Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario
Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-b...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dixon, Matthew [verfasserIn] Mahar, Alyson L. [verfasserIn] Helyer, Lucy K. [verfasserIn] Vasilevska-Ristovska, Jovanka [verfasserIn] Law, Calvin [verfasserIn] Coburn, Natalie G. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2014 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: Gastric Cancer - Springer-Verlag, 2002, 19(2014), 1 vom: 25. Nov., Seite 150-159 |
|---|---|
| Übergeordnetes Werk: |
volume:19 ; year:2014 ; number:1 ; day:25 ; month:11 ; pages:150-159 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10120-014-0442-3 |
|---|
| Katalog-ID: |
SPR009327746 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR009327746 | ||
| 003 | DE-627 | ||
| 005 | 20230519193101.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201005s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10120-014-0442-3 |2 doi | |
| 035 | |a (DE-627)SPR009327746 | ||
| 035 | |a (SPR)s10120-014-0442-3-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dixon, Matthew |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. | ||
| 650 | 4 | |a Metastatic cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognostic factor |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mahar, Alyson L. |e verfasserin |4 aut | |
| 700 | 1 | |a Helyer, Lucy K. |e verfasserin |4 aut | |
| 700 | 1 | |a Vasilevska-Ristovska, Jovanka |e verfasserin |4 aut | |
| 700 | 1 | |a Law, Calvin |e verfasserin |4 aut | |
| 700 | 1 | |a Coburn, Natalie G. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gastric Cancer |d Springer-Verlag, 2002 |g 19(2014), 1 vom: 25. Nov., Seite 150-159 |w (DE-627)SPR009286586 |7 nnns |
| 773 | 1 | 8 | |g volume:19 |g year:2014 |g number:1 |g day:25 |g month:11 |g pages:150-159 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s10120-014-0442-3 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 19 |j 2014 |e 1 |b 25 |c 11 |h 150-159 | ||
| author_variant |
m d md a l m al alm l k h lk lkh j v r jvr c l cl n g c ng ngc |
|---|---|
| matchkey_str |
dixonmatthewmaharalysonlhelyerlucykvasil:2014----:rgotcatrimtsaigsrcacreutoaouainaertop |
| hierarchy_sort_str |
2014 |
| publishDate |
2014 |
| allfields |
10.1007/s10120-014-0442-3 doi (DE-627)SPR009327746 (SPR)s10120-014-0442-3-e DE-627 ger DE-627 rakwb eng Dixon, Matthew verfasserin aut Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. Metastatic cancer (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Mahar, Alyson L. verfasserin aut Helyer, Lucy K. verfasserin aut Vasilevska-Ristovska, Jovanka verfasserin aut Law, Calvin verfasserin aut Coburn, Natalie G. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 19(2014), 1 vom: 25. Nov., Seite 150-159 (DE-627)SPR009286586 nnns volume:19 year:2014 number:1 day:25 month:11 pages:150-159 https://dx.doi.org/10.1007/s10120-014-0442-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2014 1 25 11 150-159 |
| spelling |
10.1007/s10120-014-0442-3 doi (DE-627)SPR009327746 (SPR)s10120-014-0442-3-e DE-627 ger DE-627 rakwb eng Dixon, Matthew verfasserin aut Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. Metastatic cancer (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Mahar, Alyson L. verfasserin aut Helyer, Lucy K. verfasserin aut Vasilevska-Ristovska, Jovanka verfasserin aut Law, Calvin verfasserin aut Coburn, Natalie G. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 19(2014), 1 vom: 25. Nov., Seite 150-159 (DE-627)SPR009286586 nnns volume:19 year:2014 number:1 day:25 month:11 pages:150-159 https://dx.doi.org/10.1007/s10120-014-0442-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2014 1 25 11 150-159 |
| allfields_unstemmed |
10.1007/s10120-014-0442-3 doi (DE-627)SPR009327746 (SPR)s10120-014-0442-3-e DE-627 ger DE-627 rakwb eng Dixon, Matthew verfasserin aut Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. Metastatic cancer (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Mahar, Alyson L. verfasserin aut Helyer, Lucy K. verfasserin aut Vasilevska-Ristovska, Jovanka verfasserin aut Law, Calvin verfasserin aut Coburn, Natalie G. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 19(2014), 1 vom: 25. Nov., Seite 150-159 (DE-627)SPR009286586 nnns volume:19 year:2014 number:1 day:25 month:11 pages:150-159 https://dx.doi.org/10.1007/s10120-014-0442-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2014 1 25 11 150-159 |
| allfieldsGer |
10.1007/s10120-014-0442-3 doi (DE-627)SPR009327746 (SPR)s10120-014-0442-3-e DE-627 ger DE-627 rakwb eng Dixon, Matthew verfasserin aut Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. Metastatic cancer (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Mahar, Alyson L. verfasserin aut Helyer, Lucy K. verfasserin aut Vasilevska-Ristovska, Jovanka verfasserin aut Law, Calvin verfasserin aut Coburn, Natalie G. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 19(2014), 1 vom: 25. Nov., Seite 150-159 (DE-627)SPR009286586 nnns volume:19 year:2014 number:1 day:25 month:11 pages:150-159 https://dx.doi.org/10.1007/s10120-014-0442-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2014 1 25 11 150-159 |
| allfieldsSound |
10.1007/s10120-014-0442-3 doi (DE-627)SPR009327746 (SPR)s10120-014-0442-3-e DE-627 ger DE-627 rakwb eng Dixon, Matthew verfasserin aut Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. Metastatic cancer (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Mahar, Alyson L. verfasserin aut Helyer, Lucy K. verfasserin aut Vasilevska-Ristovska, Jovanka verfasserin aut Law, Calvin verfasserin aut Coburn, Natalie G. verfasserin aut Enthalten in Gastric Cancer Springer-Verlag, 2002 19(2014), 1 vom: 25. Nov., Seite 150-159 (DE-627)SPR009286586 nnns volume:19 year:2014 number:1 day:25 month:11 pages:150-159 https://dx.doi.org/10.1007/s10120-014-0442-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 19 2014 1 25 11 150-159 |
| language |
English |
| source |
Enthalten in Gastric Cancer 19(2014), 1 vom: 25. Nov., Seite 150-159 volume:19 year:2014 number:1 day:25 month:11 pages:150-159 |
| sourceStr |
Enthalten in Gastric Cancer 19(2014), 1 vom: 25. Nov., Seite 150-159 volume:19 year:2014 number:1 day:25 month:11 pages:150-159 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Metastatic cancer Prognostic factor |
| isfreeaccess_bool |
false |
| container_title |
Gastric Cancer |
| authorswithroles_txt_mv |
Dixon, Matthew @@aut@@ Mahar, Alyson L. @@aut@@ Helyer, Lucy K. @@aut@@ Vasilevska-Ristovska, Jovanka @@aut@@ Law, Calvin @@aut@@ Coburn, Natalie G. @@aut@@ |
