Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton

Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to s...
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Autor*in:	Campanacci, Domenico Andrea [verfasserIn] Scoccianti, Guido [verfasserIn] Franchi, Alessandro [verfasserIn] Roselli, Giuliana [verfasserIn] Beltrami, Giovanni [verfasserIn] Ippolito, Massimiliano [verfasserIn] Caff, Giuseppe [verfasserIn] Frenos, Filippo [verfasserIn] Capanna, Rodolfo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Chondrosarcoma Bone sarcoma Bone tumors Orthopedic oncology

Übergeordnetes Werk:	Enthalten in: Journal of orthopaedics and traumatology - Milano : Springer, 2000, 14(2013), 2 vom: 06. März, Seite 101-107
Übergeordnetes Werk:	volume:14 ; year:2013 ; number:2 ; day:06 ; month:03 ; pages:101-107

Links:	Volltext

DOI / URN:	10.1007/s10195-013-0230-6

Katalog-ID:	SPR009101217

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520			\|a Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging.
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allfields	10.1007/s10195-013-0230-6 doi (DE-627)SPR009101217 (SPR)s10195-013-0230-6-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Campanacci, Domenico Andrea verfasserin aut Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging. Chondrosarcoma (dpeaa)DE-He213 Bone sarcoma (dpeaa)DE-He213 Bone tumors (dpeaa)DE-He213 Orthopedic oncology (dpeaa)DE-He213 Scoccianti, Guido verfasserin aut Franchi, Alessandro verfasserin aut Roselli, Giuliana verfasserin aut Beltrami, Giovanni verfasserin aut Ippolito, Massimiliano verfasserin aut Caff, Giuseppe verfasserin aut Frenos, Filippo verfasserin aut Capanna, Rodolfo verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 14(2013), 2 vom: 06. März, Seite 101-107 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:14 year:2013 number:2 day:06 month:03 pages:101-107 https://dx.doi.org/10.1007/s10195-013-0230-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 14 2013 2 06 03 101-107
spelling	10.1007/s10195-013-0230-6 doi (DE-627)SPR009101217 (SPR)s10195-013-0230-6-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Campanacci, Domenico Andrea verfasserin aut Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging. Chondrosarcoma (dpeaa)DE-He213 Bone sarcoma (dpeaa)DE-He213 Bone tumors (dpeaa)DE-He213 Orthopedic oncology (dpeaa)DE-He213 Scoccianti, Guido verfasserin aut Franchi, Alessandro verfasserin aut Roselli, Giuliana verfasserin aut Beltrami, Giovanni verfasserin aut Ippolito, Massimiliano verfasserin aut Caff, Giuseppe verfasserin aut Frenos, Filippo verfasserin aut Capanna, Rodolfo verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 14(2013), 2 vom: 06. März, Seite 101-107 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:14 year:2013 number:2 day:06 month:03 pages:101-107 https://dx.doi.org/10.1007/s10195-013-0230-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 14 2013 2 06 03 101-107
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allfieldsGer	10.1007/s10195-013-0230-6 doi (DE-627)SPR009101217 (SPR)s10195-013-0230-6-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Campanacci, Domenico Andrea verfasserin aut Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging. Chondrosarcoma (dpeaa)DE-He213 Bone sarcoma (dpeaa)DE-He213 Bone tumors (dpeaa)DE-He213 Orthopedic oncology (dpeaa)DE-He213 Scoccianti, Guido verfasserin aut Franchi, Alessandro verfasserin aut Roselli, Giuliana verfasserin aut Beltrami, Giovanni verfasserin aut Ippolito, Massimiliano verfasserin aut Caff, Giuseppe verfasserin aut Frenos, Filippo verfasserin aut Capanna, Rodolfo verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 14(2013), 2 vom: 06. März, Seite 101-107 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:14 year:2013 number:2 day:06 month:03 pages:101-107 https://dx.doi.org/10.1007/s10195-013-0230-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 14 2013 2 06 03 101-107
allfieldsSound	10.1007/s10195-013-0230-6 doi (DE-627)SPR009101217 (SPR)s10195-013-0230-6-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Campanacci, Domenico Andrea verfasserin aut Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging. Chondrosarcoma (dpeaa)DE-He213 Bone sarcoma (dpeaa)DE-He213 Bone tumors (dpeaa)DE-He213 Orthopedic oncology (dpeaa)DE-He213 Scoccianti, Guido verfasserin aut Franchi, Alessandro verfasserin aut Roselli, Giuliana verfasserin aut Beltrami, Giovanni verfasserin aut Ippolito, Massimiliano verfasserin aut Caff, Giuseppe verfasserin aut Frenos, Filippo verfasserin aut Capanna, Rodolfo verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 14(2013), 2 vom: 06. März, Seite 101-107 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:14 year:2013 number:2 day:06 month:03 pages:101-107 https://dx.doi.org/10.1007/s10195-013-0230-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 14 2013 2 06 03 101-107
