Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial
Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tanaka, Kenichi [verfasserIn] Nakayama, Masaaki [verfasserIn] Kanno, Makoto [verfasserIn] Kimura, Hiroshi [verfasserIn] Watanabe, Kimio [verfasserIn] Tani, Yoshihiro [verfasserIn] Hayashi, Yoshimitsu [verfasserIn] Asahi, Koichi [verfasserIn] Terawaki, Hiroyuki [verfasserIn] Watanabe, Tsuyoshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical and experimental nephrology - [Tokyo] : Springer, 1997, 19(2015), 6 vom: 13. Feb., Seite 1044-1053 |
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| Übergeordnetes Werk: |
volume:19 ; year:2015 ; number:6 ; day:13 ; month:02 ; pages:1044-1053 |
| Links: |
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| DOI / URN: |
10.1007/s10157-015-1095-1 |
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| Katalog-ID: |
SPR008974152 |
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| 245 | 1 | 0 | |a Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
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| 520 | |a Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. | ||
| 650 | 4 | |a Chronic kidney disease (CKD) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Febuxostat |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hyperuricemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Urinary albumin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Urinary beta 2 microglobulin (β2MG) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Urinary liver-type fatty acid-binding protein (L-FABP) |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Nakayama, Masaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kanno, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Kimio |e verfasserin |4 aut | |
| 700 | 1 | |a Tani, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Yoshimitsu |e verfasserin |4 aut | |
| 700 | 1 | |a Asahi, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Terawaki, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Tsuyoshi |e verfasserin |4 aut | |
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10.1007/s10157-015-1095-1 doi (DE-627)SPR008974152 (SPR)s10157-015-1095-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tanaka, Kenichi verfasserin aut Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. Chronic kidney disease (CKD) (dpeaa)DE-He213 Febuxostat (dpeaa)DE-He213 Hyperuricemia (dpeaa)DE-He213 Urinary albumin (dpeaa)DE-He213 Urinary beta 2 microglobulin (β2MG) (dpeaa)DE-He213 Urinary liver-type fatty acid-binding protein (L-FABP) (dpeaa)DE-He213 Nakayama, Masaaki verfasserin aut Kanno, Makoto verfasserin aut Kimura, Hiroshi verfasserin aut Watanabe, Kimio verfasserin aut Tani, Yoshihiro verfasserin aut Hayashi, Yoshimitsu verfasserin aut Asahi, Koichi verfasserin aut Terawaki, Hiroyuki verfasserin aut Watanabe, Tsuyoshi verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 19(2015), 6 vom: 13. Feb., Seite 1044-1053 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:19 year:2015 number:6 day:13 month:02 pages:1044-1053 https://dx.doi.org/10.1007/s10157-015-1095-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 19 2015 6 13 02 1044-1053 |
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10.1007/s10157-015-1095-1 doi (DE-627)SPR008974152 (SPR)s10157-015-1095-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tanaka, Kenichi verfasserin aut Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. Chronic kidney disease (CKD) (dpeaa)DE-He213 Febuxostat (dpeaa)DE-He213 Hyperuricemia (dpeaa)DE-He213 Urinary albumin (dpeaa)DE-He213 Urinary beta 2 microglobulin (β2MG) (dpeaa)DE-He213 Urinary liver-type fatty acid-binding protein (L-FABP) (dpeaa)DE-He213 Nakayama, Masaaki verfasserin aut Kanno, Makoto verfasserin aut Kimura, Hiroshi verfasserin aut Watanabe, Kimio verfasserin aut Tani, Yoshihiro verfasserin aut Hayashi, Yoshimitsu verfasserin aut Asahi, Koichi verfasserin aut Terawaki, Hiroyuki verfasserin aut Watanabe, Tsuyoshi verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 19(2015), 6 vom: 13. Feb., Seite 1044-1053 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:19 year:2015 number:6 day:13 month:02 pages:1044-1053 https://dx.doi.org/10.1007/s10157-015-1095-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 19 2015 6 13 02 1044-1053 |
| allfields_unstemmed |
