Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients
Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also prelimi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
van der Vorst, Joost R. [verfasserIn] Schaafsma, Boudewijn E. [verfasserIn] Verbeek, Floris P. R. [verfasserIn] Hutteman, Merlijn [verfasserIn] Mieog, J. Sven D. [verfasserIn] Lowik, Clemens W. G. M. [verfasserIn] Liefers, Gerrit-Jan [verfasserIn] Frangioni, John V. [verfasserIn] van de Velde, Cornelis J. H. [verfasserIn] Vahrmeijer, Alexander L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Annals of surgical oncology - Berlin [u.a.] : Springer, 1994, 19(2012), 13 vom: 03. Juli, Seite 4104-4111 |
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| Übergeordnetes Werk: |
volume:19 ; year:2012 ; number:13 ; day:03 ; month:07 ; pages:4104-4111 |
| Links: |
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| DOI / URN: |
10.1245/s10434-012-2466-4 |
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| Katalog-ID: |
SPR009948295 |
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| 100 | 1 | |a van der Vorst, Joost R. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients |
| 264 | 1 | |c 2012 | |
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| 520 | |a Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. | ||
| 650 | 4 | |a Sentinel Lymph Node |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sentinel Lymph Node Biopsy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gamma Probe |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sentinel Lymph Node Mapping |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sentinel Lymph Node Detection |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Schaafsma, Boudewijn E. |e verfasserin |4 aut | |
| 700 | 1 | |a Verbeek, Floris P. R. |e verfasserin |4 aut | |
| 700 | 1 | |a Hutteman, Merlijn |e verfasserin |4 aut | |
| 700 | 1 | |a Mieog, J. Sven D. |e verfasserin |4 aut | |
| 700 | 1 | |a Lowik, Clemens W. G. M. |e verfasserin |4 aut | |
| 700 | 1 | |a Liefers, Gerrit-Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Frangioni, John V. |e verfasserin |4 aut | |
| 700 | 1 | |a van de Velde, Cornelis J. H. |e verfasserin |4 aut | |
| 700 | 1 | |a Vahrmeijer, Alexander L. |e verfasserin |4 aut | |
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10.1245/s10434-012-2466-4 doi (DE-627)SPR009948295 (SPR)s10434-012-2466-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl van der Vorst, Joost R. verfasserin aut Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. Sentinel Lymph Node (dpeaa)DE-He213 Sentinel Lymph Node Biopsy (dpeaa)DE-He213 Gamma Probe (dpeaa)DE-He213 Sentinel Lymph Node Mapping (dpeaa)DE-He213 Sentinel Lymph Node Detection (dpeaa)DE-He213 Schaafsma, Boudewijn E. verfasserin aut Verbeek, Floris P. R. verfasserin aut Hutteman, Merlijn verfasserin aut Mieog, J. Sven D. verfasserin aut Lowik, Clemens W. G. M. verfasserin aut Liefers, Gerrit-Jan verfasserin aut Frangioni, John V. verfasserin aut van de Velde, Cornelis J. H. verfasserin aut Vahrmeijer, Alexander L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 13 vom: 03. Juli, Seite 4104-4111 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 https://dx.doi.org/10.1245/s10434-012-2466-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 13 03 07 4104-4111 |
| spelling |
10.1245/s10434-012-2466-4 doi (DE-627)SPR009948295 (SPR)s10434-012-2466-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl van der Vorst, Joost R. verfasserin aut Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. Sentinel Lymph Node (dpeaa)DE-He213 Sentinel Lymph Node Biopsy (dpeaa)DE-He213 Gamma Probe (dpeaa)DE-He213 Sentinel Lymph Node Mapping (dpeaa)DE-He213 Sentinel Lymph Node Detection (dpeaa)DE-He213 Schaafsma, Boudewijn E. verfasserin aut Verbeek, Floris P. R. verfasserin aut Hutteman, Merlijn verfasserin aut Mieog, J. Sven D. verfasserin aut Lowik, Clemens W. G. M. verfasserin aut Liefers, Gerrit-Jan verfasserin aut Frangioni, John V. verfasserin aut van de Velde, Cornelis J. H. verfasserin aut Vahrmeijer, Alexander L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 13 vom: 03. Juli, Seite 4104-4111 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 https://dx.doi.org/10.1245/s10434-012-2466-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 13 03 07 4104-4111 |
| allfields_unstemmed |
