Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study
Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study include...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Konta, Tsuneo [verfasserIn] Kudo, Kosuke [verfasserIn] Sato, Hiroko [verfasserIn] Ichikawa, Kazunobu [verfasserIn] Ikeda, Ami [verfasserIn] Suzuki, Kazuko [verfasserIn] Hirayama, Atsushi [verfasserIn] Shibata, Yoko [verfasserIn] Watanabe, Tetsu [verfasserIn] Daimon, Makoto [verfasserIn] Kato, Takeo [verfasserIn] Ueno, Yoshiyuki [verfasserIn] Kayama, Takamasa [verfasserIn] Kubota, Isao [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical and experimental nephrology - [Tokyo] : Springer, 1997, 17(2013), 6 vom: 24. Jan., Seite 805-810 |
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| Übergeordnetes Werk: |
volume:17 ; year:2013 ; number:6 ; day:24 ; month:01 ; pages:805-810 |
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| DOI / URN: |
10.1007/s10157-013-0770-3 |
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| Katalog-ID: |
SPR008970785 |
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| 245 | 1 | 0 | |a Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study |
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| 520 | |a Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. | ||
| 650 | 4 | |a Albuminuria |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mortality |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Population |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cohort |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kudo, Kosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Hiroko |e verfasserin |4 aut | |
| 700 | 1 | |a Ichikawa, Kazunobu |e verfasserin |4 aut | |
| 700 | 1 | |a Ikeda, Ami |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kazuko |e verfasserin |4 aut | |
| 700 | 1 | |a Hirayama, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Yoko |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Tetsu |e verfasserin |4 aut | |
| 700 | 1 | |a Daimon, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, Takeo |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kayama, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Kubota, Isao |e verfasserin |4 aut | |
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10.1007/s10157-013-0770-3 doi (DE-627)SPR008970785 (SPR)s10157-013-0770-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Konta, Tsuneo verfasserin aut Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. Albuminuria (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Population (dpeaa)DE-He213 Cohort (dpeaa)DE-He213 Kudo, Kosuke verfasserin aut Sato, Hiroko verfasserin aut Ichikawa, Kazunobu verfasserin aut Ikeda, Ami verfasserin aut Suzuki, Kazuko verfasserin aut Hirayama, Atsushi verfasserin aut Shibata, Yoko verfasserin aut Watanabe, Tetsu verfasserin aut Daimon, Makoto verfasserin aut Kato, Takeo verfasserin aut Ueno, Yoshiyuki verfasserin aut Kayama, Takamasa verfasserin aut Kubota, Isao verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2013), 6 vom: 24. Jan., Seite 805-810 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2013 number:6 day:24 month:01 pages:805-810 https://dx.doi.org/10.1007/s10157-013-0770-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2013 6 24 01 805-810 |
| spelling |
10.1007/s10157-013-0770-3 doi (DE-627)SPR008970785 (SPR)s10157-013-0770-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Konta, Tsuneo verfasserin aut Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. Albuminuria (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Population (dpeaa)DE-He213 Cohort (dpeaa)DE-He213 Kudo, Kosuke verfasserin aut Sato, Hiroko verfasserin aut Ichikawa, Kazunobu verfasserin aut Ikeda, Ami verfasserin aut Suzuki, Kazuko verfasserin aut Hirayama, Atsushi verfasserin aut Shibata, Yoko verfasserin aut Watanabe, Tetsu verfasserin aut Daimon, Makoto verfasserin aut Kato, Takeo verfasserin aut Ueno, Yoshiyuki verfasserin aut Kayama, Takamasa verfasserin aut Kubota, Isao verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2013), 6 vom: 24. Jan., Seite 805-810 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2013 number:6 day:24 month:01 pages:805-810 https://dx.doi.org/10.1007/s10157-013-0770-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2013 6 24 01 805-810 |
| allfields_unstemmed |
10.1007/s10157-013-0770-3 doi (DE-627)SPR008970785 (SPR)s10157-013-0770-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Konta, Tsuneo verfasserin aut Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. Albuminuria (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Population (dpeaa)DE-He213 Cohort (dpeaa)DE-He213 Kudo, Kosuke verfasserin aut Sato, Hiroko verfasserin aut Ichikawa, Kazunobu verfasserin aut Ikeda, Ami verfasserin aut Suzuki, Kazuko verfasserin aut Hirayama, Atsushi verfasserin aut Shibata, Yoko verfasserin aut Watanabe, Tetsu verfasserin aut Daimon, Makoto verfasserin aut Kato, Takeo verfasserin aut Ueno, Yoshiyuki verfasserin aut Kayama, Takamasa verfasserin aut Kubota, Isao verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2013), 6 vom: 24. Jan., Seite 805-810 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2013 number:6 day:24 month:01 pages:805-810 https://dx.doi.org/10.1007/s10157-013-0770-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2013 6 24 01 805-810 |
| allfieldsGer |
10.1007/s10157-013-0770-3 doi (DE-627)SPR008970785 (SPR)s10157-013-0770-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Konta, Tsuneo verfasserin aut Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. Albuminuria (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Population (dpeaa)DE-He213 Cohort (dpeaa)DE-He213 Kudo, Kosuke verfasserin aut Sato, Hiroko verfasserin aut Ichikawa, Kazunobu verfasserin aut Ikeda, Ami verfasserin aut Suzuki, Kazuko verfasserin aut Hirayama, Atsushi verfasserin aut Shibata, Yoko verfasserin aut Watanabe, Tetsu verfasserin aut Daimon, Makoto verfasserin aut Kato, Takeo verfasserin aut Ueno, Yoshiyuki verfasserin aut Kayama, Takamasa verfasserin aut Kubota, Isao verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2013), 6 vom: 24. Jan., Seite 805-810 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2013 number:6 day:24 month:01 pages:805-810 https://dx.doi.org/10.1007/s10157-013-0770-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2013 6 24 01 805-810 |
