Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas
Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) pos...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kesmodel, Susan B. [verfasserIn] Karakousis, Giorgos C. [verfasserIn] Botbyl, Jeffrey D. [verfasserIn] Canter, Robert J. [verfasserIn] Lewis, Robert T. [verfasserIn] Wahl, Peter M. [verfasserIn] Terhune, Kyla P. [verfasserIn] Alavi, Abass [verfasserIn] Elder, David E. [verfasserIn] Ming, Michael E. [verfasserIn] Guerry, DuPont [verfasserIn] Gimotty, Phyllis A. [verfasserIn] Fraker, Douglas L. [verfasserIn] Czerniecki, Brian J. [verfasserIn] Spitz, Francis R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2005 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Annals of surgical oncology - Berlin [u.a.] : Springer, 1994, 12(2005), 6 vom: 19. Apr., Seite 449-458 |
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| Übergeordnetes Werk: |
volume:12 ; year:2005 ; number:6 ; day:19 ; month:04 ; pages:449-458 |
| Links: |
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| DOI / URN: |
10.1245/ASO.2005.04.027 |
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| Katalog-ID: |
SPR009915583 |
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| 100 | 1 | |a Kesmodel, Susan B. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas |
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| 520 | |a Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. | ||
| 650 | 4 | |a Thin melanomas |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sentinel lymphadenectomy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mitotic rate |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tumor-thickness |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a SLN positivity |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Karakousis, Giorgos C. |e verfasserin |4 aut | |
| 700 | 1 | |a Botbyl, Jeffrey D. |e verfasserin |4 aut | |
| 700 | 1 | |a Canter, Robert J. |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Robert T. |e verfasserin |4 aut | |
| 700 | 1 | |a Wahl, Peter M. |e verfasserin |4 aut | |
| 700 | 1 | |a Terhune, Kyla P. |e verfasserin |4 aut | |
| 700 | 1 | |a Alavi, Abass |e verfasserin |4 aut | |
| 700 | 1 | |a Elder, David E. |e verfasserin |4 aut | |
| 700 | 1 | |a Ming, Michael E. |e verfasserin |4 aut | |
| 700 | 1 | |a Guerry, DuPont |e verfasserin |4 aut | |
| 700 | 1 | |a Gimotty, Phyllis A. |e verfasserin |4 aut | |
| 700 | 1 | |a Fraker, Douglas L. |e verfasserin |4 aut | |
| 700 | 1 | |a Czerniecki, Brian J. |e verfasserin |4 aut | |
| 700 | 1 | |a Spitz, Francis R. |e verfasserin |4 aut | |
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10.1245/ASO.2005.04.027 doi (DE-627)SPR009915583 (SPR)ASO.2005.04.027-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kesmodel, Susan B. verfasserin aut Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. Thin melanomas (dpeaa)DE-He213 Sentinel lymphadenectomy (dpeaa)DE-He213 Mitotic rate (dpeaa)DE-He213 Tumor-thickness (dpeaa)DE-He213 SLN positivity (dpeaa)DE-He213 Karakousis, Giorgos C. verfasserin aut Botbyl, Jeffrey D. verfasserin aut Canter, Robert J. verfasserin aut Lewis, Robert T. verfasserin aut Wahl, Peter M. verfasserin aut Terhune, Kyla P. verfasserin aut Alavi, Abass verfasserin aut Elder, David E. verfasserin aut Ming, Michael E. verfasserin aut Guerry, DuPont verfasserin aut Gimotty, Phyllis A. verfasserin aut Fraker, Douglas L. verfasserin aut Czerniecki, Brian J. verfasserin aut Spitz, Francis R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 12(2005), 6 vom: 19. Apr., Seite 449-458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:12 year:2005 number:6 day:19 month:04 pages:449-458 https://dx.doi.org/10.1245/ASO.2005.04.027 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 12 2005 6 19 04 449-458 |
| spelling |
10.1245/ASO.2005.04.027 doi (DE-627)SPR009915583 (SPR)ASO.2005.04.027-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kesmodel, Susan B. verfasserin aut Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. Thin melanomas (dpeaa)DE-He213 Sentinel lymphadenectomy (dpeaa)DE-He213 Mitotic rate (dpeaa)DE-He213 Tumor-thickness (dpeaa)DE-He213 SLN positivity (dpeaa)DE-He213 Karakousis, Giorgos C. verfasserin aut Botbyl, Jeffrey D. verfasserin aut Canter, Robert J. verfasserin aut Lewis, Robert T. verfasserin aut Wahl, Peter M. verfasserin aut Terhune, Kyla P. verfasserin aut Alavi, Abass verfasserin aut Elder, David E. verfasserin aut Ming, Michael E. verfasserin aut Guerry, DuPont verfasserin aut Gimotty, Phyllis A. verfasserin aut Fraker, Douglas L. verfasserin aut Czerniecki, Brian J. verfasserin aut Spitz, Francis R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 12(2005), 6 vom: 19. Apr., Seite 449-458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:12 year:2005 number:6 day:19 month:04 pages:449-458 https://dx.doi.org/10.1245/ASO.2005.04.027 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 12 2005 6 19 04 449-458 |
