Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals
Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kosaki, Keisei [verfasserIn] Kamijo-Ikemori, Atsuko [verfasserIn] Sugaya, Takeshi [verfasserIn] Tanahashi, Koichiro [verfasserIn] Kumagai, Hiroshi [verfasserIn] Sawano, Yuriko [verfasserIn] Akazawa, Nobuhiko [verfasserIn] Ra, Song-Gyu [verfasserIn] Kimura, Kenjiro [verfasserIn] Shibagaki, Yugo [verfasserIn] Maeda, Seiji [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical and experimental nephrology - [Tokyo] : Springer, 1997, 21(2017), 5 vom: 14. Feb., Seite 810-817 |
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| Übergeordnetes Werk: |
volume:21 ; year:2017 ; number:5 ; day:14 ; month:02 ; pages:810-817 |
| Links: |
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| DOI / URN: |
10.1007/s10157-017-1385-x |
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| Katalog-ID: |
SPR008977135 |
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| 245 | 1 | 0 | |a Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
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| 520 | |a Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. | ||
| 650 | 4 | |a Aerobic fitness |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Muscular strength |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Peritubular capillary blood flow |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kamijo-Ikemori, Atsuko |e verfasserin |4 aut | |
| 700 | 1 | |a Sugaya, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tanahashi, Koichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kumagai, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Sawano, Yuriko |e verfasserin |4 aut | |
| 700 | 1 | |a Akazawa, Nobuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ra, Song-Gyu |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Kenjiro |e verfasserin |4 aut | |
| 700 | 1 | |a Shibagaki, Yugo |e verfasserin |4 aut | |
| 700 | 1 | |a Maeda, Seiji |e verfasserin |4 aut | |
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10.1007/s10157-017-1385-x doi (DE-627)SPR008977135 (SPR)s10157-017-1385-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Kosaki, Keisei verfasserin aut Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. Aerobic fitness (dpeaa)DE-He213 Muscular strength (dpeaa)DE-He213 Peritubular capillary blood flow (dpeaa)DE-He213 Kamijo-Ikemori, Atsuko verfasserin aut Sugaya, Takeshi verfasserin aut Tanahashi, Koichiro verfasserin aut Kumagai, Hiroshi verfasserin aut Sawano, Yuriko verfasserin aut Akazawa, Nobuhiko verfasserin aut Ra, Song-Gyu verfasserin aut Kimura, Kenjiro verfasserin aut Shibagaki, Yugo verfasserin aut Maeda, Seiji verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 21(2017), 5 vom: 14. Feb., Seite 810-817 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:21 year:2017 number:5 day:14 month:02 pages:810-817 https://dx.doi.org/10.1007/s10157-017-1385-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 21 2017 5 14 02 810-817 |
| spelling |
10.1007/s10157-017-1385-x doi (DE-627)SPR008977135 (SPR)s10157-017-1385-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Kosaki, Keisei verfasserin aut Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. Aerobic fitness (dpeaa)DE-He213 Muscular strength (dpeaa)DE-He213 Peritubular capillary blood flow (dpeaa)DE-He213 Kamijo-Ikemori, Atsuko verfasserin aut Sugaya, Takeshi verfasserin aut Tanahashi, Koichiro verfasserin aut Kumagai, Hiroshi verfasserin aut Sawano, Yuriko verfasserin aut Akazawa, Nobuhiko verfasserin aut Ra, Song-Gyu verfasserin aut Kimura, Kenjiro verfasserin aut Shibagaki, Yugo verfasserin aut Maeda, Seiji verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 21(2017), 5 vom: 14. Feb., Seite 810-817 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:21 year:2017 number:5 day:14 month:02 pages:810-817 https://dx.doi.org/10.1007/s10157-017-1385-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 21 2017 5 14 02 810-817 |
| allfields_unstemmed |
10.1007/s10157-017-1385-x doi (DE-627)SPR008977135 (SPR)s10157-017-1385-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Kosaki, Keisei verfasserin aut Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. Aerobic fitness (dpeaa)DE-He213 Muscular strength (dpeaa)DE-He213 Peritubular capillary blood flow (dpeaa)DE-He213 Kamijo-Ikemori, Atsuko verfasserin aut Sugaya, Takeshi verfasserin aut Tanahashi, Koichiro verfasserin aut Kumagai, Hiroshi verfasserin aut Sawano, Yuriko verfasserin aut Akazawa, Nobuhiko verfasserin aut Ra, Song-Gyu verfasserin aut Kimura, Kenjiro verfasserin aut Shibagaki, Yugo verfasserin aut Maeda, Seiji verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 21(2017), 5 vom: 14. Feb., Seite 810-817 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:21 year:2017 number:5 day:14 month:02 pages:810-817 https://dx.doi.org/10.1007/s10157-017-1385-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 21 2017 5 14 02 810-817 |
| allfieldsGer |
10.1007/s10157-017-1385-x doi (DE-627)SPR008977135 (SPR)s10157-017-1385-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Kosaki, Keisei verfasserin aut Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. Aerobic fitness (dpeaa)DE-He213 Muscular strength (dpeaa)DE-He213 Peritubular capillary blood flow (dpeaa)DE-He213 Kamijo-Ikemori, Atsuko verfasserin aut Sugaya, Takeshi verfasserin aut Tanahashi, Koichiro verfasserin aut Kumagai, Hiroshi verfasserin aut Sawano, Yuriko verfasserin aut Akazawa, Nobuhiko verfasserin aut Ra, Song-Gyu verfasserin aut Kimura, Kenjiro verfasserin aut Shibagaki, Yugo verfasserin aut Maeda, Seiji verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 21(2017), 5 vom: 14. Feb., Seite 810-817 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:21 year:2017 number:5 day:14 month:02 pages:810-817 https://dx.doi.org/10.1007/s10157-017-1385-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 21 2017 5 14 02 810-817 |