10.1007/s10157-015-1095-1 doi (DE-627)SPR008974152 (SPR)s10157-015-1095-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tanaka, Kenichi verfasserin aut Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. Chronic kidney disease (CKD) (dpeaa)DE-He213 Febuxostat (dpeaa)DE-He213 Hyperuricemia (dpeaa)DE-He213 Urinary albumin (dpeaa)DE-He213 Urinary beta 2 microglobulin (β2MG) (dpeaa)DE-He213 Urinary liver-type fatty acid-binding protein (L-FABP) (dpeaa)DE-He213 Nakayama, Masaaki verfasserin aut Kanno, Makoto verfasserin aut Kimura, Hiroshi verfasserin aut Watanabe, Kimio verfasserin aut Tani, Yoshihiro verfasserin aut Hayashi, Yoshimitsu verfasserin aut Asahi, Koichi verfasserin aut Terawaki, Hiroyuki verfasserin aut Watanabe, Tsuyoshi verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 19(2015), 6 vom: 13. Feb., Seite 1044-1053 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:19 year:2015 number:6 day:13 month:02 pages:1044-1053 https://dx.doi.org/10.1007/s10157-015-1095-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 19 2015 6 13 02 1044-1053 |
| allfieldsGer |
10.1007/s10157-015-1095-1 doi (DE-627)SPR008974152 (SPR)s10157-015-1095-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tanaka, Kenichi verfasserin aut Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. Chronic kidney disease (CKD) (dpeaa)DE-He213 Febuxostat (dpeaa)DE-He213 Hyperuricemia (dpeaa)DE-He213 Urinary albumin (dpeaa)DE-He213 Urinary beta 2 microglobulin (β2MG) (dpeaa)DE-He213 Urinary liver-type fatty acid-binding protein (L-FABP) (dpeaa)DE-He213 Nakayama, Masaaki verfasserin aut Kanno, Makoto verfasserin aut Kimura, Hiroshi verfasserin aut Watanabe, Kimio verfasserin aut Tani, Yoshihiro verfasserin aut Hayashi, Yoshimitsu verfasserin aut Asahi, Koichi verfasserin aut Terawaki, Hiroyuki verfasserin aut Watanabe, Tsuyoshi verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 19(2015), 6 vom: 13. Feb., Seite 1044-1053 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:19 year:2015 number:6 day:13 month:02 pages:1044-1053 https://dx.doi.org/10.1007/s10157-015-1095-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 19 2015 6 13 02 1044-1053 |
| allfieldsSound |
10.1007/s10157-015-1095-1 doi (DE-627)SPR008974152 (SPR)s10157-015-1095-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Tanaka, Kenichi verfasserin aut Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. Chronic kidney disease (CKD) (dpeaa)DE-He213 Febuxostat (dpeaa)DE-He213 Hyperuricemia (dpeaa)DE-He213 Urinary albumin (dpeaa)DE-He213 Urinary beta 2 microglobulin (β2MG) (dpeaa)DE-He213 Urinary liver-type fatty acid-binding protein (L-FABP) (dpeaa)DE-He213 Nakayama, Masaaki verfasserin aut Kanno, Makoto verfasserin aut Kimura, Hiroshi verfasserin aut Watanabe, Kimio verfasserin aut Tani, Yoshihiro verfasserin aut Hayashi, Yoshimitsu verfasserin aut Asahi, Koichi verfasserin aut Terawaki, Hiroyuki verfasserin aut Watanabe, Tsuyoshi verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 19(2015), 6 vom: 13. Feb., Seite 1044-1053 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:19 year:2015 number:6 day:13 month:02 pages:1044-1053 https://dx.doi.org/10.1007/s10157-015-1095-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 19 2015 6 13 02 1044-1053 |
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Enthalten in Clinical and experimental nephrology 19(2015), 6 vom: 13. Feb., Seite 1044-1053 volume:19 year:2015 number:6 day:13 month:02 pages:1044-1053 |
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Chronic kidney disease (CKD) Febuxostat Hyperuricemia Urinary albumin Urinary beta 2 microglobulin (β2MG) Urinary liver-type fatty acid-binding protein (L-FABP) |
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Tanaka, Kenichi @@aut@@ Nakayama, Masaaki @@aut@@ Kanno, Makoto @@aut@@ Kimura, Hiroshi @@aut@@ Watanabe, Kimio @@aut@@ Tani, Yoshihiro @@aut@@ Hayashi, Yoshimitsu @@aut@@ Asahi, Koichi @@aut@@ Terawaki, Hiroyuki @@aut@@ Watanabe, Tsuyoshi @@aut@@ |
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| author |
Tanaka, Kenichi |
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Tanaka, Kenichi ddc 610 bkl 44.88 misc Chronic kidney disease (CKD) misc Febuxostat misc Hyperuricemia misc Urinary albumin misc Urinary beta 2 microglobulin (β2MG) misc Urinary liver-type fatty acid-binding protein (L-FABP) Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
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1437-7799 |
