The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients
Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary bre...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Taucher, S. [verfasserIn] Rudas, M. [verfasserIn] Gnant, M. [verfasserIn] Dubsky, P. [verfasserIn] Sporn, E. [verfasserIn] Roka, S. [verfasserIn] Bachleitner, T. [verfasserIn] Fitzal, F. [verfasserIn] Kandioler, D. [verfasserIn] Wenzel, C. [verfasserIn] Steger, G. [verfasserIn] Draxler, W. [verfasserIn] Mittlböck, M. [verfasserIn] Jakesz, R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European surgery - Wien : Springer, 2002, 36(2004), 1 vom: 01. Feb., Seite 41-45 |
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| Übergeordnetes Werk: |
volume:36 ; year:2004 ; number:1 ; day:01 ; month:02 ; pages:41-45 |
| Links: |
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| DOI / URN: |
10.1007/s10353-004-0028-0 |
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| Katalog-ID: |
SPR009822984 |
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| 245 | 1 | 4 | |a The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
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| 520 | |a Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. | ||
| 650 | 4 | |a Breast cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Core needle biopsy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Estrogen receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Progesterone receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Preoperative chemotherapy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Rudas, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Gnant, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Dubsky, P. |e verfasserin |4 aut | |
| 700 | 1 | |a Sporn, E. |e verfasserin |4 aut | |
| 700 | 1 | |a Roka, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Bachleitner, T. |e verfasserin |4 aut | |
| 700 | 1 | |a Fitzal, F. |e verfasserin |4 aut | |
| 700 | 1 | |a Kandioler, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Wenzel, C. |e verfasserin |4 aut | |
| 700 | 1 | |a Steger, G. |e verfasserin |4 aut | |
| 700 | 1 | |a Draxler, W. |e verfasserin |4 aut | |
| 700 | 1 | |a Mittlböck, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Jakesz, R. |e verfasserin |4 aut | |
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10.1007/s10353-004-0028-0 doi (DE-627)SPR009822984 (SPR)s10353-004-0028-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Taucher, S. verfasserin aut The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. Breast cancer (dpeaa)DE-He213 Core needle biopsy (dpeaa)DE-He213 Estrogen receptor (dpeaa)DE-He213 Progesterone receptor (dpeaa)DE-He213 Preoperative chemotherapy (dpeaa)DE-He213 Rudas, M. verfasserin aut Gnant, M. verfasserin aut Dubsky, P. verfasserin aut Sporn, E. verfasserin aut Roka, S. verfasserin aut Bachleitner, T. verfasserin aut Fitzal, F. verfasserin aut Kandioler, D. verfasserin aut Wenzel, C. verfasserin aut Steger, G. verfasserin aut Draxler, W. verfasserin aut Mittlböck, M. verfasserin aut Jakesz, R. verfasserin aut Enthalten in European surgery Wien : Springer, 2002 36(2004), 1 vom: 01. Feb., Seite 41-45 (DE-627)324655363 (DE-600)2029279-X 1682-4016 nnns volume:36 year:2004 number:1 day:01 month:02 pages:41-45 https://dx.doi.org/10.1007/s10353-004-0028-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 36 2004 1 01 02 41-45 |
| spelling |
10.1007/s10353-004-0028-0 doi (DE-627)SPR009822984 (SPR)s10353-004-0028-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Taucher, S. verfasserin aut The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. Breast cancer (dpeaa)DE-He213 Core needle biopsy (dpeaa)DE-He213 Estrogen receptor (dpeaa)DE-He213 Progesterone receptor (dpeaa)DE-He213 Preoperative chemotherapy (dpeaa)DE-He213 Rudas, M. verfasserin aut Gnant, M. verfasserin aut Dubsky, P. verfasserin aut Sporn, E. verfasserin aut Roka, S. verfasserin aut Bachleitner, T. verfasserin aut Fitzal, F. verfasserin aut Kandioler, D. verfasserin aut Wenzel, C. verfasserin aut Steger, G. verfasserin aut Draxler, W. verfasserin aut Mittlböck, M. verfasserin aut Jakesz, R. verfasserin aut Enthalten in European surgery Wien : Springer, 2002 36(2004), 1 vom: 01. Feb., Seite 41-45 (DE-627)324655363 (DE-600)2029279-X 1682-4016 nnns volume:36 year:2004 number:1 day:01 month:02 pages:41-45 https://dx.doi.org/10.1007/s10353-004-0028-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 36 2004 1 01 02 41-45 |
