A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection
Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Flores-Pérez, C. [verfasserIn] Juárez-Olguín, H. [verfasserIn] Flores-Pérez, J. [verfasserIn] Ramírez-Mendiola, B. [verfasserIn] Chávez, J. Bobadilla [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2005 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Chromatographia - Wiesbaden : Vieweg, 1968, 62(2005), 7-8 vom: Okt., Seite 373-377 |
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| Übergeordnetes Werk: |
volume:62 ; year:2005 ; number:7-8 ; month:10 ; pages:373-377 |
| Links: |
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| DOI / URN: |
10.1365/s10337-005-0650-4 |
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| Katalog-ID: |
SPR009530215 |
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| 245 | 1 | 2 | |a A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection |
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| 520 | |a Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. | ||
| 650 | 4 | |a Column liquid chromatography |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Propafenone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Plasma levels |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pharmacokinetics |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Juárez-Olguín, H. |e verfasserin |4 aut | |
| 700 | 1 | |a Flores-Pérez, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Ramírez-Mendiola, B. |e verfasserin |4 aut | |
| 700 | 1 | |a Chávez, J. Bobadilla |e verfasserin |4 aut | |
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10.1365/s10337-005-0650-4 doi (DE-627)SPR009530215 (SPR)s10337-005-0650-4-e DE-627 ger DE-627 rakwb eng 540 ASE 540 ASE 35.29 bkl Flores-Pérez, C. verfasserin aut A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. Column liquid chromatography (dpeaa)DE-He213 Propafenone (dpeaa)DE-He213 Plasma levels (dpeaa)DE-He213 Pharmacokinetics (dpeaa)DE-He213 Juárez-Olguín, H. verfasserin aut Flores-Pérez, J. verfasserin aut Ramírez-Mendiola, B. verfasserin aut Chávez, J. Bobadilla verfasserin aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 62(2005), 7-8 vom: Okt., Seite 373-377 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:62 year:2005 number:7-8 month:10 pages:373-377 https://dx.doi.org/10.1365/s10337-005-0650-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.29 ASE AR 62 2005 7-8 10 373-377 |
| spelling |
10.1365/s10337-005-0650-4 doi (DE-627)SPR009530215 (SPR)s10337-005-0650-4-e DE-627 ger DE-627 rakwb eng 540 ASE 540 ASE 35.29 bkl Flores-Pérez, C. verfasserin aut A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. Column liquid chromatography (dpeaa)DE-He213 Propafenone (dpeaa)DE-He213 Plasma levels (dpeaa)DE-He213 Pharmacokinetics (dpeaa)DE-He213 Juárez-Olguín, H. verfasserin aut Flores-Pérez, J. verfasserin aut Ramírez-Mendiola, B. verfasserin aut Chávez, J. Bobadilla verfasserin aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 62(2005), 7-8 vom: Okt., Seite 373-377 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:62 year:2005 number:7-8 month:10 pages:373-377 https://dx.doi.org/10.1365/s10337-005-0650-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.29 ASE AR 62 2005 7-8 10 373-377 |
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10.1365/s10337-005-0650-4 doi (DE-627)SPR009530215 (SPR)s10337-005-0650-4-e DE-627 ger DE-627 rakwb eng 540 ASE 540 ASE 35.29 bkl Flores-Pérez, C. verfasserin aut A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. Column liquid chromatography (dpeaa)DE-He213 Propafenone (dpeaa)DE-He213 Plasma levels (dpeaa)DE-He213 Pharmacokinetics (dpeaa)DE-He213 Juárez-Olguín, H. verfasserin aut Flores-Pérez, J. verfasserin aut Ramírez-Mendiola, B. verfasserin aut Chávez, J. Bobadilla verfasserin aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 62(2005), 7-8 vom: Okt., Seite 373-377 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:62 year:2005 number:7-8 month:10 pages:373-377 https://dx.doi.org/10.1365/s10337-005-0650-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.29 ASE AR 62 2005 7-8 10 373-377 |
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10.1365/s10337-005-0650-4 doi (DE-627)SPR009530215 (SPR)s10337-005-0650-4-e DE-627 ger DE-627 rakwb eng 540 ASE 540 ASE 35.29 bkl Flores-Pérez, C. verfasserin aut A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. Column liquid chromatography (dpeaa)DE-He213 Propafenone (dpeaa)DE-He213 Plasma levels (dpeaa)DE-He213 Pharmacokinetics (dpeaa)DE-He213 Juárez-Olguín, H. verfasserin aut Flores-Pérez, J. verfasserin aut Ramírez-Mendiola, B. verfasserin aut Chávez, J. Bobadilla verfasserin aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 62(2005), 7-8 vom: Okt., Seite 373-377 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:62 year:2005 number:7-8 month:10 pages:373-377 https://dx.doi.org/10.1365/s10337-005-0650-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.29 ASE AR 62 2005 7-8 10 373-377 |
