Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack

Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocula...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nanke, Yuki [verfasserIn] Kotake, Shigeru [verfasserIn] Goto, Mari [verfasserIn] Ujihara, Hiroshi [verfasserIn] Matsubara, Masao [verfasserIn] Kamatani, Naoyuki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Ocular attack Behcet’s disease Regulatory T

Übergeordnetes Werk:	Enthalten in: Modern rheumatology - Oxford : Oxford University Press, 2000, 18(2008), 4 vom: 22. Apr., Seite 354-358
Übergeordnetes Werk:	volume:18 ; year:2008 ; number:4 ; day:22 ; month:04 ; pages:354-358

Links:	Volltext

DOI / URN:	10.1007/s10165-008-0064-x

Katalog-ID:	SPR009020721

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520			\|a Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack.
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allfields	10.1007/s10165-008-0064-x doi (DE-627)SPR009020721 (SPR)s10165-008-0064-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.83 bkl Nanke, Yuki verfasserin aut Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack. Ocular attack (dpeaa)DE-He213 Behcet’s disease (dpeaa)DE-He213 Regulatory T (dpeaa)DE-He213 Kotake, Shigeru verfasserin aut Goto, Mari verfasserin aut Ujihara, Hiroshi verfasserin aut Matsubara, Masao verfasserin aut Kamatani, Naoyuki verfasserin aut Enthalten in Modern rheumatology Oxford : Oxford University Press, 2000 18(2008), 4 vom: 22. Apr., Seite 354-358 (DE-627)320627497 (DE-600)2023498-3 1439-7609 nnns volume:18 year:2008 number:4 day:22 month:04 pages:354-358 https://dx.doi.org/10.1007/s10165-008-0064-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_40 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_151 GBV_ILN_170 GBV_ILN_224 GBV_ILN_267 GBV_ILN_285 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2026 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4328 GBV_ILN_4333 44.83 ASE AR 18 2008 4 22 04 354-358
spelling	10.1007/s10165-008-0064-x doi (DE-627)SPR009020721 (SPR)s10165-008-0064-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.83 bkl Nanke, Yuki verfasserin aut Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack. Ocular attack (dpeaa)DE-He213 Behcet’s disease (dpeaa)DE-He213 Regulatory T (dpeaa)DE-He213 Kotake, Shigeru verfasserin aut Goto, Mari verfasserin aut Ujihara, Hiroshi verfasserin aut Matsubara, Masao verfasserin aut Kamatani, Naoyuki verfasserin aut Enthalten in Modern rheumatology Oxford : Oxford University Press, 2000 18(2008), 4 vom: 22. Apr., Seite 354-358 (DE-627)320627497 (DE-600)2023498-3 1439-7609 nnns volume:18 year:2008 number:4 day:22 month:04 pages:354-358 https://dx.doi.org/10.1007/s10165-008-0064-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_40 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_151 GBV_ILN_170 GBV_ILN_224 GBV_ILN_267 GBV_ILN_285 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2026 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4328 GBV_ILN_4333 44.83 ASE AR 18 2008 4 22 04 354-358
allfields_unstemmed	10.1007/s10165-008-0064-x doi (DE-627)SPR009020721 (SPR)s10165-008-0064-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.83 bkl Nanke, Yuki verfasserin aut Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack. Ocular attack (dpeaa)DE-He213 Behcet’s disease (dpeaa)DE-He213 Regulatory T (dpeaa)DE-He213 Kotake, Shigeru verfasserin aut Goto, Mari verfasserin aut Ujihara, Hiroshi verfasserin aut Matsubara, Masao verfasserin aut Kamatani, Naoyuki verfasserin aut Enthalten in Modern rheumatology Oxford : Oxford University Press, 2000 18(2008), 4 vom: 22. Apr., Seite 354-358 (DE-627)320627497 (DE-600)2023498-3 1439-7609 nnns volume:18 year:2008 number:4 day:22 month:04 pages:354-358 https://dx.doi.org/10.1007/s10165-008-0064-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_40 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_151 GBV_ILN_170 GBV_ILN_224 GBV_ILN_267 GBV_ILN_285 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2026 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4328 GBV_ILN_4333 44.83 ASE AR 18 2008 4 22 04 354-358
allfieldsGer	10.1007/s10165-008-0064-x doi (DE-627)SPR009020721 (SPR)s10165-008-0064-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.83 bkl Nanke, Yuki verfasserin aut Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack. Ocular attack (dpeaa)DE-He213 Behcet’s disease (dpeaa)DE-He213 Regulatory T (dpeaa)DE-He213 Kotake, Shigeru verfasserin aut Goto, Mari verfasserin aut Ujihara, Hiroshi verfasserin aut Matsubara, Masao verfasserin aut Kamatani, Naoyuki verfasserin aut Enthalten in Modern rheumatology Oxford : Oxford University Press, 2000 18(2008), 4 vom: 22. Apr., Seite 354-358 (DE-627)320627497 (DE-600)2023498-3 1439-7609 nnns volume:18 year:2008 number:4 day:22 month:04 pages:354-358 https://dx.doi.org/10.1007/s10165-008-0064-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_40 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_151 GBV_ILN_170 GBV_ILN_224 GBV_ILN_267 GBV_ILN_285 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2026 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4328 GBV_ILN_4333 44.83 ASE AR 18 2008 4 22 04 354-358
