Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan
Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patien...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sakai, Kosuke [verfasserIn] Kuramoto, Joji [verfasserIn] Kojima, Akitoshi [verfasserIn] Nishimura, Hiroaki [verfasserIn] Kuwabara, Yoshiki [verfasserIn] Toda, Maiko [verfasserIn] Kobayashi, Yumiko [verfasserIn] Kikuchi, Satoshi [verfasserIn] Hirata, Yusuke [verfasserIn] Mikami-Saito, Yuriko [verfasserIn] Mikami, Shintaro [verfasserIn] Kyoyama, Hiroyuki [verfasserIn] Moriyama, Gaku [verfasserIn] Gemma, Akihiko [verfasserIn] Uematsu, Kazutsugu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
Enthalten in: International journal of clinical oncology - Tokyo : Springer, 1996, 24(2019), 12 vom: 26. Aug., Seite 1549-1557 |
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| Übergeordnetes Werk: |
volume:24 ; year:2019 ; number:12 ; day:26 ; month:08 ; pages:1549-1557 |
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| DOI / URN: |
10.1007/s10147-019-01525-8 |
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| Katalog-ID: |
SPR008915253 |
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| 100 | 1 | |a Sakai, Kosuke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan |
| 264 | 1 | |c 2019 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. | ||
| 650 | 4 | |a Eighth edition |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TNM classification of lung cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a M Descriptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oligometastasis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a EGFR mutation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a EML4–ALK fusion gene |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kuramoto, Joji |e verfasserin |4 aut | |
| 700 | 1 | |a Kojima, Akitoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimura, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kuwabara, Yoshiki |e verfasserin |4 aut | |
| 700 | 1 | |a Toda, Maiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Yumiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kikuchi, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Hirata, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Mikami-Saito, Yuriko |e verfasserin |4 aut | |
| 700 | 1 | |a Mikami, Shintaro |e verfasserin |4 aut | |
| 700 | 1 | |a Kyoyama, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Moriyama, Gaku |e verfasserin |4 aut | |
| 700 | 1 | |a Gemma, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Uematsu, Kazutsugu |e verfasserin |4 aut | |
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10.1007/s10147-019-01525-8 doi (DE-627)SPR008915253 (SPR)s10147-019-01525-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Sakai, Kosuke verfasserin aut Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. Eighth edition (dpeaa)DE-He213 TNM classification of lung cancer (dpeaa)DE-He213 M Descriptor (dpeaa)DE-He213 Oligometastasis (dpeaa)DE-He213 EGFR mutation (dpeaa)DE-He213 EML4–ALK fusion gene (dpeaa)DE-He213 Kuramoto, Joji verfasserin aut Kojima, Akitoshi verfasserin aut Nishimura, Hiroaki verfasserin aut Kuwabara, Yoshiki verfasserin aut Toda, Maiko verfasserin aut Kobayashi, Yumiko verfasserin aut Kikuchi, Satoshi verfasserin aut Hirata, Yusuke verfasserin aut Mikami-Saito, Yuriko verfasserin aut Mikami, Shintaro verfasserin aut Kyoyama, Hiroyuki verfasserin aut Moriyama, Gaku verfasserin aut Gemma, Akihiko verfasserin aut Uematsu, Kazutsugu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 24(2019), 12 vom: 26. Aug., Seite 1549-1557 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:24 year:2019 number:12 day:26 month:08 pages:1549-1557 https://dx.doi.org/10.1007/s10147-019-01525-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2019 12 26 08 1549-1557 |
| spelling |