| allfields_unstemmed |
10.1245/ASO.2005.04.027 doi (DE-627)SPR009915583 (SPR)ASO.2005.04.027-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kesmodel, Susan B. verfasserin aut Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. Thin melanomas (dpeaa)DE-He213 Sentinel lymphadenectomy (dpeaa)DE-He213 Mitotic rate (dpeaa)DE-He213 Tumor-thickness (dpeaa)DE-He213 SLN positivity (dpeaa)DE-He213 Karakousis, Giorgos C. verfasserin aut Botbyl, Jeffrey D. verfasserin aut Canter, Robert J. verfasserin aut Lewis, Robert T. verfasserin aut Wahl, Peter M. verfasserin aut Terhune, Kyla P. verfasserin aut Alavi, Abass verfasserin aut Elder, David E. verfasserin aut Ming, Michael E. verfasserin aut Guerry, DuPont verfasserin aut Gimotty, Phyllis A. verfasserin aut Fraker, Douglas L. verfasserin aut Czerniecki, Brian J. verfasserin aut Spitz, Francis R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 12(2005), 6 vom: 19. Apr., Seite 449-458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:12 year:2005 number:6 day:19 month:04 pages:449-458 https://dx.doi.org/10.1245/ASO.2005.04.027 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 12 2005 6 19 04 449-458 |
| allfieldsGer |
10.1245/ASO.2005.04.027 doi (DE-627)SPR009915583 (SPR)ASO.2005.04.027-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kesmodel, Susan B. verfasserin aut Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. Thin melanomas (dpeaa)DE-He213 Sentinel lymphadenectomy (dpeaa)DE-He213 Mitotic rate (dpeaa)DE-He213 Tumor-thickness (dpeaa)DE-He213 SLN positivity (dpeaa)DE-He213 Karakousis, Giorgos C. verfasserin aut Botbyl, Jeffrey D. verfasserin aut Canter, Robert J. verfasserin aut Lewis, Robert T. verfasserin aut Wahl, Peter M. verfasserin aut Terhune, Kyla P. verfasserin aut Alavi, Abass verfasserin aut Elder, David E. verfasserin aut Ming, Michael E. verfasserin aut Guerry, DuPont verfasserin aut Gimotty, Phyllis A. verfasserin aut Fraker, Douglas L. verfasserin aut Czerniecki, Brian J. verfasserin aut Spitz, Francis R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 12(2005), 6 vom: 19. Apr., Seite 449-458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:12 year:2005 number:6 day:19 month:04 pages:449-458 https://dx.doi.org/10.1245/ASO.2005.04.027 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 12 2005 6 19 04 449-458 |
| allfieldsSound |
10.1245/ASO.2005.04.027 doi (DE-627)SPR009915583 (SPR)ASO.2005.04.027-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kesmodel, Susan B. verfasserin aut Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. Thin melanomas (dpeaa)DE-He213 Sentinel lymphadenectomy (dpeaa)DE-He213 Mitotic rate (dpeaa)DE-He213 Tumor-thickness (dpeaa)DE-He213 SLN positivity (dpeaa)DE-He213 Karakousis, Giorgos C. verfasserin aut Botbyl, Jeffrey D. verfasserin aut Canter, Robert J. verfasserin aut Lewis, Robert T. verfasserin aut Wahl, Peter M. verfasserin aut Terhune, Kyla P. verfasserin aut Alavi, Abass verfasserin aut Elder, David E. verfasserin aut Ming, Michael E. verfasserin aut Guerry, DuPont verfasserin aut Gimotty, Phyllis A. verfasserin aut Fraker, Douglas L. verfasserin aut Czerniecki, Brian J. verfasserin aut Spitz, Francis R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 12(2005), 6 vom: 19. Apr., Seite 449-458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:12 year:2005 number:6 day:19 month:04 pages:449-458 https://dx.doi.org/10.1245/ASO.2005.04.027 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 12 2005 6 19 04 449-458 |
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Enthalten in Annals of surgical oncology 12(2005), 6 vom: 19. Apr., Seite 449-458 volume:12 year:2005 number:6 day:19 month:04 pages:449-458 |
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Enthalten in Annals of surgical oncology 12(2005), 6 vom: 19. Apr., Seite 449-458 volume:12 year:2005 number:6 day:19 month:04 pages:449-458 |
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Thin melanomas Sentinel lymphadenectomy Mitotic rate Tumor-thickness SLN positivity |
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Kesmodel, Susan B. @@aut@@ Karakousis, Giorgos C. @@aut@@ Botbyl, Jeffrey D. @@aut@@ Canter, Robert J. @@aut@@ Lewis, Robert T. @@aut@@ Wahl, Peter M. @@aut@@ Terhune, Kyla P. @@aut@@ Alavi, Abass @@aut@@ Elder, David E. @@aut@@ Ming, Michael E. @@aut@@ Guerry, DuPont @@aut@@ Gimotty, Phyllis A. @@aut@@ Fraker, Douglas L. @@aut@@ Czerniecki, Brian J. @@aut@@ Spitz, Francis R. @@aut@@ |