allfieldsSound	10.1007/s10165-008-0064-x doi (DE-627)SPR009020721 (SPR)s10165-008-0064-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.83 bkl Nanke, Yuki verfasserin aut Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack. Ocular attack (dpeaa)DE-He213 Behcet’s disease (dpeaa)DE-He213 Regulatory T (dpeaa)DE-He213 Kotake, Shigeru verfasserin aut Goto, Mari verfasserin aut Ujihara, Hiroshi verfasserin aut Matsubara, Masao verfasserin aut Kamatani, Naoyuki verfasserin aut Enthalten in Modern rheumatology Oxford : Oxford University Press, 2000 18(2008), 4 vom: 22. Apr., Seite 354-358 (DE-627)320627497 (DE-600)2023498-3 1439-7609 nnns volume:18 year:2008 number:4 day:22 month:04 pages:354-358 https://dx.doi.org/10.1007/s10165-008-0064-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_40 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_151 GBV_ILN_170 GBV_ILN_224 GBV_ILN_267 GBV_ILN_285 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2026 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4328 GBV_ILN_4333 44.83 ASE AR 18 2008 4 22 04 354-358
language	English
source	Enthalten in Modern rheumatology 18(2008), 4 vom: 22. Apr., Seite 354-358 volume:18 year:2008 number:4 day:22 month:04 pages:354-358
sourceStr	Enthalten in Modern rheumatology 18(2008), 4 vom: 22. Apr., Seite 354-358 volume:18 year:2008 number:4 day:22 month:04 pages:354-358
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topic_facet	Ocular attack Behcet’s disease Regulatory T
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container_title	Modern rheumatology
authorswithroles_txt_mv	Nanke, Yuki @@aut@@ Kotake, Shigeru @@aut@@ Goto, Mari @@aut@@ Ujihara, Hiroshi @@aut@@ Matsubara, Masao @@aut@@ Kamatani, Naoyuki @@aut@@
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author	Nanke, Yuki
spellingShingle	Nanke, Yuki ddc 610 bkl 44.83 misc Ocular attack misc Behcet’s disease misc Regulatory T Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack
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topic_title	610 ASE 44.83 bkl Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack Ocular attack (dpeaa)DE-He213 Behcet’s disease (dpeaa)DE-He213 Regulatory T (dpeaa)DE-He213
topic	ddc 610 bkl 44.83 misc Ocular attack misc Behcet’s disease misc Regulatory T
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title	Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack
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title_full	Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack
author_sort	Nanke, Yuki
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author_browse	Nanke, Yuki Kotake, Shigeru Goto, Mari Ujihara, Hiroshi Matsubara, Masao Kamatani, Naoyuki
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title_sort	decreased percentages of regulatory t cells in peripheral blood of patients with behcet’s disease before ocular attack: a possible predictive marker of ocular attack
title_auth	Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack
abstract	Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack.
abstractGer	Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack.
abstract_unstemmed	Abstract The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet’s disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack.
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container_issue	4
title_short	Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack
url	https://dx.doi.org/10.1007/s10165-008-0064-x
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author2	Kotake, Shigeru Goto, Mari Ujihara, Hiroshi Matsubara, Masao Kamatani, Naoyuki
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up_date	2024-07-04T00:21:02.665Z
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Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were studied. Four BD patients without ocular complications (BDwo) were also evaluated as controls. All patients were prospectively followed by our outpatient clinic between autumn 2004 and spring 2005. CD4+ CD25+bright T cells (Treg cells) from peripheral blood were measured by flow cytometry. The percentages of Treg cells in CD4+ T cells from BDo were significantly decreased before ocular attack compared with those after ocular attack. Moreover, surprisingly, these levels before attack were significantly lower than normal level, whereas the percentages of Treg cells in both BDi and BDwo patients were normal. Treg cells were significantly decreased in BDa before active ocular attack. These findings suggest that Treg cells play an important role in ocular attack in BD patients. 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Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack

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