Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy

Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal...
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Autor*in:	Tsuboi, Nobuo [verfasserIn] Koike, Kentaro [verfasserIn] Hirano, Keita [verfasserIn] Utsunomiya, Yasunori [verfasserIn] Kawamura, Tetsuya [verfasserIn] Hosoya, Tatsuo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Obesity Renal dysfunction Proteinuria Renal outcome

Übergeordnetes Werk:	Enthalten in: Clinical and experimental nephrology - [Tokyo] : Springer, 1997, 17(2012), 3 vom: 08. Nov., Seite 379-385
Übergeordnetes Werk:	volume:17 ; year:2012 ; number:3 ; day:08 ; month:11 ; pages:379-385

Links:	Volltext

DOI / URN:	10.1007/s10157-012-0719-y

Katalog-ID:	SPR008970033

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520			\|a Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity.
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matchkey_str	article:14377799:2012----::lncletrsnlntrrnlucmsfaaeeainsihbs
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allfields	10.1007/s10157-012-0719-y doi (DE-627)SPR008970033 (SPR)s10157-012-0719-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tsuboi, Nobuo verfasserin aut Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity. Obesity (dpeaa)DE-He213 Renal dysfunction (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Renal outcome (dpeaa)DE-He213 Koike, Kentaro verfasserin aut Hirano, Keita verfasserin aut Utsunomiya, Yasunori verfasserin aut Kawamura, Tetsuya verfasserin aut Hosoya, Tatsuo verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2012), 3 vom: 08. Nov., Seite 379-385 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2012 number:3 day:08 month:11 pages:379-385 https://dx.doi.org/10.1007/s10157-012-0719-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2012 3 08 11 379-385
spelling	10.1007/s10157-012-0719-y doi (DE-627)SPR008970033 (SPR)s10157-012-0719-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tsuboi, Nobuo verfasserin aut Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity. Obesity (dpeaa)DE-He213 Renal dysfunction (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Renal outcome (dpeaa)DE-He213 Koike, Kentaro verfasserin aut Hirano, Keita verfasserin aut Utsunomiya, Yasunori verfasserin aut Kawamura, Tetsuya verfasserin aut Hosoya, Tatsuo verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2012), 3 vom: 08. Nov., Seite 379-385 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2012 number:3 day:08 month:11 pages:379-385 https://dx.doi.org/10.1007/s10157-012-0719-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2012 3 08 11 379-385
allfields_unstemmed	10.1007/s10157-012-0719-y doi (DE-627)SPR008970033 (SPR)s10157-012-0719-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tsuboi, Nobuo verfasserin aut Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity. Obesity (dpeaa)DE-He213 Renal dysfunction (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Renal outcome (dpeaa)DE-He213 Koike, Kentaro verfasserin aut Hirano, Keita verfasserin aut Utsunomiya, Yasunori verfasserin aut Kawamura, Tetsuya verfasserin aut Hosoya, Tatsuo verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2012), 3 vom: 08. Nov., Seite 379-385 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2012 number:3 day:08 month:11 pages:379-385 https://dx.doi.org/10.1007/s10157-012-0719-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2012 3 08 11 379-385
allfieldsGer	10.1007/s10157-012-0719-y doi (DE-627)SPR008970033 (SPR)s10157-012-0719-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tsuboi, Nobuo verfasserin aut Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity. Obesity (dpeaa)DE-He213 Renal dysfunction (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Renal outcome (dpeaa)DE-He213 Koike, Kentaro verfasserin aut Hirano, Keita verfasserin aut Utsunomiya, Yasunori verfasserin aut Kawamura, Tetsuya verfasserin aut Hosoya, Tatsuo verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2012), 3 vom: 08. Nov., Seite 379-385 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2012 number:3 day:08 month:11 pages:379-385 https://dx.doi.org/10.1007/s10157-012-0719-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2012 3 08 11 379-385
allfieldsSound	10.1007/s10157-012-0719-y doi (DE-627)SPR008970033 (SPR)s10157-012-0719-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tsuboi, Nobuo verfasserin aut Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity. Obesity (dpeaa)DE-He213 Renal dysfunction (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Renal outcome (dpeaa)DE-He213 Koike, Kentaro verfasserin aut Hirano, Keita verfasserin aut Utsunomiya, Yasunori verfasserin aut Kawamura, Tetsuya verfasserin aut Hosoya, Tatsuo verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2012), 3 vom: 08. Nov., Seite 379-385 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2012 number:3 day:08 month:11 pages:379-385 https://dx.doi.org/10.1007/s10157-012-0719-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2012 3 08 11 379-385
