Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study

PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 22...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hara, Masayasu [verfasserIn] Kanemitsu, Yukihide [verfasserIn] Hirai, Takashi [verfasserIn] Komori, Koji [verfasserIn] Kato, Tomoyuki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	Enthalten in: Diseases of the colon & rectum - Hagerstown, Md. : Lippincott Williams & Wilkins, 1958, 51(2008), 11 vom: 17. Juli
Übergeordnetes Werk:	volume:51 ; year:2008 ; number:11 ; day:17 ; month:07

Links:	Volltext

DOI / URN:	10.1007/s10350-008-9406-1

Katalog-ID:	SPR009815848

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245	1	0	\|a Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
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520			\|a PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence.
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700	1		\|a Hirai, Takashi \|e verfasserin \|4 aut
700	1		\|a Komori, Koji \|e verfasserin \|4 aut
700	1		\|a Kato, Tomoyuki \|e verfasserin \|4 aut
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matchkey_str	article:15300358:2008----::eaieeucriomroiatgnaisfiinacrcfrxldnrcrecfoptetwtdksclrcacneaayiwtlklh
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publishDate	2008
allfields	10.1007/s10350-008-9406-1 doi (DE-627)SPR009815848 (SPR)s10350-008-9406-1-e DE-627 ger DE-627 rakwb eng 610 ASE 150 610 ASE 44.87 bkl Hara, Masayasu verfasserin aut Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence. Kanemitsu, Yukihide verfasserin aut Hirai, Takashi verfasserin aut Komori, Koji verfasserin aut Kato, Tomoyuki verfasserin aut Enthalten in Diseases of the colon & rectum Hagerstown, Md. : Lippincott Williams & Wilkins, 1958 51(2008), 11 vom: 17. Juli (DE-627)329270540 (DE-600)2046914-7 1530-0358 nnns volume:51 year:2008 number:11 day:17 month:07 https://dx.doi.org/10.1007/s10350-008-9406-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_266 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2758 GBV_ILN_2869 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 44.87 ASE AR 51 2008 11 17 07
spelling	10.1007/s10350-008-9406-1 doi (DE-627)SPR009815848 (SPR)s10350-008-9406-1-e DE-627 ger DE-627 rakwb eng 610 ASE 150 610 ASE 44.87 bkl Hara, Masayasu verfasserin aut Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence. Kanemitsu, Yukihide verfasserin aut Hirai, Takashi verfasserin aut Komori, Koji verfasserin aut Kato, Tomoyuki verfasserin aut Enthalten in Diseases of the colon & rectum Hagerstown, Md. : Lippincott Williams & Wilkins, 1958 51(2008), 11 vom: 17. Juli (DE-627)329270540 (DE-600)2046914-7 1530-0358 nnns volume:51 year:2008 number:11 day:17 month:07 https://dx.doi.org/10.1007/s10350-008-9406-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_266 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2758 GBV_ILN_2869 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 44.87 ASE AR 51 2008 11 17 07
allfields_unstemmed	10.1007/s10350-008-9406-1 doi (DE-627)SPR009815848 (SPR)s10350-008-9406-1-e DE-627 ger DE-627 rakwb eng 610 ASE 150 610 ASE 44.87 bkl Hara, Masayasu verfasserin aut Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence. Kanemitsu, Yukihide verfasserin aut Hirai, Takashi verfasserin aut Komori, Koji verfasserin aut Kato, Tomoyuki verfasserin aut Enthalten in Diseases of the colon & rectum Hagerstown, Md. : Lippincott Williams & Wilkins, 1958 51(2008), 11 vom: 17. Juli (DE-627)329270540 (DE-600)2046914-7 1530-0358 nnns volume:51 year:2008 number:11 day:17 month:07 https://dx.doi.org/10.1007/s10350-008-9406-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_266 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2758 GBV_ILN_2869 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 44.87 ASE AR 51 2008 11 17 07
allfieldsGer	10.1007/s10350-008-9406-1 doi (DE-627)SPR009815848 (SPR)s10350-008-9406-1-e DE-627 ger DE-627 rakwb eng 610 ASE 150 610 ASE 44.87 bkl Hara, Masayasu verfasserin aut Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence. Kanemitsu, Yukihide verfasserin aut Hirai, Takashi verfasserin aut Komori, Koji verfasserin aut Kato, Tomoyuki verfasserin aut Enthalten in Diseases of the colon & rectum Hagerstown, Md. : Lippincott Williams & Wilkins, 1958 51(2008), 11 vom: 17. Juli (DE-627)329270540 (DE-600)2046914-7 1530-0358 nnns volume:51 year:2008 number:11 day:17 month:07 https://dx.doi.org/10.1007/s10350-008-9406-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_266 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2758 GBV_ILN_2869 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 44.87 ASE AR 51 2008 11 17 07
allfieldsSound	10.1007/s10350-008-9406-1 doi (DE-627)SPR009815848 (SPR)s10350-008-9406-1-e DE-627 ger DE-627 rakwb eng 610 ASE 150 610 ASE 44.87 bkl Hara, Masayasu verfasserin aut Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence. Kanemitsu, Yukihide verfasserin aut Hirai, Takashi verfasserin aut Komori, Koji verfasserin aut Kato, Tomoyuki verfasserin aut Enthalten in Diseases of the colon & rectum Hagerstown, Md. : Lippincott Williams & Wilkins, 1958 51(2008), 11 vom: 17. Juli (DE-627)329270540 (DE-600)2046914-7 1530-0358 nnns volume:51 year:2008 number:11 day:17 month:07 https://dx.doi.org/10.1007/s10350-008-9406-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_266 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2758 GBV_ILN_2869 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 44.87 ASE AR 51 2008 11 17 07
language	English
