misc Lymphoma misc Palonosetron |
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International journal of clinical oncology |
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International journal of clinical oncology |
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A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
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(DE-627)SPR008912882 (SPR)s10147-017-1173-3-e |
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A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
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Takahashi, Tsutomu |
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International journal of clinical oncology |
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International journal of clinical oncology |
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600 - Technology |
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2017 |
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Takahashi, Tsutomu Okada, Takahiro Ikejiri, Fumiyoshi Ito, Shunsuke Okada, Yusuke Takahashi, Fumimasa Kumanomido, Satoshi Jo, Yumi Adachi, Koji Onishi, Chie Kawakami, Koshi Miyake, Takaaki Inoue, Masaya Suzuki, Ritsuro Suzumiya, Junji |
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Takahashi, Tsutomu |
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10.1007/s10147-017-1173-3 |
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610 |
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verfasserin |
| title_sort |
prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
| title_auth |
A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
| abstract |
Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. |
| abstractGer |
Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. |
| abstract_unstemmed |
Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. Conclusion The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients. |
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A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy |
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Okada, Takahiro Ikejiri, Fumiyoshi Ito, Shunsuke Okada, Yusuke Takahashi, Fumimasa Kumanomido, Satoshi Jo, Yumi Adachi, Koji Onishi, Chie Kawakami, Koshi Miyake, Takaaki Inoue, Masaya Suzuki, Ritsuro Suzumiya, Junji |
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Okada, Takahiro Ikejiri, Fumiyoshi Ito, Shunsuke Okada, Yusuke Takahashi, Fumimasa Kumanomido, Satoshi Jo, Yumi Adachi, Koji Onishi, Chie Kawakami, Koshi Miyake, Takaaki Inoue, Masaya Suzuki, Ritsuro Suzumiya, Junji |
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10.1007/s10147-017-1173-3 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR008912882</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519224537.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10147-017-1173-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR008912882</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10147-017-1173-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Takahashi, Tsutomu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation $ 5HT_{3} $ receptor antagonist ($ 5HT_{3} $RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients. Methods Chemotherapy-naïve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy. Results A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1–98.7%) at 0–120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0–120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy. 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