Risk factors for distant metastasis of dermatofibrosarcoma protuberans

Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hayakawa, Keiko [verfasserIn] Matsumoto, Seiichi [verfasserIn] Ae, Keisuke [verfasserIn] Tanizawa, Taisuke [verfasserIn] Gokita, Tabu [verfasserIn] Funauchi, Yuki [verfasserIn] Motoi, Noriko [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Dermatofibrosarcoma protuberans (DFSP) Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) Risk factors Distant metastasis

Übergeordnetes Werk:	Enthalten in: Journal of orthopaedics and traumatology - Milano : Springer, 2000, 17(2016), 3 vom: 11. Juni, Seite 261-266
Übergeordnetes Werk:	volume:17 ; year:2016 ; number:3 ; day:11 ; month:06 ; pages:261-266

Links:	Volltext

DOI / URN:	10.1007/s10195-016-0415-x

Katalog-ID:	SPR009103147

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520			\|a Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V.
650		4	\|a Dermatofibrosarcoma protuberans (DFSP) \|7 (dpeaa)DE-He213
650		4	\|a Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) \|7 (dpeaa)DE-He213
650		4	\|a Risk factors \|7 (dpeaa)DE-He213
650		4	\|a Distant metastasis \|7 (dpeaa)DE-He213
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700	1		\|a Motoi, Noriko \|e verfasserin \|4 aut
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allfields	10.1007/s10195-016-0415-x doi (DE-627)SPR009103147 (SPR)s10195-016-0415-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Hayakawa, Keiko verfasserin aut Risk factors for distant metastasis of dermatofibrosarcoma protuberans 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V. Dermatofibrosarcoma protuberans (DFSP) (dpeaa)DE-He213 Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Distant metastasis (dpeaa)DE-He213 Matsumoto, Seiichi verfasserin aut Ae, Keisuke verfasserin aut Tanizawa, Taisuke verfasserin aut Gokita, Tabu verfasserin aut Funauchi, Yuki verfasserin aut Motoi, Noriko verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 17(2016), 3 vom: 11. Juni, Seite 261-266 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:17 year:2016 number:3 day:11 month:06 pages:261-266 https://dx.doi.org/10.1007/s10195-016-0415-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 17 2016 3 11 06 261-266
spelling	10.1007/s10195-016-0415-x doi (DE-627)SPR009103147 (SPR)s10195-016-0415-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Hayakawa, Keiko verfasserin aut Risk factors for distant metastasis of dermatofibrosarcoma protuberans 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V. Dermatofibrosarcoma protuberans (DFSP) (dpeaa)DE-He213 Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Distant metastasis (dpeaa)DE-He213 Matsumoto, Seiichi verfasserin aut Ae, Keisuke verfasserin aut Tanizawa, Taisuke verfasserin aut Gokita, Tabu verfasserin aut Funauchi, Yuki verfasserin aut Motoi, Noriko verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 17(2016), 3 vom: 11. Juni, Seite 261-266 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:17 year:2016 number:3 day:11 month:06 pages:261-266 https://dx.doi.org/10.1007/s10195-016-0415-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 17 2016 3 11 06 261-266
allfields_unstemmed	10.1007/s10195-016-0415-x doi (DE-627)SPR009103147 (SPR)s10195-016-0415-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Hayakawa, Keiko verfasserin aut Risk factors for distant metastasis of dermatofibrosarcoma protuberans 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V. Dermatofibrosarcoma protuberans (DFSP) (dpeaa)DE-He213 Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Distant metastasis (dpeaa)DE-He213 Matsumoto, Seiichi verfasserin aut Ae, Keisuke verfasserin aut Tanizawa, Taisuke verfasserin aut Gokita, Tabu verfasserin aut Funauchi, Yuki verfasserin aut Motoi, Noriko verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 17(2016), 3 vom: 11. Juni, Seite 261-266 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:17 year:2016 number:3 day:11 month:06 pages:261-266 https://dx.doi.org/10.1007/s10195-016-0415-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 17 2016 3 11 06 261-266
allfieldsGer	10.1007/s10195-016-0415-x doi (DE-627)SPR009103147 (SPR)s10195-016-0415-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Hayakawa, Keiko verfasserin aut Risk factors for distant metastasis of dermatofibrosarcoma protuberans 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V. Dermatofibrosarcoma protuberans (DFSP) (dpeaa)DE-He213 Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Distant metastasis (dpeaa)DE-He213 Matsumoto, Seiichi verfasserin aut Ae, Keisuke verfasserin aut Tanizawa, Taisuke verfasserin aut Gokita, Tabu verfasserin aut Funauchi, Yuki verfasserin aut Motoi, Noriko verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 17(2016), 3 vom: 11. Juni, Seite 261-266 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:17 year:2016 number:3 day:11 month:06 pages:261-266 https://dx.doi.org/10.1007/s10195-016-0415-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 17 2016 3 11 06 261-266