source	Enthalten in Diseases of the colon & rectum 51(2008), 11 vom: 17. Juli volume:51 year:2008 number:11 day:17 month:07
sourceStr	Enthalten in Diseases of the colon & rectum 51(2008), 11 vom: 17. Juli volume:51 year:2008 number:11 day:17 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
dewey-raw	610
isfreeaccess_bool	false
container_title	Diseases of the colon & rectum
authorswithroles_txt_mv	Hara, Masayasu @@aut@@ Kanemitsu, Yukihide @@aut@@ Hirai, Takashi @@aut@@ Komori, Koji @@aut@@ Kato, Tomoyuki @@aut@@
publishDateDaySort_date	2008-07-17T00:00:00Z
hierarchy_top_id	329270540
dewey-sort	3610
id	SPR009815848
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009815848</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519073309.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2008 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10350-008-9406-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009815848</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10350-008-9406-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">150</subfield><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.87</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hara, Masayasu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kanemitsu, Yukihide</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hirai, Takashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Komori, Koji</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kato, Tomoyuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Diseases of the colon & rectum</subfield><subfield code="d">Hagerstown, Md. : Lippincott Williams & Wilkins, 1958</subfield><subfield code="g">51(2008), 11 vom: 17. 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author	Hara, Masayasu
spellingShingle	Hara, Masayasu ddc 610 ddc 150 bkl 44.87 Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
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topic_title	610 ASE 150 610 ASE 44.87 bkl Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
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title	Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
ctrlnum	(DE-627)SPR009815848 (SPR)s10350-008-9406-1-e
title_full	Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
author_sort	Hara, Masayasu
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author_browse	Hara, Masayasu Kanemitsu, Yukihide Hirai, Takashi Komori, Koji Kato, Tomoyuki
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title_sort	negative serum carcinoembryonic antigen has insufficient accuracy for excluding recurrence from patients with dukes c colorectal cancer: analysis with likelihood ratio and posttest probability in a follow-up study
title_auth	Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
abstract	PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence.
abstractGer	PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence.
abstract_unstemmed	PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. CONCLUSIONS Whereas postoperative CEA elevation indicates recurrence with high probability, a normal postoperative CEA is not useful for excluding the probability of recurrence.
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title_short	Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study
url	https://dx.doi.org/10.1007/s10350-008-9406-1
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author2	Kanemitsu, Yukihide Hirai, Takashi Komori, Koji Kato, Tomoyuki
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doi_str	10.1007/s10350-008-9406-1
up_date	2024-07-04T03:09:43.232Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009815848</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519073309.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2008 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10350-008-9406-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009815848</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10350-008-9406-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">150</subfield><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.87</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hara, Masayasu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">PURPOSE This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence. METHODS For this study, 348 (preoperative serum CEA level elevated: CEA+, n = 119; or normal: CEA−, n = 229) patients who had undergone potentially curative surgery for colorectal cancer were enrolled. After five-year follow-up with measurements of serum CEA levels and imaging workup, posttest probabilities of recurrence were calculated. RESULTS Recurrence was observed in 39 percent of CEA+ patients and 30 percent in CEA− patients, and CEA levels were elevated in 33.3 percent of CEA+ patients and 17.5 percent of CEA− patients. With obtained sensitivity (68.4 percent, CEA+; 41 percent, CEA−), specificity (83 percent, CEA+; 91 percent, CEA−) and likelihood ratio (test positive: 4.0, CEA+; 4.4, CEA−; and test negative: 0.38, CEA+; 0.66, CEA−), posttest probability given the presence of CEA elevation in the CEA+ and CEA− was 72.2 and 65.5 percent, respectively, and that given the absence of CEA elevation was 20 and 22.2 percent, respectively. 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Negative Serum Carcinoembryonic Antigen has Insufficient Accuracy for Excluding Recurrence from Patients with Dukes C Colorectal Cancer: Analysis with Likelihood Ratio and Posttest Probability in a Follow-Up Study

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