A systematic review of surgery for non-curative gastric cancer
Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mahar, Alyson L. [verfasserIn] Coburn, Natalie G. [verfasserIn] Singh, Simron [verfasserIn] Law, Calvin [verfasserIn] Helyer, Lucy K. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Gastric Cancer - Springer-Verlag, 2002, 15(2011), Suppl 1 vom: 28. Okt., Seite 125-137 |
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| Übergeordnetes Werk: |
volume:15 ; year:2011 ; number:Suppl 1 ; day:28 ; month:10 ; pages:125-137 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10120-011-0088-3 |
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SPR009318267 |
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| 520 | |a Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. | ||
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| 700 | 1 | |a Singh, Simron |e verfasserin |4 aut | |
| 700 | 1 | |a Law, Calvin |e verfasserin |4 aut | |
| 700 | 1 | |a Helyer, Lucy K. |e verfasserin |4 aut | |
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10.1007/s10120-011-0088-3 doi (DE-627)SPR009318267 (SPR)s10120-011-0088-3-e DE-627 ger DE-627 rakwb eng Mahar, Alyson L. verfasserin aut A systematic review of surgery for non-curative gastric cancer 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. Advanced disease (dpeaa)DE-He213 Non-curative (dpeaa)DE-He213 Palliative (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Coburn, Natalie G. verfasserin aut Singh, Simron verfasserin aut Law, Calvin verfasserin aut Helyer, Lucy K. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 15(2011), Suppl 1 vom: 28. Okt., Seite 125-137 (DE-627)SPR009286586 nnns volume:15 year:2011 number:Suppl 1 day:28 month:10 pages:125-137 https://dx.doi.org/10.1007/s10120-011-0088-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 15 2011 Suppl 1 28 10 125-137 |
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10.1007/s10120-011-0088-3 doi (DE-627)SPR009318267 (SPR)s10120-011-0088-3-e DE-627 ger DE-627 rakwb eng Mahar, Alyson L. verfasserin aut A systematic review of surgery for non-curative gastric cancer 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. Advanced disease (dpeaa)DE-He213 Non-curative (dpeaa)DE-He213 Palliative (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Coburn, Natalie G. verfasserin aut Singh, Simron verfasserin aut Law, Calvin verfasserin aut Helyer, Lucy K. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 15(2011), Suppl 1 vom: 28. Okt., Seite 125-137 (DE-627)SPR009286586 nnns volume:15 year:2011 number:Suppl 1 day:28 month:10 pages:125-137 https://dx.doi.org/10.1007/s10120-011-0088-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 15 2011 Suppl 1 28 10 125-137 |
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10.1007/s10120-011-0088-3 doi (DE-627)SPR009318267 (SPR)s10120-011-0088-3-e DE-627 ger DE-627 rakwb eng Mahar, Alyson L. verfasserin aut A systematic review of surgery for non-curative gastric cancer 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. Advanced disease (dpeaa)DE-He213 Non-curative (dpeaa)DE-He213 Palliative (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Coburn, Natalie G. verfasserin aut Singh, Simron verfasserin aut Law, Calvin verfasserin aut Helyer, Lucy K. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 15(2011), Suppl 1 vom: 28. Okt., Seite 125-137 (DE-627)SPR009286586 nnns volume:15 year:2011 number:Suppl 1 day:28 month:10 pages:125-137 https://dx.doi.org/10.1007/s10120-011-0088-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 15 2011 Suppl 1 28 10 125-137 |
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10.1007/s10120-011-0088-3 doi (DE-627)SPR009318267 (SPR)s10120-011-0088-3-e DE-627 ger DE-627 rakwb eng Mahar, Alyson L. verfasserin aut A systematic review of surgery for non-curative gastric cancer 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. Advanced disease (dpeaa)DE-He213 Non-curative (dpeaa)DE-He213 Palliative (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Coburn, Natalie G. verfasserin aut Singh, Simron verfasserin aut Law, Calvin verfasserin aut Helyer, Lucy K. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 15(2011), Suppl 1 vom: 28. Okt., Seite 125-137 (DE-627)SPR009286586 nnns volume:15 year:2011 number:Suppl 1 day:28 month:10 pages:125-137 https://dx.doi.org/10.1007/s10120-011-0088-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 15 2011 Suppl 1 28 10 125-137 |
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10.1007/s10120-011-0088-3 doi (DE-627)SPR009318267 (SPR)s10120-011-0088-3-e DE-627 ger DE-627 rakwb eng Mahar, Alyson L. verfasserin aut A systematic review of surgery for non-curative gastric cancer 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. Advanced disease (dpeaa)DE-He213 Non-curative (dpeaa)DE-He213 Palliative (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Coburn, Natalie G. verfasserin aut Singh, Simron verfasserin aut Law, Calvin verfasserin aut Helyer, Lucy K. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 15(2011), Suppl 1 vom: 28. Okt., Seite 125-137 (DE-627)SPR009286586 nnns volume:15 year:2011 number:Suppl 1 day:28 month:10 pages:125-137 https://dx.doi.org/10.1007/s10120-011-0088-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 15 2011 Suppl 1 28 10 125-137 |
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A systematic review of surgery for non-curative gastric cancer |
| abstract |
Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. |
| abstractGer |
Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. |
| abstract_unstemmed |
Background Most gastric cancer patients present with advanced stage disease precluding curative surgical treatment. These patients may be considered for palliative resection or bypass in the presence of major symptoms; however, the utility of surgery for non-curative, asymptomatic advanced disease is debated and the appropriate treatment strategy unclear. Purpose To evaluate the non-curative surgical literature to better understand the limitations and benefits of non-curative surgery for advanced gastric cancer. Methods A literature search for non-curative surgical interventions in gastric cancer was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases from 1 January 1985 to 1 December 2009. All abstracts were independently rated for relevance by a minimum of two reviewers. Outcomes of interest were procedure-related morbidity, mortality, and survival. Results Fifty-nine articles were included; the majority were retrospective, single institution case series. Definitions describing the treatment intent for gastrectomy were incomplete in most studies. Only five were truly performed with relief of symptoms as the primary indication for surgery, while the majority were considered non-curative or not otherwise specified. High rates of procedure-related morbidity and mortality were demonstrated for all surgeries across the majority of studies and treatment-intent categories. Median and 1-year survival were poor, and values ranged widely within surgical approaches and across studies. Conclusions A lack of transparent documentation of disease burden and symptoms limits the surgical literature in non-curative gastric cancer. Improved survival is not evident for all patients receiving non-curative gastrectomy. Further prospective research is required to determine the optimal intervention for palliative gastric cancer patients. |
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GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA |
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Suppl 1 |
| title_short |
A systematic review of surgery for non-curative gastric cancer |
| url |
https://dx.doi.org/10.1007/s10120-011-0088-3 |
| remote_bool |
true |
| author2 |
Coburn, Natalie G. Singh, Simron Law, Calvin Helyer, Lucy K. |
| author2Str |
Coburn, Natalie G. Singh, Simron Law, Calvin Helyer, Lucy K. |
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SPR009286586 |
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c |
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false |
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false |
| doi_str |
10.1007/s10120-011-0088-3 |
| up_date |
2024-07-04T01:35:23.467Z |
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1803610408586575872 |
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7.401535 |