| publishDateDaySort_date |
2014-11-25T00:00:00Z |
| hierarchy_top_id |
SPR009286586 |
| id |
SPR009327746 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009327746</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519193101.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10120-014-0442-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009327746</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10120-014-0442-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dixon, Matthew</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Metastatic cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Prognostic factor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mahar, Alyson L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Helyer, Lucy K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vasilevska-Ristovska, Jovanka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Law, Calvin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coburn, Natalie G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Gastric Cancer</subfield><subfield code="d">Springer-Verlag, 2002</subfield><subfield code="g">19(2014), 1 vom: 25. Nov., Seite 150-159</subfield><subfield code="w">(DE-627)SPR009286586</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:19</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:1</subfield><subfield code="g">day:25</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:150-159</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s10120-014-0442-3</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">19</subfield><subfield code="j">2014</subfield><subfield code="e">1</subfield><subfield code="b">25</subfield><subfield code="c">11</subfield><subfield code="h">150-159</subfield></datafield></record></collection>
|
| author |
Dixon, Matthew |
| spellingShingle |
Dixon, Matthew misc Metastatic cancer misc Prognostic factor Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario |
| authorStr |
Dixon, Matthew |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR009286586 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario Metastatic cancer (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 |
| topic |
misc Metastatic cancer misc Prognostic factor |
| topic_unstemmed |
misc Metastatic cancer misc Prognostic factor |
| topic_browse |
misc Metastatic cancer misc Prognostic factor |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Gastric Cancer |
| hierarchy_parent_id |
SPR009286586 |
| hierarchy_top_title |
Gastric Cancer |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)SPR009286586 |
| title |
Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario |
| ctrlnum |
(DE-627)SPR009327746 (SPR)s10120-014-0442-3-e |
| title_full |
Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario |
| author_sort |
Dixon, Matthew |
| journal |
Gastric Cancer |
| journalStr |
Gastric Cancer |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2014 |
| contenttype_str_mv |
txt |
| container_start_page |
150 |
| author_browse |
Dixon, Matthew Mahar, Alyson L. Helyer, Lucy K. Vasilevska-Ristovska, Jovanka Law, Calvin Coburn, Natalie G. |
| container_volume |
19 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Dixon, Matthew |
| doi_str_mv |
10.1007/s10120-014-0442-3 |
| author2-role |
verfasserin |
| title_sort |
prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in ontario |
| title_auth |
Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario |
| abstract |
Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. |
| abstractGer |
Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. |
| abstract_unstemmed |
Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA |
| container_issue |
1 |
| title_short |
Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario |
| url |
https://dx.doi.org/10.1007/s10120-014-0442-3 |
| remote_bool |
true |
| author2 |
Mahar, Alyson L. Helyer, Lucy K. Vasilevska-Ristovska, Jovanka Law, Calvin Coburn, Natalie G. |
| author2Str |
Mahar, Alyson L. Helyer, Lucy K. Vasilevska-Ristovska, Jovanka Law, Calvin Coburn, Natalie G. |
| ppnlink |
SPR009286586 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s10120-014-0442-3 |
| up_date |
2024-07-04T01:37:33.080Z |
| _version_ |
1803610544492511232 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009327746</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519193101.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10120-014-0442-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009327746</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10120-014-0442-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dixon, Matthew</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Stage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations. Methods A population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95 % confidence intervals (CIs) are presented. Results On multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95 % CI 1.02–1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95 % CI 0.94–1.27) or middle of the stomach (HR 1.14; 95 % CI 0.97–1.35), presence of carcinomatosis (HR 1.61; 95 % CI 1.42–1.83) and a larger burden of metastatic disease (2–3 sites of metastatic disease: HR 1.17; 95 % CI 1.03–1.32; ≥4 sites: HR 1.69; 95 % CI 1.30–2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival. Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Metastatic cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Prognostic factor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mahar, Alyson L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Helyer, Lucy K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vasilevska-Ristovska, Jovanka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Law, Calvin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coburn, Natalie G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Gastric Cancer</subfield><subfield code="d">Springer-Verlag, 2002</subfield><subfield code="g">19(2014), 1 vom: 25. Nov., Seite 150-159</subfield><subfield code="w">(DE-627)SPR009286586</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:19</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:1</subfield><subfield code="g">day:25</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:150-159</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s10120-014-0442-3</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">19</subfield><subfield code="j">2014</subfield><subfield code="e">1</subfield><subfield code="b">25</subfield><subfield code="c">11</subfield><subfield code="h">150-159</subfield></datafield></record></collection>
|
| score |
7.4013777 |