Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection
Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ghoshal, Ujjala [verfasserIn] Tripathi, Shweta [verfasserIn] Kumar, Sushil [verfasserIn] Mittal, Balraj [verfasserIn] Chourasia, Dipti [verfasserIn] Kumari, Niraj [verfasserIn] Krishnani, Narendra [verfasserIn] Ghoshal, Uday C. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Gastric Cancer - Springer-Verlag, 2002, 17(2013), 2 vom: 19. Mai, Seite 226-234 |
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| Übergeordnetes Werk: |
volume:17 ; year:2013 ; number:2 ; day:19 ; month:05 ; pages:226-234 |
| Links: |
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| DOI / URN: |
10.1007/s10120-013-0269-3 |
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SPR009319646 |
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| 100 | 1 | |a Ghoshal, Ujjala |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection |
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| 520 | |a Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. | ||
| 650 | 4 | |a Genetic polymorphism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gastric cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Peptic ulcer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Functional dyspepsia |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tripathi, Shweta |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Sushil |e verfasserin |4 aut | |
| 700 | 1 | |a Mittal, Balraj |e verfasserin |4 aut | |
| 700 | 1 | |a Chourasia, Dipti |e verfasserin |4 aut | |
| 700 | 1 | |a Kumari, Niraj |e verfasserin |4 aut | |
| 700 | 1 | |a Krishnani, Narendra |e verfasserin |4 aut | |
| 700 | 1 | |a Ghoshal, Uday C. |e verfasserin |4 aut | |
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10.1007/s10120-013-0269-3 doi (DE-627)SPR009319646 (SPR)s10120-013-0269-3-e DE-627 ger DE-627 rakwb eng Ghoshal, Ujjala verfasserin aut Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. Genetic polymorphism (dpeaa)DE-He213 Gastric cancer (dpeaa)DE-He213 Peptic ulcer (dpeaa)DE-He213 Functional dyspepsia (dpeaa)DE-He213 Tripathi, Shweta verfasserin aut Kumar, Sushil verfasserin aut Mittal, Balraj verfasserin aut Chourasia, Dipti verfasserin aut Kumari, Niraj verfasserin aut Krishnani, Narendra verfasserin aut Ghoshal, Uday C. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 17(2013), 2 vom: 19. Mai, Seite 226-234 (DE-627)SPR009286586 nnns volume:17 year:2013 number:2 day:19 month:05 pages:226-234 https://dx.doi.org/10.1007/s10120-013-0269-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 17 2013 2 19 05 226-234 |
| spelling |
10.1007/s10120-013-0269-3 doi (DE-627)SPR009319646 (SPR)s10120-013-0269-3-e DE-627 ger DE-627 rakwb eng Ghoshal, Ujjala verfasserin aut Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. Genetic polymorphism (dpeaa)DE-He213 Gastric cancer (dpeaa)DE-He213 Peptic ulcer (dpeaa)DE-He213 Functional dyspepsia (dpeaa)DE-He213 Tripathi, Shweta verfasserin aut Kumar, Sushil verfasserin aut Mittal, Balraj verfasserin aut Chourasia, Dipti verfasserin aut Kumari, Niraj verfasserin aut Krishnani, Narendra verfasserin aut Ghoshal, Uday C. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 17(2013), 2 vom: 19. Mai, Seite 226-234 (DE-627)SPR009286586 nnns volume:17 year:2013 number:2 day:19 month:05 pages:226-234 https://dx.doi.org/10.1007/s10120-013-0269-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 17 2013 2 19 05 226-234 |
| allfields_unstemmed |
10.1007/s10120-013-0269-3 doi (DE-627)SPR009319646 (SPR)s10120-013-0269-3-e DE-627 ger DE-627 rakwb eng Ghoshal, Ujjala verfasserin aut Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. Genetic polymorphism (dpeaa)DE-He213 Gastric cancer (dpeaa)DE-He213 Peptic ulcer (dpeaa)DE-He213 Functional dyspepsia (dpeaa)DE-He213 Tripathi, Shweta verfasserin aut Kumar, Sushil verfasserin aut Mittal, Balraj verfasserin aut Chourasia, Dipti verfasserin aut Kumari, Niraj verfasserin aut Krishnani, Narendra verfasserin aut Ghoshal, Uday C. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 17(2013), 2 vom: 19. Mai, Seite 226-234 (DE-627)SPR009286586 nnns volume:17 year:2013 number:2 day:19 month:05 pages:226-234 https://dx.doi.org/10.1007/s10120-013-0269-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 17 2013 2 19 05 226-234 |
| allfieldsGer |