| allfieldsSound |
10.1007/s10157-017-1385-x doi (DE-627)SPR008977135 (SPR)s10157-017-1385-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.88 bkl Kosaki, Keisei verfasserin aut Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. Aerobic fitness (dpeaa)DE-He213 Muscular strength (dpeaa)DE-He213 Peritubular capillary blood flow (dpeaa)DE-He213 Kamijo-Ikemori, Atsuko verfasserin aut Sugaya, Takeshi verfasserin aut Tanahashi, Koichiro verfasserin aut Kumagai, Hiroshi verfasserin aut Sawano, Yuriko verfasserin aut Akazawa, Nobuhiko verfasserin aut Ra, Song-Gyu verfasserin aut Kimura, Kenjiro verfasserin aut Shibagaki, Yugo verfasserin aut Maeda, Seiji verfasserin aut Enthalten in Clinical and experimental nephrology [Tokyo] : Springer, 1997 21(2017), 5 vom: 14. Feb., Seite 810-817 (DE-627)306646900 (DE-600)1499111-1 1437-7799 nnns volume:21 year:2017 number:5 day:14 month:02 pages:810-817 https://dx.doi.org/10.1007/s10157-017-1385-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 21 2017 5 14 02 810-817 |
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Enthalten in Clinical and experimental nephrology 21(2017), 5 vom: 14. Feb., Seite 810-817 volume:21 year:2017 number:5 day:14 month:02 pages:810-817 |
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Enthalten in Clinical and experimental nephrology 21(2017), 5 vom: 14. Feb., Seite 810-817 volume:21 year:2017 number:5 day:14 month:02 pages:810-817 |
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Aerobic fitness Muscular strength Peritubular capillary blood flow |
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Kosaki, Keisei @@aut@@ Kamijo-Ikemori, Atsuko @@aut@@ Sugaya, Takeshi @@aut@@ Tanahashi, Koichiro @@aut@@ Kumagai, Hiroshi @@aut@@ Sawano, Yuriko @@aut@@ Akazawa, Nobuhiko @@aut@@ Ra, Song-Gyu @@aut@@ Kimura, Kenjiro @@aut@@ Shibagaki, Yugo @@aut@@ Maeda, Seiji @@aut@@ |
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2017-02-14T00:00:00Z |
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Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. 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Kosaki, Keisei |
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Kosaki, Keisei ddc 610 bkl 44.88 misc Aerobic fitness misc Muscular strength misc Peritubular capillary blood flow Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
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610 ASE 44.88 bkl Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals Aerobic fitness (dpeaa)DE-He213 Muscular strength (dpeaa)DE-He213 Peritubular capillary blood flow (dpeaa)DE-He213 |
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ddc 610 bkl 44.88 misc Aerobic fitness misc Muscular strength misc Peritubular capillary blood flow |
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Clinical and experimental nephrology |
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Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
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(DE-627)SPR008977135 (SPR)s10157-017-1385-x-e |
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Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
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Kosaki, Keisei |
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Clinical and experimental nephrology |
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Kosaki, Keisei Kamijo-Ikemori, Atsuko Sugaya, Takeshi Tanahashi, Koichiro Kumagai, Hiroshi Sawano, Yuriko Akazawa, Nobuhiko Ra, Song-Gyu Kimura, Kenjiro Shibagaki, Yugo Maeda, Seiji |
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10.1007/s10157-017-1385-x |
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relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
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Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
| abstract |
Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. |
| abstractGer |
Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. |
| abstract_unstemmed |
Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction. |
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Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals |
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Kamijo-Ikemori, Atsuko Sugaya, Takeshi Tanahashi, Koichiro Kumagai, Hiroshi Sawano, Yuriko Akazawa, Nobuhiko Ra, Song-Gyu Kimura, Kenjiro Shibagaki, Yugo Maeda, Seiji |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR008977135</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519110737.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10157-017-1385-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR008977135</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10157-017-1385-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.88</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kosaki, Keisei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Methods This was a cross-sectional study of 187 middle-aged and older individuals (aged 50–83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$), and grip strength. Results Urinary L-FABP levels inversely correlated with both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ (rs = −0.349) and grip strength (rs = −0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength (%$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 ± 1.43 μg/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 ± 0.76 μg/g creatinine). The difference between the two groups was significant (P < 0.001). Conclusion Our results demonstrate that both %$\dot{\text{V}}{{\text{O}}_{\text{2peak}}}%$ and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. 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