10.1245/s10434-012-2466-4 doi (DE-627)SPR009948295 (SPR)s10434-012-2466-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl van der Vorst, Joost R. verfasserin aut Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. Sentinel Lymph Node (dpeaa)DE-He213 Sentinel Lymph Node Biopsy (dpeaa)DE-He213 Gamma Probe (dpeaa)DE-He213 Sentinel Lymph Node Mapping (dpeaa)DE-He213 Sentinel Lymph Node Detection (dpeaa)DE-He213 Schaafsma, Boudewijn E. verfasserin aut Verbeek, Floris P. R. verfasserin aut Hutteman, Merlijn verfasserin aut Mieog, J. Sven D. verfasserin aut Lowik, Clemens W. G. M. verfasserin aut Liefers, Gerrit-Jan verfasserin aut Frangioni, John V. verfasserin aut van de Velde, Cornelis J. H. verfasserin aut Vahrmeijer, Alexander L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 13 vom: 03. Juli, Seite 4104-4111 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 https://dx.doi.org/10.1245/s10434-012-2466-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 13 03 07 4104-4111 |
| allfieldsGer |
10.1245/s10434-012-2466-4 doi (DE-627)SPR009948295 (SPR)s10434-012-2466-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl van der Vorst, Joost R. verfasserin aut Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. Sentinel Lymph Node (dpeaa)DE-He213 Sentinel Lymph Node Biopsy (dpeaa)DE-He213 Gamma Probe (dpeaa)DE-He213 Sentinel Lymph Node Mapping (dpeaa)DE-He213 Sentinel Lymph Node Detection (dpeaa)DE-He213 Schaafsma, Boudewijn E. verfasserin aut Verbeek, Floris P. R. verfasserin aut Hutteman, Merlijn verfasserin aut Mieog, J. Sven D. verfasserin aut Lowik, Clemens W. G. M. verfasserin aut Liefers, Gerrit-Jan verfasserin aut Frangioni, John V. verfasserin aut van de Velde, Cornelis J. H. verfasserin aut Vahrmeijer, Alexander L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 13 vom: 03. Juli, Seite 4104-4111 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 https://dx.doi.org/10.1245/s10434-012-2466-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 13 03 07 4104-4111 |
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10.1245/s10434-012-2466-4 doi (DE-627)SPR009948295 (SPR)s10434-012-2466-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl van der Vorst, Joost R. verfasserin aut Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. Sentinel Lymph Node (dpeaa)DE-He213 Sentinel Lymph Node Biopsy (dpeaa)DE-He213 Gamma Probe (dpeaa)DE-He213 Sentinel Lymph Node Mapping (dpeaa)DE-He213 Sentinel Lymph Node Detection (dpeaa)DE-He213 Schaafsma, Boudewijn E. verfasserin aut Verbeek, Floris P. R. verfasserin aut Hutteman, Merlijn verfasserin aut Mieog, J. Sven D. verfasserin aut Lowik, Clemens W. G. M. verfasserin aut Liefers, Gerrit-Jan verfasserin aut Frangioni, John V. verfasserin aut van de Velde, Cornelis J. H. verfasserin aut Vahrmeijer, Alexander L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 13 vom: 03. Juli, Seite 4104-4111 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 https://dx.doi.org/10.1245/s10434-012-2466-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 13 03 07 4104-4111 |
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Enthalten in Annals of surgical oncology 19(2012), 13 vom: 03. Juli, Seite 4104-4111 volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 |
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Enthalten in Annals of surgical oncology 19(2012), 13 vom: 03. Juli, Seite 4104-4111 volume:19 year:2012 number:13 day:03 month:07 pages:4104-4111 |
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Sentinel Lymph Node Sentinel Lymph Node Biopsy Gamma Probe Sentinel Lymph Node Mapping Sentinel Lymph Node Detection |
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van der Vorst, Joost R. @@aut@@ Schaafsma, Boudewijn E. @@aut@@ Verbeek, Floris P. R. @@aut@@ Hutteman, Merlijn @@aut@@ Mieog, J. Sven D. @@aut@@ Lowik, Clemens W. G. M. @@aut@@ Liefers, Gerrit-Jan @@aut@@ Frangioni, John V. @@aut@@ van de Velde, Cornelis J. H. @@aut@@ Vahrmeijer, Alexander L. @@aut@@ |
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2012-07-03T00:00:00Z |
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|
| author |
van der Vorst, Joost R. |
| spellingShingle |
van der Vorst, Joost R. ddc 610 bkl 44.81 bkl 44.65 misc Sentinel Lymph Node misc Sentinel Lymph Node Biopsy misc Gamma Probe misc Sentinel Lymph Node Mapping misc Sentinel Lymph Node Detection Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients |
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van der Vorst, Joost R. |