10.1007/s10120-013-0269-3 doi (DE-627)SPR009319646 (SPR)s10120-013-0269-3-e DE-627 ger DE-627 rakwb eng Ghoshal, Ujjala verfasserin aut Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. Genetic polymorphism (dpeaa)DE-He213 Gastric cancer (dpeaa)DE-He213 Peptic ulcer (dpeaa)DE-He213 Functional dyspepsia (dpeaa)DE-He213 Tripathi, Shweta verfasserin aut Kumar, Sushil verfasserin aut Mittal, Balraj verfasserin aut Chourasia, Dipti verfasserin aut Kumari, Niraj verfasserin aut Krishnani, Narendra verfasserin aut Ghoshal, Uday C. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 17(2013), 2 vom: 19. Mai, Seite 226-234 (DE-627)SPR009286586 nnns volume:17 year:2013 number:2 day:19 month:05 pages:226-234 https://dx.doi.org/10.1007/s10120-013-0269-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 17 2013 2 19 05 226-234 |
| allfieldsSound |
10.1007/s10120-013-0269-3 doi (DE-627)SPR009319646 (SPR)s10120-013-0269-3-e DE-627 ger DE-627 rakwb eng Ghoshal, Ujjala verfasserin aut Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. Genetic polymorphism (dpeaa)DE-He213 Gastric cancer (dpeaa)DE-He213 Peptic ulcer (dpeaa)DE-He213 Functional dyspepsia (dpeaa)DE-He213 Tripathi, Shweta verfasserin aut Kumar, Sushil verfasserin aut Mittal, Balraj verfasserin aut Chourasia, Dipti verfasserin aut Kumari, Niraj verfasserin aut Krishnani, Narendra verfasserin aut Ghoshal, Uday C. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 17(2013), 2 vom: 19. Mai, Seite 226-234 (DE-627)SPR009286586 nnns volume:17 year:2013 number:2 day:19 month:05 pages:226-234 https://dx.doi.org/10.1007/s10120-013-0269-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 17 2013 2 19 05 226-234 |
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Ghoshal, Ujjala @@aut@@ Tripathi, Shweta @@aut@@ Kumar, Sushil @@aut@@ Mittal, Balraj @@aut@@ Chourasia, Dipti @@aut@@ Kumari, Niraj @@aut@@ Krishnani, Narendra @@aut@@ Ghoshal, Uday C. @@aut@@ |
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We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. 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Ghoshal, Ujjala misc Genetic polymorphism misc Gastric cancer misc Peptic ulcer misc Functional dyspepsia Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection |
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Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection Genetic polymorphism (dpeaa)DE-He213 Gastric cancer (dpeaa)DE-He213 Peptic ulcer (dpeaa)DE-He213 Functional dyspepsia (dpeaa)DE-He213 |
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Ghoshal, Ujjala Tripathi, Shweta Kumar, Sushil Mittal, Balraj Chourasia, Dipti Kumari, Niraj Krishnani, Narendra Ghoshal, Uday C. |
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genetic polymorphism of cytochrome p450 (cyp) 1a1, cyp1a2, and cyp2e1 genes modulate susceptibility to gastric cancer in patients with helicobacter pylori infection |
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Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection |
| abstract |
Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. |
| abstractGer |
Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. |
| abstract_unstemmed |
Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. Serum IgG antibody (all subjects), rapid urease test, and histology (GC, FD, and PU patients) were used to test for H. pylori. Results CYP2E1 gene polymorphism was more common among patients with GC than HC and PU [48/88 (54.5 %) vs. 67/170 (39.4 %); OR 1.9, 95 % CI 1.1–3.2, p = 0.016) and [PU 18/53 (34 %); OR 2.3 (1–4.7), p = 0.02]. CYP1A2 CC or CT genotypes was lower among patients with GC than HC [50/88 (56.8 %) vs. 120/170 (70.6 %); OR 0.54 (0.31–0.92), p = 0.023]. CYP1A1 polymorphism and CYP1A1–CYP1A2 haplotypes were comparable among different groups. CYP2E1 was also more common in patients with GC than HC and PU in the absence of H. pylori [33/60 (55 %) vs. 19/52 (36.5 %); OR 4 (1.5–11.4), p = 0.007 and PU 7/22 (31.8 %); OR 3.4 (1–11.6), p = 0.05]. CYP1A1 (CT + TT) was more common in patients with GC than PU in presence of H. pylori [17/26 (65.4 %) vs. 11/29 (38 %); OR 3.0 (1.03–9.3), p = 0.045]. Conclusions The presence of CYP2E1 (96-bp insertion) is associated with increased risk of GC even in absence of H. pylori. CYP1A2 CC or CT is associated with reduced risk of GC. |
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