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10.1007/s10353-004-0028-0 doi (DE-627)SPR009822984 (SPR)s10353-004-0028-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Taucher, S. verfasserin aut The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. Breast cancer (dpeaa)DE-He213 Core needle biopsy (dpeaa)DE-He213 Estrogen receptor (dpeaa)DE-He213 Progesterone receptor (dpeaa)DE-He213 Preoperative chemotherapy (dpeaa)DE-He213 Rudas, M. verfasserin aut Gnant, M. verfasserin aut Dubsky, P. verfasserin aut Sporn, E. verfasserin aut Roka, S. verfasserin aut Bachleitner, T. verfasserin aut Fitzal, F. verfasserin aut Kandioler, D. verfasserin aut Wenzel, C. verfasserin aut Steger, G. verfasserin aut Draxler, W. verfasserin aut Mittlböck, M. verfasserin aut Jakesz, R. verfasserin aut Enthalten in European surgery Wien : Springer, 2002 36(2004), 1 vom: 01. Feb., Seite 41-45 (DE-627)324655363 (DE-600)2029279-X 1682-4016 nnns volume:36 year:2004 number:1 day:01 month:02 pages:41-45 https://dx.doi.org/10.1007/s10353-004-0028-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 36 2004 1 01 02 41-45 |
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10.1007/s10353-004-0028-0 doi (DE-627)SPR009822984 (SPR)s10353-004-0028-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Taucher, S. verfasserin aut The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. Breast cancer (dpeaa)DE-He213 Core needle biopsy (dpeaa)DE-He213 Estrogen receptor (dpeaa)DE-He213 Progesterone receptor (dpeaa)DE-He213 Preoperative chemotherapy (dpeaa)DE-He213 Rudas, M. verfasserin aut Gnant, M. verfasserin aut Dubsky, P. verfasserin aut Sporn, E. verfasserin aut Roka, S. verfasserin aut Bachleitner, T. verfasserin aut Fitzal, F. verfasserin aut Kandioler, D. verfasserin aut Wenzel, C. verfasserin aut Steger, G. verfasserin aut Draxler, W. verfasserin aut Mittlböck, M. verfasserin aut Jakesz, R. verfasserin aut Enthalten in European surgery Wien : Springer, 2002 36(2004), 1 vom: 01. Feb., Seite 41-45 (DE-627)324655363 (DE-600)2029279-X 1682-4016 nnns volume:36 year:2004 number:1 day:01 month:02 pages:41-45 https://dx.doi.org/10.1007/s10353-004-0028-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 36 2004 1 01 02 41-45 |
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10.1007/s10353-004-0028-0 doi (DE-627)SPR009822984 (SPR)s10353-004-0028-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Taucher, S. verfasserin aut The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. Breast cancer (dpeaa)DE-He213 Core needle biopsy (dpeaa)DE-He213 Estrogen receptor (dpeaa)DE-He213 Progesterone receptor (dpeaa)DE-He213 Preoperative chemotherapy (dpeaa)DE-He213 Rudas, M. verfasserin aut Gnant, M. verfasserin aut Dubsky, P. verfasserin aut Sporn, E. verfasserin aut Roka, S. verfasserin aut Bachleitner, T. verfasserin aut Fitzal, F. verfasserin aut Kandioler, D. verfasserin aut Wenzel, C. verfasserin aut Steger, G. verfasserin aut Draxler, W. verfasserin aut Mittlböck, M. verfasserin aut Jakesz, R. verfasserin aut Enthalten in European surgery Wien : Springer, 2002 36(2004), 1 vom: 01. Feb., Seite 41-45 (DE-627)324655363 (DE-600)2029279-X 1682-4016 nnns volume:36 year:2004 number:1 day:01 month:02 pages:41-45 https://dx.doi.org/10.1007/s10353-004-0028-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 36 2004 1 01 02 41-45 |
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English |
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Enthalten in European surgery 36(2004), 1 vom: 01. Feb., Seite 41-45 volume:36 year:2004 number:1 day:01 month:02 pages:41-45 |
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Enthalten in European surgery 36(2004), 1 vom: 01. Feb., Seite 41-45 volume:36 year:2004 number:1 day:01 month:02 pages:41-45 |
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Breast cancer Core needle biopsy Estrogen receptor Progesterone receptor Preoperative chemotherapy |
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European surgery |
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Taucher, S. @@aut@@ Rudas, M. @@aut@@ Gnant, M. @@aut@@ Dubsky, P. @@aut@@ Sporn, E. @@aut@@ Roka, S. @@aut@@ Bachleitner, T. @@aut@@ Fitzal, F. @@aut@@ Kandioler, D. @@aut@@ Wenzel, C. @@aut@@ Steger, G. @@aut@@ Draxler, W. @@aut@@ Mittlböck, M. @@aut@@ Jakesz, R. @@aut@@ |