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Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. 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Kesmodel, Susan B. |
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Kesmodel, Susan B. ddc 610 bkl 44.81 bkl 44.65 misc Thin melanomas misc Sentinel lymphadenectomy misc Mitotic rate misc Tumor-thickness misc SLN positivity Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas |
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610 ASE 44.81 bkl 44.65 bkl Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas Thin melanomas (dpeaa)DE-He213 Sentinel lymphadenectomy (dpeaa)DE-He213 Mitotic rate (dpeaa)DE-He213 Tumor-thickness (dpeaa)DE-He213 SLN positivity (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.65 misc Thin melanomas misc Sentinel lymphadenectomy misc Mitotic rate misc Tumor-thickness misc SLN positivity |
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ddc 610 bkl 44.81 bkl 44.65 misc Thin melanomas misc Sentinel lymphadenectomy misc Mitotic rate misc Tumor-thickness misc SLN positivity |
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ddc 610 bkl 44.81 bkl 44.65 misc Thin melanomas misc Sentinel lymphadenectomy misc Mitotic rate misc Tumor-thickness misc SLN positivity |
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Annals of surgical oncology |
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Annals of surgical oncology |
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Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas |
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(DE-627)SPR009915583 (SPR)ASO.2005.04.027-e |
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Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas |
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Kesmodel, Susan B. |
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Annals of surgical oncology |
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Annals of surgical oncology |
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2005 |
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Kesmodel, Susan B. Karakousis, Giorgos C. Botbyl, Jeffrey D. Canter, Robert J. Lewis, Robert T. Wahl, Peter M. Terhune, Kyla P. Alavi, Abass Elder, David E. Ming, Michael E. Guerry, DuPont Gimotty, Phyllis A. Fraker, Douglas L. Czerniecki, Brian J. Spitz, Francis R. |
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Elektronische Aufsätze |
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Kesmodel, Susan B. |
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10.1245/ASO.2005.04.027 |
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610 |
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verfasserin |
| title_sort |
mitotic rate as a predictor of sentinel lymph nodepositivity in patients with thin melanomas |
| title_auth |
Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas |
| abstract |
Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. |
| abstractGer |
Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. |
| abstract_unstemmed |
Background Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients. |
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Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin Melanomas |
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Karakousis, Giorgos C. Botbyl, Jeffrey D. Canter, Robert J. Lewis, Robert T. Wahl, Peter M. Terhune, Kyla P. Alavi, Abass Elder, David E. Ming, Michael E. Guerry, DuPont Gimotty, Phyllis A. Fraker, Douglas L. Czerniecki, Brian J. Spitz, Francis R. |
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10.1245/ASO.2005.04.027 |
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Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL. Methods Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were defined on the basis of the development of a classification tree. Results The overall SLN positivity rate was 5%. All patients with positive SLNs had an MR of >0. By univariate analysis, MR and thickness were significant predictors of SLN positivity. The association between MR and SLN positivity remained significant controlling for each of the other variables evaluated. On the basis of a classification tree, patients with an MR >0 and tumor thickness ≥.76 mm were identified as a higher-risk group, with an SLN positivity rate of 12.3%. Conclusions In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. 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|
| score |
7.401101 |