Simple recipe for accurate T2 quantification with multi spin-echo acquisitions

Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinic...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Neumann, Daniel [verfasserIn] Blaimer, Martin [verfasserIn] Jakob, Peter M. [verfasserIn] Breuer, Felix A. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Relaxometry Multi spin-echo Stimulated echoes quantification

Übergeordnetes Werk:	Enthalten in: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, 1993, 27(2014), 6 vom: 19. März, Seite 567-577
Übergeordnetes Werk:	volume:27 ; year:2014 ; number:6 ; day:19 ; month:03 ; pages:567-577

Links:	Volltext

DOI / URN:	10.1007/s10334-014-0438-3

Katalog-ID:	SPR009483586

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245	1	0	\|a Simple recipe for accurate T2 quantification with multi spin-echo acquisitions
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520			\|a Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required.
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700	1		\|a Jakob, Peter M. \|e verfasserin \|4 aut
700	1		\|a Breuer, Felix A. \|e verfasserin \|4 aut
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allfields	10.1007/s10334-014-0438-3 doi (DE-627)SPR009483586 (SPR)s10334-014-0438-3-e DE-627 ger DE-627 rakwb eng 610 570 530 ASE 610 ASE 33.07 bkl 35.25 bkl 44.64 bkl Neumann, Daniel verfasserin aut Simple recipe for accurate T2 quantification with multi spin-echo acquisitions 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required. Relaxometry (dpeaa)DE-He213 Multi spin-echo (dpeaa)DE-He213 Stimulated echoes (dpeaa)DE-He213 quantification (dpeaa)DE-He213 Blaimer, Martin verfasserin aut Jakob, Peter M. verfasserin aut Breuer, Felix A. verfasserin aut Enthalten in Magnetic resonance materials in physics, biology and medicine Heidelberg : Springer, 1993 27(2014), 6 vom: 19. März, Seite 567-577 (DE-627)308449711 (DE-600)1502491-X 1352-8661 nnns volume:27 year:2014 number:6 day:19 month:03 pages:567-577 https://dx.doi.org/10.1007/s10334-014-0438-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.07 ASE 35.25 ASE 44.64 ASE AR 27 2014 6 19 03 567-577
spelling	10.1007/s10334-014-0438-3 doi (DE-627)SPR009483586 (SPR)s10334-014-0438-3-e DE-627 ger DE-627 rakwb eng 610 570 530 ASE 610 ASE 33.07 bkl 35.25 bkl 44.64 bkl Neumann, Daniel verfasserin aut Simple recipe for accurate T2 quantification with multi spin-echo acquisitions 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required. Relaxometry (dpeaa)DE-He213 Multi spin-echo (dpeaa)DE-He213 Stimulated echoes (dpeaa)DE-He213 quantification (dpeaa)DE-He213 Blaimer, Martin verfasserin aut Jakob, Peter M. verfasserin aut Breuer, Felix A. verfasserin aut Enthalten in Magnetic resonance materials in physics, biology and medicine Heidelberg : Springer, 1993 27(2014), 6 vom: 19. März, Seite 567-577 (DE-627)308449711 (DE-600)1502491-X 1352-8661 nnns volume:27 year:2014 number:6 day:19 month:03 pages:567-577 https://dx.doi.org/10.1007/s10334-014-0438-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.07 ASE 35.25 ASE 44.64 ASE AR 27 2014 6 19 03 567-577
allfields_unstemmed	10.1007/s10334-014-0438-3 doi (DE-627)SPR009483586 (SPR)s10334-014-0438-3-e DE-627 ger DE-627 rakwb eng 610 570 530 ASE 610 ASE 33.07 bkl 35.25 bkl 44.64 bkl Neumann, Daniel verfasserin aut Simple recipe for accurate T2 quantification with multi spin-echo acquisitions 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required. Relaxometry (dpeaa)DE-He213 Multi spin-echo (dpeaa)DE-He213 Stimulated echoes (dpeaa)DE-He213 quantification (dpeaa)DE-He213 Blaimer, Martin verfasserin aut Jakob, Peter M. verfasserin aut Breuer, Felix A. verfasserin aut Enthalten in Magnetic resonance materials in physics, biology and medicine Heidelberg : Springer, 1993 27(2014), 6 vom: 19. März, Seite 567-577 (DE-627)308449711 (DE-600)1502491-X 1352-8661 nnns volume:27 year:2014 number:6 day:19 month:03 pages:567-577 https://dx.doi.org/10.1007/s10334-014-0438-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.07 ASE 35.25 ASE 44.64 ASE AR 27 2014 6 19 03 567-577
allfieldsGer	10.1007/s10334-014-0438-3 doi (DE-627)SPR009483586 (SPR)s10334-014-0438-3-e DE-627 ger DE-627 rakwb eng 610 570 530 ASE 610 ASE 33.07 bkl 35.25 bkl 44.64 bkl Neumann, Daniel verfasserin aut Simple recipe for accurate T2 quantification with multi spin-echo acquisitions 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required. Relaxometry (dpeaa)DE-He213 Multi spin-echo (dpeaa)DE-He213 Stimulated echoes (dpeaa)DE-He213 quantification (dpeaa)DE-He213 Blaimer, Martin verfasserin aut Jakob, Peter M. verfasserin aut Breuer, Felix A. verfasserin aut Enthalten in Magnetic resonance materials in physics, biology and medicine Heidelberg : Springer, 1993 27(2014), 6 vom: 19. März, Seite 567-577 (DE-627)308449711 (DE-600)1502491-X 1352-8661 nnns volume:27 year:2014 number:6 day:19 month:03 pages:567-577 https://dx.doi.org/10.1007/s10334-014-0438-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.07 ASE 35.25 ASE 44.64 ASE AR 27 2014 6 19 03 567-577
