Low urinary 6-sulphatoxymelatonin concentrations in acute migraine

Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A...
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Autor*in:	Masruha, Marcelo Rodrigues [verfasserIn] de Souza Vieira, Domingos Sávio [verfasserIn] Minett, Thais Soares Cianciarullo [verfasserIn] Cipolla-Neto, José [verfasserIn] Zukerman, Eliova [verfasserIn] Vilanova, Luiz Celso Pereira [verfasserIn] Peres, Mario Fernando Prieto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Circadian rhythm Pathophysiology Melatonin Migraine Headache

Übergeordnetes Werk:	Enthalten in: The journal of headache and pain - Milano : Springer Italia, 2000, 9(2008), 4 vom: 02. Juli, Seite 221-224
Übergeordnetes Werk:	volume:9 ; year:2008 ; number:4 ; day:02 ; month:07 ; pages:221-224

Links:	Volltext

DOI / URN:	10.1007/s10194-008-0047-5

Katalog-ID:	SPR00907502X

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allfieldsGer	10.1007/s10194-008-0047-5 doi (DE-627)SPR00907502X (SPR)s10194-008-0047-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Masruha, Marcelo Rodrigues verfasserin aut Low urinary 6-sulphatoxymelatonin concentrations in acute migraine 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated—146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 ± 7.3 vs. 49.4 ± 19.0; t(143) = −15.1; 95% CI = −40.0 to −30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 ± 19.0 vs. 42.5 ± 27.9; t(140) = 1.7; 95% CI = −1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine. Circadian rhythm (dpeaa)DE-He213 Pathophysiology (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Migraine (dpeaa)DE-He213 Headache (dpeaa)DE-He213 de Souza Vieira, Domingos Sávio verfasserin aut Minett, Thais Soares Cianciarullo verfasserin aut Cipolla-Neto, José verfasserin aut Zukerman, Eliova verfasserin aut Vilanova, Luiz Celso Pereira verfasserin aut Peres, Mario Fernando Prieto verfasserin aut Enthalten in The journal of headache and pain Milano : Springer Italia, 2000 9(2008), 4 vom: 02. Juli, Seite 221-224 (DE-627)320600963 (DE-600)2020168-0 1129-2377 nnns volume:9 year:2008 number:4 day:02 month:07 pages:221-224 https://dx.doi.org/10.1007/s10194-008-0047-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 ASE AR 9 2008 4 02 07 221-224
allfieldsSound	10.1007/s10194-008-0047-5 doi (DE-627)SPR00907502X (SPR)s10194-008-0047-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Masruha, Marcelo Rodrigues verfasserin aut Low urinary 6-sulphatoxymelatonin concentrations in acute migraine 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated—146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 ± 7.3 vs. 49.4 ± 19.0; t(143) = −15.1; 95% CI = −40.0 to −30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 ± 19.0 vs. 42.5 ± 27.9; t(140) = 1.7; 95% CI = −1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine. Circadian rhythm (dpeaa)DE-He213 Pathophysiology (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Migraine (dpeaa)DE-He213 Headache (dpeaa)DE-He213 de Souza Vieira, Domingos Sávio verfasserin aut Minett, Thais Soares Cianciarullo verfasserin aut Cipolla-Neto, José verfasserin aut Zukerman, Eliova verfasserin aut Vilanova, Luiz Celso Pereira verfasserin aut Peres, Mario Fernando Prieto verfasserin aut Enthalten in The journal of headache and pain Milano : Springer Italia, 2000 9(2008), 4 vom: 02. Juli, Seite 221-224 (DE-627)320600963 (DE-600)2020168-0 1129-2377 nnns volume:9 year:2008 number:4 day:02 month:07 pages:221-224 https://dx.doi.org/10.1007/s10194-008-0047-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 ASE AR 9 2008 4 02 07 221-224
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author	Masruha, Marcelo Rodrigues
spellingShingle	Masruha, Marcelo Rodrigues ddc 610 bkl 44.90 misc Circadian rhythm misc Pathophysiology misc Melatonin misc Migraine misc Headache Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
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topic_title	610 ASE 44.90 bkl Low urinary 6-sulphatoxymelatonin concentrations in acute migraine Circadian rhythm (dpeaa)DE-He213 Pathophysiology (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Migraine (dpeaa)DE-He213 Headache (dpeaa)DE-He213
topic	ddc 610 bkl 44.90 misc Circadian rhythm misc Pathophysiology misc Melatonin misc Migraine misc Headache
topic_unstemmed	ddc 610 bkl 44.90 misc Circadian rhythm misc Pathophysiology misc Melatonin misc Migraine misc Headache
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title	Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
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title_full	Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
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title_sort	low urinary 6-sulphatoxymelatonin concentrations in acute migraine
title_auth	Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
abstract	Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated—146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 ± 7.3 vs. 49.4 ± 19.0; t(143) = −15.1; 95% CI = −40.0 to −30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 ± 19.0 vs. 42.5 ± 27.9; t(140) = 1.7; 95% CI = −1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
abstractGer	Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated—146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 ± 7.3 vs. 49.4 ± 19.0; t(143) = −15.1; 95% CI = −40.0 to −30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 ± 19.0 vs. 42.5 ± 27.9; t(140) = 1.7; 95% CI = −1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
abstract_unstemmed	Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated—146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 ± 7.3 vs. 49.4 ± 19.0; t(143) = −15.1; 95% CI = −40.0 to −30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 ± 19.0 vs. 42.5 ± 27.9; t(140) = 1.7; 95% CI = −1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
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title_short	Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
url	https://dx.doi.org/10.1007/s10194-008-0047-5
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author2	de Souza Vieira, Domingos Sávio Minett, Thais Soares Cianciarullo Cipolla-Neto, José Zukerman, Eliova Vilanova, Luiz Celso Pereira Peres, Mario Fernando Prieto
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up_date	2024-07-04T00:33:47.177Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR00907502X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519194404.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2008 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10194-008-0047-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR00907502X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10194-008-0047-5-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Masruha, Marcelo Rodrigues</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Low urinary 6-sulphatoxymelatonin concentrations in acute migraine</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated—146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 ± 7.3 vs. 49.4 ± 19.0; t(143) = −15.1; 95% CI = −40.0 to −30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 ± 19.0 vs. 42.5 ± 27.9; t(140) = 1.7; 95% CI = −1.2 to 14.8; P = 0.094]. 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Low urinary 6-sulphatoxymelatonin concentrations in acute migraine

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