| allfieldsSound |
10.1007/s10157-013-0770-3 doi (DE-627)SPR008970785 (SPR)s10157-013-0770-3-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Konta, Tsuneo verfasserin aut Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. Albuminuria (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Population (dpeaa)DE-He213 Cohort (dpeaa)DE-He213 Kudo, Kosuke verfasserin aut Sato, Hiroko verfasserin aut Ichikawa, Kazunobu verfasserin aut Ikeda, Ami verfasserin aut Suzuki, Kazuko verfasserin aut Hirayama, Atsushi verfasserin aut Shibata, Yoko verfasserin aut Watanabe, Tetsu verfasserin aut Daimon, Makoto verfasserin aut Kato, Takeo verfasserin aut Ueno, Yoshiyuki verfasserin aut Kayama, Takamasa verfasserin aut Kubota, Isao verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 17(2013), 6 vom: 24. Jan., Seite 805-810 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:17 year:2013 number:6 day:24 month:01 pages:805-810 https://dx.doi.org/10.1007/s10157-013-0770-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 17 2013 6 24 01 805-810 |
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Enthalten in Clinical and experimental nephrology 17(2013), 6 vom: 24. Jan., Seite 805-810 volume:17 year:2013 number:6 day:24 month:01 pages:805-810 |
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Konta, Tsuneo @@aut@@ Kudo, Kosuke @@aut@@ Sato, Hiroko @@aut@@ Ichikawa, Kazunobu @@aut@@ Ikeda, Ami @@aut@@ Suzuki, Kazuko @@aut@@ Hirayama, Atsushi @@aut@@ Shibata, Yoko @@aut@@ Watanabe, Tetsu @@aut@@ Daimon, Makoto @@aut@@ Kato, Takeo @@aut@@ Ueno, Yoshiyuki @@aut@@ Kayama, Takamasa @@aut@@ Kubota, Isao @@aut@@ |
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Konta, Tsuneo |
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Konta, Tsuneo ddc 610 bkl 44.88 misc Albuminuria misc Mortality misc Population misc Cohort Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study |
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610 ASE 44.88 bkl Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study Albuminuria (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Population (dpeaa)DE-He213 Cohort (dpeaa)DE-He213 |
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ddc 610 bkl 44.88 misc Albuminuria misc Mortality misc Population misc Cohort |
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ddc 610 bkl 44.88 misc Albuminuria misc Mortality misc Population misc Cohort |
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ddc 610 bkl 44.88 misc Albuminuria misc Mortality misc Population misc Cohort |
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Clinical and experimental nephrology |
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Clinical and experimental nephrology |
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Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study |
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(DE-627)SPR008970785 (SPR)s10157-013-0770-3-e |
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Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study |
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Konta, Tsuneo |
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Clinical and experimental nephrology |
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Clinical and experimental nephrology |
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600 - Technology |
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2013 |
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Konta, Tsuneo Kudo, Kosuke Sato, Hiroko Ichikawa, Kazunobu Ikeda, Ami Suzuki, Kazuko Hirayama, Atsushi Shibata, Yoko Watanabe, Tetsu Daimon, Makoto Kato, Takeo Ueno, Yoshiyuki Kayama, Takamasa Kubota, Isao |
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Elektronische Aufsätze |
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Konta, Tsuneo |
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10.1007/s10157-013-0770-3 |
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610 |
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verfasserin |
| title_sort |
albuminuria is an independent predictor of all-cause and cardiovascular mortality in the japanese population: the takahata study |
| title_auth |
Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study |
| abstract |
Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. |
| abstractGer |
Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. |
| abstract_unstemmed |
Background Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful. |
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| title_short |
Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: the Takahata study |
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https://dx.doi.org/10.1007/s10157-013-0770-3 |
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Kudo, Kosuke Sato, Hiroko Ichikawa, Kazunobu Ikeda, Ami Suzuki, Kazuko Hirayama, Atsushi Shibata, Yoko Watanabe, Tetsu Daimon, Makoto Kato, Takeo Ueno, Yoshiyuki Kayama, Takamasa Kubota, Isao |
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Kudo, Kosuke Sato, Hiroko Ichikawa, Kazunobu Ikeda, Ami Suzuki, Kazuko Hirayama, Atsushi Shibata, Yoko Watanabe, Tetsu Daimon, Makoto Kato, Takeo Ueno, Yoshiyuki Kayama, Takamasa Kubota, Isao |
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10.1007/s10157-013-0770-3 |
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However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12–2.56 and HR 2.27, 95 % CI 1.10–4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. 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