language	English
source	Enthalten in Clinical and experimental nephrology 17(2012), 3 vom: 08. Nov., Seite 379-385 volume:17 year:2012 number:3 day:08 month:11 pages:379-385
sourceStr	Enthalten in Clinical and experimental nephrology 17(2012), 3 vom: 08. Nov., Seite 379-385 volume:17 year:2012 number:3 day:08 month:11 pages:379-385
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Obesity Renal dysfunction Proteinuria Renal outcome
dewey-raw	610
isfreeaccess_bool	false
container_title	Clinical and experimental nephrology
authorswithroles_txt_mv	Tsuboi, Nobuo @@aut@@ Koike, Kentaro @@aut@@ Hirano, Keita @@aut@@ Utsunomiya, Yasunori @@aut@@ Kawamura, Tetsuya @@aut@@ Hosoya, Tatsuo @@aut@@
publishDateDaySort_date	2012-11-08T00:00:00Z
hierarchy_top_id	306646900
dewey-sort	3610
id	SPR008970033
language_de	englisch
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However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). 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author	Tsuboi, Nobuo
spellingShingle	Tsuboi, Nobuo ddc 610 bkl 44.88 misc Obesity misc Renal dysfunction misc Proteinuria misc Renal outcome Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy
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topic_title	610 ASE 44.88 bkl Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy Obesity (dpeaa)DE-He213 Renal dysfunction (dpeaa)DE-He213 Proteinuria (dpeaa)DE-He213 Renal outcome (dpeaa)DE-He213
topic	ddc 610 bkl 44.88 misc Obesity misc Renal dysfunction misc Proteinuria misc Renal outcome
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title	Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy
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title_full	Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy
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author_browse	Tsuboi, Nobuo Koike, Kentaro Hirano, Keita Utsunomiya, Yasunori Kawamura, Tetsuya Hosoya, Tatsuo
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title_sort	clinical features and long-term renal outcomes of japanese patients with obesity-related glomerulopathy
title_auth	Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy
abstract	Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity.
abstractGer	Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity.
abstract_unstemmed	Background Studies have suggested that obesity-related glomerulopathy (ORG) is one of the important disease entities leading to end-stage renal disease. However, information is limited regarding the clinical features and renal outcomes of Japanese ORG patients. Methods Among the patients whose renal biopsy was performed at our institute during the past 10 years, we identified 28 ORG patients. Among them, the renal prognosis of the 20 patients with more than 2 years of follow-up was further analyzed. The clinical features at biopsy and the renal outcomes were compared with those of other ORG cohorts. Results The average values at diagnosis were a body mass index of 32.0 kg/$ m^{2} $, eGFR of 65 ml/min/1.73 $ m^{2} $, and urinary protein excretion of 1.7 g/day. These features were less serious than those of the US cohort or the Spanish cohort and were compatible with those of the Chinese cohort. At the last observation, seven patients (35 %) showed a 50 % increase in their serum creatinine, and two patients (10 %) had a 100 % increase in serum creatinine and/or end-stage renal disease (end point). A multivariate analysis identified the time-averaged proteinuria during follow-up as an independent factor that was associated with the slope of renal function. The annual rate of patients reaching the end point in the US cohort, the Spanish cohort and the current cohort were 6.7, 6.9 and 1.6 % per year, respectively. Conclusion The long-term outcomes of Japanese ORG patients include progression to renal failure, emphasizing the importance of an accurate early diagnosis of this entity.
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container_issue	3
title_short	Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy
url	https://dx.doi.org/10.1007/s10157-012-0719-y
remote_bool	true
author2	Koike, Kentaro Hirano, Keita Utsunomiya, Yasunori Kawamura, Tetsuya Hosoya, Tatsuo
author2Str	Koike, Kentaro Hirano, Keita Utsunomiya, Yasunori Kawamura, Tetsuya Hosoya, Tatsuo
ppnlink	306646900
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s10157-012-0719-y
up_date	2024-07-04T00:06:32.651Z
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Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy

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