allfieldsSound	10.1007/s10195-016-0415-x doi (DE-627)SPR009103147 (SPR)s10195-016-0415-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.65 bkl 44.83 bkl Hayakawa, Keiko verfasserin aut Risk factors for distant metastasis of dermatofibrosarcoma protuberans 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V. Dermatofibrosarcoma protuberans (DFSP) (dpeaa)DE-He213 Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Distant metastasis (dpeaa)DE-He213 Matsumoto, Seiichi verfasserin aut Ae, Keisuke verfasserin aut Tanizawa, Taisuke verfasserin aut Gokita, Tabu verfasserin aut Funauchi, Yuki verfasserin aut Motoi, Noriko verfasserin aut Enthalten in Journal of orthopaedics and traumatology Milano : Springer, 2000 17(2016), 3 vom: 11. Juni, Seite 261-266 (DE-627)325293538 (DE-600)2034945-2 1590-9999 nnns volume:17 year:2016 number:3 day:11 month:06 pages:261-266 https://dx.doi.org/10.1007/s10195-016-0415-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.65 ASE 44.83 ASE AR 17 2016 3 11 06 261-266
language	English
source	Enthalten in Journal of orthopaedics and traumatology 17(2016), 3 vom: 11. Juni, Seite 261-266 volume:17 year:2016 number:3 day:11 month:06 pages:261-266
sourceStr	Enthalten in Journal of orthopaedics and traumatology 17(2016), 3 vom: 11. Juni, Seite 261-266 volume:17 year:2016 number:3 day:11 month:06 pages:261-266
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topic_facet	Dermatofibrosarcoma protuberans (DFSP) Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) Risk factors Distant metastasis
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authorswithroles_txt_mv	Hayakawa, Keiko @@aut@@ Matsumoto, Seiichi @@aut@@ Ae, Keisuke @@aut@@ Tanizawa, Taisuke @@aut@@ Gokita, Tabu @@aut@@ Funauchi, Yuki @@aut@@ Motoi, Noriko @@aut@@
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Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. 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author	Hayakawa, Keiko
spellingShingle	Hayakawa, Keiko ddc 610 bkl 44.65 bkl 44.83 misc Dermatofibrosarcoma protuberans (DFSP) misc Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) misc Risk factors misc Distant metastasis Risk factors for distant metastasis of dermatofibrosarcoma protuberans
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topic_title	610 ASE 44.65 bkl 44.83 bkl Risk factors for distant metastasis of dermatofibrosarcoma protuberans Dermatofibrosarcoma protuberans (DFSP) (dpeaa)DE-He213 Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Distant metastasis (dpeaa)DE-He213
topic	ddc 610 bkl 44.65 bkl 44.83 misc Dermatofibrosarcoma protuberans (DFSP) misc Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) misc Risk factors misc Distant metastasis
topic_unstemmed	ddc 610 bkl 44.65 bkl 44.83 misc Dermatofibrosarcoma protuberans (DFSP) misc Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) misc Risk factors misc Distant metastasis
topic_browse	ddc 610 bkl 44.65 bkl 44.83 misc Dermatofibrosarcoma protuberans (DFSP) misc Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) misc Risk factors misc Distant metastasis
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title_full	Risk factors for distant metastasis of dermatofibrosarcoma protuberans
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title_sort	risk factors for distant metastasis of dermatofibrosarcoma protuberans
title_auth	Risk factors for distant metastasis of dermatofibrosarcoma protuberans
abstract	Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V.
abstractGer	Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V.
abstract_unstemmed	Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test: p = 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test: p < 0.0001). Conclusions In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important. Level of evidence V.
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container_issue	3
title_short	Risk factors for distant metastasis of dermatofibrosarcoma protuberans
url	https://dx.doi.org/10.1007/s10195-016-0415-x
remote_bool	true
author2	Matsumoto, Seiichi Ae, Keisuke Tanizawa, Taisuke Gokita, Tabu Funauchi, Yuki Motoi, Noriko
author2Str	Matsumoto, Seiichi Ae, Keisuke Tanizawa, Taisuke Gokita, Tabu Funauchi, Yuki Motoi, Noriko
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doi_str	10.1007/s10195-016-0415-x
up_date	2024-07-04T00:40:15.062Z
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Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis. Patients and methods This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis. Results Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. 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