allfieldsSound	10.1007/s10334-014-0438-3 doi (DE-627)SPR009483586 (SPR)s10334-014-0438-3-e DE-627 ger DE-627 rakwb eng 610 570 530 ASE 610 ASE 33.07 bkl 35.25 bkl 44.64 bkl Neumann, Daniel verfasserin aut Simple recipe for accurate T2 quantification with multi spin-echo acquisitions 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required. Relaxometry (dpeaa)DE-He213 Multi spin-echo (dpeaa)DE-He213 Stimulated echoes (dpeaa)DE-He213 quantification (dpeaa)DE-He213 Blaimer, Martin verfasserin aut Jakob, Peter M. verfasserin aut Breuer, Felix A. verfasserin aut Enthalten in Magnetic resonance materials in physics, biology and medicine Heidelberg : Springer, 1993 27(2014), 6 vom: 19. März, Seite 567-577 (DE-627)308449711 (DE-600)1502491-X 1352-8661 nnns volume:27 year:2014 number:6 day:19 month:03 pages:567-577 https://dx.doi.org/10.1007/s10334-014-0438-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.07 ASE 35.25 ASE 44.64 ASE AR 27 2014 6 19 03 567-577
language	English
source	Enthalten in Magnetic resonance materials in physics, biology and medicine 27(2014), 6 vom: 19. März, Seite 567-577 volume:27 year:2014 number:6 day:19 month:03 pages:567-577
sourceStr	Enthalten in Magnetic resonance materials in physics, biology and medicine 27(2014), 6 vom: 19. März, Seite 567-577 volume:27 year:2014 number:6 day:19 month:03 pages:567-577
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Relaxometry Multi spin-echo Stimulated echoes quantification
dewey-raw	610
isfreeaccess_bool	false
container_title	Magnetic resonance materials in physics, biology and medicine
authorswithroles_txt_mv	Neumann, Daniel @@aut@@ Blaimer, Martin @@aut@@ Jakob, Peter M. @@aut@@ Breuer, Felix A. @@aut@@
publishDateDaySort_date	2014-03-19T00:00:00Z
hierarchy_top_id	308449711
dewey-sort	3610
id	SPR009483586
language_de	englisch
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Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. 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author	Neumann, Daniel
spellingShingle	Neumann, Daniel ddc 610 bkl 33.07 bkl 35.25 bkl 44.64 misc Relaxometry misc Multi spin-echo misc Stimulated echoes misc quantification Simple recipe for accurate T2 quantification with multi spin-echo acquisitions
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topic_title	610 570 530 ASE 610 ASE 33.07 bkl 35.25 bkl 44.64 bkl Simple recipe for accurate T2 quantification with multi spin-echo acquisitions Relaxometry (dpeaa)DE-He213 Multi spin-echo (dpeaa)DE-He213 Stimulated echoes (dpeaa)DE-He213 quantification (dpeaa)DE-He213
topic	ddc 610 bkl 33.07 bkl 35.25 bkl 44.64 misc Relaxometry misc Multi spin-echo misc Stimulated echoes misc quantification
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title	Simple recipe for accurate T2 quantification with multi spin-echo acquisitions
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title_full	Simple recipe for accurate T2 quantification with multi spin-echo acquisitions
author_sort	Neumann, Daniel
journal	Magnetic resonance materials in physics, biology and medicine
journalStr	Magnetic resonance materials in physics, biology and medicine
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author_browse	Neumann, Daniel Blaimer, Martin Jakob, Peter M. Breuer, Felix A.
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title_sort	simple recipe for accurate t2 quantification with multi spin-echo acquisitions
title_auth	Simple recipe for accurate T2 quantification with multi spin-echo acquisitions
abstract	Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required.
abstractGer	Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required.
abstract_unstemmed	Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required.
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title_short	Simple recipe for accurate T2 quantification with multi spin-echo acquisitions
url	https://dx.doi.org/10.1007/s10334-014-0438-3
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author2	Blaimer, Martin Jakob, Peter M. Breuer, Felix A.
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up_date	2024-07-04T02:15:20.788Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009483586</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519073552.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2014 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10334-014-0438-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009483586</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10334-014-0438-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="a">570</subfield><subfield code="a">530</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">33.07</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.25</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.64</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Neumann, Daniel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Simple recipe for accurate T2 quantification with multi spin-echo acquisitions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective The quantification of magnetic resonance relaxation parameters T1 and T2 have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T2 values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T2 values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T2 from MSE acquisitions. Materials and methods Correction factors for T2 values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results Simulations and phantom experiments show high accuracy of corrected T2 values for a wide range of clinically relevant T2 values and for different nominal refocusing flip angles. In addition, corrected T2 maps of the human brain are presented. Conclusion A simple recipe is provided to correct T2 values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. 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Simple recipe for accurate T2 quantification with multi spin-echo acquisitions

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