Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor
Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sharma, P. S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
Molecularly imprinted solid-phase extraction |
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| Anmerkung: |
© Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Chromatographia - Wiesbaden : Vieweg, 1968, 65(2007), 7-8 vom: 06. Feb., Seite 419-427 |
|---|---|
| Übergeordnetes Werk: |
volume:65 ; year:2007 ; number:7-8 ; day:06 ; month:02 ; pages:419-427 |
| Links: |
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| DOI / URN: |
10.1365/s10337-007-0172-3 |
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| Katalog-ID: |
SPR009534199 |
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| 100 | 1 | |a Sharma, P. S. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor |
| 264 | 1 | |c 2007 | |
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| 500 | |a © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 | ||
| 520 | |a Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. | ||
| 650 | 4 | |a Molecularly imprinted solid-phase extraction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Imprinted polymer–silica gel |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Molecularly imprinted polymer-modified HMDE sensor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Blood serum |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Creatinine |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lakshmi, D. |4 aut | |
| 700 | 1 | |a Prasad, B. B. |4 aut | |
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10.1365/s10337-007-0172-3 doi (DE-627)SPR009534199 (SPR)s10337-007-0172-3-e DE-627 ger DE-627 rakwb eng Sharma, P. S. verfasserin aut Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. Molecularly imprinted solid-phase extraction (dpeaa)DE-He213 Imprinted polymer–silica gel (dpeaa)DE-He213 Molecularly imprinted polymer-modified HMDE sensor (dpeaa)DE-He213 Blood serum (dpeaa)DE-He213 Creatinine (dpeaa)DE-He213 Lakshmi, D. aut Prasad, B. B. aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 65(2007), 7-8 vom: 06. Feb., Seite 419-427 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:65 year:2007 number:7-8 day:06 month:02 pages:419-427 https://dx.doi.org/10.1365/s10337-007-0172-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 65 2007 7-8 06 02 419-427 |
| spelling |
10.1365/s10337-007-0172-3 doi (DE-627)SPR009534199 (SPR)s10337-007-0172-3-e DE-627 ger DE-627 rakwb eng Sharma, P. S. verfasserin aut Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. Molecularly imprinted solid-phase extraction (dpeaa)DE-He213 Imprinted polymer–silica gel (dpeaa)DE-He213 Molecularly imprinted polymer-modified HMDE sensor (dpeaa)DE-He213 Blood serum (dpeaa)DE-He213 Creatinine (dpeaa)DE-He213 Lakshmi, D. aut Prasad, B. B. aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 65(2007), 7-8 vom: 06. Feb., Seite 419-427 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:65 year:2007 number:7-8 day:06 month:02 pages:419-427 https://dx.doi.org/10.1365/s10337-007-0172-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 65 2007 7-8 06 02 419-427 |
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10.1365/s10337-007-0172-3 doi (DE-627)SPR009534199 (SPR)s10337-007-0172-3-e DE-627 ger DE-627 rakwb eng Sharma, P. S. verfasserin aut Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. Molecularly imprinted solid-phase extraction (dpeaa)DE-He213 Imprinted polymer–silica gel (dpeaa)DE-He213 Molecularly imprinted polymer-modified HMDE sensor (dpeaa)DE-He213 Blood serum (dpeaa)DE-He213 Creatinine (dpeaa)DE-He213 Lakshmi, D. aut Prasad, B. B. aut Enthalten in Chromatographia Wiesbaden : Vieweg, 1968 65(2007), 7-8 vom: 06. Feb., Seite 419-427 (DE-627)320592219 (DE-600)2019091-8 1612-1112 nnns volume:65 year:2007 number:7-8 day:06 month:02 pages:419-427 https://dx.doi.org/10.1365/s10337-007-0172-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 65 2007 7-8 06 02 419-427 |
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Molecularly imprinted solid-phase extraction Imprinted polymer–silica gel Molecularly imprinted polymer-modified HMDE sensor Blood serum Creatinine |
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Sharma, P. S. @@aut@@ Lakshmi, D. @@aut@@ Prasad, B. B. @@aut@@ |
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Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). 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Sharma, P. S. |
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Sharma, P. S. misc Molecularly imprinted solid-phase extraction misc Imprinted polymer–silica gel misc Molecularly imprinted polymer-modified HMDE sensor misc Blood serum misc Creatinine Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor |
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Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor Molecularly imprinted solid-phase extraction (dpeaa)DE-He213 Imprinted polymer–silica gel (dpeaa)DE-He213 Molecularly imprinted polymer-modified HMDE sensor (dpeaa)DE-He213 Blood serum (dpeaa)DE-He213 Creatinine (dpeaa)DE-He213 |
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misc Molecularly imprinted solid-phase extraction misc Imprinted polymer–silica gel misc Molecularly imprinted polymer-modified HMDE sensor misc Blood serum misc Creatinine |
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misc Molecularly imprinted solid-phase extraction misc Imprinted polymer–silica gel misc Molecularly imprinted polymer-modified HMDE sensor misc Blood serum misc Creatinine |
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misc Molecularly imprinted solid-phase extraction misc Imprinted polymer–silica gel misc Molecularly imprinted polymer-modified HMDE sensor misc Blood serum misc Creatinine |
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Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor |
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Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor |
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Sharma, P. S. Lakshmi, D. Prasad, B. B. |
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Sharma, P. S. |
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10.1365/s10337-007-0172-3 |
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highly sensitive and selective detection of creatinine by combined use of mispe and a complementary mip-sensor |
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Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor |
| abstract |
Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 |
| abstractGer |
Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 |
| abstract_unstemmed |
Abstract Guanidinoacetate methyltransferase deficiency is a recently discovered inborn defect of creatine biosynthesis which reduces serum creatinine concentrations to as low as 0.58 μg $ mL^{−1} $ (or 0.00058 μg $ mL^{−1} $ after 1,000-fold dilution). To measure ultra trace levels of creatinine in diluted samples, molecularly imprinted solid-phase extraction (MISPE) and molecularly imprinted polymer (MIP) sensor techniques have been found to be inadequate. A combination of these techniques (i.e. MISPE hyphenated with use of an MIP-sensor), reported in this paper, has been found to be highly suitable for direct assay of creatinine in highly diluted human blood serum without complicated pretreatment of the sample. The proposed technique has the potential to enhance the sensitivity of creatinine measurement from μg $ mL^{−1} $ to ng $ mL^{−1} $ in highly dilute aqueous samples in which the concentrations of interfering constituents are reduced to negligible levels. In this work the sensitivity to creatinine was found to be improved compared with that of the MIP-sensor method alone (limit of detection, LOD, 0.00149 μg $ mL^{−1} $). After preconcentration by MISPE and use of the sensor the detection limit for creatinine was as low as 0.00003 μg $ mL^{−1} $ (RSD = 0.94%, S/N = 3; 50-fold preconcentration factor) in aqueous samples. © Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH 2007 |
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| container_issue |
7-8 |
| title_short |
Highly Sensitive and Selective Detection of Creatinine by Combined Use of MISPE and a Complementary MIP-Sensor |
| url |
https://dx.doi.org/10.1365/s10337-007-0172-3 |
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Lakshmi, D. Prasad, B. B. |
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| doi_str |
10.1365/s10337-007-0172-3 |
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2024-07-04T02:25:47.707Z |
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| score |
7.400219 |