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1534-4681 |
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610 ASE 44.81 bkl 44.65 bkl Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients Sentinel Lymph Node (dpeaa)DE-He213 Sentinel Lymph Node Biopsy (dpeaa)DE-He213 Gamma Probe (dpeaa)DE-He213 Sentinel Lymph Node Mapping (dpeaa)DE-He213 Sentinel Lymph Node Detection (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.65 misc Sentinel Lymph Node misc Sentinel Lymph Node Biopsy misc Gamma Probe misc Sentinel Lymph Node Mapping misc Sentinel Lymph Node Detection |
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ddc 610 bkl 44.81 bkl 44.65 misc Sentinel Lymph Node misc Sentinel Lymph Node Biopsy misc Gamma Probe misc Sentinel Lymph Node Mapping misc Sentinel Lymph Node Detection |
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ddc 610 bkl 44.81 bkl 44.65 misc Sentinel Lymph Node misc Sentinel Lymph Node Biopsy misc Gamma Probe misc Sentinel Lymph Node Mapping misc Sentinel Lymph Node Detection |
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Annals of surgical oncology |
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Annals of surgical oncology |
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Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients |
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(DE-627)SPR009948295 (SPR)s10434-012-2466-4-e |
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Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients |
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van der Vorst, Joost R. |
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Annals of surgical oncology |
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Annals of surgical oncology |
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eng |
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2012 |
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4104 |
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van der Vorst, Joost R. Schaafsma, Boudewijn E. Verbeek, Floris P. R. Hutteman, Merlijn Mieog, J. Sven D. Lowik, Clemens W. G. M. Liefers, Gerrit-Jan Frangioni, John V. van de Velde, Cornelis J. H. Vahrmeijer, Alexander L. |
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Elektronische Aufsätze |
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van der Vorst, Joost R. |
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10.1245/s10434-012-2466-4 |
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610 |
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verfasserin |
| title_sort |
randomized comparison of near-infrared fluorescence imaging using indocyanine green and $ 99^{m} $ technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients |
| title_auth |
Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients |
| abstract |
Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. |
| abstractGer |
Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. |
| abstract_unstemmed |
Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using $ 99^{m} $ technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. Results SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. Conclusions This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and $ 99^{m} $ technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients. |
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13 |
| title_short |
Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and $ 99^{m} $ Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients |
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https://dx.doi.org/10.1245/s10434-012-2466-4 |
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Schaafsma, Boudewijn E. Verbeek, Floris P. R. Hutteman, Merlijn Mieog, J. Sven D. Lowik, Clemens W. G. M. Liefers, Gerrit-Jan Frangioni, John V. van de Velde, Cornelis J. H. Vahrmeijer, Alexander L. |
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Schaafsma, Boudewijn E. Verbeek, Floris P. R. Hutteman, Merlijn Mieog, J. Sven D. Lowik, Clemens W. G. M. Liefers, Gerrit-Jan Frangioni, John V. van de Velde, Cornelis J. H. Vahrmeijer, Alexander L. |
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10.1245/s10434-012-2466-4 |
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2024-07-04T03:38:02.675Z |
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| score |
7.401457 |