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We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. 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author	Campanacci, Domenico Andrea
spellingShingle	Campanacci, Domenico Andrea ddc 610 bkl 44.65 bkl 44.83 misc Chondrosarcoma misc Bone sarcoma misc Bone tumors misc Orthopedic oncology Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton
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topic_title	610 ASE 44.65 bkl 44.83 bkl Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton Chondrosarcoma (dpeaa)DE-He213 Bone sarcoma (dpeaa)DE-He213 Bone tumors (dpeaa)DE-He213 Orthopedic oncology (dpeaa)DE-He213
topic	ddc 610 bkl 44.65 bkl 44.83 misc Chondrosarcoma misc Bone sarcoma misc Bone tumors misc Orthopedic oncology
topic_unstemmed	ddc 610 bkl 44.65 bkl 44.83 misc Chondrosarcoma misc Bone sarcoma misc Bone tumors misc Orthopedic oncology
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title	Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton
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title_full	Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton
author_sort	Campanacci, Domenico Andrea
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author_browse	Campanacci, Domenico Andrea Scoccianti, Guido Franchi, Alessandro Roselli, Giuliana Beltrami, Giovanni Ippolito, Massimiliano Caff, Giuseppe Frenos, Filippo Capanna, Rodolfo
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title_sort	surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton
title_auth	Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton
abstract	Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging.
abstractGer	Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging.
abstract_unstemmed	Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. Wide resection, following surgical principles of malignant bone tumors, should be considered only when aggressive biologic behavior is evident on imaging.
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title_short	Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton
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author2	Scoccianti, Guido Franchi, Alessandro Roselli, Giuliana Beltrami, Giovanni Ippolito, Massimiliano Caff, Giuseppe Frenos, Filippo Capanna, Rodolfo
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up_date	2024-07-04T00:39:47.129Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009101217</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519072826.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2013 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10195-013-0230-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009101217</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10195-013-0230-6-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.65</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.83</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Campanacci, Domenico Andrea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Diagnosis and treatment of low-grade chondrosarcoma remain controversial. We performed a review of a single-center series with the aims of assessing the oncologic outcome of these patients, verifying if intralesional curettage can be adequate treatment, and defining clinical criteria to support the surgeon and the oncologist in decision-making for surgery and subsequent follow-up. Materials and methods A retrospective review of 85 patients was performed (61 females and 24 males, age range 20–76 years). The site of the lesion was the femur in 35 cases, humerus in 33, tibia in 15, and fibula in 2. Sixty-four patients were treated by intralesional curettage. Twenty-one patients with aggressive radiological patterns were treated with wide resection. Results Mean follow-up was 67 months (range 24–206 months). Two patients developed local recurrence, both after intralesional curettage. The difference in incidence of recurrence was not statistically significant between the two groups. No distant metastases were observed. Postsurgical complications were significantly higher in the resection group. Conclusions Low-grade chondrosarcoma of the appendicular skeleton without aggressive radiological patterns can be treated with intralesional surgery with good oncological outcome and very low rate of postsurgical complications. 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Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton

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