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10.1365/s10337-005-0650-4 doi (DE-627)SPR009530215 (SPR)s10337-005-0650-4-e DE-627 ger DE-627 rakwb eng 540 ASE 540 ASE 35.29 bkl Flores-Pérez, C. verfasserin aut A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. Column liquid chromatography (dpeaa)DE-He213 Propafenone (dpeaa)DE-He213 Plasma levels (dpeaa)DE-He213 Pharmacokinetics (dpeaa)DE-He213 Juárez-Olguín, H. verfasserin aut Flores-Pérez, J. verfasserin aut Ramírez-Mendiola, B. verfasserin aut Chávez, J. Bobadilla verfasserin aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 62(2005), 7-8 vom: Okt., Seite 373-377 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:62 year:2005 number:7-8 month:10 pages:373-377 https://dx.doi.org/10.1365/s10337-005-0650-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.29 ASE AR 62 2005 7-8 10 373-377 |
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Enthalten in Chromatographia 62(2005), 7-8 vom: Okt., Seite 373-377 volume:62 year:2005 number:7-8 month:10 pages:373-377 |
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Enthalten in Chromatographia 62(2005), 7-8 vom: Okt., Seite 373-377 volume:62 year:2005 number:7-8 month:10 pages:373-377 |
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Column liquid chromatography Propafenone Plasma levels Pharmacokinetics |
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Flores-Pérez, C. @@aut@@ Juárez-Olguín, H. @@aut@@ Flores-Pérez, J. @@aut@@ Ramírez-Mendiola, B. @@aut@@ Chávez, J. Bobadilla @@aut@@ |
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2005-10-01T00:00:00Z |
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| author |
Flores-Pérez, C. |
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Flores-Pérez, C. ddc 540 bkl 35.29 misc Column liquid chromatography misc Propafenone misc Plasma levels misc Pharmacokinetics A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection |
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540 ASE 35.29 bkl A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection Column liquid chromatography (dpeaa)DE-He213 Propafenone (dpeaa)DE-He213 Plasma levels (dpeaa)DE-He213 Pharmacokinetics (dpeaa)DE-He213 |
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ddc 540 bkl 35.29 misc Column liquid chromatography misc Propafenone misc Plasma levels misc Pharmacokinetics |
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ddc 540 bkl 35.29 misc Column liquid chromatography misc Propafenone misc Plasma levels misc Pharmacokinetics |
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ddc 540 bkl 35.29 misc Column liquid chromatography misc Propafenone misc Plasma levels misc Pharmacokinetics |
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A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection |
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A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection |
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Flores-Pérez, C. |
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Flores-Pérez, C. Juárez-Olguín, H. Flores-Pérez, J. Ramírez-Mendiola, B. Chávez, J. Bobadilla |
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Flores-Pérez, C. |
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simple method to measure plasma levels of propafenone with fluorescence detection |
| title_auth |
A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection |
| abstract |
Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. |
| abstractGer |
Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. |
| abstract_unstemmed |
Abstract The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng $ mL^{−1} $ and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng $ mL^{−1} $ and 50 ng $ mL^{−1} $, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. |
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A Simple Method to Measure Plasma Levels of Propafenone with Fluorescence Detection |
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Juárez-Olguín, H. Flores-Pérez, J. Ramírez-Mendiola, B. Chávez, J. Bobadilla |
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10.1365/s10337-005-0650-4 |
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| score |
7.400463 |