10.1007/s10147-019-01525-8 doi (DE-627)SPR008915253 (SPR)s10147-019-01525-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Sakai, Kosuke verfasserin aut Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. Eighth edition (dpeaa)DE-He213 TNM classification of lung cancer (dpeaa)DE-He213 M Descriptor (dpeaa)DE-He213 Oligometastasis (dpeaa)DE-He213 EGFR mutation (dpeaa)DE-He213 EML4–ALK fusion gene (dpeaa)DE-He213 Kuramoto, Joji verfasserin aut Kojima, Akitoshi verfasserin aut Nishimura, Hiroaki verfasserin aut Kuwabara, Yoshiki verfasserin aut Toda, Maiko verfasserin aut Kobayashi, Yumiko verfasserin aut Kikuchi, Satoshi verfasserin aut Hirata, Yusuke verfasserin aut Mikami-Saito, Yuriko verfasserin aut Mikami, Shintaro verfasserin aut Kyoyama, Hiroyuki verfasserin aut Moriyama, Gaku verfasserin aut Gemma, Akihiko verfasserin aut Uematsu, Kazutsugu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 24(2019), 12 vom: 26. Aug., Seite 1549-1557 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:24 year:2019 number:12 day:26 month:08 pages:1549-1557 https://dx.doi.org/10.1007/s10147-019-01525-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2019 12 26 08 1549-1557 |
| allfields_unstemmed |
10.1007/s10147-019-01525-8 doi (DE-627)SPR008915253 (SPR)s10147-019-01525-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Sakai, Kosuke verfasserin aut Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. Eighth edition (dpeaa)DE-He213 TNM classification of lung cancer (dpeaa)DE-He213 M Descriptor (dpeaa)DE-He213 Oligometastasis (dpeaa)DE-He213 EGFR mutation (dpeaa)DE-He213 EML4–ALK fusion gene (dpeaa)DE-He213 Kuramoto, Joji verfasserin aut Kojima, Akitoshi verfasserin aut Nishimura, Hiroaki verfasserin aut Kuwabara, Yoshiki verfasserin aut Toda, Maiko verfasserin aut Kobayashi, Yumiko verfasserin aut Kikuchi, Satoshi verfasserin aut Hirata, Yusuke verfasserin aut Mikami-Saito, Yuriko verfasserin aut Mikami, Shintaro verfasserin aut Kyoyama, Hiroyuki verfasserin aut Moriyama, Gaku verfasserin aut Gemma, Akihiko verfasserin aut Uematsu, Kazutsugu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 24(2019), 12 vom: 26. Aug., Seite 1549-1557 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:24 year:2019 number:12 day:26 month:08 pages:1549-1557 https://dx.doi.org/10.1007/s10147-019-01525-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2019 12 26 08 1549-1557 |
| allfieldsGer |
10.1007/s10147-019-01525-8 doi (DE-627)SPR008915253 (SPR)s10147-019-01525-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Sakai, Kosuke verfasserin aut Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. Eighth edition (dpeaa)DE-He213 TNM classification of lung cancer (dpeaa)DE-He213 M Descriptor (dpeaa)DE-He213 Oligometastasis (dpeaa)DE-He213 EGFR mutation (dpeaa)DE-He213 EML4–ALK fusion gene (dpeaa)DE-He213 Kuramoto, Joji verfasserin aut Kojima, Akitoshi verfasserin aut Nishimura, Hiroaki verfasserin aut Kuwabara, Yoshiki verfasserin aut Toda, Maiko verfasserin aut Kobayashi, Yumiko verfasserin aut Kikuchi, Satoshi verfasserin aut Hirata, Yusuke verfasserin aut Mikami-Saito, Yuriko verfasserin aut Mikami, Shintaro verfasserin aut Kyoyama, Hiroyuki verfasserin aut Moriyama, Gaku verfasserin aut Gemma, Akihiko verfasserin aut Uematsu, Kazutsugu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 24(2019), 12 vom: 26. Aug., Seite 1549-1557 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:24 year:2019 number:12 day:26 month:08 pages:1549-1557 https://dx.doi.org/10.1007/s10147-019-01525-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2019 12 26 08 1549-1557 |
| allfieldsSound |
10.1007/s10147-019-01525-8 doi (DE-627)SPR008915253 (SPR)s10147-019-01525-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl Sakai, Kosuke verfasserin aut Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. Eighth edition (dpeaa)DE-He213 TNM classification of lung cancer (dpeaa)DE-He213 M Descriptor (dpeaa)DE-He213 Oligometastasis (dpeaa)DE-He213 EGFR mutation (dpeaa)DE-He213 EML4–ALK fusion gene (dpeaa)DE-He213 Kuramoto, Joji verfasserin aut Kojima, Akitoshi verfasserin aut Nishimura, Hiroaki verfasserin aut Kuwabara, Yoshiki verfasserin aut Toda, Maiko verfasserin aut Kobayashi, Yumiko verfasserin aut Kikuchi, Satoshi verfasserin aut Hirata, Yusuke verfasserin aut Mikami-Saito, Yuriko verfasserin aut Mikami, Shintaro verfasserin aut Kyoyama, Hiroyuki verfasserin aut Moriyama, Gaku verfasserin aut Gemma, Akihiko verfasserin aut Uematsu, Kazutsugu verfasserin aut Enthalten in International journal of clinical oncology Tokyo : Springer, 1996 24(2019), 12 vom: 26. Aug., Seite 1549-1557 (DE-627)300187033 (DE-600)1481773-1 1437-7772 nnns volume:24 year:2019 number:12 day:26 month:08 pages:1549-1557 https://dx.doi.org/10.1007/s10147-019-01525-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 24 2019 12 26 08 1549-1557 |