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2004-02-01T00:00:00Z |
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The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. 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Taucher, S. |
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Taucher, S. ddc 610 bkl 44.65 misc Breast cancer misc Core needle biopsy misc Estrogen receptor misc Progesterone receptor misc Preoperative chemotherapy The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
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610 ASE 44.65 bkl The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients Breast cancer (dpeaa)DE-He213 Core needle biopsy (dpeaa)DE-He213 Estrogen receptor (dpeaa)DE-He213 Progesterone receptor (dpeaa)DE-He213 Preoperative chemotherapy (dpeaa)DE-He213 |
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ddc 610 bkl 44.65 misc Breast cancer misc Core needle biopsy misc Estrogen receptor misc Progesterone receptor misc Preoperative chemotherapy |
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ddc 610 bkl 44.65 misc Breast cancer misc Core needle biopsy misc Estrogen receptor misc Progesterone receptor misc Preoperative chemotherapy |
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ddc 610 bkl 44.65 misc Breast cancer misc Core needle biopsy misc Estrogen receptor misc Progesterone receptor misc Preoperative chemotherapy |
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The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
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The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
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Taucher, S. |
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European surgery |
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Taucher, S. Rudas, M. Gnant, M. Dubsky, P. Sporn, E. Roka, S. Bachleitner, T. Fitzal, F. Kandioler, D. Wenzel, C. Steger, G. Draxler, W. Mittlböck, M. Jakesz, R. |
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Taucher, S. |
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impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
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The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
| abstract |
Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. |
| abstractGer |
Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. |
| abstract_unstemmed |
Summary BACKGROUND: The benefit of preoperative chemotherapy on outcome in breast cancer has been shown to be highest in patients with complete pathological response (pCR). The objective of this analysis was to determine the predictive value of progesterone receptor status on pCR rate in primary breast cancer patients receiving preoperative chemotherapy. METHODS: Preoperative chemotherapy was administered to 213 patients with primary breast cancer. We assessed the predictive impact of estrogen (ER) and progesterone receptor (PR) in biopsy tissue on response to preoperative chemotherapy. The association of steroid receptor status and pCR was tested by Fisher's exact and Chi-square test. RESULTS: pCR was achieved in 23 patients (10.8%). All patients experiencing pCR were PR negative (100%). ER and PR negativity was significantly associated with pCR, p = 0.00028 and p = 0.0003, respectively. CONCLUSIONS: We conclude from our results that ER and PR negativity represent valuable markers predicting pCR after primary chemotherapy. In PR-positive breast cancer patients, no single case of pCR was observed; therefore, we may recommend no preoperative chemotherapy in PR-positive patients. |
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The impact of progesterone receptor in prediction of complete pathological response to preoperative chemotherapy in primary breast cancer patients |
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Rudas, M. Gnant, M. Dubsky, P. Sporn, E. Roka, S. Bachleitner, T. Fitzal, F. Kandioler, D. Wenzel, C. Steger, G. Draxler, W. Mittlböck, M. Jakesz, R. |
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Rudas, M. Gnant, M. Dubsky, P. Sporn, E. Roka, S. Bachleitner, T. Fitzal, F. Kandioler, D. Wenzel, C. Steger, G. Draxler, W. Mittlböck, M. Jakesz, R. |
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| score |
7.39892 |