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610 ASE 44.88 bkl Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial Chronic kidney disease (CKD) (dpeaa)DE-He213 Febuxostat (dpeaa)DE-He213 Hyperuricemia (dpeaa)DE-He213 Urinary albumin (dpeaa)DE-He213 Urinary beta 2 microglobulin (β2MG) (dpeaa)DE-He213 Urinary liver-type fatty acid-binding protein (L-FABP) (dpeaa)DE-He213 |
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ddc 610 bkl 44.88 misc Chronic kidney disease (CKD) misc Febuxostat misc Hyperuricemia misc Urinary albumin misc Urinary beta 2 microglobulin (β2MG) misc Urinary liver-type fatty acid-binding protein (L-FABP) |
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ddc 610 bkl 44.88 misc Chronic kidney disease (CKD) misc Febuxostat misc Hyperuricemia misc Urinary albumin misc Urinary beta 2 microglobulin (β2MG) misc Urinary liver-type fatty acid-binding protein (L-FABP) |
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ddc 610 bkl 44.88 misc Chronic kidney disease (CKD) misc Febuxostat misc Hyperuricemia misc Urinary albumin misc Urinary beta 2 microglobulin (β2MG) misc Urinary liver-type fatty acid-binding protein (L-FABP) |
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Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
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(DE-627)SPR008974152 (SPR)s10157-015-1095-1-e |
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Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
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Tanaka, Kenichi |
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Clinical and experimental nephrology |
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Tanaka, Kenichi Nakayama, Masaaki Kanno, Makoto Kimura, Hiroshi Watanabe, Kimio Tani, Yoshihiro Hayashi, Yoshimitsu Asahi, Koichi Terawaki, Hiroyuki Watanabe, Tsuyoshi |
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Tanaka, Kenichi |
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10.1007/s10157-015-1095-1 |
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renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
| title_auth |
Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
| abstract |
Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. |
| abstractGer |
Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. |
| abstract_unstemmed |
Background Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. Methods A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD. Patients were randomly assigned to treatment with febuxostat (n = 21) or to continue conventional therapy (n = 19). Treatment was continued for 12 weeks. The efficacy of febuxostat was determined by monitoring serum uric acid (UA) levels, blood pressures, renal function, and urinary protein levels. In addition, urinary liver-type fatty acid-binding protein (L-FABP), urinary albumin, urinary beta 2 microglobulin (β2MG), and serum high sensitivity C-reactive protein were measured before and 12 weeks after febuxostat was added to the treatment. Results Febuxostat resulted in a significantly greater reduction in serum UA (−2.2 mg/dL) than conventional therapy (−0.3 mg/dL, P < 0.001). Serum creatinine and estimated glomerular filtration rate changed little during the study period in each group. However, treatment with febuxostat for 12 weeks reduced the urinary levels of L-FABP, albumin, and β2MG, whereas the levels of these markers did not change in the control group. Conclusion Febuxostat reduced serum UA levels more effectively than conventional therapy and might have a renoprotective effect in hyperuricemic patients with CKD. Further studies should clarify whether febuxostat prevents the progression of renal disease and improves the prognosis of CKD. |
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Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial |
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https://dx.doi.org/10.1007/s10157-015-1095-1 |
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Nakayama, Masaaki Kanno, Makoto Kimura, Hiroshi Watanabe, Kimio Tani, Yoshihiro Hayashi, Yoshimitsu Asahi, Koichi Terawaki, Hiroyuki Watanabe, Tsuyoshi |
| author2Str |
Nakayama, Masaaki Kanno, Makoto Kimura, Hiroshi Watanabe, Kimio Tani, Yoshihiro Hayashi, Yoshimitsu Asahi, Koichi Terawaki, Hiroyuki Watanabe, Tsuyoshi |
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10.1007/s10157-015-1095-1 |
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2024-07-04T00:07:48.682Z |
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| score |
7.3997936 |