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Enthalten in International journal of clinical oncology 24(2019), 12 vom: 26. Aug., Seite 1549-1557 volume:24 year:2019 number:12 day:26 month:08 pages:1549-1557 |
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Eighth edition TNM classification of lung cancer M Descriptor Oligometastasis EGFR mutation EML4–ALK fusion gene |
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Sakai, Kosuke @@aut@@ Kuramoto, Joji @@aut@@ Kojima, Akitoshi @@aut@@ Nishimura, Hiroaki @@aut@@ Kuwabara, Yoshiki @@aut@@ Toda, Maiko @@aut@@ Kobayashi, Yumiko @@aut@@ Kikuchi, Satoshi @@aut@@ Hirata, Yusuke @@aut@@ Mikami-Saito, Yuriko @@aut@@ Mikami, Shintaro @@aut@@ Kyoyama, Hiroyuki @@aut@@ Moriyama, Gaku @@aut@@ Gemma, Akihiko @@aut@@ Uematsu, Kazutsugu @@aut@@ |
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To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). 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|
| author |
Sakai, Kosuke |
| spellingShingle |
Sakai, Kosuke ddc 610 bkl 44.81 misc Eighth edition misc TNM classification of lung cancer misc M Descriptor misc Oligometastasis misc EGFR mutation misc EML4–ALK fusion gene Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan |
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Sakai, Kosuke |
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610 - Medicine & health |
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1437-7772 |
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610 ASE 44.81 bkl Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan Eighth edition (dpeaa)DE-He213 TNM classification of lung cancer (dpeaa)DE-He213 M Descriptor (dpeaa)DE-He213 Oligometastasis (dpeaa)DE-He213 EGFR mutation (dpeaa)DE-He213 EML4–ALK fusion gene (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Eighth edition misc TNM classification of lung cancer misc M Descriptor misc Oligometastasis misc EGFR mutation misc EML4–ALK fusion gene |
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ddc 610 bkl 44.81 misc Eighth edition misc TNM classification of lung cancer misc M Descriptor misc Oligometastasis misc EGFR mutation misc EML4–ALK fusion gene |
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ddc 610 bkl 44.81 misc Eighth edition misc TNM classification of lung cancer misc M Descriptor misc Oligometastasis misc EGFR mutation misc EML4–ALK fusion gene |
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International journal of clinical oncology |
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300187033 |
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610 - Medicine & health |
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International journal of clinical oncology |
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(DE-627)300187033 (DE-600)1481773-1 |
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Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan |
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(DE-627)SPR008915253 (SPR)s10147-019-01525-8-e |
| title_full |
Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan |
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Sakai, Kosuke |
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International journal of clinical oncology |
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International journal of clinical oncology |
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eng |
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600 - Technology |
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2019 |
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1549 |
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Sakai, Kosuke Kuramoto, Joji Kojima, Akitoshi Nishimura, Hiroaki Kuwabara, Yoshiki Toda, Maiko Kobayashi, Yumiko Kikuchi, Satoshi Hirata, Yusuke Mikami-Saito, Yuriko Mikami, Shintaro Kyoyama, Hiroyuki Moriyama, Gaku Gemma, Akihiko Uematsu, Kazutsugu |
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610 ASE 44.81 bkl |
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Elektronische Aufsätze |
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Sakai, Kosuke |
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10.1007/s10147-019-01525-8 |
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610 |
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verfasserin |
| title_sort |
validation of prognostic impact of number of extrathoracic metastases according to the eighth tnm classification: a single-institution retrospective study in japan |
| title_auth |
Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan |
| abstract |
Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. |
| abstractGer |
Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. |
| abstract_unstemmed |
Background In the eighth edition of the TNM classification of lung cancer, the M1b and M1c descriptors are newly defined by the number of extrathoracic metastases. To verify the prognostic value of these descriptors in Japan, we reclassified our cases and re-evaluated prognosis in M1b and M1c patients. Methods All non-small cell lung cancer (NSCLC) patients with extrathoracic metastases who visited Saitama Medical Center from 2010 to 2016 were evaluated, divided according to the eighth edition of the TNM classification criteria into two groups (M1b, patients with single extrathoracic metastasis, and M1c, patients with multiple extrathoracic metastases), and followed up until December 31, 2017. Survival time analysis was performed using the Kaplan–Meier method, and between-group differences in overall survival time (OS) were evaluated by the log-rank test. Results A total of 231 NSCLC patients were divided into 57 patients with M1b and 174 with M1c. Median OS was 15.2 months (95% confidence interval [CI]: 9.3–19.9) and 7.3 months (95% CI 5.7–10.7) for M1b and M1c, respectively, with no significant between-group difference (P = 0.239). However, after excluding patients with epidermal growth factor receptor (EGFR) mutation or echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (EML4–ALK) fusion gene, median OS was 12.9 months (95% CI 7.2–19.9) for M1b and 5.4 months (95% CI 3.8–6.3) for M1c, respectively, showing a significant difference (P = 0.029). Conclusions The effect of therapy directed toward EGFR mutation or EML4–ALK fusion gene might obscure the significant prognostic difference between M1b and M1c. |
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Validation of prognostic impact of number of extrathoracic metastases according to the eighth TNM classification: a single-institution retrospective study in Japan |
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https://dx.doi.org/10.1007/s10147-019-01525-8 |
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Kuramoto, Joji Kojima, Akitoshi Nishimura, Hiroaki Kuwabara, Yoshiki Toda, Maiko Kobayashi, Yumiko Kikuchi, Satoshi Hirata, Yusuke Mikami-Saito, Yuriko Mikami, Shintaro Kyoyama, Hiroyuki Moriyama, Gaku Gemma, Akihiko Uematsu, Kazutsugu |
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Kuramoto, Joji Kojima, Akitoshi Nishimura, Hiroaki Kuwabara, Yoshiki Toda, Maiko Kobayashi, Yumiko Kikuchi, Satoshi Hirata, Yusuke Mikami-Saito, Yuriko Mikami, Shintaro Kyoyama, Hiroyuki Moriyama, Gaku Gemma, Akihiko Uematsu, Kazutsugu |
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10.1007/s10147-019-01525-8 |
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2024-07-03T23:51:02.912Z |
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| score |
7.399768 |